Published in J Am Med Inform Assoc on January 25, 2012
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review. Pharmacol Ther (2013) 2.64
The discriminatory cost of ICD-10-CM transition between clinical specialties: metrics, case study, and mitigating tools. J Am Med Inform Assoc (2013) 1.35
Defining a comprehensive verotype using electronic health records for personalized medicine. J Am Med Inform Assoc (2013) 1.13
Concordance of deregulated mechanisms unveiled in underpowered experiments: PTBP1 knockdown case study. BMC Med Genomics (2014) 0.98
'N-of-1-pathways' unveils personal deregulated mechanisms from a single pair of RNA-Seq samples: towards precision medicine. J Am Med Inform Assoc (2014) 0.96
Disease risk factors identified through shared genetic architecture and electronic medical records. Sci Transl Med (2014) 0.94
Translating Mendelian and complex inheritance of Alzheimer's disease genes for predicting unique personal genome variants. J Am Med Inform Assoc (2012) 0.93
Comparative analysis of a novel disease phenotype network based on clinical manifestations. J Biomed Inform (2014) 0.88
SNP-SNP interaction network in angiogenesis genes associated with prostate cancer aggressiveness. PLoS One (2013) 0.88
Using the bipartite human phenotype network to reveal pleiotropy and epistasis beyond the gene. Pac Symp Biocomput (2014) 0.83
The multiscale backbone of the human phenotype network based on biological pathways. BioData Min (2014) 0.83
Network-based prediction and knowledge mining of disease genes. BMC Med Genomics (2015) 0.82
Towards a PBMC "virogram assay" for precision medicine: Concordance between ex vivo and in vivo viral infection transcriptomes. J Biomed Inform (2015) 0.82
Dynamic changes of RNA-sequencing expression for precision medicine: N-of-1-pathways Mahalanobis distance within pathways of single subjects predicts breast cancer survival. Bioinformatics (2015) 0.79
Integrative genomics analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions. NPJ Genom Med (2016) 0.78
eQTL networks unveil enriched mRNA master integrators downstream of complex disease-associated SNPs. J Biomed Inform (2015) 0.77
Genome-wide genetic interaction analysis of glaucoma using expert knowledge derived from human phenotype networks. Pac Symp Biocomput (2015) 0.76
kMEn: Analyzing noisy and bidirectional transcriptional pathway responses in single subjects. J Biomed Inform (2016) 0.75
AN INTEGRATED NETWORK APPROACH TO IDENTIFYING BIOLOGICAL PATHWAYS AND ENVIRONMENTAL EXPOSURE INTERACTIONS IN COMPLEX DISEASES. Pac Symp Biocomput (2016) 0.75
COPD Hospitalization Risk Increased with Distinct Patterns of Multiple Systems Comorbidities Unveiled by Network Modeling. AMIA Annu Symp Proc (2014) 0.75
Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet (2000) 336.52
dbSNP: the NCBI database of genetic variation. Nucleic Acids Res (2001) 76.97
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science (2007) 43.16
A census of human cancer genes. Nat Rev Cancer (2004) 36.20
STRING 8--a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res (2008) 20.62
The human disease network. Proc Natl Acad Sci U S A (2007) 19.58
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature (2005) 18.43
Drug-target network. Nat Biotechnol (2007) 11.15
A human phenome-interactome network of protein complexes implicated in genetic disorders. Nat Biotechnol (2007) 9.90
Mendelian Inheritance in Man and its online version, OMIM. Am J Hum Genet (2007) 9.61
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet (2009) 6.39
Creation and implications of a phenome-genome network. Nat Biotechnol (2006) 5.79
Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci Transl Med (2011) 5.77
Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease. Sci Transl Med (2011) 5.30
Semantic similarity in biomedical ontologies. PLoS Comput Biol (2009) 5.05
Human disease classification in the postgenomic era: a complex systems approach to human pathobiology. Mol Syst Biol (2007) 5.02
Edgetic perturbation models of human inherited disorders. Mol Syst Biol (2009) 3.96
