Published in Development on January 25, 2012
Diet-induced developmental acceleration independent of TOR and insulin in C. elegans. Cell (2013) 1.51
Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans. Cell Rep (2013) 1.06
Germline stem cells: origin and destiny. Cell Stem Cell (2012) 1.04
C. elegans AMPKs promote survival and arrest germline development during nutrient stress. Biol Open (2012) 1.02
Regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase. J Lipid Res (2013) 1.01
Nucleotide levels regulate germline proliferation through modulating GLP-1/Notch signaling in C. elegans. Genes Dev (2016) 0.99
Physiological control of germline development. Adv Exp Med Biol (2013) 0.96
D-beta-hydroxybutyrate extends lifespan in C. elegans. Aging (Albany NY) (2014) 0.96
Regulation of longevity by the reproductive system. Exp Gerontol (2012) 0.92
Stress response pathways protect germ cells from omega-6 polyunsaturated fatty acid-mediated toxicity in Caenorhabditis elegans. Dev Biol (2012) 0.90
Analysis of Germline Stem Cell Differentiation Following Loss of GLP-1 Notch Activity in Caenorhabditis elegans. Genetics (2015) 0.87
Mechano-logical model of C. elegans germ line suggests feedback on the cell cycle. Development (2015) 0.82
Two classes of gap junction channels mediate soma-germline interactions essential for germline proliferation and gametogenesis in Caenorhabditis elegans. Genetics (2014) 0.82
Cell-cycle quiescence maintains Caenorhabditis elegans germline stem cells independent of GLP-1/Notch. Elife (2015) 0.79
Erythroid induction of K562 cells treated with mithramycin is associated with inhibition of raptor gene transcription and mammalian target of rapamycin complex 1 (mTORC1) functions. Pharmacol Res (2014) 0.77
Aiweixin, a traditional Uyghur medicinal formula, protects against chromium toxicity in Caenorhabditis elegans. BMC Complement Altern Med (2015) 0.77
Germline Stem Cell Differentiation Entails Regional Control of Cell Fate Regulator GLD-1 in Caenorhabditis elegans. Genetics (2016) 0.76
Feeding the germline. Genes Dev (2016) 0.76
The mysterious relationship between reproduction and longevity. Worm (2015) 0.76
The effects of harvesting media on biological characteristics and repair potential of neural stem cells after traumatic brain injury. PLoS One (2014) 0.76
Cell cycle features of C. elegans germline stem/progenitor cells vary temporally and spatially. Dev Biol (2015) 0.76
Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7. PLoS Genet (2017) 0.75
Notch signaling protects animals from nucleotide deficiency. Cell Cycle (2016) 0.75
LIN-28 balances longevity and germline stem cell number in Caenorhabditis elegans through let-7/AKT/DAF-16 axis. Aging Cell (2016) 0.75
Caenorhabditis elegans as a model for cancer research. Mol Cell Oncol (2014) 0.75
C. elegans DAF-16/FOXO interacts with TGF-ß/BMP signaling to induce germline tumor formation via mTORC1 activation. PLoS Genet (2017) 0.75
C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension. Cell Rep (2016) 0.75
Maternal Diet and Insulin-Like Signaling Control Intergenerational Plasticity of Progeny Size and Starvation Resistance. PLoS Genet (2016) 0.75
Uncovering the mechanisms of Caenorhabditis elegans ageing from global quantification of the underlying landscape. J R Soc Interface (2016) 0.75
Linking the environment, DAF-7/TGFβ signaling and LAG-2/DSL ligand expression in the germline stem cell niche. Development (2017) 0.75
Lipid and Carbohydrate Metabolism in Caenorhabditis elegans. Genetics (2017) 0.75
The genetics of Caenorhabditis elegans. Genetics (1974) 102.14
TOR signaling in growth and metabolism. Cell (2006) 35.29
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature (2003) 26.58
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 17.41
THE INFLUENCE OF DIET ON TRANSPLANTED AND SPONTANEOUS MOUSE TUMORS. J Exp Med (1914) 14.24
daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science (1997) 11.60
Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene (2001) 11.09
Creation of low-copy integrated transgenic lines in Caenorhabditis elegans. Genetics (2001) 10.29
Caloric restriction delays disease onset and mortality in rhesus monkeys. Science (2009) 9.84
On the role of RNA amplification in dsRNA-triggered gene silencing. Cell (2001) 9.78
Maintenance of C. elegans. WormBook (2006) 7.91
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science (2009) 7.80
Genetics: influence of TOR kinase on lifespan in C. elegans. Nature (2003) 7.55
Drosophila S6 kinase: a regulator of cell size. Science (1999) 6.76
Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res (2004) 5.81
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell (2007) 5.51
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development (2004) 5.27
