Published in Hum Mol Genet on January 30, 2012
DISC1 genetics, biology and psychiatric illness. Front Biol (Beijing) (2013) 1.00
DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites. J Biol Chem (2015) 0.96
Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits. Hum Mol Genet (2012) 0.89
DISC1 as a therapeutic target for mental illnesses. Expert Opin Ther Targets (2012) 0.87
Impaired autophagy: a link between neurodegenerative and neuropsychiatric diseases. J Cell Mol Med (2014) 0.83
Role of DISC1 in Neuronal Trafficking and its Implication in Neuropsychiatric Manifestation and Neurotherapeutics. Neurotherapeutics (2017) 0.80
DISC1 is a coordinator of intracellular trafficking to shape neuronal development and connectivity. J Physiol (2016) 0.79
Purinergic signaling and energy homeostasis in psychiatric disorders. Curr Mol Med (2015) 0.79
Aggregation of the protein TRIOBP-1 and its potential relevance to schizophrenia. PLoS One (2014) 0.78
Utility and validity of DISC1 mouse models in biological psychiatry. Neuroscience (2016) 0.77
Network analysis of gene expression in peripheral blood identifies mTOR and NF-κB pathways involved in antipsychotic-induced extrapyramidal symptoms. Pharmacogenomics J (2015) 0.77
Converging models of schizophrenia - Network alterations of prefrontal cortex underlying cognitive impairments. Prog Neurobiol (2015) 0.76
Transfer of disrupted-in-schizophrenia 1 aggregates between neuronal-like cells occurs in tunnelling nanotubes and is promoted by dopamine. Open Biol (2017) 0.75
Increased dysbindin-1B isoform expression in schizophrenia and its propensity in aggresome formation. Cell Discov (2015) 0.75
Disrupted-in-schizophrenia 1 (DISC1) and Syntaphilin collaborate to modulate axonal mitochondrial anchoring. Mol Brain (2016) 0.75
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science (2005) 5.20
Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses. Neuron (2009) 3.49
Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. Nat Neurosci (2010) 2.90
Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1. Trends Neurosci (2009) 2.55
Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory. Nat Neurosci (2008) 2.29
Control of mitochondrial transport and localization in neurons. Trends Cell Biol (2009) 2.23
Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1. J Neurosci (2008) 2.04
Gephyrin regulates the cell surface dynamics of synaptic GABAA receptors. J Neurosci (2005) 1.95
ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities. J Pharmacol Exp Ther (2008) 1.81
The genetics and biology of DISC1--an emerging role in psychosis and cognition. Biol Psychiatry (2006) 1.79
Brain-derived neurotrophic factor modulates fast synaptic inhibition by regulating GABA(A) receptor phosphorylation, activity, and cell-surface stability. J Neurosci (2004) 1.77
The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. J Biol Chem (2002) 1.70
Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin. Neuron (2010) 1.54
Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. J Neurosci (2009) 1.52
GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons. Mol Cell Neurosci (2008) 1.43
Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia. J Pharmacol Exp Ther (2009) 1.35
DISC1 at 10: connecting psychiatric genetics and neuroscience. Trends Mol Med (2011) 1.34
Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. J Neurosci (2006) 1.27
Palmitoylation regulates the clustering and cell surface stability of GABAA receptors. Mol Cell Neurosci (2004) 1.25
A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits. Mol Cell Neurosci (2003) 1.23
NMDA receptors regulate GABAA receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the γ2 subunit. Proc Natl Acad Sci U S A (2010) 1.18
Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2. Proc Natl Acad Sci U S A (2007) 1.17
GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein. J Neurosci (2004) 1.17
The orphan GPCR, GPR88, modulates function of the striatal dopamine system: a possible therapeutic target for psychiatric disorders? Mol Cell Neurosci (2009) 1.16
The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine. J Pharmacol Exp Ther (2008) 1.15
