Caenorhabditis elegans as a model for cancer research.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27308424)

Published in Mol Cell Oncol on December 01, 2014

Authors

Emmanouil Kyriakakis1, Maria Markaki1, Nektarios Tavernarakis2

Author Affiliations

1: Institute of Molecular Biology and Biotechnology; Foundation for Research and Technology-Hellas.
2: Institute of Molecular Biology and Biotechnology; Foundation for Research and Technology-Hellas; Department of Basic Sciences; Faculty of Medicine; University of Crete Heraklion; Crete, Greece.

Articles cited by this

Hallmarks of cancer: the next generation. Cell (2011) 140.01

Global cancer statistics, 2002. CA Cancer J Clin (2005) 119.22

ras oncogenes in human cancer: a review. Cancer Res (1989) 22.03

Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell (2004) 21.68

The Bcl-2 protein family: arbiters of cell survival. Science (1998) 16.08

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A (2003) 15.59

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ (2008) 10.45

The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene (2007) 10.08

Eaten alive: a history of macroautophagy. Nat Cell Biol (2010) 8.83

Autophagy and metabolism. Science (2010) 8.10

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature (2013) 7.51

Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet (2005) 7.15

Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer (2012) 6.14

The impact of the gut microbiota on human health: an integrative view. Cell (2012) 6.01

Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans. Genetics (1985) 5.83

glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans. Cell (1987) 5.07

Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans. Genetics (1980) 4.78

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell (1994) 4.66

WormBase: a multi-species resource for nematode biology and genomics. Nucleic Acids Res (2004) 4.14

Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer Res (2005) 4.13

A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans. Mol Cell (2000) 4.11

Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell (2006) 3.97

Direct conversion of C. elegans germ cells into specific neuron types. Science (2010) 3.31

The ras gene family and human carcinogenesis. Mutat Res (1988) 3.20

Cell death modalities: classification and pathophysiological implications. Cell Death Differ (2007) 3.19

Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance. Science (2001) 3.16

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell (2013) 3.10

The microbiome and cancer. Nat Rev Cancer (2013) 2.86

Extending life span by increasing oxidative stress. Free Radic Biol Med (2011) 2.70

Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta (2013) 2.61

Tackling the cancer stem cells - what challenges do they pose? Nat Rev Drug Discov (2014) 2.55

Can autophagy promote longevity? Nat Cell Biol (2010) 2.55

Mutations that increase the life span of C. elegans inhibit tumor growth. Science (2006) 2.48

HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Nature (2010) 2.23

The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis. Curr Biol (2001) 2.22

DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Nat Genet (2007) 2.17

BH3-only proteins in apoptosis and beyond: an overview. Oncogene (2008) 2.13

Microbes, microbiota, and colon cancer. Cell Host Microbe (2014) 2.06

Alterations in the apoptotic machinery and their potential role in anticancer drug resistance. Oncogene (2003) 2.03

Developmental apoptosis in C. elegans: a complex CEDnario. Nat Rev Mol Cell Biol (2006) 1.99

Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors. Development (1997) 1.94

Autophagy and cell death in model organisms. Cell Death Differ (2008) 1.90

The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans. PLoS One (2009) 1.81

Autophagy is required for necrotic cell death in Caenorhabditis elegans. Cell Death Differ (2007) 1.80

Ceramide-orchestrated signalling in cancer cells. Nat Rev Cancer (2012) 1.79

Insulin signaling promotes germline proliferation in C. elegans. Development (2010) 1.77

RTK/Ras/MAPK signaling. WormBook (2006) 1.75

Caenorhabditis elegans: a versatile platform for drug discovery. Biotechnol J (2006) 1.72

Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans. Nature (2009) 1.62

Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia. Gastroenterology (2010) 1.61

Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature (2014) 1.59

Mitochondrial dysfunction in cancer. Front Oncol (2013) 1.57

C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage. Cell Death Differ (2005) 1.57

Translational regulators maintain totipotency in the Caenorhabditis elegans germline. Science (2006) 1.54

Germline survival and apoptosis. WormBook (2008) 1.47

C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis. Genes Dev (2008) 1.41

S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells. Development (2012) 1.35

Colon carcinogenesis with azoxymethane and dimethylhydrazine in germ-free rats. Cancer Res (1975) 1.35

Bacterial nitric oxide extends the lifespan of C. elegans. Cell (2013) 1.35

Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi. Curr Biol (2006) 1.35

Mechanism of activation of the Caenorhabditis elegans ras homologue let-60 by a novel, temperature-sensitive, gain-of-function mutation. Genetics (1997) 1.33