Exploiting indirect neighbours and topological weight to predict protein function from protein-protein interactions. Bioinformatics (2006) 3.94
Network medicine--from obesity to the "diseasome". N Engl J Med (2007) 3.83
A dynamic network approach for the study of human phenotypes. PLoS Comput Biol (2009) 3.62
The implications of human metabolic network topology for disease comorbidity. Proc Natl Acad Sci U S A (2008) 3.41
Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets. PLoS Comput Biol (2010) 3.23
Assessment of prediction accuracy of protein function from protein--protein interaction data. Yeast (2001) 2.90
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. Nat Genet (2009) 2.85
The impact of cellular networks on disease comorbidity. Mol Syst Biol (2009) 2.23
Information theory applied to the sparse gene ontology annotation network to predict novel gene function. Bioinformatics (2007) 2.15
A compendium of genome-wide associations for cancer: critical synopsis and reappraisal. J Natl Cancer Inst (2010) 2.00
Autoimmune disease classification by inverse association with SNP alleles. PLoS Genet (2009) 1.96
Generating genome-scale candidate gene lists for pharmacogenomics. Clin Pharmacol Ther (2009) 1.66
MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness. FASEB J (2009) 1.51
Network properties of complex human disease genes identified through genome-wide association studies. PLoS One (2009) 1.42
Discovery of protein interaction networks shared by diseases. Pac Symp Biocomput (2007) 1.30
A genome-wide analysis identifies genetic variants in the RELN gene associated with otosclerosis. Am J Hum Genet (2009) 1.11
The emergence of genome-based drug repositioning. Sci Transl Med (2011) 1.07
Involvement of T-cell receptor-beta alterations in the development of otosclerosis linked to OTSC2. Genes Immun (2010) 0.79
Stem cell factor and chronic myeloid leukemia CD34+ cells. Leuk Lymphoma (2000) 0.77
Isolation and culture of rat and mouse oligodendrocyte precursor cells. Nat Protoc (2007) 2.46
A broad-spectrum antiviral targeting entry of enveloped viruses. Proc Natl Acad Sci U S A (2010) 2.41
Translational bioinformatics: linking knowledge across biological and clinical realms. J Am Med Inform Assoc (2011) 2.36
Information theory applied to the sparse gene ontology annotation network to predict novel gene function. Bioinformatics (2007) 2.15
Sex without disclosure of positive HIV serostatus in a US probability sample of persons receiving medical care for HIV infection. Am J Public Health (2003) 2.14
ECgene: genome annotation for alternative splicing. Nucleic Acids Res (2005) 2.06
Overexpression of Bmi-1 oncoprotein correlates with axillary lymph node metastases in invasive ductal breast cancer. Breast (2004) 2.01
Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis. PLoS Comput Biol (2010) 1.92
Use of consomic rats for genomic insights into ventilator-associated lung injury. Am J Physiol Lung Cell Mol Physiol (2007) 1.86
Information Visualization Techniques in Bioinformatics during the Postgenomic Era. Drug Discov Today Biosilico (2004) 1.85
Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G(alpha)i proteins and enhances engraftment of competitive, repopulating stem cells. J Leukoc Biol (2003) 1.80
The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nat Neurosci (2009) 1.60
Fifty-year trends in serial body mass index during adolescence in girls: the Fels Longitudinal Study. Am J Clin Nutr (2004) 1.51
Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation. J Neurosci (2004) 1.45
MicroRNA expression characterizes oligometastasis(es). PLoS One (2011) 1.45
Glutathione peroxidase-catalase cooperativity is required for resistance to hydrogen peroxide by mature rat oligodendrocytes. J Neurosci (2004) 1.42
P21waf-1-Chk1 pathway monitors G1 phase microtubule integrity and is crucial for restriction point transition. Cell Cycle (2002) 1.40
Essential role of pre-B-cell colony enhancing factor in ventilator-induced lung injury. Am J Respir Crit Care Med (2008) 1.38
Mining OMIM for insight into complex diseases. Stud Health Technol Inform (2004) 1.37
