Published in PLoS Genet on January 19, 2012
The Rat Genome Database 2013--data, tools and users. Brief Bioinform (2013) 1.94
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development. J Immunol (2013) 1.19
Differential function of Themis CABIT domains during T cell development. PLoS One (2014) 0.86
Therapeutic approaches for celiac disease. Best Pract Res Clin Gastroenterol (2015) 0.81
Disrupted regulatory T cell homeostasis in inflammatory bowel diseases. World J Gastroenterol (2016) 0.78
Combining genetic mapping with genome-wide expression in experimental autoimmune encephalomyelitis highlights a gene network enriched for T cell functions and candidate genes regulating autoimmunity. Hum Mol Genet (2013) 0.77
Genome-wide association study of recalcitrant atopic dermatitis in Korean children. J Allergy Clin Immunol (2015) 0.77
Increased THEMIS First Exon Usage in CD4+ T-Cells Is Associated with a Genotype that Is Protective against Multiple Sclerosis. PLoS One (2016) 0.75
Proteomic analysis of regulatory T cells reveals the importance of Themis1 in the control of their suppressive function. Mol Cell Proteomics (2017) 0.75
An orthologous non-MHC locus in rats and mice is linked to CD4(+) and CD8(+) T-cell proportion. Genes Immun (2017) 0.75
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
R/qtl: QTL mapping in experimental crosses. Bioinformatics (2003) 22.38
Inflammatory bowel disease. N Engl J Med (2002) 21.17
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Inflammatory bowel disease. N Engl J Med (2009) 8.62
The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol (2008) 7.91
Multiple common variants for celiac disease influencing immune gene expression. Nat Genet (2010) 6.90
Gene-environment interactions in human diseases. Nat Rev Genet (2005) 5.93
Defective acute inflammation in Crohn's disease: a clinical investigation. Lancet (2006) 5.83
Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol (2009) 3.80
Autoimmune diseases: insights from genome-wide association studies. Hum Mol Genet (2008) 2.94
High prevalence of celiac disease among patients affected by Crohn's disease. Inflamm Bowel Dis (2005) 2.25
Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol (2009) 2.12
Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol (2009) 2.00
Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Nat Immunol (2009) 1.84
Prevalence of celiac disease in inflammatory bowel diseases: An IG-IBD multicentre study. Dig Liver Dis (2009) 1.82
LAT-mediated signaling in CD4+CD25+ regulatory T cell development. J Exp Med (2005) 1.65
Genome-wide association studies: a new window into immune-mediated diseases. Nat Rev Immunol (2008) 1.59
ENU mutagenesis, a way forward to understand gene function. Annu Rev Genomics Hum Genet (2008) 1.59
The genetics of autoimmune diseases: a networked perspective. Curr Opin Immunol (2009) 1.56
A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease. PLoS Genet (2011) 1.54
Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection. J Exp Med (2005) 1.49
T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. J Biol Chem (2010) 1.44
Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes. Proc Natl Acad Sci U S A (2009) 1.37
Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance. J Exp Med (2010) 1.32
The role of the LAT-PLC-gamma1 interaction in T regulatory cell function. J Immunol (2010) 1.14
The rat Toxo1 locus directs toxoplasmosis outcome and controls parasite proliferation and spreading by macrophage-dependent mechanisms. Proc Natl Acad Sci U S A (2006) 1.12
A deletion mutation of the protein tyrosine phosphatase kappa (Ptprk) gene is responsible for T-helper immunodeficiency (thid) in the LEC rat. Mamm Genome (2007) 1.12
Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase kappa gene in LEC rats. Genomics (2007) 0.91
Discovery genetics: serendipity in basic research. ILAR J (2005) 0.91
Inflammatory bowel disease and celiac disease: overlaps in the pathology and genetics, and their potential drug targets. Endocr Metab Immune Disord Drug Targets (2009) 0.89
Contiguous gene deletion of Ptprk and Themis causes T-helper immunodeficiency (thid) in the LEC rat. Biomed Res (2010) 0.87
Maturational arrest from CD4+8+ to CD4+8- thymocytes in a mutant strain (LEC) of rat. J Exp Med (1990) 0.86
Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat Genet (2009) 4.49
Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state. J Exp Med (2003) 4.39
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol (2009) 4.31
Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood (2008) 3.71