Interplay of palmitoylation and phosphorylation in the trafficking and localization of phosphodiesterase 10A: implications for the treatment of schizophrenia. J Neurosci (2010) 1.15
Estrogen receptor ß activity modulates synaptic signaling and structure. J Neurosci (2010) 1.15
Ubiquitin-dependent lysosomal targeting of GABA(A) receptors regulates neuronal inhibition. Proc Natl Acad Sci U S A (2009) 1.13
Mitochondrial trafficking and the provision of energy and calcium buffering at excitatory synapses. Eur J Neurosci (2010) 1.12
GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders. Neuropharmacology (2009) 1.09
Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents. ACS Chem Neurosci (2014) 1.06
Regulation of GABA(A) receptor membrane trafficking and synaptic localization. Pharmacol Ther (2009) 1.04
Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice. Drug Metab Dispos (2012) 1.02
Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes. Proc Natl Acad Sci U S A (2010) 0.99
Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1. Proc Natl Acad Sci U S A (2005) 0.99
DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness. Ann Med (2004) 0.98
How has DISC1 enabled drug discovery? Mol Cell Neurosci (2007) 0.94
Fyn kinase contributes to tyrosine phosphorylation of the GABA(A) receptor gamma2 subunit. Mol Cell Neurosci (2010) 0.93
Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins. Biochem Soc Trans (2013) 0.92
Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors. J Neurochem (2002) 0.91
Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism. J Neurosci (2013) 0.91
The cell biology of synaptic inhibition in health and disease. Curr Opin Neurobiol (2010) 0.91
A cell-based ultra-high-throughput screening assay for identifying inhibitors of D-amino acid oxidase. J Biomol Screen (2006) 0.90
Stabilization of GABA(A) receptors at endocytic zones is mediated by an AP2 binding motif within the GABA(A) receptor β3 subunit. J Neurosci (2012) 0.89
Regulation of inhibitory synaptic transmission by a conserved atypical interaction of GABA(A) receptor beta- and gamma-subunits with the clathrin AP2 adaptor. Neuropharmacology (2008) 0.89
Estrogen receptor neurobiology and its potential for translation into broad spectrum therapeutics for CNS disorders. Curr Mol Pharmacol (2009) 0.88
The receptor subunits generating NMDA receptor mediated currents in oligodendrocytes. J Physiol (2010) 0.88
Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex. J Neurochem (2007) 0.87
Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors. J Med Chem (2010) 0.87
What can we learn from the disrupted in schizophrenia 1 interactome: lessons for target identification and disease biology? Novartis Found Symp (2008) 0.84
Impaired alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking and function by mutant huntingtin. J Biol Chem (2011) 0.84
Regulation of the cytoskeleton by Disrupted-in-schizophrenia 1 (DISC1). Mol Cell Neurosci (2011) 0.84
Assessing the role of endooligopeptidase activity of Ndel1 (nuclear-distribution gene E homolog like-1) in neurite outgrowth. Mol Cell Neurosci (2010) 0.82
Highly potent, selective, and orally active phosphodiesterase 10A inhibitors. J Med Chem (2011) 0.81
Differential function of phosphodiesterase families in the brain: gaining insights through the use of genetically modified animals. Prog Brain Res (2009) 0.80
d-amino acid oxidase knockout (Dao(-/-) ) mice show enhanced short-term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption. Eur J Neurosci (2015) 0.79
Future viable models of psychiatry drug discovery in pharma. J Biomol Screen (2013) 0.78
D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. J Biol Chem (2011) 0.77
Increased burst-firing of ventral tegmental area dopaminergic neurons in D-amino acid oxidase knockout mice in vivo. Eur J Neurosci (2014) 0.77
Chemoproteomics demonstrates target engagement and exquisite selectivity of the clinical phosphodiesterase 10A inhibitor MP-10 in its native environment. ACS Chem Biol (2014) 0.76
Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system. Eur J Neurosci (2014) 0.76
Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons. Mol Cell Neurosci (2010) 0.75
Novel triazines as potent and selective phosphodiesterase 10A inhibitors. Bioorg Med Chem Lett (2012) 0.75