Published in Endocrinology on February 14, 2012
WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nat Med (2013) 4.52
Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Nature (2014) 2.42
Cortical-Bone Fragility--Insights from sFRP4 Deficiency in Pyle's Disease. N Engl J Med (2016) 2.15
A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength. Proc Natl Acad Sci U S A (2012) 1.48
Regulation of tissue morphogenesis by endothelial cell-derived signals. Trends Cell Biol (2014) 0.97
BMP signaling in mesenchymal stem cell differentiation and bone formation. J Biomed Sci Eng (2013) 0.89
Systemic injection of CK2.3, a novel peptide acting downstream of bone morphogenetic protein receptor BMPRIa, leads to increased trabecular bone mass. J Orthop Res (2014) 0.80
Dynamics and cellular localization of Bmp2, Bmp4, and Noggin transcription in the postnatal mouse skeleton. J Bone Miner Res (2015) 0.78
The effect of noggin interference in a rabbit posterolateral spinal fusion model. Eur Spine J (2014) 0.75
Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res (1987) 24.27
Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res (2010) 9.95
The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell (1996) 5.66
The amazing osteocyte. J Bone Miner Res (2011) 5.32
Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. Cell (1992) 5.31
Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res (2008) 4.82
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science (1998) 4.72
Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem (2002) 4.52
Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol (2002) 4.14
Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev (2003) 3.85
Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res (2006) 3.44
Age-related changes in trabecular architecture differ in female and male C57BL/6J mice. J Bone Miner Res (2007) 3.38
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell (2001) 3.30
The CCN family: a new stimulus package. J Endocrinol (2003) 3.16
The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways. J Biol Chem (2001) 2.59
Bone morphogenetic proteins: a critical review. Cell Signal (2010) 2.54
Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength. J Bone Miner Res (2010) 2.52
Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression. Proc Natl Acad Sci U S A (2000) 2.20
Bone morphogenetic proteins and their antagonists. Rev Endocr Metab Disord (2006) 2.03
Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin. J Bone Miner Res (2000) 2.03
Effect of primary and secondary structure of oligodeoxyribonucleotides on the fluorescent properties of conjugated dyes. Nucleic Acids Res (2002) 1.98
BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development (2008) 1.86
Identification of mammalian noggin and its expression in the adult nervous system. J Neurosci (1995) 1.81
Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells. Endocrinology (1992) 1.75
Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts. J Clin Invest (1998) 1.74
Multiplex quantitative PCR using self-quenched primers labeled with a single fluorophore. Nucleic Acids Res (2002) 1.72
Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. Nat Genet (1999) 1.67
Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling. J Biol Chem (2006) 1.61
Skeletal overexpression of noggin results in osteopenia and reduced bone formation. Endocrinology (2003) 1.60
Skeletal overexpression of gremlin impairs bone formation and causes osteopenia. Endocrinology (2004) 1.58
Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development. J Bone Miner Res (2006) 1.56
Noggin suppression enhances in vitro osteogenesis and accelerates in vivo bone formation. J Biol Chem (2007) 1.55
Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts. J Bone Miner Res (2010) 1.54
Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kappa B ligand (RANKL)-induced JNK activation. J Biol Chem (2000) 1.47
Update on estrogens and the skeleton. J Clin Endocrinol Metab (2010) 1.25
Further biochemical and molecular characterization of primary rat parietal bone cell cultures. J Bone Miner Res (1988) 1.23
Enhanced osteoclastogenesis causes osteopenia in twisted gastrulation-deficient mice through increased BMP signaling. J Bone Miner Res (2009) 1.19
Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteins. Bone (1999) 1.16
Validation of peripheral dual-energy X-ray absorptiometry for the measurement of bone mineral in intact and excised long bones of rats. J Bone Miner Res (2001) 1.15
