Published in Science on June 15, 2007
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The parathyroid is a target organ for FGF23 in rats. J Clin Invest (2007) 4.47
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Active Ca(2+) reabsorption in the connecting tubule. Pflugers Arch (2008) 1.26
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A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease. PLoS One (2013) 1.15
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Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis. Gastroenterology (2009) 1.15
FGF-23 and secondary hyperparathyroidism in chronic kidney disease. Nat Rev Nephrol (2013) 1.14
Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling. Am J Physiol Renal Physiol (2012) 1.12
Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion. PLoS Genet (2013) 1.09
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FGF23 promotes renal calcium reabsorption through the TRPV5 channel. EMBO J (2014) 0.97
Soluble Klotho Protects against Uremic Cardiomyopathy Independently of Fibroblast Growth Factor 23 and Phosphate. J Am Soc Nephrol (2014) 0.96
The role of Klotho in energy metabolism. Nat Rev Endocrinol (2012) 0.95
Klotho and kidney disease. J Nephrol (2010) 0.95
Deletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- mice. PLoS Genet (2012) 0.94
Hyperaldosteronism in Klotho-deficient mice. Am J Physiol Renal Physiol (2010) 0.94
Phosphate sensing. Adv Chronic Kidney Dis (2011) 0.93
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Klotho regulates retinal pigment epithelial functions and protects against oxidative stress. J Neurosci (2013) 0.91
Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice. J Neurosci (2015) 0.91
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Klotho lacks a vitamin D independent physiological role in glucose homeostasis, bone turnover, and steady-state PTH secretion in vivo. PLoS One (2012) 0.88
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Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer's disease. Mol Neurodegener (2014) 0.85
Serum 25-Hydroxyvitamin D, Plasma Klotho, and Lower-Extremity Physical Performance Among Older Adults: Findings From the InCHIANTI Study. J Gerontol A Biol Sci Med Sci (2015) 0.84
Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice. Nat Commun (2015) 0.84
Discovery of alpha-Klotho unveiled new insights into calcium and phosphate homeostasis. Proc Jpn Acad Ser B Phys Biol Sci (2009) 0.84
Low cardiovascular risks in the middle aged males and females excreting greater 24-hour urinary taurine and magnesium in 41 WHO-CARDIAC study populations in the world. J Biomed Sci (2010) 0.83
Accelerated suicidal erythrocyte death in Klotho-deficient mice. Pflugers Arch (2009) 0.83
Histological and elemental analyses of impaired bone mineralization in klotho-deficient mice. J Anat (2008) 0.82
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Renal phosphate handling: Physiology. Indian J Endocrinol Metab (2013) 0.80
Infection and smoking are associated with decreased plasma concentration of the anti-aging protein, α-klotho. J Perinat Med (2013) 0.80
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Development and characterization of monoclonal antibodies to detect klotho. Monoclon Antib Immunodiagn Immunother (2014) 0.78
The role of bone in CKD-mediated mineral and vascular disease. Pediatr Nephrol (2014) 0.78
Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging. Brain Imaging Behav (2016) 0.78
Long-Term Estrogen Receptor Beta Agonist Treatment Modifies the Hippocampal Transcriptome in Middle-Aged Ovariectomized Rats. Front Cell Neurosci (2016) 0.78
Klotho sensitivity of the neuronal excitatory amino acid transporters EAAT3 and EAAT4. PLoS One (2013) 0.78
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Serum vitamin D and parathyroid hormone profiles in patients with various stages of renal disease. Australas Med J (2015) 0.77
Hypophosphatemic rickets due to perturbations in renal tubular function. Pediatr Nephrol (2013) 0.77
The anti-aging factor α-klotho during human pregnancy and its expression in pregnancies complicated by small-for-gestational-age neonates and/or preeclampsia. J Matern Fetal Neonatal Med (2013) 0.77
Longevity factor klotho and chronic psychological stress. Transl Psychiatry (2015) 0.76
Klotho: a novel and early biomarker of acute kidney injury after cardiac valve replacement surgery in adults. Int J Clin Exp Med (2015) 0.76
Molecular and cellular aspects of age-related cognitive decline and Alzheimer's disease. Behav Brain Res (2016) 0.76
Stimulating parathyroid cell proliferation and PTH release with phosphate in organ cultures obtained from patients with primary and secondary hyperparathyroidism for a prolonged period. J Bone Miner Metab (2009) 0.76
The age-regulating protein klotho is vital to sustain retinal function. Invest Ophthalmol Vis Sci (2013) 0.76
Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle. Ageing Res Rev (2017) 0.75
1,25(OH)2D3 dependent overt hyperactivity phenotype in klotho-hypomorphic mice. Sci Rep (2016) 0.75
2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside Promotes Expression of the Longevity Gene Klotho. Oxid Med Cell Longev (2016) 0.75
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What can FGF23 do without Klotho? Bonekey Rep (2014) 0.75
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Klotho: a humeral mediator in CSF and plasma that influences longevity and susceptibility to multiple complex disorders, including depression. Transl Psychiatry (2016) 0.75
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Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice. Oncotarget (2017) 0.75
Association of Serum Klotho with Loss of Bone Mineral Density and Fracture Risk in Older Adults. J Am Geriatr Soc (2016) 0.75
Proangiogenic effects of soluble α-Klotho on systemic sclerosis dermal microvascular endothelial cells. Arthritis Res Ther (2017) 0.75
The impact of klotho gene polymorphisms on urinary tract stone disease. World J Urol (2015) 0.75
