Developmental programming in response to maternal overnutrition.

PubWeight™: 1.38‹?› | Rank: Top 10%

🔗 View Article (PMC 3268582)

Published in Front Genet on June 03, 2011

Authors

Maria Z Alfaradhi1, Susan E Ozanne

Author Affiliations

1: Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge Cambridge, UK.

Articles citing this

Maternal adiposity--a determinant of perinatal and offspring outcomes? Nat Rev Endocrinol (2012) 1.62

Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery. Proc Natl Acad Sci U S A (2013) 1.28

Can we modify the intrauterine environment to halt the intergenerational cycle of obesity? Int J Environ Res Public Health (2012) 1.11

Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity. Physiol Rev (2015) 1.10

Association of trimester-specific gestational weight gain with fetal growth, offspring obesity, and cardiometabolic traits in early childhood. Am J Obstet Gynecol (2014) 1.10

Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms. Mol Metab (2014) 1.03

High fat diet and in utero exposure to maternal obesity disrupts circadian rhythm and leads to metabolic programming of liver in rat offspring. PLoS One (2014) 1.01

Mechanisms of lipotoxicity in the cardiovascular system. Curr Hypertens Rep (2012) 0.98

Animal models of in utero exposure to a high fat diet: a review. Biochim Biophys Acta (2013) 0.97

Maternal obesity, inflammation, and developmental programming. Biomed Res Int (2014) 0.94

Maternal obesity and diabetes induces latent metabolic defects and widespread epigenetic changes in isogenic mice. Epigenetics (2013) 0.94

Methylation and expression of immune and inflammatory genes in the offspring of bariatric bypass surgery patients. J Obes (2013) 0.91

High fat and/or high salt intake during pregnancy alters maternal meta-inflammation and offspring growth and metabolic profiles. Physiol Rep (2014) 0.90

Maternal obesity during pregnancy and cardiovascular development and disease in the offspring. Eur J Epidemiol (2015) 0.89

Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth. Obesity (Silver Spring) (2015) 0.87

Endocrine pancreatic development: impact of obesity and diet. Front Physiol (2013) 0.85

Fetal programming of the neuroendocrine-immune system and metabolic disease. J Pregnancy (2012) 0.84

Healthy living in pregnancy: a cluster-randomized controlled trial to prevent excessive gestational weight gain - rationale and design of the GeliS study. BMC Pregnancy Childbirth (2014) 0.84

Non-alcoholic fatty pancreas disease pathogenesis: a role for developmental programming and altered circadian rhythms. PLoS One (2014) 0.84

Study protocol: fit for delivery - can a lifestyle intervention in pregnancy result in measurable health benefits for mothers and newborns? A randomized controlled trial. BMC Public Health (2013) 0.84

The Impact of Kidney Development on the Life Course: A Consensus Document for Action. Nephron (2017) 0.82

RNA-seq analysis of the rat placentation site reveals maternal obesity-associated changes in placental and offspring thyroid hormone signaling. Placenta (2014) 0.82

Do all roads lead to Rome? The role of neuro-immune interactions before birth in the programming of offspring obesity. Front Neurosci (2015) 0.81

MicroRNA-194 Modulates Glucose Metabolism and Its Skeletal Muscle Expression Is Reduced in Diabetes. PLoS One (2016) 0.81

Maternal Obesity and the Fetal Origins of the Metabolic Syndrome. Curr Cardiovasc Risk Rep (2012) 0.80

Developmental Programming, a Pathway to Disease. Endocrinology (2016) 0.80

Maternal high fat and/or salt consumption induces sex-specific inflammatory and nutrient transport in the rat placenta. Physiol Rep (2015) 0.80

Effect of GLP-1 Receptor Activation on Offspring Kidney Health in a Rat Model of Maternal Obesity. Sci Rep (2016) 0.80

Maternal high-fat diet and obesity compromise fetal hematopoiesis. Mol Metab (2014) 0.79

