Published in J Biol Chem on June 05, 2006
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Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat Cell Biol (2006) 3.63
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. EMBO J (2006) 3.53
Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses. Neuron (2009) 3.49
Skp2-mediated degradation of p27 regulates progression into mitosis. Dev Cell (2004) 3.27
Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis. J Cell Biol (2006) 3.17
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Nat Cell Biol (2004) 3.14
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature (2010) 3.09
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nat Cell Biol (2009) 2.91
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Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature (2002) 2.68
Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis. Nat Cell Biol (2003) 2.64
Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination. Mol Cell Biol (2005) 2.62
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem (2003) 2.59
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Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. Proc Natl Acad Sci U S A (2003) 2.45
Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell (2007) 2.41
Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase. Neuron (2007) 2.38
Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy. Blood (2008) 2.36
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The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell (2012) 2.30
Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory. Nat Neurosci (2008) 2.29
Control of mitochondrial transport and localization in neurons. Trends Cell Biol (2009) 2.23
An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. Proc Natl Acad Sci U S A (2005) 2.18
Sequential signals toward podosome formation in NIH-src cells. J Cell Biol (2008) 2.18
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Nebulin and N-WASP cooperate to cause IGF-1-induced sarcomeric actin filament formation. Science (2010) 2.14
Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes. Am J Pathol (2007) 2.13
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Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev (2008) 2.12
Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking. Proc Natl Acad Sci U S A (2004) 2.10
WAVE2 is required for directed cell migration and cardiovascular development. Nature (2003) 2.09
Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy. J Neurosci (2007) 2.00
Large-scale analysis of the human ubiquitin-related proteome. Proteomics (2005) 2.00
Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J Exp Med (2007) 1.99
Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts. Cancer Res (2002) 1.96
Gephyrin regulates the cell surface dynamics of synaptic GABAA receptors. J Neurosci (2005) 1.95
Developmental switch from GABA to glycine release in single central synaptic terminals. Nat Neurosci (2003) 1.93
PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia. Nat Cell Biol (2004) 1.92
Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell (2011) 1.89
Illuminating cell-cycle progression in the developing zebrafish embryo. Proc Natl Acad Sci U S A (2009) 1.88
Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex. J Biol Chem (2007) 1.85
Protrudin induces neurite formation by directional membrane trafficking. Science (2006) 1.84
The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin. J Neurosci (2008) 1.83
Brain-derived neurotrophic factor modulates fast synaptic inhibition by regulating GABA(A) receptor phosphorylation, activity, and cell-surface stability. J Neurosci (2004) 1.77
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Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo. Proc Natl Acad Sci U S A (2009) 1.76
CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis. Nat Cell Biol (2009) 1.75
Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2. J Biol Chem (2007) 1.75
The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo. Cell Metab (2011) 1.74
Synaptic GABAA receptors are directly recruited from their extrasynaptic counterparts. EMBO J (2006) 1.74
miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-1. Blood (2011) 1.73
Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction. J Biol Chem (2004) 1.73
Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation. J Neurosci (2007) 1.72
The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. J Biol Chem (2002) 1.70
Focal adhesion kinase regulation of N-WASP subcellular localization and function. J Biol Chem (2003) 1.70
Inter-regional contribution of enhanced activity of the primary somatosensory cortex to the anterior cingulate cortex accelerates chronic pain behavior. J Neurosci (2011) 1.67
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NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currents. Nat Neurosci (2011) 1.65
CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Mol Cell Biol (2005) 1.64
Regulation of actin dynamics by WASP family proteins. J Biochem (2003) 1.63
Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus. J Neurosci (2008) 1.63
Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury. J Clin Invest (2005) 1.61
Suppression of apoptosis in the protein kinase Cdelta null mouse in vivo. J Biol Chem (2006) 1.61
Lysosomal turnover of GABARAP-phospholipid conjugate is activated during differentiation of C2C12 cells to myotubes without inactivation of the mTor kinase-signaling pathway. Autophagy (2006) 1.60
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Sustained activation of N-WASP through phosphorylation is essential for neurite extension. Dev Cell (2002) 1.58
Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligase. Cardiovasc Res (2008) 1.57
Molecular clearance of ataxin-3 is regulated by a mammalian E4. EMBO J (2004) 1.57
Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission. Proc Natl Acad Sci U S A (2005) 1.56
The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation. J Biol Chem (2006) 1.56
Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation. J Cell Biol (2011) 1.56
Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. J Cell Biol (2002) 1.55
Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin. Neuron (2010) 1.54
Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. J Clin Invest (2006) 1.52
Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac. J Cell Biol (2006) 1.50