Published in J Biol Chem on January 06, 2006
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med (2008) 3.64
Dimorphic effects of Notch signaling in bone homeostasis. Nat Med (2008) 2.82
Heart valve development: regulatory networks in development and disease. Circ Res (2009) 2.41
Notch inhibits osteoblast differentiation and causes osteopenia. Endocrinology (2008) 1.78
The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis. Mol Cell Biol (2008) 1.70
Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation. J Cell Biochem (2011) 1.59
Notch and the skeleton. Mol Cell Biol (2009) 1.49
Non-canonical Notch signaling: emerging role and mechanism. Trends Cell Biol (2012) 1.37
miRNA-34c regulates Notch signaling during bone development. Hum Mol Genet (2012) 1.31
Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. Development (2008) 1.30
Wnt signaling in bone formation and its therapeutic potential for bone diseases. Ther Adv Musculoskelet Dis (2013) 1.25
Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches. Nat Rev Endocrinol (2013) 1.23
Beta-catenin up-regulates Atoh1 expression in neural progenitor cells by interaction with an Atoh1 3' enhancer. J Biol Chem (2009) 1.21
NOTCHing the bone: insights into multi-functionality. Bone (2009) 1.19
Mesenchymal Stem Cells in Bone Regeneration. Adv Wound Care (New Rochelle) (2013) 1.18
Communications between bone cells and hematopoietic stem cells. Arch Biochem Biophys (2008) 1.18
Microfibril-associate glycoprotein-2 (MAGP-2) promotes angiogenic cell sprouting by blocking notch signaling in endothelial cells. Microvasc Res (2008) 1.08
Notch regulation of bone development and remodeling and related skeletal disorders. Calcif Tissue Int (2011) 1.05
Update in new anabolic therapies for osteoporosis. J Clin Endocrinol Metab (2010) 1.03
Ethanol may suppress Wnt/beta-catenin signaling on human bone marrow stroma cells: a preliminary study. Clin Orthop Relat Res (2008) 1.03
Connective tissue growth factor enhances osteoblastogenesis in vitro. J Biol Chem (2008) 1.02
REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells. PLoS One (2010) 1.02
Conditional inactivation of noggin in the postnatal skeleton causes osteopenia. Endocrinology (2012) 1.01
Reciprocal regulation of Notch and nuclear factor of activated T-cells (NFAT) c1 transactivation in osteoblasts. J Biol Chem (2010) 0.99
Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. Proc Natl Acad Sci U S A (2014) 0.97
Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche? Blood Cancer J (2012) 0.96
Ligand-independent traffic of Notch buffers activated Armadillo in Drosophila. PLoS Biol (2009) 0.96
Temporal gene expression profiling during rat femoral marrow ablation-induced intramembranous bone regeneration. PLoS One (2010) 0.96
The Notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells. J Cell Biochem (2009) 0.94
Bicuspid aortic valve disease: the role of oxidative stress in Lrp5 bone formation. Cardiovasc Pathol (2011) 0.90
Galectin-3 inhibits osteoblast differentiation through notch signaling. Neoplasia (2014) 0.90
mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway. PLoS Genet (2015) 0.90
Hematopoietic niche and bone meet. Curr Opin Support Palliat Care (2008) 0.89
Gremlin1 is required for skeletal development and postnatal skeletal homeostasis. J Cell Physiol (2012) 0.89
The different role of Notch1 and Notch2 in astrocytic gliomas. PLoS One (2013) 0.89
Macrophage and T-lymphocyte infiltrates in human peritoneal adhesions indicate a chronic inflammatory disease. World J Surg (2008) 0.87
Notch signaling in skeletal stem cells. Calcif Tissue Int (2013) 0.86
Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. J Virol (2009) 0.86
Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development. J Bone Miner Metab (2010) 0.86
A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse. Genetics (2006) 0.85
Osteogenesis of Adipose-Derived Stem Cells. Bone Res (2013) 0.84
Notch signaling and bone remodeling. Curr Osteoporos Rep (2013) 0.83
Notch Signaling and the Skeleton. Endocr Rev (2016) 0.82
The Regulatory Roles of MicroRNAs in Bone Remodeling and Perspectives as Biomarkers in Osteoporosis. Biomed Res Int (2016) 0.82
Time series gene expression profiling and temporal regulatory pathway analysis of BMP6 induced osteoblast differentiation and mineralization. BMC Syst Biol (2011) 0.81
Connective tissue growth factor is a target of notch signaling in cells of the osteoblastic lineage. Bone (2014) 0.80
Calcific aortic stenosis. Nat Rev Dis Prim (2016) 0.79
Hypothesis: cell signalling influences age-related risk of colorectal cancer. J Cell Mol Med (2014) 0.79