Exercise rescues obese mothers' insulin sensitivity, placental hypoxia and male offspring insulin sensitivity. Sci Rep (2017) 0.78

Maternal Obesity Promotes Diabetic Nephropathy in Rodent Offspring. Sci Rep (2016) 0.78

Gestational Hyperandrogenism in Developmental Programming. Endocrinology (2016) 0.78

Increased placental fatty acid transporter 6 and binding protein 3 expression and fetal liver lipid accumulation in a mouse model of obesity in pregnancy. Am J Physiol Regul Integr Comp Physiol (2015) 0.77

Diet before and during Pregnancy and Offspring Health: The Importance of Animal Models and What Can Be Learned from Them. Int J Environ Res Public Health (2016) 0.77

Developmental influences on circuits programming susceptibility to obesity. Front Neuroendocrinol (2015) 0.76

Maternal high-fat diet prevents developmental programming by early-life stress. Transl Psychiatry (2016) 0.76

Influences of gestational obesity on associations between genotypes and gene expression levels in offspring following maternal gastrointestinal bypass surgery for obesity. PLoS One (2015) 0.76

Maternal obesity disrupts the methionine cycle in baboon pregnancy. Physiol Rep (2015) 0.76

Little appetite for obesity: meta-analysis of the effects of maternal obesogenic diets on offspring food intake and body mass in rodents. Int J Obes (Lond) (2015) 0.76

Maternal high-fat diet-induced programing of gut taste receptor and inflammatory gene expression in rat offspring is ameliorated by CLA supplementation. Physiol Rep (2015) 0.75

The intrauterine and nursing period is a window of susceptibility for development of obesity and intestinal tumorigenesis by a high fat diet in Min/+ mice as adults. J Obes (2015) 0.75

Maternal diabetes modulates dental epithelial stem cells proliferation and self-renewal in offspring through apurinic/apyrimidinicendonuclease 1-mediated DNA methylation. Sci Rep (2017) 0.75

A short-term transition from a high-fat diet to a normal-fat diet before pregnancy exacerbates female mouse offspring obesity. Int J Obes (Lond) (2015) 0.75

Epigenetic Mechanisms of Transmission of Metabolic Disease across Generations. Cell Metab (2017) 0.75

Maternal exposure to a Western-style diet causes differences in intestinal microbiota composition and gene expression of suckling mouse pups. Mol Nutr Food Res (2016) 0.75

Gestational Weight Gain and Offspring Longitudinal Growth in Early Life. Ann Nutr Metab (2015) 0.75

Nutritional recovery promotes hypothalamic inflammation in rats during adulthood. Mediators Inflamm (2014) 0.75

Is there A Role for Alpha-Linolenic Acid in the Fetal Programming of Health? J Clin Med (2016) 0.75

Development, brain plasticity and reward: early high-fat diet exposure confers vulnerability to obesity-view from the chair. Int J Obes Suppl (2012) 0.75

Offspring subcutaneous adipose markers are sensitive to the timing of maternal gestational weight gain. Reprod Biol Endocrinol (2015) 0.75

Maternal butyrate supplementation induces insulin resistance associated with enhanced intramuscular fat deposition in the offspring. Oncotarget (2016) 0.75

Developmental Origins of Cardiometabolic Diseases: Role of the Maternal Diet. Front Physiol (2016) 0.75

Nutritional Programming of Lifespan by FOXO Inhibition on Sugar-Rich Diets. Cell Rep (2017) 0.75

Perspectives on the design and methodology of periconceptional nutrient supplementation trials. Trials (2016) 0.75

Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowth. Am J Physiol Regul Integr Comp Physiol (2015) 0.75

The Association between High Fat Diet around Gestation and Metabolic Syndrome-related Phenotypes in Rats: A Systematic Review and Meta-Analysis. Sci Rep (2017) 0.75

The effect of maternal habitus on macronutrient content of human milk colostrum. J Perinatol (2017) 0.75