TRPV4 ion channel as important cell sensors. J Anesth (2016) 0.75
Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol (2003) 5.74
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Heat-evoked activation of the ion channel, TRPV4. J Neurosci (2002) 4.69
Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int Immunol (2004) 4.59
Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett (2004) 4.02
Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat Chem Biol (2006) 3.66
Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron (2003) 3.61
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PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol (2005) 3.30
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Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol (2003) 3.15
Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1. Dev Cell (2007) 3.06
TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J Clin Invest (2005) 3.05
Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis. Int Immunol (2006) 2.93
Bone marrow stromal cells generate muscle cells and repair muscle degeneration. Science (2005) 2.89
Dual roles for DNA polymerase eta in homologous DNA recombination and translesion DNA synthesis. Mol Cell (2005) 2.88
Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. J Biol Chem (2002) 2.79
The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages. Curr Biol (2002) 2.74
Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest (2007) 2.66
Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation. Development (2004) 2.65
Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho. J Clin Invest (2005) 2.62
Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration. Nat Cell Biol (2005) 2.61
The enzymatic activity of CEM15/Apobec-3G is essential for the regulation of the infectivity of HIV-1 virion but not a sole determinant of its antiviral activity. J Biol Chem (2003) 2.59
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The genome of the pear (Pyrus bretschneideri Rehd.). Genome Res (2012) 2.55
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Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity. Nature (2007) 2.48
FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev (2002) 2.41
Long-term outcome in patients harboring intracranial ependymoma. J Neurosurg (2005) 2.28
Unique multipotent cells in adult human mesenchymal cell populations. Proc Natl Acad Sci U S A (2010) 2.27
Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J Clin Invest (2005) 2.25
Regenerative treatment for tympanic membrane perforation. Otol Neurotol (2011) 2.22
TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J (2006) 2.21
Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif function. J Biol Chem (2005) 2.21
Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat Neurosci (2010) 2.18
Age- and sex-specific prevalence of diabetes and impaired glucose regulation in 11 Asian cohorts. Diabetes Care (2003) 2.18
Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nat Cell Biol (2010) 2.18
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The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. Mol Cell Biol (2006) 2.11
Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice. Proc Natl Acad Sci U S A (2006) 2.09
The first round of mouse spermatogenesis is a distinctive program that lacks the self-renewing spermatogonia stage. Development (2006) 2.07
Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells. Cancer Res (2005) 2.05
Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. J Neurosci (2004) 2.04
Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. Genes Cells (2006) 2.03
Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development. PLoS One (2011) 2.01
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Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. Circulation (2004) 2.00
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Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. Mol Pain (2005) 1.94
The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration. EMBO J (2003) 1.92
Structural determinant of TRPV1 desensitization interacts with calmodulin. Proc Natl Acad Sci U S A (2003) 1.92
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene. Endocrinology (2002) 1.90
Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis. Crit Care Med (2004) 1.88
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Amelioration of progressive renal injury by genetic manipulation of Klotho gene. Proc Natl Acad Sci U S A (2007) 1.83
APOBEC3G targets specific virus species. J Virol (2004) 1.78
Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain. Brain (2008) 1.78
Bradykinin lowers the threshold temperature for heat activation of vanilloid receptor 1. J Neurophysiol (2002) 1.76
TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch (2009) 1.75
Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese Population: the Funagata study. Diabetes Care (2003) 1.72
Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol (2002) 1.70
IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice. Am J Physiol Gastrointest Liver Physiol (2003) 1.70
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Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase. Mol Carcinog (2010) 1.69
Active establishment of centromeric CENP-A chromatin by RSF complex. J Cell Biol (2009) 1.69
Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity. J Neurosci (2003) 1.69
Simvastatin suppresses the progression of experimentally induced cerebral aneurysms in rats. Stroke (2008) 1.67
Relevant use of Klotho in FGF19 subfamily signaling system in vivo. Proc Natl Acad Sci U S A (2010) 1.66
Natural alpha interferon-producing cells respond to human immunodeficiency virus type 1 with alpha interferon production and maturation into dendritic cells. J Virol (2003) 1.64
Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells. Dev Biol (2006) 1.64
Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Stroke (2008) 1.64
Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells. Mol Biol Cell (2008) 1.63