Alzheimer's disease and environmental exposure to lead: the epidemiologic evidence and potential role of epigenetics.

PubWeight™: 0.86‹?›

🔗 View Article (PMC 3567843)

Published in Curr Alzheimer Res on June 01, 2012

Authors

Kelly M Bakulski1, Laura S Rozek, Dana C Dolinoy, Henry L Paulson, Howard Hu

Author Affiliations

1: University of Michigan, School of Public Health, Department of Environmental Health Sciences, MI, USA.

Articles cited by this

(truncated to the top 100)

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology (1984) 119.59

Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol (2004) 21.56

Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol (2007) 18.62

Epigenetics in cancer. N Engl J Med (2008) 17.36

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet (2009) 14.86

Fetal and placental size and risk of hypertension in adult life. BMJ (1990) 12.43

Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet (1986) 12.13

Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med (2002) 11.20

Cellular differentiation, cytidine analogs and DNA methylation. Cell (1980) 10.15

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07

Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science (2005) 10.02

Active DNA demethylation: many roads lead to Rome. Nat Rev Mol Cell Biol (2010) 9.35

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23

Glucose tolerance in adults after prenatal exposure to famine. Lancet (1998) 8.87

The decline in blood lead levels in the United States. The National Health and Nutrition Examination Surveys (NHANES) JAMA (1994) 6.96

Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nat Med (2007) 6.80

Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry (2006) 6.68

Intra-individual change over time in DNA methylation with familial clustering. JAMA (2008) 6.17

Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Nat Genet (2004) 5.64

The role of apolipoprotein E in Alzheimer's disease. Neuron (2009) 5.55

Diagnosis-independent Alzheimer disease biomarker signature in cognitively normal elderly people. Arch Neurol (2010) 5.53

Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study. BMJ (2005) 5.34

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem (2004) 5.14

MR-based hippocampal volumetry in the diagnosis of Alzheimer's disease. Neurology (1992) 4.87

Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci (1997) 4.57

Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol (2001) 4.56

Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol (1998) 4.48

A diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. J Nucl Med (1995) 4.44

Evolution in health and medicine Sackler colloquium: Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease. Proc Natl Acad Sci U S A (2009) 4.40

Kinetic analysis of lead metabolism in healthy humans. J Clin Invest (1976) 4.12

Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. Lancet Neurol (2005) 3.95

The relationship of bone and blood lead to hypertension. The Normative Aging Study. JAMA (1996) 3.87

Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol (2002) 3.85

Epigenetic mechanisms in Alzheimer's disease. Neurobiol Aging (2011) 3.83

Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias. Neurology (2000) 3.61

Bone lead as a biological marker in epidemiologic studies of chronic toxicity: conceptual paradigms. Environ Health Perspect (1998) 3.51

Epigenetics and aging: the targets and the marks. Trends Genet (2007) 3.44

Diabetes mellitus and risk of Alzheimer's disease and dementia with stroke in a multiethnic cohort. Am J Epidemiol (2001) 3.43

DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One (2007) 3.30

Depressive symptoms and risk of dementia: the Framingham Heart Study. Neurology (2010) 3.27

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies. Lancet Neurol (2009) 3.05

Potential mechanisms of metabolic imprinting that lead to chronic disease. Am J Clin Nutr (1999) 2.98

Lead concentrations in human tissues. Br J Ind Med (1970) 2.96

Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet (2002) 2.90

Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects. Am J Hum Genet (2002) 2.73

Heritability for Alzheimer's disease: the study of dementia in Swedish twins. J Gerontol A Biol Sci Med Sci (1997) 2.59

Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. Chem Res Toxicol (2007) 2.59

Environmental lead exposure: a public health problem of global dimensions. Bull World Health Organ (2000) 2.51

DNA methylation in white blood cells: association with risk factors in epidemiologic studies. Epigenetics (2011) 2.51

Economic gains resulting from the reduction in children's exposure to lead in the United States. Environ Health Perspect (2002) 2.49

Epigenetic gene regulation: linking early developmental environment to adult disease. Reprod Toxicol (2006) 2.49

Lead and osteoporosis: mobilization of lead from bone in postmenopausal women. Environ Res (1988) 2.46

The developmental origins of chronic adult disease. Acta Paediatr Suppl (2004) 2.41

Lead in bone. IV. Distribution of lead in the human skeleton. Arch Environ Health (1988) 2.37

Toxicokinetics of bone lead. Environ Health Perspect (1991) 2.35

Age-varying association between statin use and incident Alzheimer's disease. J Am Geriatr Soc (2010) 2.34

Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation. PLoS One (2010) 2.26

Brain inflammation and Alzheimer's-like pathology in individuals exposed to severe air pollution. Toxicol Pathol (2004) 2.23

Past adult lead exposure is associated with longitudinal decline in cognitive function. Neurology (2000) 2.08

Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. FASEB J (2006) 2.07

Heavy smoking in midlife and long-term risk of Alzheimer disease and vascular dementia. Arch Intern Med (2010) 2.04

Developmental origins of health and disease: brief history of the approach and current focus on epigenetic mechanisms. Semin Reprod Med (2009) 2.03

Age-specific epigenetic drift in late-onset Alzheimer's disease. PLoS One (2008) 2.01

Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation. Exp Cell Res (2003) 1.99

Brain reserve hypothesis in dementia. J Alzheimers Dis (2007) 1.99

A critical review of biomarkers used for monitoring human exposure to lead: advantages, limitations, and future needs. Environ Health Perspect (2005) 1.99

Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. J Neurosci (2005) 1.99

Bone lead and blood lead levels in relation to baseline blood pressure and the prospective development of hypertension: the Normative Aging Study. Am J Epidemiol (2001) 1.97

Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead. Environ Health Perspect (2006) 1.94

Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies. Obes Rev (2011) 1.93

Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD. J Neurosci (2008) 1.92

The epidemiology of lead toxicity in adults: measuring dose and consideration of other methodologic issues. Environ Health Perspect (2006) 1.91

The role of epigenetics in aging and age-related diseases. Ageing Res Rev (2009) 1.89

Cumulative lead exposure and prospective change in cognition among elderly men: the VA Normative Aging Study. Am J Epidemiol (2004) 1.86

Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease. J Alzheimers Dis (2006) 1.82

Cellular and molecular toxicity of lead in bone. Environ Health Perspect (1991) 1.80

Early environmental origins of neurodegenerative disease in later life. Environ Health Perspect (2005) 1.80

Lead in bone: implications for toxicology during pregnancy and lactation. Environ Health Perspect (1991) 1.78

Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease. Neurology (2011) 1.77

Influence of prenatal lead exposure on genomic methylation of cord blood DNA. Environ Health Perspect (2009) 1.74

Early-life risk factors for Alzheimer disease. Alzheimer Dis Assoc Disord (2006) 1.73

The role of nutrition in Alzheimer's disease: epidemiological evidence. Eur J Neurol (2009) 1.71

APOE genotype effects on Alzheimer's disease onset and epidemiology. J Mol Neurosci (2004) 1.69

Lead neurotoxicity: from exposure to molecular effects. Brain Res Brain Res Rev (2005) 1.69

Timing is everything: the when and how of environmentally induced changes in the epigenome of animals. Epigenetics (2011) 1.67

Global approach to reducing lead exposure and poisoning. Mutat Res (2008) 1.66

Neurodegenerative diseases and exposure to pesticides in the elderly. Am J Epidemiol (2003) 1.65

Epigenetic changes in Alzheimer's disease: decrements in DNA methylation. Neurobiol Aging (2008) 1.60

Confounding of the relation between homocysteine and peripheral arterial disease by lead, cadmium, and renal function. Am J Epidemiol (2006) 1.59

Lead exposure and amyotrophic lateral sclerosis. Epidemiology (2002) 1.59

Epidemiological studies of the effect of stroke on incident dementia: a systematic review. Stroke (2009) 1.58

Community characteristics associated with elevated blood lead levels in children. Pediatrics (1998) 1.58

Biomarkers of lead exposure and DNA methylation within retrotransposons. Environ Health Perspect (2010) 1.58

Elevated blood lead in young children due to lead-contaminated drinking water: Washington, DC, 2001-2004. Environ Sci Technol (2009) 1.57

Carcinogen exposure and gene promoter hypermethylation in bladder cancer. Carcinogenesis (2005) 1.55

Lead levels among children who live in public housing. Epidemiology (2003) 1.55

A prospective study of bone lead concentration and death from all causes, cardiovascular diseases, and cancer in the Department of Veterans Affairs Normative Aging Study. Circulation (2009) 1.54

Relations of bone and blood lead to cognitive function: the VA Normative Aging Study. Neurotoxicol Teratol (1998) 1.50

Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. PLoS One (2009) 1.49

Articles by these authors

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 50.94

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet (2015) 7.99

siRNA-mediated gene silencing in vitro and in vivo. Nat Biotechnol (2002) 5.65

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model. Proc Natl Acad Sci U S A (2005) 4.79

Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet (2007) 4.69

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Nat Med (2004) 4.63

Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort. Am J Epidemiol (2008) 3.54

