Published in J Immunol on February 03, 2010
Protein kinase C-η controls CTLA-4-mediated regulatory T cell function. Nat Immunol (2014) 1.76
Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub. Nat Immunol (2014) 1.07
The importance of LAT in the activation, homeostasis, and regulatory function of T cells. J Biol Chem (2010) 0.98
A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease. PLoS Genet (2012) 0.97
T cell receptor signalling in the control of regulatory T cell differentiation and function. Nat Rev Immunol (2016) 0.97
Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease. J Exp Med (2012) 0.90
SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex. Nat Immunol (2016) 0.90
The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation. Wiley Interdiscip Rev Syst Biol Med (2012) 0.88
Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes. Cell Signal (2014) 0.85
Protective and detrimental roles for regulatory T cells in a viral model for multiple sclerosis. Brain Pathol (2014) 0.85
Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression. PLoS One (2011) 0.83
The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity. J Immunol (2012) 0.79
The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis. J Immunol (2014) 0.79
Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1. Sci Transl Med (2016) 0.79
T cell receptor signaling that regulates the development of intrathymic natural regulatory T cells. Immune Netw (2011) 0.79
Disrupted regulatory T cell homeostasis in inflammatory bowel diseases. World J Gastroenterol (2016) 0.78
A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation, and autoimmunity. Immunol Res (2011) 0.78
Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance. J Immunol (2015) 0.77
Thwarting galectin-induced immunosuppression in breast cancer. Oncoimmunology (2013) 0.77
The requirement of linker for activation of T cells in the primary and memory responses of CD8 T cells. J Immunol (2013) 0.77
Glycerol Monolaurate (GML) inhibits human T cell signaling and function by disrupting lipid dynamics. Sci Rep (2016) 0.76
The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity. J Immunol (2015) 0.75
An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol (2003) 19.16
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An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med (1999) 10.67
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity (2008) 9.82
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol (2007) 6.94
T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity (2007) 6.61
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol (2008) 6.56
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CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med (2003) 6.00
Modulation of tryptophan catabolism by regulatory T cells. Nat Immunol (2003) 5.47
CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J Exp Med (2002) 4.56
TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med (2003) 4.40
Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science (2002) 4.02
Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol (2008) 3.98
Suppression of allergic airway inflammation by helminth-induced regulatory T cells. J Exp Med (2005) 3.63
CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells. Eur J Immunol (2000) 3.63
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity (1998) 3.36
Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. J Biol Chem (2000) 3.03
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A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science (2002) 2.35
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med (2009) 2.23
A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol (2005) 2.16
Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Immunity (2009) 2.13
Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol Cell Biol (2007) 2.05
Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science (2002) 2.01
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Calcium signaling in immune cells. Nat Immunol (2009) 1.97
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Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow. J Exp Med (2005) 1.86
Identification of the minimal tyrosine residues required for linker for activation of T cell function. J Biol Chem (2001) 1.81
Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression. Immunology (2006) 1.79
Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells. J Immunol (2008) 1.78
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Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development. J Immunol (2003) 1.50
Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection. J Exp Med (2005) 1.49
TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation. Eur J Immunol (2005) 1.46
Regulation of the inositol 1,4,5-trisphosphate receptor by tyrosine phosphorylation. Science (1996) 1.42
Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development. J Exp Med (2001) 1.25
Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. J Exp Med (1998) 1.20
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The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage. J Immunol (2009) 0.98