Epigenetic effects of the pregnancy Mediterranean diet adherence on the offspring metabolic syndrome markers. J Physiol Biochem (2017) 0.75

Effects of Maternal Obesity on Fetal Programming: Molecular Approaches. Cold Spring Harb Perspect Med (2015) 0.75

Articles cited by this

(truncated to the top 100)

Prevalence and trends in obesity among US adults, 1999-2008. JAMA (2010) 50.58

Prevalence and trends in obesity among US adults, 1999-2000. JAMA (2002) 33.23

Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol (2006) 21.58

Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest (2004) 13.42

Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia (1992) 13.20

Fetal and infant growth and impaired glucose tolerance at age 64. BMJ (1991) 12.33

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest (1995) 9.59

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science (1995) 9.09

Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics (2005) 8.99

Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia (1993) 8.86

Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet (2007) 6.55

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring. Nature (2010) 6.23

Being big or growing fast: systematic review of size and growth in infancy and later obesity. BMJ (2005) 6.17

Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes (2000) 5.83

Are poor living conditions in childhood and adolescence an important risk factor for arteriosclerotic heart disease? Br J Prev Soc Med (1977) 5.76

Gestational weight gain and child adiposity at age 3 years. Am J Obstet Gynecol (2007) 5.65

Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell (2010) 5.22

Duration of breastfeeding and risk of overweight: a meta-analysis. Am J Epidemiol (2005) 5.09

Interpregnancy weight change and risk of adverse pregnancy outcomes: a population-based study. Lancet (2006) 4.15

Association of maternal weight gain in pregnancy with offspring obesity and metabolic and vascular traits in childhood. Circulation (2010) 4.12

Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming. Hypertension (2007) 3.62

Neonatal leptin treatment reverses developmental programming. Endocrinology (2005) 3.51

Weight gain in the first week of life and overweight in adulthood: a cohort study of European American subjects fed infant formula. Circulation (2005) 3.28

Epigenetic gene promoter methylation at birth is associated with child's later adiposity. Diabetes (2011) 3.18

Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. Hepatology (2009) 3.11

Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates. J Clin Invest (2009) 3.10

Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition (2004) 3.08

Child to adult body mass index in the 1958 British birth cohort: associations with parental obesity. Arch Dis Child (1997) 2.97

Leptin signaling, adiposity, and energy balance. Ann N Y Acad Sci (2002) 2.54

A maternal 'junk food' diet in pregnancy and lactation promotes an exacerbated taste for 'junk food' and a greater propensity for obesity in rat offspring. Br J Nutr (2007) 2.54

Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet. J Physiol (2008) 2.41

Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice. J Neurosci (2004) 2.37

Family social class, maternal body mass index, childhood body mass index, and age at menarche as predictors of adult obesity. Am J Clin Nutr (2001) 2.24

Lower protein in infant formula is associated with lower weight up to age 2 y: a randomized clinical trial. Am J Clin Nutr (2009) 2.23

Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice. J Hepatol (2010) 2.18

Association of weight gain in infancy and early childhood with metabolic risk in young adults. J Clin Endocrinol Metab (2006) 2.15

Maternal triglyceride levels and newborn weight in pregnant women with normal glucose tolerance. Diabet Med (2005) 2.10

Maternal obesity at conception programs obesity in the offspring. Am J Physiol Regul Integr Comp Physiol (2007) 2.08

Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes. Endocrinology (2010) 2.02

Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years. Pediatrics (2006) 2.00

Oxidative stress is associated with adiposity and insulin resistance in men. J Clin Endocrinol Metab (2003) 1.92

Maternal obesity induced by diet in rats permanently influences central processes regulating food intake in offspring. PLoS One (2009) 1.88

Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity. Metabolism (2008) 1.88

A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring. Am J Physiol Regul Integr Comp Physiol (2004) 1.87

Maternal high-fat diet effects on third-generation female body size via the paternal lineage. Endocrinology (2011) 1.85

Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes. PLoS One (2010) 1.83

Comparing maternal and paternal intergenerational transmission of obesity risk in a large population-based sample. Am J Clin Nutr (2010) 1.79

The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation. J Clin Endocrinol Metab (2001) 1.77

Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome. J Physiol (2009) 1.74

Metabolic imprinting: critical impact of the perinatal environment on the regulation of energy homeostasis. Philos Trans R Soc Lond B Biol Sci (2006) 1.72

Maternal high-fat diet promotes body length increases and insulin insensitivity in second-generation mice. Endocrinology (2009) 1.71

Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood. Am J Physiol Endocrinol Metab (2006) 1.69

AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep. J Physiol (2008) 1.68

Role of neuropeptides in appetite regulation and obesity--a review. Neuropeptides (2006) 1.67

Effects of maternal surgical weight loss in mothers on intergenerational transmission of obesity. J Clin Endocrinol Metab (2009) 1.65

Postnatal environment overrides genetic and prenatal factors influencing offspring obesity and insulin resistance. Am J Physiol Regul Integr Comp Physiol (2006) 1.59

Gestational diabetes induces placental genes for chronic stress and inflammatory pathways. Diabetes (2003) 1.56

Changes in booking body mass index over a decade: retrospective analysis from a Glasgow Maternity Hospital. BJOG (2005) 1.55

Breastmilk feeding and lipoprotein profile in adolescents born preterm: follow-up of a prospective randomised study. Lancet (2004) 1.54

Impaired glucose homeostasis and mitochondrial abnormalities in offspring of rats fed a fat-rich diet in pregnancy. Am J Physiol Regul Integr Comp Physiol (2004) 1.53

Maternal obesity is necessary for programming effect of high-fat diet on offspring. Am J Physiol Regul Integr Comp Physiol (2009) 1.49

Dietary energy intake at the age of 4 months predicts postnatal weight gain and childhood body mass index. Pediatrics (2006) 1.43

Development of metabolic systems. Physiol Behav (2005) 1.43

Established diet-induced obesity in female rats leads to offspring hyperphagia, adiposity and insulin resistance. Diabetologia (2009) 1.41

Perinatal elevation of hypothalamic insulin, acquired malformation of hypothalamic galaninergic neurons, and syndrome x-like alterations in adulthood of neonatally overfed rats. Brain Res (1999) 1.37

The effect of neonatal leptin treatment on postnatal weight gain in male rats is dependent on maternal nutritional status during pregnancy. Endocrinology (2008) 1.36

Distribution of leptin-sensitive cells in the postnatal and adult mouse brain. J Comp Neurol (2010) 1.35

Maternal obesity accelerates fetal pancreatic beta-cell but not alpha-cell development in sheep: prenatal consequences. Am J Physiol Regul Integr Comp Physiol (2009) 1.30

Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring. BMC Genomics (2009) 1.29

A maternal cafeteria diet during gestation and lactation promotes adiposity and impairs skeletal muscle development and metabolism in rat offspring at weaning. J Physiol (2005) 1.29

Insulin receptor signaling in the development of neuronal structure and function. Neural Dev (2010) 1.29

Up-regulation of Toll-like receptor 4/nuclear factor-kappaB signaling is associated with enhanced adipogenesis and insulin resistance in fetal skeletal muscle of obese sheep at late gestation. Endocrinology (2009) 1.27

Relation of immediate postnatal growth with obesity and related metabolic risk factors in adulthood: the northern Finland birth cohort 1966 study. Am J Epidemiol (2010) 1.26

Early overnutrition results in early-onset arcuate leptin resistance and increased sensitivity to high-fat diet. Endocrinology (2010) 1.25

Maternal obesity downregulates myogenesis and beta-catenin signaling in fetal skeletal muscle. Am J Physiol Endocrinol Metab (2009) 1.24

Nutrition in infancy and long-term risk of obesity: evidence from 2 randomized controlled trials. Am J Clin Nutr (2010) 1.24