Recommendations for medical management of adult lead exposure. Environ Health Perspect (2006) 3.38

Exposure to bisphenol A and other phenols in neonatal intensive care unit premature infants. Environ Health Perspect (2008) 3.17

Allele-specific silencing of dominant disease genes. Proc Natl Acad Sci U S A (2003) 3.00

Maternal fish consumption, hair mercury, and infant cognition in a U.S. Cohort. Environ Health Perspect (2005) 2.99

CGG repeat-associated translation mediates neurodegeneration in fragile X tremor ataxia syndrome. Neuron (2013) 2.94

Plasminogen is a critical host pathogenicity factor for group A streptococcal infection. Science (2004) 2.91

Maternal methyl supplements increase offspring DNA methylation at Axin Fused. Genesis (2006) 2.70

Polyglutamine neurodegeneration: protein misfolding revisited. Trends Neurosci (2008) 2.63

Genetic variation in 8q24 associated with risk of colorectal cancer. Cancer Biol Ther (2007) 2.32

Associations of early childhood manganese and lead coexposure with neurodevelopment. Environ Health Perspect (2011) 2.31

RNA-mediated neurodegeneration in repeat expansion disorders. Ann Neurol (2010) 2.30

Accumulated lead exposure and risk of age-related cataract in men. JAMA (2004) 2.29

Longitudinal associations between blood lead concentrations lower than 10 microg/dL and neurobehavioral development in environmentally exposed children in Mexico City. Pediatrics (2006) 2.17

The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. J Biol Chem (2008) 2.09

Brain structure in preclinical Huntington's disease. Biol Psychiatry (2005) 2.05

Early autophagic response in a novel knock-in model of Huntington disease. Hum Mol Genet (2010) 1.99

Mapping for prevention: GIS models for directing childhood lead poisoning prevention programs. Environ Health Perspect (2002) 1.95

Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead. Environ Health Perspect (2006) 1.94

Outcome-dependent sampling: an efficient sampling and inference procedure for studies with a continuous outcome. Epidemiology (2007) 1.92

Maternal arsenic exposure and impaired glucose tolerance during pregnancy. Environ Health Perspect (2009) 1.91

The faroes statement: human health effects of developmental exposure to chemicals in our environment. Basic Clin Pharmacol Toxicol (2008) 1.91

Cumulative exposure to lead in relation to cognitive function in older women. Environ Health Perspect (2008) 1.87

Cumulative lead exposure and prospective change in cognition among elderly men: the VA Normative Aging Study. Am J Epidemiol (2004) 1.86

Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism. Mol Cell (2005) 1.84

Association between iron deficiency and blood lead level in a longitudinal analysis of children followed in an urban primary care clinic. J Pediatr (2003) 1.83

Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR). Hum Mutat (2008) 1.76

Influence of prenatal lead exposure on genomic methylation of cord blood DNA. Environ Health Perspect (2009) 1.74

Aberrant cellular behavior of mutant torsinA implicates nuclear envelope dysfunction in DYT1 dystonia. J Neurosci (2004) 1.71

Maternal bone lead as an independent risk factor for fetal neurotoxicity: a prospective study. Pediatrics (2002) 1.67

Timing is everything: the when and how of environmentally induced changes in the epigenome of animals. Epigenetics (2011) 1.67

Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. J Nutr Biochem (2012) 1.65

Urinary phthalate metabolites in relation to preterm birth in Mexico city. Environ Health Perspect (2009) 1.59

HFE genotype, particulate air pollution, and heart rate variability: a gene-environment interaction. Circulation (2006) 1.59

Lead exposure and amyotrophic lateral sclerosis. Epidemiology (2002) 1.59

Apolipoprotein E genotype predicts 24-month bayley scales infant development score. Pediatr Res (2003) 1.59

Biomarkers of lead exposure and DNA methylation within retrotransposons. Environ Health Perspect (2010) 1.58

Early postnatal blood manganese levels and children's neurodevelopment. Epidemiology (2010) 1.58

CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo. J Neurosci (2005) 1.57

A prospective study of bone lead concentration and death from all causes, cardiovascular diseases, and cancer in the Department of Veterans Affairs Normative Aging Study. Circulation (2009) 1.54

Silencing primary dystonia: lentiviral-mediated RNA interference therapy for DYT1 dystonia. J Neurosci (2005) 1.53

Spinocerebellar ataxias: an update. Curr Opin Neurol (2007) 1.48

Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis. Proc Natl Acad Sci U S A (2002) 1.48

Bone lead levels and blood pressure endpoints: a meta-analysis. Epidemiology (2008) 1.48

Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. Gastroenterology (2010) 1.46

Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3. J Neurosci (2011) 1.46

Cumulative lead exposure and cognitive performance among elderly men. Epidemiology (2007) 1.46

Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3. EMBO J (2009) 1.46

Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer. Cancer Prev Res (Phila) (2010) 1.45

Lead, diabetes, hypertension, and renal function: the normative aging study. Environ Health Perspect (2004) 1.45

Poly-ubiquitin binding by the polyglutamine disease protein ataxin-3 links its normal function to protein surveillance pathways. J Biol Chem (2003) 1.44

Maternal lead exposure and the secondary sex ratio. Hum Reprod (2006) 1.44

Lead exposure biomarkers and mini-mental status exam scores in older men. Epidemiology (2003) 1.44

Toward understanding Machado-Joseph disease. Prog Neurobiol (2011) 1.42

Bisphenol a exposure in Mexico City and risk of prematurity: a pilot nested case control study. Environ Health (2010) 1.42

Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration. Curr Opin Genet Dev (2003) 1.41

Impact of bone lead and bone resorption on plasma and whole blood lead levels during pregnancy. Am J Epidemiol (2004) 1.40

Maternal blood manganese levels and infant birth weight. Epidemiology (2009) 1.40

Effect of calcium supplementation on blood lead levels in pregnancy: a randomized placebo-controlled trial. Environ Health Perspect (2008) 1.37

Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP. Mol Cell (2011) 1.37

Defining the role of ubiquitin-interacting motifs in the polyglutamine disease protein, ataxin-3. J Biol Chem (2005) 1.34

Lead exposure and behavior among young children in Chennai, India. Environ Health Perspect (2009) 1.31

Effect of maternal bone lead on length and head circumference of newborns and 1-month-old infants. Arch Environ Health (2003) 1.30

Genome-wide methylation and expression differences in HPV(+) and HPV(-) squamous cell carcinoma cell lines are consistent with divergent mechanisms of carcinogenesis. Epigenetics (2011) 1.29

In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis. Neurobiol Dis (2008) 1.28

Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology (2003) 1.28

Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex. J Alzheimers Dis (2012) 1.27

Traffic-related particles are associated with elevated homocysteine: the VA normative aging study. Am J Respir Crit Care Med (2008) 1.27

Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles. Nucleic Acids Res (2004) 1.27

Epigenetic responses following maternal dietary exposure to physiologically relevant levels of bisphenol A. Environ Mol Mutagen (2012) 1.27

Use of di(2-ethylhexyl) phthalate-containing medical products and urinary levels of mono(2-ethylhexyl) phthalate in neonatal intensive care unit infants. Environ Health Perspect (2005) 1.27

The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer. Nat Genet (2004) 1.25

Stress as a potential modifier of the impact of lead levels on blood pressure: the normative aging study. Environ Health Perspect (2007) 1.23

Effect of breast milk lead on infant blood lead levels at 1 month of age. Environ Health Perspect (2004) 1.23

The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability. Hum Mol Genet (2010) 1.21

Molecular medicine for the brain: silencing of disease genes with RNA interference. Lancet Neurol (2004) 1.20

Adult lead exposure: time for change. Environ Health Perspect (2006) 1.20

Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration. Hum Mol Genet (2009) 1.18

Impacts of climate change on public health in India: future research directions. Environ Health Perspect (2011) 1.18

Obsessive and compulsive symptoms in prediagnosed Huntington's disease. J Clin Psychiatry (2008) 1.17

Balancing act: deubiquitinating enzymes in the nervous system. Trends Neurosci (2011) 1.17

Clinical characteristics of patients with spinocerebellar ataxias 1, 2, 3 and 6 in the US; a prospective observational study. Orphanet J Rare Dis (2013) 1.15

Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study. Environ Health Perspect (2004) 1.15

Correlates of bone and blood lead levels among middle-aged and elderly women. Am J Epidemiol (2002) 1.15

Cellular turnover of the polyglutamine disease protein ataxin-3 is regulated by its catalytic activity. J Biol Chem (2007) 1.14

A pilot study of blood lead levels and neurobehavioral function in children living in Chennai, India. Int J Occup Environ Health (2005) 1.14

Exposure to phthalates in neonatal intensive care unit infants: urinary concentrations of monoesters and oxidative metabolites. Environ Health Perspect (2006) 1.14

Multiple genome-wide analyses of smoking behavior in the Framingham Heart Study. BMC Genet (2003) 1.14

Variants in iron metabolism genes predict higher blood lead levels in young children. Environ Health Perspect (2008) 1.14