The discriminatory cost of ICD-10-CM transition between clinical specialties: metrics, case study, and mitigating tools. J Am Med Inform Assoc (2013) 1.35
Novel transcriptional regulation of the schlafen-2 gene in macrophages in response to TLR-triggered stimulation. Mol Immunol (2007) 1.32
Exprtarget: an integrative approach to predicting human microRNA targets. PLoS One (2010) 1.31
Discovery of protein interaction networks shared by diseases. Pac Symp Biocomput (2007) 1.30
Protein interaction network underpins concordant prognosis among heterogeneous breast cancer signatures. J Biomed Inform (2010) 1.28
Ribose 2'-O methylation of the vesicular stomatitis virus mRNA cap precedes and facilitates subsequent guanine-N-7 methylation by the large polymerase protein. J Virol (2009) 1.27
Willingness to use instant home HIV tests: data from the California Behavioral Risk Factor Surveillance Survey. Am J Prev Med (2003) 1.26
Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains. PLoS Comput Biol (2007) 1.26
Variants affecting exon skipping contribute to complex traits. PLoS Genet (2012) 1.24
Kinase inhibition-related adverse events predicted from in vitro kinome and clinical trial data. J Biomed Inform (2010) 1.24
Microfluidic compartmentalized co-culture platform for CNS axon myelination research. Biomed Microdevices (2009) 1.20
Generating executable knowledge for evidence-based medicine using natural language and semantic processing. AMIA Annu Symp Proc (2006) 1.20
Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury. Am J Respir Cell Mol Biol (2010) 1.19
An oligosaccharide at the C-terminus of the F-specific domain in the stalk of the human parainfluenza virus 3 hemagglutinin-neuraminidase modulates fusion. Virus Res (2004) 1.19
Single sample expression-anchored mechanisms predict survival in head and neck cancer. PLoS Comput Biol (2012) 1.16
Integration of curated databases to identify genotype-phenotype associations. BMC Genomics (2006) 1.15
Putting data integration into practice: using biomedical terminologies to add structure to existing data sources. AMIA Annu Symp Proc (2003) 1.14
Extended attributes of event monitor systems for criteria-based notification modalities. Proc AMIA Symp (2002) 1.14
Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension. Physiol Genomics (2008) 1.14
Inactivation of a human norovirus surrogate by high-pressure processing: effectiveness, mechanism, and potential application in the fresh produce industry. Appl Environ Microbiol (2010) 1.13
Basic fibroblast growth factor activates ERK and induces c-fos in human embryonic stem cell line MizhES1. Stem Cells Dev (2005) 1.12
Protein-network modeling of prostate cancer gene signatures reveals essential pathways in disease recurrence. J Am Med Inform Assoc (2011) 1.12
Nitric oxide-induced cell death in developing oligodendrocytes is associated with mitochondrial dysfunction and apoptosis-inducing factor translocation. Eur J Neurosci (2004) 1.12
An integrative genomic approach to uncover molecular mechanisms of prokaryotic traits. PLoS Comput Biol (2006) 1.12
Synthesis and crystal structures of multidimensional coordination polymers based on W/Cu/S clusters with flexible imidazole ligands. Inorg Chem (2006) 1.11
12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes. Eur J Neurosci (2004) 1.11
Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2. J Biol Chem (2003) 1.11
Detection of practice pattern trends through Natural Language Processing of clinical narratives and biomedical literature. AMIA Annu Symp Proc (2007) 1.10
Murine lung responses to ambient particulate matter: genomic analysis and influence on airway hyperresponsiveness. Environ Health Perspect (2008) 1.09
Genestrace: phenomic knowledge discovery via structured terminology. Pac Symp Biocomput (2005) 1.09
Inactivation of a human norovirus surrogate, human norovirus virus-like particles, and vesicular stomatitis virus by gamma irradiation. Appl Environ Microbiol (2011) 1.09
A microchip for quantitative analysis of CNS axon growth under localized biomolecular treatments. J Neurosci Methods (2013) 1.08
