Published in Lancet on February 25, 2006
Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*). Annu Rev Immunol (2009) 5.91
Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome. Lancet (2012) 5.16
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J Exp Med (2009) 3.58
Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J Clin Invest (2008) 2.88
Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nat Rev Genet (2013) 2.85
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J (2007) 2.72
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm Bowel Dis (2010) 1.84
Probiotics promote gut health through stimulation of epithelial innate immunity. Proc Natl Acad Sci U S A (2009) 1.61
Isotretinoin use and the risk of inflammatory bowel disease: a population-based cohort study. J Invest Dermatol (2012) 1.59
Revisiting Crohn's disease as a primary immunodeficiency of macrophages. J Exp Med (2009) 1.54
Mycobacterium avium subspecies paratuberculosis infection in cases of irritable bowel syndrome and comparison with Crohn's disease and Johne's disease: common neural and immune pathogenicities. J Clin Microbiol (2007) 1.54
Cd1d-dependent regulation of bacterial colonization in the intestine of mice. J Clin Invest (2009) 1.49
Toll-like receptors regulate B cell cytokine production in patients with diabetes. Diabetologia (2010) 1.48
The neutrophil respiratory burst and bacterial digestion in Crohn's disease. Dig Dis Sci (2010) 1.43
The immunopathogenesis of Crohn's disease: a three-stage model. Curr Opin Immunol (2009) 1.33
Adherent and invasive Escherichia coli is associated with granulomatous colitis in boxer dogs. Infect Immun (2006) 1.26
Inflammatory bowel disease: pathogenesis. World J Gastroenterol (2014) 1.26
The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation. Semin Immunopathol (2007) 1.21
Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes. J Exp Med (2013) 1.21
Is Crohn's disease due to defective immunity? Gut (2007) 1.21
Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model. Infect Immun (2010) 1.20
New insights into the dichotomous role of innate cytokines in gut homeostasis and inflammation. Cytokine (2012) 1.17
Autophagy in immunity: implications in etiology of autoimmune/autoinflammatory diseases. Autophagy (2012) 1.16
Innate immunity in inflammatory bowel disease. World J Gastroenterol (2007) 1.13
Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease. Gut (2007) 1.13
The role of bacteria in the pathogenesis of inflammatory bowel disease. Gut Liver (2010) 1.12
Crohn's disease patients homozygous for the 3020insC NOD2 mutation have a defective NOD2/TLR4 cross-tolerance to intestinal stimuli. Immunology (2007) 1.12
Crohn's disease: an immune deficiency state. Clin Rev Allergy Immunol (2010) 1.10
Innate immunity in inflammatory bowel disease: a disease hypothesis. J Pathol (2008) 1.08
Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger. Immunol Cell Biol (2011) 1.07
Impact of human granulocyte and monocyte isolation procedures on functional studies. Clin Vaccine Immunol (2012) 1.06
Hyperactivated B cells in human inflammatory bowel disease. J Leukoc Biol (2009) 1.03
Acute stress elicited by bungee jumping suppresses human innate immunity. Mol Med (2010) 1.03
X-linked inhibitor of apoptosis protein deficiency: more than an X-linked lymphoproliferative syndrome. J Clin Immunol (2015) 1.02
Impaired neutrophil chemotaxis in Crohn's disease relates to reduced production of chemokines and can be augmented by granulocyte-colony stimulating factor. Aliment Pharmacol Ther (2006) 1.02
Replication of Colonic Crohn's Disease Mucosal Escherichia coli Isolates within Macrophages and Their Susceptibility to Antibiotics. Antimicrob Agents Chemother (2007) 1.01
The role of Escherichia coli in inflammatory bowel disease. Gut (2007) 1.00
Defective tumor necrosis factor release from Crohn's disease macrophages in response to Toll-like receptor activation: relationship to phenotype and genome-wide association susceptibility loci. Inflamm Bowel Dis (2012) 0.98
A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease. PLoS Genet (2012) 0.97
Macrophage-related diseases of the gut: a pathologist's perspective. Virchows Arch (2012) 0.96