Glucocorticoids impair bone formation of bone marrow stromal stem cells by reciprocally regulating microRNA-34a-5p. Osteoporos Int (2015) 0.79
Establishment of fibrillin-deficient osteoprogenitor cell lines identifies molecular abnormalities associated with extracellular matrix perturbation of osteogenic differentiation. Cell Tissue Res (2011) 0.78
Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl. Oncotarget (2016) 0.77
Canonical Notch activation in osteocytes causes osteopetrosis. Am J Physiol Endocrinol Metab (2015) 0.77
Nephroblastoma overexpressed (Nov) induces gremlin in ST-2 stromal cell lines by post-transcriptional mechanisms. J Cell Biochem (2011) 0.76
Anabolic actions of Notch on mature bone. Proc Natl Acad Sci U S A (2016) 0.76
Notch signaling represses hypoxia-inducible factor-1α-induced activation of Wnt/β-catenin signaling in osteoblasts under cobalt-mimicked hypoxia. Mol Med Rep (2016) 0.76
PS1/γ-Secretase-Mediated Cadherin Cleavage Induces β-Catenin Nuclear Translocation and Osteogenic Differentiation of Human Bone Marrow Stromal Cells. Stem Cells Int (2016) 0.75
Targeting the Notch signaling pathway in cancer therapeutics. Thorac Cancer (2014) 0.75
Nemo-like kinase regulates postnatal skeletal homeostasis. J Cell Physiol (2014) 0.75
Maintenance of Bone Homeostasis by DLL1-Mediated Notch Signaling. J Cell Physiol (2016) 0.75
Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification. J Am Heart Assoc (2017) 0.75
Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev (2003) 3.85
Age-related changes in trabecular architecture differ in female and male C57BL/6J mice. J Bone Miner Res (2007) 3.38
Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev (2008) 2.64
Bone morphogenetic proteins and their antagonists. Rev Endocr Metab Disord (2006) 2.03
Glucocorticoid-induced osteoporosis: an update. Trends Endocrinol Metab (2006) 1.91
Notch inhibits osteoblast differentiation and causes osteopenia. Endocrinology (2008) 1.78
Genetic analyses of the HRPT2 gene in primary hyperparathyroidism: germline and somatic mutations in familial and sporadic parathyroid tumors. J Clin Endocrinol Metab (2004) 1.75
Clinical significance of rare copy number variations in epilepsy: a case-control survey using microarray-based comparative genomic hybridization. Arch Neurol (2011) 1.61
Skeletal overexpression of gremlin impairs bone formation and causes osteopenia. Endocrinology (2004) 1.58
Notch 1 impairs osteoblastic cell differentiation. Endocrinology (2003) 1.57
PPARG by dietary fat interaction influences bone mass in mice and humans. J Bone Miner Res (2008) 1.50
Notch and the skeleton. Mol Cell Biol (2009) 1.49
A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength. Proc Natl Acad Sci U S A (2012) 1.48
Phenotypic characterization of hypomyelination and congenital cataract. Ann Neurol (2007) 1.46
A soluble activin type IIA receptor induces bone formation and improves skeletal integrity. Proc Natl Acad Sci U S A (2008) 1.42
Infrared analysis of the mineral and matrix in bones of osteonectin-null mice and their wildtype controls. J Bone Miner Res (2003) 1.39
The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. J Endocrinol (2006) 1.37
Osteonectin-null mutation compromises osteoblast formation, maturation, and survival. Endocrinology (2003) 1.37
The fate of circulating osteoblasts. N Engl J Med (2005) 1.36
Expression and regulation of CCN genes in murine osteoblasts. Bone (2005) 1.32
Serum IGF-1 determines skeletal strength by regulating subperiosteal expansion and trait interactions. J Bone Miner Res (2009) 1.29
Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia. J Biol Chem (2007) 1.28
Genetic dissection of mouse distal chromosome 1 reveals three linked BMD QTLs with sex-dependent regulation of bone phenotypes. J Bone Miner Res (2007) 1.26
Effects of cortisol and bone morphogenetic protein-2 on stromal cell differentiation: correlation with CCAAT-enhancer binding protein expression. Bone (2002) 1.22
CCAAT/enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation. Endocrinology (2003) 1.21
Localized treatment with a novel FDA-approved proteasome inhibitor blocks the degradation of dystrophin and dystrophin-associated proteins in mdx mice. Cell Cycle (2007) 1.18
Importance of SPP1 genotype as a covariate in clinical trials in Duchenne muscular dystrophy. Neurology (2012) 1.17
Drug-induced osteoporosis: mechanisms and clinical implications. Am J Med (2010) 1.15
CCAAT/Enhancer-binding protein homologous protein (CHOP) decreases bone formation and causes osteopenia. Bone (2006) 1.14
Misexpression of CCAAT/enhancer binding protein beta causes osteopenia. J Endocrinol (2009) 1.14