The nucleotide excision repair pathway is required for UV-C-induced apoptosis in Caenorhabditis elegans. Cell Death Differ (2007) 1.33

Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APCMin/+ mice. Carcinogenesis (2012) 1.31

Adhesion in the stem cell niche: biological roles and regulation. Development (2013) 1.30

Dedifferentiation of primary spermatocytes into germ cell tumors in C. elegans lacking the pumilio-like protein PUF-8. Curr Biol (2003) 1.27

Isolation and characterization of mutations causing abnormal eversion of the vulva in Caenorhabditis elegans. Dev Biol (1993) 1.26

A Caenorhabditis elegans model for epithelial-neuronal transdifferentiation. Proc Natl Acad Sci U S A (2008) 1.23

Scratching the niche that controls Caenorhabditis elegans germline stem cells. Semin Cell Dev Biol (2009) 1.22

Translational repression of cyclin E prevents precocious mitosis and embryonic gene activation during C. elegans meiosis. Dev Cell (2009) 1.19

Associations between adipokines and obesity-related cancer. Front Biosci (Landmark Ed) (2011) 1.19

Epigenetic factors influencing resistance to nuclear reprogramming. Trends Genet (2011) 1.14

C. elegans cell cycles: invariance and stem cell divisions. Nat Rev Mol Cell Biol (2005) 1.14

Worms under stress: C. elegans stress response and its relevance to complex human disease and aging. Trends Genet (2013) 1.14

Sensory regulation of the C. elegans germline through TGF-β-dependent signaling in the niche. Curr Biol (2012) 1.13

Caenorhabditis elegans as a model for stem cell biology. Dev Dyn (2010) 1.11

Targeting the mevalonate pathway for improved anticancer therapy. Curr Cancer Drug Targets (2009) 1.07

Worms need microbes too: microbiota, health and aging in Caenorhabditis elegans. EMBO Mol Med (2013) 1.00

Folliculin regulates ampk-dependent autophagy and metabolic stress survival. PLoS Genet (2014) 1.00

Discovery of two GLP-1/Notch target genes that account for the role of GLP-1/Notch signaling in stem cell maintenance. Proc Natl Acad Sci U S A (2014) 0.98

Cancer models in Caenorhabditis elegans. Dev Dyn (2010) 0.98

Fatal infantile cardiac glycogenosis with phosphorylase kinase deficiency and a mutation in the gamma2-subunit of AMP-activated protein kinase. Pediatr Res (2007) 0.97

Increased in situ expression of nitric oxide synthase in human colorectal cancer. Virchows Arch (2000) 0.97

FBF represses the Cip/Kip cell-cycle inhibitor CKI-2 to promote self-renewal of germline stem cells in C. elegans. EMBO J (2011) 0.97

Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics. Xenobiotica (2013) 0.94

The C. elegans pvf-1 gene encodes a PDGF/VEGF-like factor able to bind mammalian VEGF receptors and to induce angiogenesis. FASEB J (2006) 0.93

C. elegans as a model organism for in vivo screening in cancer: effects of human c-Met in lung cancer affect C. elegans vulva phenotypes. Cancer Biol Ther (2008) 0.92

Members of the NODE (Nanog and Oct4-associated deacetylase) complex and SOX-2 promote the initiation of a natural cellular reprogramming event in vivo. Proc Natl Acad Sci U S A (2012) 0.91

You are what you eat: multifaceted functions of autophagy during C. elegans development. Cell Res (2013) 0.89

Autophagy links lipid metabolism to longevity in C. elegans. Autophagy (2012) 0.89

Effect of beta-glucuronidase inhibitor on azoxymethane-induced colonic carcinogenesis in rats. Cancer Res (1982) 0.86

RNA-based regulation of pluripotency. Trends Genet (2012) 0.85

cep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad. Aging (Albany NY) (2012) 0.83

LET-418/Mi2 and SPR-5/LSD1 cooperatively prevent somatic reprogramming of C. elegans germline stem cells. Stem Cell Reports (2014) 0.82

Cell plasticity in Caenorhabditis elegans: from induced to natural cell reprogramming. Genesis (2011) 0.79

Understanding the role of asymmetric cell division in cancer using C. elegans. Dev Dyn (2010) 0.77

Pushing on through. Nat Rev Cancer (2010) 0.76

An in vivo C. elegans model system for screening EGFR-inhibiting anti-cancer drugs. PLoS One (2012) 0.76

The TP53 signaling network in mammals and worms. Brief Funct Genomics (2012) 0.76