STAT6 deletion converts the Th2 inflammatory pathology afflicting Lat(Y136F) mice into a lymphoproliferative disorder involving Th1 and CD8 effector T cells. J Immunol (2009) 0.88
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The Arabidopsis CORONATINE INSENSITIVE1 protein is a jasmonate receptor. Plant Cell (2009) 3.31
Requirement for Abl kinases in T cell receptor signaling. Curr Biol (2004) 2.24
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Flagellin induces innate immunity in nonhost interactions that is suppressed by Pseudomonas syringae effectors. Proc Natl Acad Sci U S A (2005) 1.94
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Reactive oxygen species impair sympathetic vasoregulation in skeletal muscle in angiotensin II-dependent hypertension. Hypertension (2006) 1.82
Maspin functions as tumor suppressor by increasing cell adhesion to extracellular matrix in prostate tumor cells. J Urol (2003) 1.79
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Phase I study of sorafenib in patients with refractory or relapsed acute leukemias. Haematologica (2010) 1.65
S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites. Cancer Cell (2012) 1.64
LAB: a new membrane-associated adaptor molecule in B cell activation. Nat Immunol (2003) 1.58
The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes. Chromosoma (2005) 1.57
Molecular editing of cellular responses by the high-affinity receptor for IgE. Science (2014) 1.53
Distribution of lymphoid neoplasms in China: analysis of 4,638 cases according to the World Health Organization classification. Am J Clin Pathol (2012) 1.53
Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development. J Immunol (2003) 1.50
Megator, an essential coiled-coil protein that localizes to the putative spindle matrix during mitosis in Drosophila. Mol Biol Cell (2004) 1.47
Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. J Immunol (2007) 1.47
High-sensitivity C-reactive protein predicts target organ damage in Chinese patients with metabolic syndrome. Metabolism (2007) 1.45
Polytene chromosome squash methods for studying transcription and epigenetic chromatin modification in Drosophila using antibodies. Methods (2009) 1.45
Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. J Exp Med (2004) 1.44
Sympathetic nerves and the progression of chronic kidney disease during 5/6 nephrectomy: studies in sympathectomized rats. Clin Exp Pharmacol Physiol (2009) 1.42
Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc Natl Acad Sci U S A (2008) 1.38
Potential role of sorafenib in the treatment of acute myeloid leukemia. Leuk Lymphoma (2008) 1.35
Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia. Cancer Res (2006) 1.25
Anterior cruciate ligament reconstruction with LARS artificial ligament: a multicenter study with 3- to 5-year follow-up. Arthroscopy (2010) 1.20
Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling. J Biol Chem (2002) 1.19
A preliminary study of heavy metal contamination in Yangtze River intertidal zone due to urbanization. Mar Pollut Bull (2004) 1.19
An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. J Exp Med (2006) 1.15
Loss-of-function alleles of the JIL-1 kinase are strong suppressors of position effect variegation of the wm4 allele in Drosophila. Genetics (2006) 1.14
Negative regulation of lymphocyte activation by the adaptor protein LAX. J Immunol (2005) 1.13
Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding. J Immunol (2004) 1.12
Reduced levels of Su(var)3-9 but not Su(var)2-5 (HP1) counteract the effects on chromatin structure and viability in loss-of-function mutants of the JIL-1 histone H3S10 kinase. Genetics (2007) 1.11
Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1. J Nutr Biochem (2011) 1.11
Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells. Mol Cancer Ther (2006) 1.10
Cutting Edge: Localization of linker for activation of T cells to lipid rafts is not essential in T cell activation and development. J Immunol (2005) 1.09
The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB. J Biol Chem (2004) 1.08
Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression. J Immunol (2012) 1.08
Antihypertensive effects and mechanisms of chlorogenic acids. Hypertens Res (2011) 1.07
Sympathetic overactivity as a cause of hypertension in chronic renal failure. J Hypertens (2002) 1.07
Hepatitis Bx antigen stimulates expression of a novel cellular gene, URG4, that promotes hepatocellular growth and survival. Neoplasia (2002) 1.06
B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin. J Biol Chem (2009) 1.06
The chromodomain protein, Chromator, interacts with JIL-1 kinase and regulates the structure of Drosophila polytene chromosomes. J Cell Sci (2006) 1.04
Metal contamination in sediments of the western Bohai Bay and adjacent estuaries, China. J Environ Manage (2010) 1.02
Negative regulation of T cell activation and autoimmunity by the transmembrane adaptor protein LAB. Immunity (2006) 1.02
Palmitoylation-dependent plasma membrane transport but lipid raft-independent signaling by linker for activation of T cells. J Immunol (2009) 1.00
