Published in Nat Rev Genet on September 01, 2007
Human genetic variation and its contribution to complex traits. Nat Rev Genet (2009) 12.11
Uncovering the roles of rare variants in common disease through whole-genome sequencing. Nat Rev Genet (2010) 9.53
Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies. Am J Hum Genet (2009) 5.65
Power of deep, all-exon resequencing for discovery of human trait genes. Proc Natl Acad Sci U S A (2009) 5.61
Genomewide association studies: history, rationale, and prospects for psychiatric disorders. Am J Psychiatry (2009) 4.74
Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes (2008) 4.57
Genomewide association for schizophrenia in the CATIE study: results of stage 1. Mol Psychiatry (2008) 4.14
Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry (2008) 3.85
Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes. PLoS Genet (2010) 3.75
Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry. Ann Intern Med (2009) 3.68
Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. Diabetes (2008) 3.45
Beyond odds ratios--communicating disease risk based on genetic profiles. Nat Rev Genet (2009) 3.01
Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes (2009) 2.92
A network view of disease and compound screening. Nat Rev Drug Discov (2009) 2.90
Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell (2009) 2.79
Advances in autism. Annu Rev Med (2009) 2.75
PGA: power calculator for case-control genetic association analyses. BMC Genet (2008) 2.71
Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC Med Genet (2008) 2.63
Identification of new genetic risk variants for type 2 diabetes. PLoS Genet (2010) 2.62
Genome-wide association studies in type 2 diabetes. Curr Diab Rep (2009) 2.60
Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men. Diabetes (2009) 2.51
Quality control procedures for genome-wide association studies. Curr Protoc Hum Genet (2011) 2.48
Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Diabetes (2008) 2.46
Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians. Diabetes (2010) 2.16
Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies. Diabetes Care (2010) 2.14
Meta-analysis of 32 genome-wide linkage studies of schizophrenia. Mol Psychiatry (2008) 2.07
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2009) 2.03
Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes. Diabetes (2008) 2.01
Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value. PLoS One (2008) 1.94
No association of multiple type 2 diabetes loci with type 1 diabetes. Diabetologia (2009) 1.92
Genetic variation at the FTO locus influences RBL2 gene expression. Diabetes (2009) 1.91
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. Diabetes (2009) 1.90
Diabetes prevalence and body mass index differ by ethnicity: the Multiethnic Cohort. Ethn Dis (2009) 1.88
Case-control genome-wide association study of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry (2010) 1.86
Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue. Diabetes (2009) 1.72
Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program. Diabetes (2008) 1.71
Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects. Ann N Y Acad Sci (2008) 1.69
Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study. PLoS Genet (2008) 1.67
Considerations for designing a prototype genetic test for use in translational research. Public Health Genomics (2009) 1.67
Pharmacological approaches to restore mitochondrial function. Nat Rev Drug Discov (2013) 1.66
Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr Rev (2008) 1.66
The clinical application of genetic testing in type 2 diabetes: a patient and physician survey. Diabetologia (2009) 1.63
Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008. J Clin Endocrinol Metab (2008) 1.61
Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program. Diabetologia (2007) 1.60
Cognitive ontologies for neuropsychiatric phenomics research. Cogn Neuropsychiatry (2009) 1.59
Type 2 diabetes risk alleles are associated with reduced size at birth. Diabetes (2009) 1.58
Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits. PLoS One (2012) 1.58
Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases. PLoS Genet (2012) 1.55
1H NMR metabonomics approach to the disease continuum of diabetic complications and premature death. Mol Syst Biol (2008) 1.51
From monogenic to polygenic obesity: recent advances. Eur Child Adolesc Psychiatry (2010) 1.49
The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis. Am J Epidemiol (2010) 1.49
Lessons from "lower" organisms: what worms, flies, and zebrafish can teach us about human energy metabolism. PLoS Genet (2007) 1.43
Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men. Am J Clin Nutr (2009) 1.43
Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review. Exp Gerontol (2008) 1.41
Developmental programming in response to maternal overnutrition. Front Genet (2011) 1.38
Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study. J Health Popul Nutr (2017) 1.38
