Published in J Pharmacol Sci on February 03, 2012
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J Exp Med (2005) 6.86
Heat-evoked activation of the ion channel, TRPV4. J Neurosci (2002) 4.69
Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat Chem Biol (2006) 3.66
Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron (2003) 3.61
Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals. J Allergy Clin Immunol (2006) 3.24
Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A (2006) 3.24
TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J Clin Invest (2005) 3.05
Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. J Biol Chem (2002) 2.79
alpha-Klotho as a regulator of calcium homeostasis. Science (2007) 2.71
Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest (2007) 2.66
Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3. Nat Immunol (2005) 2.24
TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J (2006) 2.21
Age- and sex-specific prevalence of diabetes and impaired glucose regulation in 11 Asian cohorts. Diabetes Care (2003) 2.18
Predicting successful guidewire crossing through chronic total occlusion of native coronary lesions within 30 minutes: the J-CTO (Multicenter CTO Registry in Japan) score as a difficulty grading and time assessment tool. JACC Cardiovasc Interv (2011) 2.12
Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. J Neurosci (2004) 2.04
Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. Mol Pain (2005) 1.94
Structural determinant of TRPV1 desensitization interacts with calmodulin. Proc Natl Acad Sci U S A (2003) 1.92
Comparison of infliximab versus ciclosporin during the initial 6-month treatment period in Behçet disease. Br J Ophthalmol (2009) 1.91
Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain. Brain (2008) 1.78
Bradykinin lowers the threshold temperature for heat activation of vanilloid receptor 1. J Neurophysiol (2002) 1.76
TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch (2009) 1.75
Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese Population: the Funagata study. Diabetes Care (2003) 1.72
Effectiveness of paclitaxel-eluting balloon catheter in patients with sirolimus-eluting stent restenosis. JACC Cardiovasc Interv (2011) 1.70
Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity. J Neurosci (2003) 1.69
Synthetic pores with reactive signal amplifiers as artificial tongues. Nat Mater (2007) 1.63
The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures. J Biol Chem (2009) 1.61
Neuroprotection by Brazilian Green Propolis against In vitro and In vivo Ischemic Neuronal Damage. Evid Based Complement Alternat Med (2005) 1.59
Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice. J Neurosci (2011) 1.58
Multiple hepatic peribiliary cysts with cirrhosis. J Gastroenterol (2004) 1.57
Drosophila painless is a Ca2+-requiring channel activated by noxious heat. J Neurosci (2008) 1.55
Periostin promotes chronic allergic inflammation in response to Th2 cytokines. J Clin Invest (2012) 1.51
Seven-year clinical outcomes of unprotected left main coronary artery stenting with drug-eluting stent and bare-metal stent. Circ J (2013) 1.48
Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett (2002) 1.45
Effects of body temperature on neural activity in the hippocampus: regulation of resting membrane potentials by transient receptor potential vanilloid 4. J Neurosci (2007) 1.43
Type 2 diabetes is not a risk factor for asymptomatic ischemic brain lesion--the Funagata study. Intern Med (2002) 1.41
Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCepsilon-mediated phosphorylation at S800. Pain (2006) 1.41
Optimal treatment of recurrent restenosis lesions after drug-eluting stent implantation for in-stent restenosis lesions. EuroIntervention (2013) 1.38
The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. J Pharmacol Exp Ther (2003) 1.38
Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes. J Physiol (2011) 1.37
Local inflammation increases vanilloid receptor 1 expression within distinct subgroups of DRG neurons. Brain Res (2003) 1.35
Orexins activate histaminergic neurons via the orexin 2 receptor. Biochem Biophys Res Commun (2002) 1.33
Activation of protein kinase C reverses capsaicin-induced calcium-dependent desensitization of TRPV1 ion channels. Cell Calcium (2004) 1.33
Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity. Nat Immunol (2003) 1.32
Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease. J Immunol (2008) 1.30
Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. Diabetes (2010) 1.29
Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats. J Am Soc Nephrol (2003) 1.28