Preweaning food intake influences the adiposity of young adult baboons. J Clin Invest (1986) 1.23

Maternal "junk-food" feeding of rat dams alters food choices and development of the mesolimbic reward pathway in the offspring. FASEB J (2011) 1.22

Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse. Endocrinology (1993) 1.22

Maternal overweight programs insulin and adiponectin signaling in the offspring. Endocrinology (2010) 1.21

Maternal obesity up-regulates inflammatory signaling pathways and enhances cytokine expression in the mid-gestation sheep placenta. Placenta (2010) 1.20

Altered body composition and metabolism in the male offspring of high fat-fed rats. Metabolism (2005) 1.18

Increased maternal nutrition stimulates peroxisome proliferator activated receptor-gamma, adiponectin, and leptin messenger ribonucleic acid expression in adipose tissue before birth. Endocrinology (2006) 1.17

Obesity and enhanced diabetes and cardiovascular risk in adult rats due to early postnatal overfeeding. Exp Clin Endocrinol (1992) 1.15

Appetite and reward. Front Neuroendocrinol (2009) 1.14

Maternal antioxidant supplementation prevents adiposity in the offspring of Western diet-fed rats. Diabetes (2010) 1.13

Developmental changes in hypothalamic leptin receptor: relationship with the postnatal leptin surge and energy balance neuropeptides in the postnatal rat. Am J Physiol Regul Integr Comp Physiol (2009) 1.12

Fetal programming of glucose-insulin metabolism. Mol Cell Endocrinol (2008) 1.10

Epigenetic malprogramming of the insulin receptor promoter due to developmental overfeeding. J Perinat Med (2010) 1.10

The intake of physiological doses of leptin during lactation in rats prevents obesity in later life. Int J Obes (Lond) (2007) 1.10

Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity. Nat Med (2002) 1.09

Maternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-fat diet in male offspring. Am J Physiol Regul Integr Comp Physiol (2009) 1.08

Leptin regulates appetite-related neuropeptides in the hypothalamus of developing rats without affecting food intake. Endocrinology (2002) 1.07

Maternal obesity markedly increases placental fatty acid transporter expression and fetal blood triglycerides at midgestation in the ewe. Am J Physiol Regul Integr Comp Physiol (2010) 1.05

Dietary intervention prior to pregnancy reverses metabolic programming in male offspring of obese rats. J Physiol (2010) 1.03

Prenatal high protein exposure decreases energy expenditure and increases adiposity in young rats. J Nutr (2002) 1.02

Resistance to high-fat diet in the female progeny of obese mice fed a control diet during the periconceptual, gestation, and lactation periods. Am J Physiol Endocrinol Metab (2006) 1.02

Insulin resistance of hypothalamic arcuate neurons in neonatally overfed rats. Neuroreport (2007) 1.00

Altered responses to orexigenic (AGRP, MCH) and anorexigenic (alpha-MSH, CART) neuropeptides of paraventricular hypothalamic neurons in early postnatally overfed rats. Eur J Neurosci (2003) 1.00

Oral supplementation with physiological doses of leptin during lactation in rats improves insulin sensitivity and affects food preferences later in life. Endocrinology (2007) 1.00

Articles by these authors

Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming. Hypertension (2007) 3.62

Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice. J Hepatol (2010) 2.18

Protein restriction in lactation confers nephroprotective effects in the male rat and is associated with increased antioxidant expression. Am J Physiol Regul Integr Comp Physiol (2007) 2.15

DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res (2007) 2.09

Mechanisms involved in the developmental programming of adulthood disease. Biochem J (2010) 1.95

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. Proc Natl Acad Sci U S A (2011) 1.95

Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease. Lancet (2013) 1.73

Leptin-independent programming of adult body weight and adiposity in mice. Endocrinology (2011) 1.49

Sex differences in developmental programming models. Reproduction (2013) 1.37

Early life nutrition and metabolic programming. Ann N Y Acad Sci (2010) 1.24

Altered body composition and metabolism in the male offspring of high fat-fed rats. Metabolism (2005) 1.18