Linkage between Toll-like receptor (TLR) 2 promotor and intron polymorphisms: functional effects and relevance to sarcoidosis. Clin Exp Immunol (2007) 0.94
Development of ulcerative colitis in a patient with multiple sclerosis following treatment with interferon beta 1a. World J Gastroenterol (2007) 0.94
Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome. Int J Med Microbiol (2014) 0.93
Dysregulated NOD2 predisposes SAMP1/YitFc mice to chronic intestinal inflammation. Proc Natl Acad Sci U S A (2013) 0.91
Impaired macrophage function following bacterial stimulation in chronic granulomatous disease. Immunology (2009) 0.91
Crohn's disease as an immunodeficiency. Expert Rev Clin Immunol (2010) 0.89
Macrophages promote epithelial repair through hepatocyte growth factor secretion. Clin Exp Immunol (2013) 0.89
Use of atorvastatin as an anti-inflammatory treatment in Crohn's disease. Br J Pharmacol (2008) 0.89
Retinoic acid-induced gene-I (RIG-I) associates with nucleotide-binding oligomerization domain-2 (NOD2) to negatively regulate inflammatory signaling. J Biol Chem (2011) 0.89
The role of the innate immune system in granulomatous disorders. Front Immunol (2013) 0.89
The nucleotide synthesis enzyme CAD inhibits NOD2 antibacterial function in human intestinal epithelial cells. Gastroenterology (2012) 0.88
Synergy between intraepithelial lymphocytes and lamina propria T cells drives intestinal inflammation during infection. Mucosal Immunol (2011) 0.88
Association between the Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma 2 and inflammatory bowel disease: a meta-analysis. PLoS One (2012) 0.88
Inducible CYP2J2 and its product 11,12-EET promotes bacterial phagocytosis: a role for CYP2J2 deficiency in the pathogenesis of Crohn's disease? PLoS One (2013) 0.87
Peripheral monocyte functions and activation in patients with quiescent Crohn's disease. PLoS One (2013) 0.86
Diminished macrophage apoptosis and reactive oxygen species generation after phorbol ester stimulation in Crohn's disease. PLoS One (2009) 0.85
Crohn's disease: innate immunodeficiency? World J Gastroenterol (2006) 0.84
Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients. Immunology (2015) 0.84
Modified skin window technique for the extended characterisation of acute inflammation in humans. Inflamm Res (2007) 0.84
Peripheral neutrophil functions and cell signalling in Crohn`s disease. PLoS One (2013) 0.84
The effect of age on the gingival crevicular fluid composition during experimental gingivitis. A pilot study. Open Dent J (2010) 0.84
Pathway-based approaches to the treatment of inflammatory bowel disease. Transl Res (2015) 0.83
The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins. Hum Mol Genet (2015) 0.83
Delayed resolution of acute inflammation in ulcerative colitis is associated with elevated cytokine release downstream of TLR4. PLoS One (2010) 0.83
An exuberant inflammatory response to E coli: implications for the pathogenesis of ulcerative colitis and pyoderma gangrenosum. Gut (2006) 0.83
Characterisation of leukocytes in a human skin blister model of acute inflammation and resolution. PLoS One (2014) 0.83
Immunology of inflammatory bowel disease and molecular targets for biologics. Gastroenterol Clin North Am (2014) 0.82
Inflammatory bowel disease: An archetype disorder of outer environment sensor systems. World J Gastrointest Pharmacol Ther (2013) 0.82
If the treatment works, do we need to know why?: the promise of immunotherapy for experimental medicine. J Exp Med (2007) 0.82
Evidence for impaired CARD15 signalling in Crohn's disease without disease linked variants. PLoS One (2009) 0.82
A NOD for autophagy. Nat Med (2010) 0.82
Cigarette smoke extract (CSE) delays NOD2 expression and affects NOD2/RIPK2 interactions in intestinal epithelial cells. PLoS One (2011) 0.81
Human inflammatory bowel disease does not associate with Lawsonia intracellularis infection. BMC Microbiol (2006) 0.81
Gene expression analysis of peripheral cells for subclassification of pediatric inflammatory bowel disease in remission. PLoS One (2013) 0.80
Food derived bioactive peptides and intestinal barrier function. Int J Mol Sci (2014) 0.80
A novel crosstalk between TLR4- and NOD2-mediated signaling in the regulation of intestinal inflammation. Sci Rep (2015) 0.80
Defective acute inflammation in Crohn's disease. Lancet (2006) 0.79