Extending the timescale and range of ecosystem services through paleoenvironmental analyses, exemplified in the lower Yangtze basin. Proc Natl Acad Sci U S A (2012) 1.00
The COOH-terminal domain of the JIL-1 histone H3S10 kinase interacts with histone H3 and is required for correct targeting to chromatin. J Biol Chem (2008) 0.99
JIL-1 kinase, a member of the male-specific lethal (MSL) complex, is necessary for proper dosage compensation of eye pigmentation in Drosophila. Genesis (2005) 0.99
Mediastinal solitary fibrous tumor with right diaphragm invasion: report of a case. Surg Today (2009) 0.99
Background progenitor activation is associated with recurrence after hepatectomy of combined hepatocellular-cholangiocarcinoma. Hepatology (2012) 0.98
The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage. J Immunol (2009) 0.98
The importance of LAT in the activation, homeostasis, and regulatory function of T cells. J Biol Chem (2010) 0.98
Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A (2013) 0.96
Fabrication and cell affinity of biomimetic structured PLGA/articular cartilage ECM composite scaffold. J Mater Sci Mater Med (2011) 0.96
Intrinsic gemcitabine resistance in a novel pancreatic cancer cell line is associated with cancer stem cell-like phenotype. Int J Oncol (2011) 0.96
Regulation of lymphocyte development and activation by the LAT family of adapter proteins. Immunol Rev (2009) 0.96
FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7. Oncotarget (2013) 0.96
Maspin mediates increased tumor cell apoptosis upon induction of the mitochondrial permeability transition. Mol Cell Biol (2005) 0.95
Mesenchymal Stem Cells Overexpressing IFN-β Inhibit Breast Cancer Growth and Metastases through Stat3 Signaling in a Syngeneic Tumor Model. Cancer Microenviron (2010) 0.95
Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion. Am J Physiol Endocrinol Metab (2002) 0.95
Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. Am Heart J (2011) 0.94
Human inhibitor of growth 1 inhibits hepatoma cell growth and influences p53 stability in a variant-dependent manner. Hepatology (2009) 0.94
Mutations in the C-terminus of the X protein of hepatitis B virus regulate Wnt-5a expression in hepatoma Huh7 cells: cDNA microarray and proteomic analyses. Carcinogenesis (2008) 0.94
Sex difference in cardiometabolic risk profile and adiponectin expression in subjects with visceral fat obesity. Transl Res (2009) 0.94
Heart rate, lifespan, and mortality risk. Ageing Res Rev (2008) 0.93
Prognostic significance of miR-34a and its target proteins of FOXP1, p53, and BCL2 in gastric MALT lymphoma and DLBCL. Gastric Cancer (2013) 0.93
The CXCR4 antagonist AMD3465 regulates oncogenic signaling and invasiveness in vitro and prevents breast cancer growth and metastasis in vivo. PLoS One (2013) 0.91
Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regeneration. Biotechnol Lett (2010) 0.91
An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion. EMBO J (2004) 0.90
The effects of insulin-like growth factor-1 and basic fibroblast growth factor on the proliferation of chondrocytes embedded in the collagen gel using an integrated microfluidic device. Tissue Eng Part C Methods (2010) 0.90
Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB. J Biol Chem (2009) 0.90
ShRNA-targeted centromere protein A inhibits hepatocellular carcinoma growth. PLoS One (2011) 0.89
Activation-induced endocytosis of the raft-associated transmembrane adaptor protein LAB/NTAL in B lymphocytes: evidence for a role in internalization of the B cell receptor. Int Immunol (2006) 0.89
Hepatitis B virus X protein mutants exhibit distinct biological activities in hepatoma Huh7 cells. Biochem Biophys Res Commun (2008) 0.89
L-NAME- and ADMA-induced sympathetic neural activation in conscious rats. Am J Physiol Regul Integr Comp Physiol (2005) 0.89
Maternal docosahexaenoic acid feeding protects against impairment of learning and memory and oxidative stress in prenatally stressed rats: possible role of neuronal mitochondria metabolism. Antioxid Redox Signal (2011) 0.89
Negative regulation of Fc epsilonRI-mediated signaling and mast cell function by the adaptor protein LAX. J Biol Chem (2006) 0.88
Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function. Blood (2013) 0.88
The role of Ras guanine nucleotide releasing protein 4 in Fc epsilonRI-mediated signaling, mast cell function, and T cell development. J Biol Chem (2012) 0.88
Role of LAT in the granule-mediated cytotoxicity of CD8 T cells. Mol Cell Biol (2012) 0.88
The JIL-1 kinase interacts with lamin Dm0 and regulates nuclear lamina morphology of Drosophila nurse cells. J Cell Sci (2005) 0.88
Mesenchymal stem cell and chondrocyte fates in a multishear microdevice are regulated by Yes-associated protein. Stem Cells Dev (2013) 0.87
Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation. Mol Cell Biol (2010) 0.87
Posterior short segment pedicle screw fixation and TLIF for the treatment of unstable thoracolumbar/lumbar fracture. BMC Musculoskelet Disord (2014) 0.86
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Solo or doppio: how many CENP-As make a centromeric nucleosome? Nat Struct Mol Biol (2013) 0.86
Adaptor proteins in lymphocyte activation. Curr Opin Immunol (2003) 0.86