Published in Science on May 29, 1998
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Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev (1998) 3.46
Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. Genome Res (2005) 2.61
Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. J Dent Res (2008) 2.45
Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling. Genes Dev (1999) 2.34
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BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development (2009) 2.21
Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation. Genes Dev (2004) 2.18
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A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis. Dev Biol (2008) 2.09
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Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification. J Bone Miner Res (2012) 1.49
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Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. Dev Biol (2010) 1.34
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Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin. Am J Hum Genet (2002) 1.16
Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding. Proc Natl Acad Sci U S A (2001) 1.14
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The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival. Genesis (2007) 1.13
Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid. Am J Hum Genet (2011) 1.12
The FOP metamorphogene encodes a novel type I receptor that dysregulates BMP signaling. Cytokine Growth Factor Rev (2009) 1.11
Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases. Am J Pathol (2007) 1.10
Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN. PLoS Genet (2009) 1.09
TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways. J Bone Miner Res (2010) 1.08
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BMP signaling in the development of the mouse esophagus and forestomach. Development (2010) 1.06
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Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cells. Arthritis Res Ther (2008) 1.05
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BMP action in skeletogenesis involves attenuation of retinoid signaling. J Cell Biol (2006) 1.05
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Identification of genes associated with regenerative success of Xenopus laevis hindlimbs. BMC Dev Biol (2008) 1.03
Noggin regulates Bmp4 activity during pituitary induction. Dev Biol (2007) 1.03
The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis. PLoS One (2011) 1.03
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Cooperative activity of noggin and gremlin 1 in axial skeleton development. Development (2011) 1.03
Smad6 is essential to limit BMP signaling during cartilage development. J Bone Miner Res (2011) 1.02
Involvement of Notch signaling in initiation of prechondrogenic condensation and nodule formation in limb bud micromass cultures. J Bone Miner Metab (2006) 1.02
Conditional inactivation of noggin in the postnatal skeleton causes osteopenia. Endocrinology (2012) 1.01
Notochord-derived BMP antagonists inhibit endothelial cell generation and network formation. Dev Biol (2008) 1.00
Dkk1 and noggin cooperate in mammalian head induction. Genes Dev (2003) 1.00
Tail gut endoderm and gut/genitourinary/tail development: a new tissue-specific role for Hoxa13. Development (2002) 1.00
Epimorphin expression in intestinal myofibroblasts induces epithelial morphogenesis. J Clin Invest (2002) 0.99
Genetic evidence that SOST inhibits WNT signaling in the limb. Dev Biol (2010) 0.98
Signaling networks regulating development of the lower respiratory tract. Cold Spring Harb Perspect Biol (2012) 0.97
Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects. J Biol Chem (2010) 0.97
Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine. Dev Biol (2010) 0.96
The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms. Dev Biol (2006) 0.96
BMP-driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitis. J Clin Invest (2015) 0.96
The role of the BMP signaling antagonist noggin in the development of prostate cancer osteolytic bone metastasis. PLoS One (2011) 0.94
Enhanced BMP signaling prevents degeneration and leads to endochondral ossification of Meckel's cartilage in mice. Dev Biol (2013) 0.94
Expression and function of BMP3 during chick limb development. Dev Dyn (2008) 0.93
Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene. Am J Hum Genet (2009) 0.93
MicroRNA-140 and the silencing of osteoarthritis. Genes Dev (2010) 0.93
Precise spatial restriction of BMP signaling is essential for articular cartilage differentiation. Development (2015) 0.92
Identification of NOG as a specific breast cancer bone metastasis-supporting gene. J Biol Chem (2012) 0.92
Could inflammatory arthritis be triggered by progenitor cells in the joints? Ann Rheum Dis (2002) 0.92
Genetic predisposition to fracture non-union: a case control study of a preliminary single nucleotide polymorphisms analysis of the BMP pathway. BMC Musculoskelet Disord (2011) 0.91
Genesis and morphogenesis of limb synovial joints and articular cartilage. Matrix Biol (2014) 0.89
BMP signaling in mesenchymal stem cell differentiation and bone formation. J Biomed Sci Eng (2013) 0.89
BMPRIA mediated signaling is essential for temporomandibular joint development in mice. PLoS One (2014) 0.88
ANA deficiency enhances bone morphogenetic protein-induced ectopic bone formation via transcriptional events. J Biol Chem (2009) 0.88
Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation. J Orthop Res (2009) 0.88
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Role of hindbrain in inner ear morphogenesis: analysis of Noggin knockout mice. Dev Biol (2007) 0.88
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Noggin attenuates cerulein-induced acute pancreatitis and impaired autophagy. Pancreas (2013) 0.87
The BMP ligand Gdf6 prevents differentiation of coronal suture mesenchyme in early cranial development. PLoS One (2012) 0.86
Noggin and basic FGF were implicated in forebrain fate and caudal fate, respectively, of the neural tube-like structures emerging in mouse ES cell culture. Exp Brain Res (2005) 0.86
The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation. Dev Biol (2011) 0.86
Digit patterning during limb development as a result of the BMP-receptor interaction. Sci Rep (2012) 0.85
Joint shape morphogenesis precedes cavitation of the developing hip joint. J Anat (2013) 0.85
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Molecular regulation of limb growth. J Bone Joint Surg Am (2009) 0.84
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Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev (1999) 8.43
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The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell (1996) 5.66
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