Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1.

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Published in Trends Neurosci on August 26, 2009

Authors

Hanna Jaaro-Peled1, Akiko Hayashi-Takagi, Saurav Seshadri, Atsushi Kamiya, Nicholas J Brandon, Akira Sawa

Author Affiliations

1: Department of Psychiatry and Behavioral Neurosciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse. Proc Natl Acad Sci U S A (2005) 1.14

Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5. Biochem Biophys Res Commun (2012) 1.12

Alternatively spliced neuronal nitric oxide synthase mediates penile erection. Proc Natl Acad Sci U S A (2006) 1.09

Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood. Behav Brain Res (2009) 1.09

Schizophrenia and epilepsy: is there a shared susceptibility? Neurosci Res (2009) 1.09

GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders. Neuropharmacology (2009) 1.09

Autophagosome-like vacuole formation in Huntington's disease lymphoblasts. Neuroreport (2004) 1.08

Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents. ACS Chem Neurosci (2014) 1.06

Differential expression of disrupted-in-schizophrenia (DISC1) in bipolar disorder. Biol Psychiatry (2006) 1.06

Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner. Proc Natl Acad Sci U S A (2011) 1.05

Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: utility and limitation of the surrogate tissues in research for brain disorders. Neurosci Res (2013) 1.04

Oxidative stress and schizophrenia: recent breakthroughs from an old story. Curr Opin Psychiatry (2014) 1.03

Neuroanatomic and cognitive abnormalities related to herpes simplex virus type 1 in schizophrenia. Schizophr Res (2010) 1.03

Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice. Drug Metab Dispos (2012) 1.02

Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin. Neurobiol Dis (2005) 1.01

Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model. Proc Natl Acad Sci U S A (2013) 1.01

Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi. Biochem Biophys Res Commun (2010) 1.01

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome. J Cell Biol (2012) 1.01

Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1. Proc Natl Acad Sci U S A (2005) 0.99

Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes. Proc Natl Acad Sci U S A (2010) 0.99

PC12 cell model of inducible expression of mutant DISC1: new evidence for a dominant-negative mechanism of abnormal neuronal differentiation. Neurosci Res (2007) 0.99

Negative symptoms of schizophrenia correlate with impairment on the University of Pennsylvania smell identification test. Neurosci Res (2009) 0.99

Modulation of D-serine levels in brains of mice lacking PICK1. Biol Psychiatry (2008) 0.98

Animal models of gene-environment interactions in schizophrenia. Behav Brain Res (2009) 0.98

DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness. Ann Med (2004) 0.98

Nitric oxide signaling and nitrosative stress in neurons: role for S-nitrosylation. Antioxid Redox Signal (2011) 0.97