Published in J Neurosci on July 09, 2003
Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. Mol Pain (2005) 1.94
Structure and function of TRPV1. Pflugers Arch (2005) 1.91
Capsaicin-evoked iCGRP release from human dental pulp: a model system for the study of peripheral neuropeptide secretion in normal healthy tissue. Pain (2009) 1.59
The thermo-TRP ion channel family: properties and therapeutic implications. Br J Pharmacol (2012) 1.39
Purinergic regulation of guinea pig suburothelial myofibroblasts. J Physiol (2004) 1.37
Inflammatory pain: the cellular basis of heat hyperalgesia. Curr Neuropharmacol (2006) 1.37
Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation. Mol Cell Neurosci (2009) 1.37
Protein kinase C mediates up-regulation of tetrodotoxin-resistant, persistent Na+ current in rat and mouse sensory neurones. J Physiol (2005) 1.34
Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1. Mol Cell Neurosci (2007) 1.28
TRPV1: on the road to pain relief. Curr Mol Pharmacol (2008) 1.26
Properties of the inner pore region of TRPV1 channels revealed by block with quaternary ammoniums. J Gen Physiol (2008) 1.24
Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2. Pain (2008) 1.20
Nucleotide signaling and cutaneous mechanisms of pain transduction. Brain Res Rev (2008) 1.19
Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat. J Neurosci (2008) 1.18
Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity. Mol Pain (2014) 1.16
Transient receptor potential vanilloid type-1 (TRPV-1) channels contribute to cutaneous thermal hyperaemia in humans. J Physiol (2010) 1.14
P2Y receptors and pain transmission. Purinergic Signal (2004) 1.12
Protein kinase C in pain: involvement of multiple isoforms. Pharmacol Res (2007) 1.09
Crossing the pain barrier: P2 receptors as targets for novel analgesics. J Physiol (2003) 1.03
Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling. J Biol Chem (2013) 1.03
A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory pain. Br J Pharmacol (2010) 1.02
Transient receptor potential channels in pain and inflammation: therapeutic opportunities. Pain Pract (2010) 0.99
Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5-HT receptors in rat primary sensory neurons. J Physiol (2006) 0.99
Moving towards supraspinal TRPV1 receptors for chronic pain relief. Mol Pain (2010) 0.99
Co-activation of P2Y2 receptor and TRPV channel by ATP: implications for ATP induced pain. Cell Mol Neurobiol (2005) 0.99
Purinergic receptor P2Y1 regulates polymodal C-fiber thermal thresholds and sensory neuron phenotypic switching during peripheral inflammation. Pain (2011) 0.98
Altered ATP release and metabolism in dorsal root ganglia of neuropathic rats. Mol Pain (2008) 0.97
Endothelin potentiates TRPV1 via ETA receptor-mediated activation of protein kinase C. Mol Pain (2007) 0.97
TRPV1: a target for next generation analgesics. Curr Neuropharmacol (2008) 0.95
Metabotropic P2Y receptors inhibit P2X3 receptor-channels via G protein-dependent facilitation of their desensitization. Br J Pharmacol (2007) 0.93
The P2Y2 receptor sensitizes mouse bladder sensory neurons and facilitates purinergic currents. J Neurosci (2010) 0.92
TRPV1: A Potential Drug Target for Treating Various Diseases. Cells (2014) 0.91
Distribution of ecto-nucleotidases in mouse sensory circuits suggests roles for nucleoside triphosphate diphosphohydrolase-3 in nociception and mechanoreception. Neuroscience (2011) 0.89
Regulation of neuronal ion channels via P2Y receptors. Purinergic Signal (2004) 0.89
The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors. Mol Pain (2011) 0.88
Reactive oxygen species mediate TNFR1 increase after TRPV1 activation in mouse DRG neurons. Mol Pain (2009) 0.88
Functions of neuronal P2Y receptors. Pflugers Arch (2006) 0.88
Inhibition of G protein-coupled P2Y2 receptor induced analgesia in a rat model of trigeminal neuropathic pain. Mol Pain (2014) 0.87
The effects of sympathetic outflow on upregulation of vanilloid receptors TRPV(1) in primary afferent neurons evoked by intradermal capsaicin. Exp Neurol (2009) 0.86
Interaction of P2 purinergic receptors with cellular macromolecules. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.86
Nucleotides control the excitability of sensory neurons via two P2Y receptors and a bifurcated signaling cascade. Pain (2011) 0.85
ATP receptors in pain sensation: Involvement of spinal microglia and P2X(4) receptors. Purinergic Signal (2005) 0.85
New perspectives on the endothelin axis in pain. Pharmacol Res (2011) 0.84
Emerging peripheral receptor targets for deep-tissue craniofacial pain therapies. J Dent Res (2009) 0.84