Transgenerational developmental programming. Hum Reprod Update (2013) 1.17

The involvement of microRNAs in Type 2 diabetes. Biochem Soc Trans (2010) 1.17

Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts. J Biol Chem (2004) 1.14

Fetal programming of glucose-insulin metabolism. Mol Cell Endocrinol (2008) 1.10

Mechanisms of early life programming: current knowledge and future directions. Am J Clin Nutr (2011) 1.10

Maternal low-protein diet programs cardiac beta-adrenergic response and signaling in 3-mo-old male offspring. Am J Physiol Regul Integr Comp Physiol (2006) 1.09

Altered PI3-kinase/Akt signalling in skeletal muscle of young men with low birth weight. PLoS One (2008) 1.08

Nutritional programming of insulin resistance: causes and consequences. Trends Endocrinol Metab (2013) 1.06

Fetal determinants of type 2 diabetes. Curr Drug Targets (2007) 1.06

Programming of appetite and type 2 diabetes. Early Hum Dev (2005) 1.03

Maternal protein restriction affects postnatal growth and the expression of key proteins involved in lifespan regulation in mice. PLoS One (2009) 1.03

Developmental programming of energy balance and the metabolic syndrome. Proc Nutr Soc (2007) 0.99

Poor maternal nutrition leads to alterations in oxidative stress, antioxidant defense capacity, and markers of fibrosis in rat islets: potential underlying mechanisms for development of the diabetic phenotype in later life. FASEB J (2010) 0.99

Long-term programming of blood pressure by maternal dietary iron restriction in the rat. Br J Nutr (2002) 0.99

Intra-uterine origins of type 2 diabetes. Arch Physiol Biochem (2007) 0.99

Altered skeletal muscle insulin signaling and mitochondrial complex II-III linked activity in adult offspring of obese mice. Am J Physiol Regul Integr Comp Physiol (2009) 0.98

Maternal protein restriction leads to early life alterations in the expression of key molecules involved in the aging process in rat offspring. Am J Physiol Regul Integr Comp Physiol (2007) 0.98

DNA methylation at differentially methylated regions of imprinted genes is resistant to developmental programming by maternal nutrition. Epigenetics (2012) 0.97

Mechanisms underlying the developmental origins of disease. Rev Endocr Metab Disord (2012) 0.96

Fetal and perinatal programming of appetite. Clin Sci (Lond) (2005) 0.95

The programming of cardiac hypertrophy in the offspring by maternal obesity is associated with hyperinsulinemia, AKT, ERK, and mTOR activation. Endocrinology (2012) 0.95

Programming of hypothalamic neuropeptide gene expression in rats by maternal dietary protein content during pregnancy and lactation. Clin Sci (Lond) (2009) 0.94

Poor maternal nutrition followed by accelerated postnatal growth leads to alterations in DNA damage and repair, oxidative and nitrosative stress, and oxidative defense capacity in rat heart. FASEB J (2012) 0.92

Heterogeneity in premature senescence by oxidative stress correlates with differential DNA damage during the cell cycle. DNA Repair (Amst) (2005) 0.92

Differential effects of maternal obesity and weight loss in the periconceptional period on the epigenetic regulation of hepatic insulin-signaling pathways in the offspring. FASEB J (2013) 0.91

Developmental and environmental epigenetic programming of the endocrine pancreas: consequences for type 2 diabetes. Cell Mol Life Sci (2013) 0.91

Lower antioxidant capacity and elevated p53 and p21 may be a link between gender disparity in renal telomere shortening, albuminuria, and longevity. Am J Physiol Renal Physiol (2005) 0.90

Coenzyme Q10 prevents accelerated cardiac aging in a rat model of poor maternal nutrition and accelerated postnatal growth. Mol Metab (2013) 0.88