Impaired peripheral Th1 CD4+ T cell response to Escherichia coli proteins in patients with Crohn's disease and ankylosing spondylitis. J Clin Immunol (2011) 0.79
Carbohydrate Elimination or Adaptation Diet for Symptoms of Intestinal Discomfort in IBD: Rationales for "Gibsons' Conundrum". Int J Inflam (2012) 0.79
Toll-like receptor-induced granulocyte-macrophage colony-stimulating factor secretion is impaired in Crohn's disease by nucleotide oligomerization domain 2-dependent and -independent pathways. Clin Exp Immunol (2008) 0.78
Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis. Dis Model Mech (2015) 0.78
Crohn's disease: bacterial clearance in Crohn's disease pathogenesis. Nat Rev Gastroenterol Hepatol (2010) 0.78
Impact of T300A Variant of ATG16L1 on Antibacterial Response, Risk of Culture Positive Infections, and Clinical Course of Crohn's Disease. Clin Transl Gastroenterol (2015) 0.78
Impotent immune system: an underlying problem in Crohn's disease. Gastroenterology (2007) 0.77
Inflammatory bowel diseases: when natural friends turn into enemies-the importance of CpG motifs of bacterial DNA in intestinal homeostasis and chronic intestinal inflammation. Int J Inflam (2010) 0.77
What is wrong with granulocytes in inflammatory bowel diseases? Dig Dis (2013) 0.77
Role of defective autophagia and the intestinal flora in Crohn disease. Self Nonself (2012) 0.77
Recent advances in basic and clinical aspects of inflammatory bowel disease: which steps in the mucosal inflammation should we block for the treatment of inflammatory bowel disease? World J Gastroenterol (2007) 0.77
Species-specific engagement of human nucleotide oligomerization domain 2 (NOD)2 and Toll-like receptor (TLR) signalling upon intracellular bacterial infection: role of Crohn's associated NOD2 gene variants. Clin Exp Immunol (2015) 0.77
Crohn's disease-associated Escherichia coli survive in macrophages by suppressing NFκB signaling. Inflamm Bowel Dis (2014) 0.76
New treatment options in the management of IBD - focus on colony stimulating factors. Biologics (2008) 0.76
Association of Interleukin-23 receptor gene polymorphisms with susceptibility to Crohn's disease: A meta-analysis. Sci Rep (2015) 0.76
Functional defects in NOD2 signaling in experimental and human Crohn disease. Gut Microbes (2014) 0.76
Innate immunity and adaptive immunity in Crohn's disease. Ann Transl Med (2015) 0.76
Treatment of Crohn's disease with colony-stimulating factors: An overview. Ther Clin Risk Manag (2008) 0.76
Site-Specific Immunomodulator: A Novel Treatment for Crohn's Disease. Gastroenterol Res Pract (2015) 0.76
Killing of Escherichia coli by Crohn's Disease Monocyte-derived Macrophages and Its Enhancement by Hydroxychloroquine and Vitamin D. Inflamm Bowel Dis (2015) 0.75
The Dual Role of Neutrophils in Inflammatory Bowel Diseases. J Clin Med (2016) 0.75
Granulocyte Macrophage Colony-Stimulating Factor-Activated CD39(+)/CD73(+) Murine Monocytes Modulate Intestinal Inflammation via Induction of Regulatory T Cells. Cell Mol Gastroenterol Hepatol (2015) 0.75
Linkage between genotype and immunological phenotype in Crohn's disease. Ann Transl Med (2015) 0.75
ChEMBL: a large-scale bioactivity database for drug discovery. Nucleic Acids Res (2011) 14.51
How many drug targets are there? Nat Rev Drug Discov (2006) 14.22
Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature (2002) 7.53
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med (2009) 7.53
The genome of the blood fluke Schistosoma mansoni. Nature (2009) 5.94
Guidelines for the management of inflammatory bowel disease in adults. Gut (2011) 5.42
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (2008) 3.99
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J Exp Med (2009) 3.58
Genomic-scale prioritization of drug targets: the TDR Targets database. Nat Rev Drug Discov (2008) 2.58
The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems. Biochim Biophys Acta (2004) 2.39
Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission. Cancer Res (2003) 2.24
Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase. Arterioscler Thromb Vasc Biol (2003) 2.19
Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice. J Hepatol (2010) 2.18
The β-adrenoceptor agonist isoproterenol rescues acetaminophen-injured livers through increasing progenitor numbers by Wnt in mice. Hepatology (2014) 2.03
Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure. Am J Physiol Regul Integr Comp Physiol (2003) 1.95
Retracted The large-conductance Ca2+-activated K+ channel is essential for innate immunity. Nature (2004) 1.85
Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett's esophagus. Nat Med (2012) 1.83
The use of immunoglobulin g4 immunostaining in diagnosing pancreatic and extrapancreatic involvement in autoimmune pancreatitis. Clin Gastroenterol Hepatol (2007) 1.83
Radiofrequency ablation and endoscopic mucosal resection for dysplastic barrett's esophagus and early esophageal adenocarcinoma: outcomes of the UK National Halo RFA Registry. Gastroenterology (2013) 1.77
Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor. Gut (2011) 1.77
Autoimmune pancreatitis: clinical and radiological features and objective response to steroid therapy in a UK series. Am J Gastroenterol (2007) 1.75
Presentation and management of post-treatment relapse in autoimmune pancreatitis/immunoglobulin G4-associated cholangitis. Clin Gastroenterol Hepatol (2009) 1.70
Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori gastritis. Gastroenterology (2002) 1.63
Inflammatory bowel disease in CGD reproduces the clinicopathological features of Crohn's disease. Am J Gastroenterol (2009) 1.62
AtERF14, a member of the ERF family of transcription factors, plays a nonredundant role in plant defense. Plant Physiol (2006) 1.54
Are Helicobacter species and enterotoxigenic Bacteroides fragilis involved in inflammatory bowel disease? Dig Dis Sci (2004) 1.51
Giant cell (temporal) arteritis: an overview and update. Surv Ophthalmol (2005) 1.51
A HIF-regulated VHL-PTP1B-Src signaling axis identifies a therapeutic target in renal cell carcinoma. Sci Transl Med (2011) 1.48
Minimum information about a bioactive entity (MIABE). Nat Rev Drug Discov (2011) 1.44
The neutrophil respiratory burst and bacterial digestion in Crohn's disease. Dig Dis Sci (2010) 1.43
Could NICE guidance on the choice of blood pressure lowering drugs be simplified? BMJ (2012) 1.41
canSAR: an integrated cancer public translational research and drug discovery resource. Nucleic Acids Res (2011) 1.41
Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers. Proc Natl Acad Sci U S A (2010) 1.41
Non-perforating small bowel Crohn's disease assessed by MRI enterography: derivation and histopathological validation of an MR-based activity index. Eur J Radiol (2011) 1.35
Objective assessment of cancer genes for drug discovery. Nat Rev Drug Discov (2013) 1.34
The immunopathogenesis of Crohn's disease: a three-stage model. Curr Opin Immunol (2009) 1.33
Phagocyte dysfunction and inflammatory bowel disease. Inflamm Bowel Dis (2008) 1.29
Ym1 is a neutrophil granule protein that crystallizes in p47phox-deficient mice. J Biol Chem (2001) 1.28
Effective function annotation through catalytic residue conservation. Proc Natl Acad Sci U S A (2005) 1.28
Lipid rafts determine efficiency of NADPH oxidase activation in neutrophils. FEBS Lett (2003) 1.28
Mural inflammation in Crohn disease: location-matched histologic validation of MR imaging features. Radiology (2009) 1.22
Reassessment of the microbicidal activity of reactive oxygen species and hypochlorous acid with reference to the phagocytic vacuole of the neutrophil granulocyte. J Med Microbiol (2003) 1.15
canSAR: updated cancer research and drug discovery knowledgebase. Nucleic Acids Res (2013) 1.15
Catalase negative Staphylococcus aureus retain virulence in mouse model of chronic granulomatous disease. FEBS Lett (2002) 1.13
Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis. Am J Pathol (2007) 1.13
Maternal obesity programs offspring nonalcoholic fatty liver disease by innate immune dysfunction in mice. Hepatology (2013) 1.13
Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations. Am J Gastroenterol (2013) 1.12
The complement of enzymatic sets in different species. J Mol Biol (2005) 1.10
Crohn's disease: an immune deficiency state. Clin Rev Allergy Immunol (2010) 1.10
Different susceptibilities of PECAM-deficient mouse strains to spontaneous idiopathic pneumonitis. Exp Mol Pathol (2006) 1.09
Use of multivariate analysis to suggest a new molecular classification of colorectal cancer. J Pathol (2013) 1.09