Interacting genes in nematode dauer larva formation. Nature (1981) 5.21
Timing requirements for insulin/IGF-1 signaling in C. elegans. Science (2002) 4.06
Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell (2009) 4.01
Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline. Development (1999) 3.97
Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science (2002) 3.85
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell (2007) 3.78
Identification of a conserved motif required for mTOR signaling. Curr Biol (2002) 3.78
Tumours with PI3K activation are resistant to dietary restriction. Nature (2009) 3.60
Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell (2009) 3.43
Controls of germline stem cells, entry into meiosis, and the sperm/oocyte decision in Caenorhabditis elegans. Annu Rev Cell Dev Biol (2007) 3.26
Nutrition-responsive glia control exit of neural stem cells from quiescence. Cell (2010) 3.19
Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (1999) 3.19
Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans. Genetics (1995) 3.11
gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans. Genetics (1995) 2.94
The glp-1 locus and cellular interactions in early C. elegans embryos. Cell (1987) 2.81
The mTOR pathway in the control of protein synthesis. Physiology (Bethesda) (2006) 2.71
Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. Nature (2011) 2.65
HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet (2009) 2.60
TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr Biol (2002) 2.51
Mutations in gld-1, a female germ cell-specific tumor suppressor gene in Caenorhabditis elegans, affect a conserved domain also found in Src-associated protein Sam68. Genes Dev (1995) 2.41
Lifespan extension by preserving proliferative homeostasis in Drosophila. PLoS Genet (2010) 2.39
Regulation of tissue growth through nutrient sensing. Annu Rev Genet (2009) 2.18
Analysis of the multiple roles of gld-1 in germline development: interactions with the sex determination cascade and the glp-1 signaling pathway. Genetics (1995) 2.04
Nutrient control of TORC1, a cell-cycle regulator. Trends Cell Biol (2009) 1.88
The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging. Curr Biol (2008) 1.86
Insulin signaling promotes germline proliferation in C. elegans. Development (2010) 1.77
Genetic analysis of Caenorhabditis elegans glp-1 mutants suggests receptor interaction or competition. Genetics (2003) 1.74
Multi-pathway control of the proliferation versus meiotic development decision in the Caenorhabditis elegans germline. Dev Biol (2004) 1.72
Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans. J Biol Chem (2004) 1.71
Nutrition in relation to cancer. Adv Cancer Res (1953) 1.69
Functional characterization of five eIF4E isoforms in Caenorhabditis elegans. J Biol Chem (2000) 1.57
From bacteria to man: archaic proton-dependent peptide transporters at work. Physiology (Bethesda) (2006) 1.53
An isoform of eIF4E is a component of germ granules and is required for spermatogenesis in C. elegans. Development (2001) 1.53
Stem cells, their niches and the systemic environment: an aging network. Genetics (2008) 1.46
Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8. EMBO J (2009) 1.46
The regulatory network controlling the proliferation-meiotic entry decision in the Caenorhabditis elegans germ line. Curr Top Dev Biol (2006) 1.39
Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary. Development (2010) 1.37
Caenorhabditis elegans germline patterning requires coordinated development of the somatic gonadal sheath and the germ line. Dev Biol (2005) 1.32
Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline. Development (2011) 1.31
An emerging role for TOR signaling in mammalian tissue and stem cell physiology. Development (2011) 1.27
Caenorhabditis elegans germ line: a model for stem cell biology. Dev Dyn (2007) 1.21
A "latent niche" mechanism for tumor initiation. Proc Natl Acad Sci U S A (2009) 1.17
TSC1/2 tumour suppressor complex maintains Drosophila germline stem cells by preventing differentiation. Development (2010) 1.13
Does malnutrition affect fecundity? A summary of evidence. Science (1980) 1.10
The establishment of Caenorhabditis elegans germline pattern is controlled by overlapping proximal and distal somatic gonad signals. Dev Biol (2003) 1.01
Differential requirements for STRAD in LKB1-dependent functions in C. elegans. Development (2010) 0.97
A germline-specific isoform of eIF4E (IFE-1) is required for efficient translation of stored mRNAs and maturation of both oocytes and sperm. J Cell Sci (2009) 0.97
Two oligopeptide transporters from Caenorhabditis elegans: molecular cloning and functional expression. Biochem J (1998) 0.96
Caloric restriction and experimental carcinogenesis. Toxicol Sci (1999) 0.94