Myeloid-derived suppressor cells in inflammatory bowel disease: a new immunoregulatory pathway. Gastroenterology (2008) 2.56
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. J Neurosci (2004) 2.42
Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr Rev (2005) 2.42
BSE agent signatures in a goat. Vet Rec (2005) 2.35
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. J Physiol (2006) 2.34
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2. Am J Pathol (2002) 2.16
Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice. Proc Natl Acad Sci U S A (2002) 2.10
Role for protease activity in visceral pain in irritable bowel syndrome. J Clin Invest (2007) 2.09
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice. J Physiol (2006) 2.07
Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis. Blood (2004) 1.90
Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology (2011) 1.82
Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis. Sci Transl Med (2012) 1.73
Mutations in FAM111B cause hereditary fibrosing poikiloderma with tendon contracture, myopathy, and pulmonary fibrosis. Am J Hum Genet (2013) 1.70
Multigenic control of hepatic iron loading in a murine model of hemochromatosis. Gastroenterology (2004) 1.65
Autoimmune-mediated intestinal inflammation-impact and regulation of antigen-specific CD8+ T cells. Gastroenterology (2006) 1.62
Myelin/oligodendrocyte glycoprotein-deficient (MOG-deficient) mice reveal lack of immune tolerance to MOG in wild-type mice. J Clin Invest (2003) 1.59
Therapeutic potential of self-antigen-specific CD4+ CD25+ regulatory T cells selected in vitro from a polyclonal repertoire. Eur J Immunol (2006) 1.52
Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation. Blood (2004) 1.48
Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage. Proc Natl Acad Sci U S A (2006) 1.47
BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression. Blood (2009) 1.47
NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondii-infected monocytic cells. Infect Immun (2010) 1.46
A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis. Proc Natl Acad Sci U S A (2005) 1.45
V gamma 9V delta 2 T cell response to colon carcinoma cells. J Immunol (2005) 1.45
Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats. Gastroenterology (2002) 1.41
Real-time allele-specific amplification for sensitive detection of the BRAF mutation V600E. Mol Cell Probes (2004) 1.39
Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability. J Immunol (2003) 1.38
Sheep and goat BSE propagate more efficiently than cattle BSE in human PrP transgenic mice. PLoS Pathog (2011) 1.38
Similar biochemical signatures and prion protein genotypes in atypical scrapie and Nor98 cases, France and Norway. Emerg Infect Dis (2007) 1.33
Proteinase-activated receptor 1 activation induces epithelial apoptosis and increases intestinal permeability. Proc Natl Acad Sci U S A (2003) 1.32
Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling. Blood (2012) 1.32
Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms. Gastroenterology (2008) 1.31
Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice. J Immunol (2002) 1.31
Neutrophil-mediated activation of epithelial protease-activated receptors-1 and -2 regulates barrier function and transepithelial migration. J Immunol (2008) 1.26
Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice. Blood Cells Mol Dis (2004) 1.25
Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis. J Exp Med (2006) 1.25
Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia. J Biol Chem (2007) 1.23
Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains. Gastroenterology (2002) 1.23
CD40Ig treatment results in allograft acceptance mediated by CD8CD45RC T cells, IFN-gamma, and indoleamine 2,3-dioxygenase. J Clin Invest (2007) 1.23
Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo. FASEB J (2003) 1.22
Differential role of N-type calcium channel splice isoforms in pain. J Neurosci (2007) 1.22
Disturbed regulatory T cell homeostasis in multiple sclerosis. Trends Mol Med (2010) 1.21
Classic scrapie in sheep with the ARR/ARR prion genotype in Germany and France. Emerg Infect Dis (2007) 1.20
Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway. J Immunol (2009) 1.19
Cultured peripheral neuroglial cells are highly permissive to sheep prion infection. J Virol (2004) 1.19
Associated malformations in patients with limb reduction deficiencies. Eur J Med Genet (2010) 1.17
Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism. Can J Physiol Pharmacol (2003) 1.17
Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B. J Invest Dermatol (2005) 1.16