Conditional deletion of gremlin causes a transient increase in bone formation and bone mass. J Biol Chem (2007) 1.12
Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia. Endocrinology (2008) 1.08
The bone morphogenetic proteins antagonist Noggin inhibits membranous ossification. J Bone Miner Res (2001) 1.06
Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts. Endocrinology (2000) 1.05
Phosphatidylinositol 3 kinase/Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony stimulating factor-1 (CSF-1) expression and osteoclast differentiation. Endocrinology (2009) 1.05
Expression of the BMP 2 gene during bone cell differentiation. Crit Rev Eukaryot Gene Expr (1994) 1.04
Update in new anabolic therapies for osteoporosis. J Clin Endocrinol Metab (2010) 1.03
Cooperative activity of noggin and gremlin 1 in axial skeleton development. Development (2011) 1.03
Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice. Endocrinology (2010) 1.02
C/EBP homologous protein is necessary for normal osteoblastic function. J Cell Biochem (2006) 0.99
Activity of the osteocalcin promoter in skeletal sites of transgenic mice and during osteoblast differentiation in bone marrow-derived stromal cell cultures: effects of age and sex. Endocrinology (1997) 0.97
Noggin arrests stromal cell differentiation in vitro. Bone (2003) 0.92
Gremlin1 is required for skeletal development and postnatal skeletal homeostasis. J Cell Physiol (2012) 0.89
Activation of the ERK pathway in osteoblastic cells, role of gremlin and BMP-2. J Cell Biochem (2008) 0.82
New treatment modalities in osteoporosis. Endocr Pract (2011) 0.80
Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning. Nat Genet (2003) 2.31
The BMP antagonist noggin regulates cranial suture fusion. Nature (2003) 2.09
Learned recognition of maternal signature odors mediates the first suckling episode in mice. Curr Biol (2012) 1.63
Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice. J Clin Invest (2003) 1.63
Noggin suppression enhances in vitro osteogenesis and accelerates in vivo bone formation. J Biol Chem (2007) 1.55
Osteoblast lineage-specific effects of notch activation in the skeleton. Endocrinology (2012) 1.32
Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia. J Biol Chem (2007) 1.28
Convection-enhanced delivery of cintredekin besudotox (interleukin-13-PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant gliomas: phase 1 study of final safety results. Neurosurgery (2007) 1.27
Conditional deletion of gremlin causes a transient increase in bone formation and bone mass. J Biol Chem (2007) 1.12
Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia. Endocrinology (2008) 1.08
Cooperative activity of noggin and gremlin 1 in axial skeleton development. Development (2011) 1.03
Connective tissue growth factor enhances osteoblastogenesis in vitro. J Biol Chem (2008) 1.02
Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice. Endocrinology (2010) 1.02
Spatial patterns of gene expression in the olfactory bulb. Proc Natl Acad Sci U S A (2004) 1.01
Notch signaling in osteocytes differentially regulates cancellous and cortical bone remodeling. J Biol Chem (2013) 0.98
Nephroblastoma overexpressed (Nov) inactivation sensitizes osteoblasts to bone morphogenetic protein-2, but nov is dispensable for skeletal homeostasis. Endocrinology (2009) 0.97
Role of MT1-MMP in the osteogenic differentiation. Bone (2008) 0.89
Gremlin1 is required for skeletal development and postnatal skeletal homeostasis. J Cell Physiol (2012) 0.89
Role of hindbrain in inner ear morphogenesis: analysis of Noggin knockout mice. Dev Biol (2007) 0.88
Report of the CCFA pediatric bone, growth and muscle health workshop, New York City, November 11-12, 2011, with updates. Inflamm Bowel Dis (2013) 0.77
Nephroblastoma overexpressed (Nov) induces gremlin in ST-2 stromal cell lines by post-transcriptional mechanisms. J Cell Biochem (2011) 0.76
Noggin is required for correct guidance of dorsal root ganglion axons. Dev Biol (2002) 0.76
Connective tissue growth factor (CTGF) transactivates nuclear factor of activated T-cells (NFAT) in cells of the osteoblastic lineage. J Cell Biochem (2010) 0.75
Nemo-like kinase regulates postnatal skeletal homeostasis. J Cell Physiol (2014) 0.75
Over-expression of X-linked inhibitor of apoptosis protein modulates multiple aspects of neuronal Ca2+ signaling. Neurochem Res (2013) 0.75