Altered signalling from germline to intestine pushes daf-2;pept-1 Caenorhabditis elegans into extreme longevity. Aging Cell (2010) 0.87
Soma-germline interactions that influence germline proliferation in Caenorhabditis elegans. Dev Dyn (2010) 0.84
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27
A Vibrio cholerae protease needed for killing of Caenorhabditis elegans has a role in protection from natural predator grazing. Proc Natl Acad Sci U S A (2006) 1.78
Insulin signaling promotes germline proliferation in C. elegans. Development (2010) 1.77
Genetic analysis of Caenorhabditis elegans glp-1 mutants suggests receptor interaction or competition. Genetics (2003) 1.74
Multi-pathway control of the proliferation versus meiotic development decision in the Caenorhabditis elegans germline. Dev Biol (2004) 1.72
ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells. Cell (2007) 1.64
Defects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutants. PLoS Genet (2009) 1.62
MSP and GLP-1/Notch signaling coordinately regulate actomyosin-dependent cytoplasmic streaming and oocyte growth in C. elegans. Development (2009) 1.34
Caenorhabditis elegans germline patterning requires coordinated development of the somatic gonadal sheath and the germ line. Dev Biol (2005) 1.32
Computational insights into Caenorhabditis elegans vulval development. Proc Natl Acad Sci U S A (2005) 1.29
Quantitative analysis of germline mitosis in adult C. elegans. Dev Biol (2006) 1.20
The C. elegans P4-ATPase TAT-1 regulates lysosome biogenesis and endocytosis. Traffic (2008) 1.19
Stress response in Caenorhabditis elegans caused by optical tweezers: wavelength, power, and time dependence. Biophys J (2002) 1.18
A "latent niche" mechanism for tumor initiation. Proc Natl Acad Sci U S A (2009) 1.17
A "FLP-Out" system for controlled gene expression in Caenorhabditis elegans. Genetics (2008) 1.16
A Caenorhabditis elegans mutant lacking functional nicotinamide nucleotide transhydrogenase displays increased sensitivity to oxidative stress. Free Radic Biol Med (2005) 1.16
TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in Caenorhabditis elegans. Mol Biol Cell (2010) 1.16
Sensory regulation of the C. elegans germline through TGF-β-dependent signaling in the niche. Curr Biol (2012) 1.13
C. elegans SUR-6/PR55 cooperates with LET-92/protein phosphatase 2A and promotes Raf activity independently of inhibitory Akt phosphorylation sites. Development (2004) 1.11
Autosomal genes of autosomal/X-linked duplicated gene pairs and germ-line proliferation in Caenorhabditis elegans. Genetics (2005) 1.11
Alterations in ribosome biogenesis cause specific defects in C. elegans hermaphrodite gonadogenesis. Dev Biol (2006) 1.08
C. elegans pro-1 activity is required for soma/germline interactions that influence proliferation and differentiation in the germ line. Development (2004) 1.07
The establishment of Caenorhabditis elegans germline pattern is controlled by overlapping proximal and distal somatic gonad signals. Dev Biol (2003) 1.01
Toward verified biological models. IEEE/ACM Trans Comput Biol Bioinform (2008) 1.00
Caenorhabditis elegans num-1 negatively regulates endocytic recycling. Genetics (2008) 0.98
Increased or decreased levels of Caenorhabditis elegans lon-3, a gene encoding a collagen, cause reciprocal changes in body length. Genetics (2002) 0.98
Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2011) 0.96
MAA-1, a novel acyl-CoA-binding protein involved in endosomal vesicle transport in Caenorhabditis elegans. Mol Biol Cell (2006) 0.93
Characterization of the Caenorhabditis elegans Islet LIM-homeodomain ortholog, lim-7. FEBS Lett (2008) 0.92
lin-1 has both positive and negative functions in specifying multiple cell fates induced by Ras/MAP kinase signaling in C. elegans. Dev Biol (2005) 0.91
Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling. Proc Natl Acad Sci U S A (2005) 0.88
A scenario-based approach to modeling development: a prototype model of C. elegans vulval fate specification. Dev Biol (2008) 0.88
A model of stem cell population dynamics: in silico analysis and in vivo validation. Development (2012) 0.86
Soma-germline interactions that influence germline proliferation in Caenorhabditis elegans. Dev Dyn (2010) 0.84
Caenorhabditis elegans numb inhibits endocytic recycling by binding TAT-1 aminophospholipid translocase. Traffic (2011) 0.83
Tissue- and paralogue-specific functions of acyl-CoA-binding proteins in lipid metabolism in Caenorhabditis elegans. Biochem J (2011) 0.81
Diet-dependent depletion of queuosine in tRNAs in Caenorhabditis elegans does not lead to a developmental block. J Biosci (2007) 0.80
A sense of life: computational and experimental investigations with models of biochemical and evolutionary processes. OMICS (2003) 0.77