Effective and selective immune surveillance of the brain by MHC class I-restricted cytotoxic T lymphocytes. Eur J Immunol (2003) 1.16
PAR2 activation alters colonic paracellular permeability in mice via IFN-gamma-dependent and -independent pathways. J Physiol (2004) 1.15
Phenotypic and functional characterization of intrahepatic T lymphocytes during chronic hepatitis C. Hepatology (2003) 1.15
Visualizing the course of antigen-specific CD8 and CD4 T cell responses to a growing tumor. Eur J Immunol (2003) 1.14
The rat Toxo1 locus directs toxoplasmosis outcome and controls parasite proliferation and spreading by macrophage-dependent mechanisms. Proc Natl Acad Sci U S A (2006) 1.12
Proteinase-activated receptors in the nervous system. Nat Rev Neurosci (2003) 1.12
Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility. Brain (2011) 1.11
Development, plasticity and modulation of visceral afferents. Brain Res Rev (2008) 1.11
Chronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion protein. J Gen Virol (2012) 1.09
Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin. Hepatology (2013) 1.08
Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br J Pharmacol (2004) 1.08
Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs). Biol Chem (2006) 1.07
Protease-activated receptor-2 activation: a major role in the pathogenesis of Porphyromonas gingivalis infection. Am J Pathol (2006) 1.07
Familial Creutzfeldt-Jakob disease with an R208H-129V haplotype and Kuru plaques. Arch Neurol (2006) 1.05
Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis. J Immunol (2003) 1.05
Neonatal immune challenge alters nociception in the adult rat. Pain (2005) 1.05
Proteinase-activated receptor-2 induction by neuroinflammation prevents neuronal death during HIV infection. J Immunol (2005) 1.04
Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity. Gut (2010) 1.03
Haemonchus contortus (Nematoda: Trichostrongylidae) infection in lambs elicits an unequivocal Th2 immune response. Vet Res (2006) 1.03
Neutrophils and the kallikrein-kinin system in proteinase-activated receptor 4-mediated inflammation in rodents. Br J Pharmacol (2005) 1.03
Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli. Br J Pharmacol (2002) 1.03
Alloreactive CD4 T lymphocytes responsible for acute and chronic graft-versus-host disease are contained within the CD45RChigh but not the CD45RClow subset. Eur J Immunol (2004) 1.02
Orexins acting at native OX(1) receptor in colon cancer and neuroblastoma cells or at recombinant OX(1) receptor suppress cell growth by inducing apoptosis. J Biol Chem (2004) 1.02
Triggering of proteinase-activated receptor 4 leads to joint pain and inflammation in mice. Arthritis Rheum (2009) 1.01
Human regulatory T cells inhibit polarization of T helper cells toward antigen-presenting cells via a TGF-beta-dependent mechanism. Proc Natl Acad Sci U S A (2008) 1.00
Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor. Endocrinology (2006) 1.00
Expression of human TFF3 in relation to growth of HT-29 cell subpopulations: involvement of PI3-K but not STAT6. Differentiation (2005) 1.00
Unusual use of objects after unilateral brain damage: the technical reasoning model. Cortex (2008) 0.99
Omphalocele and gastroschisis and associated malformations. Am J Med Genet A (2008) 0.99
Brain-gut interactions increase peripheral nociceptive signaling in mice with postinfectious irritable bowel syndrome. Gastroenterology (2011) 0.99
Rapamycin inhibits growth and survival of D816V-mutated c-kit mast cells. Blood (2006) 0.99
Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis. Gastroenterology (2011) 0.99
The Th2 lymphoproliferation developing in LatY136F mutant mice triggers polyclonal B cell activation and systemic autoimmunity. J Immunol (2006) 0.99
Mechanisms behind the anti-inflammatory actions of insulin. Crit Rev Immunol (2011) 0.98
Use of denaturing HPLC and a heteroduplex generator to detect the HFE C282Y mutation associated with genetic hemochromatosis. Clin Chem (2003) 0.98
A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation. Blood (2013) 0.98
Iron overload induces BMP6 expression in the liver but not in the duodenum. Haematologica (2010) 0.97
Protective effect of proteinase-activated receptor 2 activation on motility impairment and tissue damage induced by intestinal ischemia/reperfusion in rodents. Am J Pathol (2006) 0.97
Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6. Blood (2010) 0.97
Engineering lactococci and lactobacilli for human health. Curr Opin Microbiol (2013) 0.96
Proteinase-mediated cell signalling: targeting proteinase-activated receptors (PARs) by kallikreins and more. Biol Chem (2006) 0.96