Genetic and biochemical analyses of Pfh1 DNA helicase function in fission yeast. Nucleic Acids Res (2004) 1.28
Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3. Proc Natl Acad Sci U S A (2005) 1.28
Intracellular alkalization causes pain sensation through activation of TRPA1 in mice. J Clin Invest (2008) 1.27
Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice. Am J Respir Cell Mol Biol (2004) 1.27
Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Biochim Biophys Acta (2006) 1.26
Effects of skin surface temperature on epidermal permeability barrier homeostasis. J Invest Dermatol (2006) 1.24
Preparation of a fast dissolving oral thin film containing dexamethasone: a possible application to antiemesis during cancer chemotherapy. Eur J Pharm Biopharm (2009) 1.23
Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model. Exp Neurol (2010) 1.23
A 3.5-nm structure of rat TRPV4 cation channel revealed by Zernike phase-contrast cryoelectron microscopy. J Biol Chem (2009) 1.20
Nociception and TRP Channels. Curr Drug Targets CNS Neurol Disord (2004) 1.20
CARM1 regulates proliferation of PC12 cells by methylating HuD. Mol Cell Biol (2006) 1.19
Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1. EMBO Rep (2008) 1.19
MLL2 and KDM6A mutations in patients with Kabuki syndrome. Am J Med Genet A (2013) 1.19
Is the measurement of glycated hemoglobin A1c alone an efficient screening test for undiagnosed diabetes? Japan National Diabetes Survey. Diabetes Res Clin Pract (2006) 1.17
Cardiovascular risk factors and retinal microvascular signs in an adult Japanese population: the Funagata Study. Ophthalmology (2006) 1.17
DIP (mDia interacting protein) is a key molecule regulating Rho and Rac in a Src-dependent manner. EMBO J (2004) 1.17
Guidelines on the management and treatment of glucocorticoid-induced osteoporosis of the Japanese Society for Bone and Mineral Research (2004). J Bone Miner Metab (2005) 1.17
Role of Th2 responses in the development of allergen-induced airway remodelling in a murine model of allergic asthma. Br J Pharmacol (2003) 1.17
TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons. J Neurosci (2010) 1.16
Role of prostaglandin I2 in airway remodeling induced by repeated allergen challenge in mice. Am J Respir Cell Mol Biol (2003) 1.14
Wnt4-transformed mouse embryonic stem cells differentiate into renal tubular cells. Biochem Biophys Res Commun (2005) 1.14
Incidence, risk factors, and clinical sequelae of angiographic peri-stent contrast staining after sirolimus-eluting stent implantation. Circulation (2011) 1.13
Endocannabinoid system modulates relapse to methamphetamine seeking: possible mediation by the arachidonic acid cascade. Neuropsychopharmacology (2004) 1.13
Drastic Ca2+ sensitization of myofilament associated with a small structural change in troponin I in inherited restrictive cardiomyopathy. Biochem Biophys Res Commun (2005) 1.12
Prevention of type 2 diabetes in a primary healthcare setting: three-year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance. BMC Public Health (2011) 1.10
Augmentation of allergic inflammation in prostanoid IP receptor deficient mice. Br J Pharmacol (2002) 1.09
Double aortic arch in an adult. Interact Cardiovasc Thorac Surg (2012) 1.09
Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function. J Neurosci (2014) 1.08
Hepatocyte growth factor activator inhibitor type 1 regulates epithelial to mesenchymal transition through membrane-bound serine proteinases. Cancer Res (2009) 1.08
Therapeutic strategy for treating aortoesophageal fistulas. Gen Thorac Cardiovasc Surg (2014) 1.08
The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J Biol Chem (2010) 1.07
Preoperative evaluation of perigastric vascular anatomy by 3-dimensional computed tomographic angiography using 16-channel multidetector-row computed tomography for laparoscopic gastrectomy in patients with early gastric cancer. J Comput Assist Tomogr (2007) 1.07
Heterozygous orthodenticle homeobox 2 mutations are associated with variable pituitary phenotype. J Clin Endocrinol Metab (2009) 1.05
Unusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal. J Neurosci (2011) 1.05
Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of alpha-tocopherol. Neurosci Lett (2004) 1.04
Comparisons of metabolic syndrome definitions in four populations of the Asia-Pacific region. Metab Syndr Relat Disord (2008) 1.04
The role of disulfide bond in the amyloidogenic state of beta(2)-microglobulin studied by heteronuclear NMR. Protein Sci (2002) 1.04
[Prosthetic valve endocarditis caused by Streptococcus constellatus infection complicated with perivalvular abscess: serial observation by transesophageal echocardiography: a case report]. J Cardiol (2003) 1.04