School-based obesity screening in rural Appalachia. Prev Med (2003) 1.08
Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication. Neurosci Res (2011) 1.07
The emergence of genome-based drug repositioning. Sci Transl Med (2011) 1.07
Topological analysis of large-scale biomedical terminology structures. J Am Med Inform Assoc (2007) 1.06
ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function. BMC Biol (2010) 1.06
GADD45a is a novel candidate gene in inflammatory lung injury via influences on Akt signaling. FASEB J (2009) 1.06
Identifying clinically disruptive International Classification of Diseases 10th Revision Clinical Modification conversions to mitigate financial costs using an online tool. J Oncol Pract (2014) 1.05
ECgene: an alternative splicing database update. Nucleic Acids Res (2006) 1.05
Enhancement of NF-kappaB expression and activity upon differentiation of human embryonic stem cell line SNUhES3. Stem Cells Dev (2007) 1.04
GO-Module: functional synthesis and improved interpretation of Gene Ontology patterns. Bioinformatics (2011) 1.02
Chronic intestinal inflammation induces stress-response genes in commensal Escherichia coli. Gastroenterology (2011) 1.02
Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia. Cell Death Dis (2013) 1.01
PhenoGO: an integrated resource for the multiscale mining of clinical and biological data. BMC Bioinformatics (2009) 1.01
NF-kappaB-dependent regulation of matrix metalloproteinase-9 gene expression by lipopolysaccharide in a macrophage cell line RAW 264.7. J Biochem Mol Biol (2007) 1.01
Web-based tailoring and its effect on self-efficacy: results from the MI-HEART randomized controlled trial. Proc AMIA Symp (2002) 1.01
Developmental up-regulation of MnSOD in rat oligodendrocytes confers protection against oxidative injury. Eur J Neurosci (2004) 1.01
Enhancement of cell survival by stromal cell-derived factor-1/CXCL12 involves activation of CREB and induction of Mcl-1 and c-Fos in factor-dependent human cell line MO7e. Stem Cells Dev (2004) 1.00
Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases. Biochemistry (2010) 1.00
Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs. FASEB J (2011) 0.98
Deregulation of a Hox protein regulatory network spanning prostate cancer initiation and progression. Clin Cancer Res (2012) 0.98
Antioxidant rich grape pomace extract suppresses postprandial hyperglycemia in diabetic mice by specifically inhibiting alpha-glucosidase. Nutr Metab (Lond) (2010) 0.98
Concordance of deregulated mechanisms unveiled in underpowered experiments: PTBP1 knockdown case study. BMC Med Genomics (2014) 0.98
Upregulation of the cycline kinase subunit CKS2 increases cell proliferation rate in gastric cancer. J Cancer Res Clin Oncol (2008) 0.98
Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression. Am J Respir Cell Mol Biol (2010) 0.98
Effect of prebiotic xylooligosaccharides on growth performances and digestive enzyme activities of allogynogenetic crucian carp (Carassius auratus gibelio). Fish Physiol Biochem (2008) 0.98
Multi-compartment neuron-glia co-culture platform for localized CNS axon-glia interaction study. Lab Chip (2012) 0.96
Intracellular zinc release and ERK phosphorylation are required upstream of 12-lipoxygenase activation in peroxynitrite toxicity to mature rat oligodendrocytes. J Biol Chem (2006) 0.96
Vesicular stomatitis virus as a vector to deliver virus-like particles of human norovirus: a new vaccine candidate against an important noncultivable virus. J Virol (2011) 0.96
Visualizing information across multidimensional post-genomic structured and textual databases. Bioinformatics (2004) 0.96
Functional outcome of en bloc excision and osteoarticular allograft replacement with the Sauve-Kapandji procedure for Campanacci grade 3 giant-cell tumor of the distal radius. J Hand Surg Am (2006) 0.96
Immunostimulatory oligodeoxynucleotide isolated from genome wide screening of Mycobacterium bovis chromosomal DNA. Mol Immunol (2006) 0.95
Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases. J Am Med Inform Assoc (2013) 0.95