A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase beta gene is associated with proteinuria in patients with type 2 diabetes. PLoS Genet (2010) 1.38
Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose. Genet Epidemiol (2010) 1.34
Genomics of type 2 diabetes mellitus: implications for the clinician. Nat Rev Endocrinol (2009) 1.34
The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes. J Clin Endocrinol Metab (2008) 1.32
Learning from molecular genetics: novel insights arising from the definition of genes for monogenic and type 2 diabetes. Diabetes (2008) 1.31
Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance. Proc Natl Acad Sci U S A (2010) 1.30
Human genetic factors and respiratory syncytial virus disease severity. Clin Microbiol Rev (2008) 1.30
Genome-wide linkage and admixture mapping of type 2 diabetes in African American families from the American Diabetes Association GENNID (Genetics of NIDDM) Study Cohort. Diabetes (2008) 1.27
Comparisons of seven algorithms for pathway analysis using the WTCCC Crohn's Disease dataset. BMC Res Notes (2011) 1.24
Candidate gene association study for diabetic retinopathy in persons with type 2 diabetes: the Candidate gene Association Resource (CARe). Invest Ophthalmol Vis Sci (2011) 1.22
Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes. Curr Diabetes Rev (2013) 1.21
Genetic variants and the risk of gestational diabetes mellitus: a systematic review. Hum Reprod Update (2013) 1.21
Individual and cumulative effects of GWAS susceptibility loci in lung cancer: associations after sub-phenotyping for COPD. PLoS One (2011) 1.20
A dynamic model for genome-wide association studies. Hum Genet (2011) 1.15
Type 2 Diabetes Mellitus: New Genetic Insights will Lead to New Therapeutics. Curr Genomics (2009) 1.14
Identifying modifier genes of monogenic disease: strategies and difficulties. Hum Genet (2008) 1.13
African ancestry and its correlation to type 2 diabetes in African Americans: a genetic admixture analysis in three U.S. population cohorts. PLoS One (2012) 1.12
Increased risk of type 2 diabetes in elderly twins. Diabetes (2009) 1.12
MOPAT: a graph-based method to predict recurrent cis-regulatory modules from known motifs. Nucleic Acids Res (2008) 1.11
A replication study of GWAS-derived lipid genes in Asian Indians: the chromosomal region 11q23.3 harbors loci contributing to triglycerides. PLoS One (2012) 1.11
Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: a study of 3,310 subjects from India and the US. BMC Med Genet (2011) 1.10
A new methodology to associate SNPs with human diseases according to their pathway related context. PLoS One (2011) 1.09
Genome-wide association studies for atherosclerotic vascular disease and its risk factors. Circ Cardiovasc Genet (2009) 1.09
Meta-analysis approach identifies candidate genes and associated molecular networks for type-2 diabetes mellitus. BMC Genomics (2008) 1.08
Gene expression in skeletal muscle biopsies from people with type 2 diabetes and relatives: differential regulation of insulin signaling pathways. PLoS One (2009) 1.07
The FTO gene, implicated in human obesity, is found only in vertebrates and marine algae. J Mol Evol (2007) 1.07
Effects of normalization on quantitative traits in association test. BMC Bioinformatics (2009) 1.07
Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium. Am J Epidemiol (2012) 1.05
Common genetic determinants of glucose homeostasis in healthy children: the European Youth Heart Study. Diabetes (2009) 1.05
Personalized medicine for diabetes. J Diabetes Sci Technol (2008) 1.05
Identifying genetic marker sets associated with phenotypes via an efficient adaptive score test. Biostatistics (2012) 1.04
Genome-wide association studies and the genetic dissection of complex traits. Am J Hematol (2009) 1.04
Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts. Am J Epidemiol (2012) 1.03
Identification of KCNJ15 as a susceptibility gene in Asian patients with type 2 diabetes mellitus. Am J Hum Genet (2010) 1.01
A likelihood ratio-based Mann-Whitney approach finds novel replicable joint gene action for type 2 diabetes. Genet Epidemiol (2012) 1.00
ATHENA: A knowledge-based hybrid backpropagation-grammatical evolution neural network algorithm for discovering epistasis among quantitative trait Loci. BioData Min (2010) 1.00
Phenomics: building scaffolds for biological hypotheses in the post-genomic era. Biol Psychiatry (2008) 0.99
Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA). Genet Epidemiol (2012) 0.99
Genetics factors contributing to type 2 diabetes across ethnicities. J Diabetes Sci Technol (2009) 0.98
FAM13A locus in COPD is independently associated with lung cancer - evidence of a molecular genetic link between COPD and lung cancer. Appl Clin Genet (2010) 0.97
The association between KCNQ1 gene polymorphism and type 2 diabetes risk: a meta-analysis. PLoS One (2012) 0.95
Elevating optimal human nutrition to a central goal of plant breeding and production of plant-based foods. Plant Sci (2009) 0.95
Spatio-temporal analysis of type 2 diabetes mellitus based on differential expression networks. Sci Rep (2013) 0.94