G6PC3 mutations are associated with a major defect of glycosylation: a novel mechanism for neutrophil dysfunction. Glycobiology (2011) 1.08
Survival after radiofrequency ablation in 122 patients with inoperable colorectal lung metastases. Cardiovasc Intervent Radiol (2012) 1.05
C-terminal SRC kinase controls acute inflammation and granulocyte adhesion. Immunity (2004) 1.03
Evaluation of Crohn's disease activity: initial validation of a magnetic resonance enterography global score (MEGS) against faecal calprotectin. Eur Radiol (2013) 1.03
Mural Crohn disease: correlation of dynamic contrast-enhanced MR imaging findings with angiogenesis and inflammation at histologic examination--pilot study. Radiology (2009) 1.02
Oral bisphosphonates and risk of atrial fibrillation and flutter in women: a self-controlled case-series safety analysis. PLoS One (2009) 1.01
Quantified terminal ileal motility during MR enterography as a potential biomarker of Crohn's disease activity: a preliminary study. Eur Radiol (2012) 1.01
Post-marketing assessment of the safety of strontium ranelate; a novel case-only approach to the early detection of adverse drug reactions. Br J Clin Pharmacol (2008) 1.01
Sequence, structure and energetic determinants of phosphopeptide selectivity of SH2 domains. J Mol Biol (2003) 1.01
Obstetric and gynecologic complications in women with Marfan syndrome. J Reprod Med (2003) 0.99
SCOPEC: a database of protein catalytic domains. Bioinformatics (2004) 0.98
Remote ischemic conditioning: from experimental observation to clinical application: report from the 8th Biennial Hatter Cardiovascular Institute Workshop. Basic Res Cardiol (2014) 0.98
Defective tumor necrosis factor release from Crohn's disease macrophages in response to Toll-like receptor activation: relationship to phenotype and genome-wide association susceptibility loci. Inflamm Bowel Dis (2012) 0.98
Ligand efficiency indices for an effective mapping of chemico-biological space: the concept of an atlas-like representation. Drug Discov Today (2010) 0.97
Photodynamic therapy using verteporfin photosensitization in the pancreas and surrounding tissues in the Syrian golden hamster. Pancreatology (2007) 0.96
NO contributes to EDHF-like responses in rat small arteries: a role for NO stores. Cardiovasc Res (2003) 0.96
Drugging cancer genomes. Nat Rev Drug Discov (2013) 0.96
Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN. Oncotarget (2012) 0.94
Collation and data-mining of literature bioactivity data for drug discovery. Biochem Soc Trans (2011) 0.94
PX domain takes shape. Curr Opin Hematol (2003) 0.91
Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncology. Curr Opin Pharmacol (2013) 0.91
Impaired macrophage function following bacterial stimulation in chronic granulomatous disease. Immunology (2009) 0.91
Validation of novel optical imaging technologies: the pathologists' view. J Biomed Opt (2007) 0.90
Crohn's disease as an immunodeficiency. Expert Rev Clin Immunol (2010) 0.89
Radiofrequency ablation for early oesophageal squamous neoplasia: outcomes form United Kingdom registry. World J Gastroenterol (2013) 0.89
Phenotypic heterogeneity and evidence of a founder effect associated with G6PC3 mutations in patients with severe congenital neutropenia. Br J Haematol (2012) 0.89
An individual with Muir-Torre syndrome found to have a pathogenic MSH6 gene mutation. Fam Cancer (2007) 0.88
Granulocyte function in grancalcin-deficient mice. Mol Cell Biol (2003) 0.88
Maternal obesity programmes offspring development of non-alcoholic fatty pancreas disease. Biochem Biophys Res Commun (2010) 0.88
Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition. Int J Biochem Cell Biol (2012) 0.88
Unusual presentation of Lynch Syndrome. Hered Cancer Clin Pract (2009) 0.87
Subproteome analysis of the neutrophil cytoskeleton. Proteomics (2009) 0.87
Characterization of the timing and prevalence of receptor tyrosine kinase expression changes in oesophageal carcinogenesis. J Pathol (2013) 0.86
Increased gene and protein expression of the novel eNOS regulatory protein NOSTRIN and a variant in alcoholic hepatitis. Gastroenterology (2006) 0.86
Diminished macrophage apoptosis and reactive oxygen species generation after phorbol ester stimulation in Crohn's disease. PLoS One (2009) 0.85