Mechanisms linking suboptimal early nutrition and increased risk of type 2 diabetes and obesity. J Nutr (2010) 0.86

Maternal diet-induced obesity programs cardiovascular dysfunction in adult male mouse offspring independent of current body weight. Endocrinology (2014) 0.86

Methods of cellular senescence induction using oxidative stress. Methods Mol Biol (2007) 0.85

Deep senescent human fibroblasts show diminished DNA damage foci but retain checkpoint capacity to oxidative stress. FEBS Lett (2006) 0.84

Postnatal development of hypothalamic leptin receptors. Vitam Horm (2010) 0.84

Early-life nutrition influences thymic growth in male mice that may be related to the regulation of longevity. Clin Sci (Lond) (2009) 0.84

Early life programming of obesity. Med Wieku Rozwoj (2013) 0.84

Suboptimal nutrition in utero causes DNA damage and accelerated aging of the female reproductive tract. FASEB J (2013) 0.84

Periconceptional undernutrition programs changes in insulin-signaling molecules and microRNAs in skeletal muscle in singleton and twin fetal sheep. Biol Reprod (2014) 0.84

Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetes. Diabetologia (2014) 0.83

Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep. Am J Physiol Endocrinol Metab (2014) 0.81

Early nutrition, epigenetics, and cardiovascular disease. Curr Opin Lipidol (2016) 0.81

Maternal protein restriction affects gene expression profiles in the kidney at weaning with implications for the regulation of renal function and lifespan. Clin Sci (Lond) (2010) 0.81

Developmental programming of type 2 diabetes: early nutrition and epigenetic mechanisms. Curr Opin Clin Nutr Metab Care (2015) 0.81

Maternal diet amplifies the hepatic aging trajectory of Cidea in male mice and leads to the development of fatty liver. FASEB J (2014) 0.79

Suckling a protein-restricted rat dam leads to diminished albuminuria in her male offspring in adult life: a longitudinal study. BMC Nephrol (2006) 0.78

Adverse effects of reduced oxygen tension on the proliferative capacity of rat kidney and insulin-secreting cell lines involve DNA damage and stress responses. Exp Cell Res (2008) 0.78

Cannabis use is associated with increased CCL11 plasma levels in young healthy volunteers. Prog Neuropsychopharmacol Biol Psychiatry (2013) 0.77

Epigenetic signatures of obesity. N Engl J Med (2015) 0.77

The effect of maternal body condition score before and during pregnancy on the glucose tolerance of adult sheep offspring. Reprod Sci (2008) 0.77

Analysis of expression of growth factor receptors in replicatively and oxidatively senescent human fibroblasts. FEBS Lett (2005) 0.77

Effects of cortisol and dexamethasone on insulin signalling pathways in skeletal muscle of the ovine fetus during late gestation. PLoS One (2012) 0.77

Impact of embryo number and periconceptional undernutrition on factors regulating adipogenesis, lipogenesis, and metabolism in adipose tissue in the sheep fetus. Am J Physiol Endocrinol Metab (2013) 0.77

Proteomic analysis of the maternal protein restriction rat model for schizophrenia: identification of translational changes in hormonal signaling pathways and glutamate neurotransmission. Proteomics (2012) 0.76

Poor maternal nutrition programmes a pro-atherosclerotic phenotype in ApoE-/- mice. Clin Sci (Lond) (2012) 0.76

Lower maternal body condition during pregnancy affects skeletal muscle structure and glut-4 protein levels but not glucose tolerance in mature adult sheep. Reprod Sci (2013) 0.75

The relationship between poor growth rate and increased risk of Type 2 diabetes, insulin resistance and obesity. Expert Rev Pharmacoecon Outcomes Res (2006) 0.75

Analysis of the rat hypothalamus proteome by data-independent label-free LC-MS/MS. Proteomics (2012) 0.75

5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats. Development (2016) 0.75

Early determinants of chronic disease. Preface. Best Pract Res Clin Endocrinol Metab (2012) 0.75