αCGRP is essential for algesic exocytotic mobilization of TRPV1 channels in peptidergic nociceptors. Proc Natl Acad Sci U S A (2014) 0.83
P2Y2 receptors mediate ATP-induced resensitization of TRPV1 expressed by kidney projecting sensory neurons. Am J Physiol Regul Integr Comp Physiol (2010) 0.83
Molecular determinants of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) binding to transient receptor potential V1 (TRPV1) channels. J Biol Chem (2014) 0.83
P2 receptors and chronic pain. Purinergic Signal (2007) 0.83
The purinergic system and glial cells: emerging costars in nociception. Biomed Res Int (2014) 0.82
Opportunistic activation of TRP receptors by endogenous lipids: exploiting lipidomics to understand TRP receptor cellular communication. Life Sci (2012) 0.82
IB4(+) and TRPV1(+) sensory neurons mediate pain but not proliferation in a mouse model of squamous cell carcinoma. Behav Brain Funct (2014) 0.81
Propofol-induced pain sensation involves multiple mechanisms in sensory neurons. Pflugers Arch (2014) 0.80
Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways. J Biol Chem (2012) 0.80
P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction. Neural Plast (2016) 0.79
P2X₃ and TRPV1 functionally interact and mediate sensitization of trigeminal sensory neurons. Neuroscience (2012) 0.79
CFTR mediates noradrenaline-induced ATP efflux from DRG neurons. Mol Pain (2011) 0.78
Activation of TRPV1 by capsaicin induces functional kinin B(1) receptor in rat spinal cord microglia. J Neuroinflammation (2012) 0.78
Adenosine 5'-triphosphate and its relationship with other mediators that activate pelvic nerve afferent neurons in the rat colorectum. Purinergic Signal (2006) 0.78
Tissue injury and related mediators of pain exacerbation. Curr Neuropharmacol (2013) 0.78
The timing of endocytosis after activation of a G-protein-coupled receptor in a sensory neuron. Biophys J (2006) 0.77
Enhancement of purinergic signalling by excessive endogenous ATP in resiniferatoxin (RTX) neuropathy. Purinergic Signal (2012) 0.77
P2Y1, P2Y2, and TRPV1 Receptors Are Increased in Diarrhea-Predominant Irritable Bowel Syndrome and P2Y2 Correlates with Abdominal Pain. Dig Dis Sci (2016) 0.76
Hyperalgesic activity of kisspeptin in mice. Mol Pain (2011) 0.76
Enhancement of acid-sensing ion channel activity by metabotropic P2Y UTP receptors in primary sensory neurons. Purinergic Signal (2015) 0.75
TRP channels: potential drug target for neuropathic pain. Inflammopharmacology (2016) 0.75
Molecular sensors and modulators of thermoreception. Channels (Austin) (2015) 0.75
Invited Lectures : Overviews Purinergic signalling: past, present and future. Purinergic Signal (2006) 0.75
P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome. World J Gastroenterol (2017) 0.75
Deletion of the murine ATP/UTP receptor P2Y2 alters mechanical and thermal response properties in polymodal cutaneous afferents. Neuroscience (2016) 0.75
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature (2005) 7.07
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature (2003) 6.04
International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev (2006) 5.28
Heat-evoked activation of the ion channel, TRPV4. J Neurosci (2002) 4.69
Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia. Trends Neurosci (2005) 4.01
UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature (2007) 3.78
Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors. J Comp Neurol (2005) 3.72
Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nat Chem Biol (2006) 3.66
Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron (2003) 3.61
Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci U S A (2006) 3.24
TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J Clin Invest (2005) 3.05
Platelet-derived serotonin mediates liver regeneration. Science (2006) 2.98
Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues. J Biol Chem (2002) 2.79
alpha-Klotho as a regulator of calcium homeostasis. Science (2007) 2.71
Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest (2007) 2.66
Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. J Am Coll Cardiol (2010) 2.55
Neuronal 'On' and 'Off' signals control microglia. Trends Neurosci (2007) 2.55
Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. Trends Pharmacol Sci (2003) 2.37
TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. EMBO J (2006) 2.21
Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4. J Neurosci (2005) 2.21
Age- and sex-specific prevalence of diabetes and impaired glucose regulation in 11 Asian cohorts. Diabetes Care (2003) 2.18
Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia. J Neurosci (2004) 2.09
Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. J Neurosci (2004) 2.04
Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation. J Neurosci (2004) 1.99
Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization. J Neurosci (2002) 1.96
Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. Mol Pain (2005) 1.94
Structural determinant of TRPV1 desensitization interacts with calmodulin. Proc Natl Acad Sci U S A (2003) 1.92
Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development. Cancer Res (2004) 1.84
MAPK activation in nociceptive neurons and pain hypersensitivity. Life Sci (2004) 1.81
Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain. Brain (2008) 1.78
Bradykinin lowers the threshold temperature for heat activation of vanilloid receptor 1. J Neurophysiol (2002) 1.76
TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP. Pflugers Arch (2009) 1.75
P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury. J Neurosci (2008) 1.74
Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese Population: the Funagata study. Diabetes Care (2003) 1.72
Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane. Blood (2013) 1.65
Cardiovascular mortality in chronic kidney disease patients undergoing percutaneous coronary intervention is mainly related to impaired P2Y12 inhibition by clopidogrel. J Am Coll Cardiol (2011) 1.64
The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures. J Biol Chem (2009) 1.61
Acute optogenetic silencing of orexin/hypocretin neurons induces slow-wave sleep in mice. J Neurosci (2011) 1.58
IFN-gamma receptor signaling mediates spinal microglia activation driving neuropathic pain. Proc Natl Acad Sci U S A (2009) 1.57
Microparticles are new biomarkers of septic shock-induced disseminated intravascular coagulopathy. Intensive Care Med (2013) 1.56
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo. J Exp Med (2003) 1.56
Drosophila painless is a Ca2+-requiring channel activated by noxious heat. J Neurosci (2008) 1.55
Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures. Proc Natl Acad Sci U S A (2003) 1.55
P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain. J Neurosci (2008) 1.55
Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42. Blood (2013) 1.52
MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice. J Pharmacol Exp Ther (2005) 1.51
Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats. Exp Neurol (2006) 1.48
Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation. Pain (2011) 1.48
Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis. Glia (2007) 1.47
Biogenesis of the demarcation membrane system (DMS) in megakaryocytes. Blood (2013) 1.47
Functional roles of Otx2 transcription factor in postnatal mouse retinal development. Mol Cell Biol (2007) 1.46
NMDA receptor-independent synaptic plasticity in the central amygdala in the rat model of neuropathic pain. Pain (2006) 1.46
Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD. Blood (2012) 1.45
Effects of body temperature on neural activity in the hippocampus: regulation of resting membrane potentials by transient receptor potential vanilloid 4. J Neurosci (2007) 1.43
Impact of P2Y12 inhibition by clopidogrel on cardiovascular mortality in unselected patients treated by percutaneous coronary angioplasty: a prospective registry. JACC Cardiovasc Interv (2010) 1.42
Ca2+ waves in keratinocytes are transmitted to sensory neurons: the involvement of extracellular ATP and P2Y2 receptor activation. Biochem J (2004) 1.42
Overexpression of SPACIA1/SAAL1, a newly identified gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans. Arthritis Rheum (2011) 1.41
Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation. Development (2006) 1.41
Type 2 diabetes is not a risk factor for asymptomatic ischemic brain lesion--the Funagata study. Intern Med (2002) 1.41
Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCepsilon-mediated phosphorylation at S800. Pain (2006) 1.41
Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury. J Neurosci (2003) 1.40
Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons. J Comp Neurol (2008) 1.38
BDNF in sensory neurons and chronic pain. Neurosci Res (2006) 1.38
P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis. EMBO J (2008) 1.38
Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes. J Physiol (2011) 1.37
Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology. J Cell Biol (2013) 1.35
Local inflammation increases vanilloid receptor 1 expression within distinct subgroups of DRG neurons. Brain Res (2003) 1.35
JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats. Brain (2011) 1.34
Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury. J Neurosci (2008) 1.34