Conditional deletion of gremlin causes a transient increase in bone formation and bone mass. J Biol Chem (2007) 1.12
Impairment of ceramide synthesis causes a novel progressive myoclonus epilepsy. Ann Neurol (2014) 1.11
Deficiency of hyccin, a newly identified membrane protein, causes hypomyelination and congenital cataract. Nat Genet (2006) 1.11
Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia. Endocrinology (2008) 1.08
Notch regulation of bone development and remodeling and related skeletal disorders. Calcif Tissue Int (2011) 1.05
The heparin-binding domain of IGFBP-2 has insulin-like growth factor binding-independent biologic activity in the growing skeleton. J Biol Chem (2011) 1.02
Connective tissue growth factor enhances osteoblastogenesis in vitro. J Biol Chem (2008) 1.02
Notch signaling in skeletal health and disease. Eur J Endocrinol (2013) 1.00
Reciprocal regulation of Notch and nuclear factor of activated T-cells (NFAT) c1 transactivation in osteoblasts. J Biol Chem (2010) 0.99
C/EBP homologous protein is necessary for normal osteoblastic function. J Cell Biochem (2006) 0.99
A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis. J Endocrinol (2009) 0.97
Cortisol regulates the expression of Notch in osteoblasts. J Cell Biochem (2002) 0.97
Caveolin-3 T78M and T78K missense mutations lead to different phenotypes in vivo and in vitro. Lab Invest (2008) 0.96
Aquaporin-4 expression is severely reduced in human sarcoglycanopathies and dysferlinopathies. Cell Cycle (2008) 0.95
AU-rich elements in the collagenase 3 mRNA mediate stabilization of the transcript by cortisol in osteoblasts. J Biol Chem (2003) 0.95
Subclinical myopathy in a child with neutral lipid storage disease and mutations in the PNPLA2 gene. Biochem Biophys Res Commun (2012) 0.93
HES1 (hairy and enhancer of split 1) is a determinant of bone mass. J Biol Chem (2010) 0.92
The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome. Development (2008) 0.92
Potentiating role of IGFBP-2 on IGF-II-stimulated alkaline phosphatase activity in differentiating osteoblasts. Am J Physiol Endocrinol Metab (2003) 0.92
Bone loss or lost bone: rationale and recommendations for the diagnosis and treatment of early postmenopausal bone loss. Curr Osteoporos Rep (2009) 0.91
Effects of activated T cells on osteoclastogenesis depend on how they are activated. Bone (2004) 0.90
Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function. Bone (2006) 0.90
Activated alveolar epithelial cells initiate fibrosis through autocrine and paracrine secretion of connective tissue growth factor. Am J Physiol Lung Cell Mol Physiol (2014) 0.88
A reappraisal of the Rb1 gene abnormalities in the diagnosis of parathyroid cancer. Clin Endocrinol (Oxf) (2004) 0.87
Glucocorticoid-induced osteoporosis in rheumatic diseases. Clinics (Sao Paulo) (2010) 0.87
Notch suppresses nuclear factor of activated T cells (NFAT) transactivation and Nfatc1 expression in chondrocytes. Endocrinology (2012) 0.86
Overexpression of twisted gastrulation inhibits bone morphogenetic protein action and prevents osteoblast cell differentiation in vitro. Endocrinology (2005) 0.86
Nuclear factor of activated T-cells (NFAT)C2 inhibits Notch receptor signaling in osteoblasts. J Biol Chem (2012) 0.86
The spectrum of GNE mutations: allelic heterogeneity for a common phenotype. Neurol Sci (2010) 0.85
Gene delivery by retroviruses. Methods Mol Biol (2008) 0.85
BMD regulation on mouse distal chromosome 1, candidate genes, and response to ovariectomy or dietary fat. J Bone Miner Res (2011) 0.84
Hairy and Enhancer of Split-related with YRPW motif (HEY)2 regulates bone remodeling in mice. J Biol Chem (2013) 0.82
Activation of the ERK pathway in osteoblastic cells, role of gremlin and BMP-2. J Cell Biochem (2008) 0.82
Col3.6-HSD2 transgenic mice: a glucocorticoid loss-of-function model spanning early and late osteoblast differentiation. Bone (2010) 0.81
Deficiency of Sef is associated with increased postnatal cortical bone mass by regulating Runx2 activity. J Bone Miner Res (2014) 0.81
Loss of gremlin delays primordial follicle assembly but does not affect female fertility in mice. Biol Reprod (2011) 0.81
Bone morphogenetic protein-2 suppresses collagenase-3 promoter activity in osteoblasts through a runt domain factor 2 binding site. J Cell Physiol (2005) 0.81
Role of the RAM domain and ankyrin repeats on notch signaling and activity in cells of osteoblastic lineage. J Bone Miner Res (2006) 0.80
Activation of Nfatc2 in osteoblasts causes osteopenia. J Cell Physiol (2015) 0.79
Nemo-like kinase inhibits osteoblastogenesis by suppressing bone morphogenetic protein and WNT canonical signaling. J Cell Biochem (2012) 0.79
Glucocorticoid-induced osteoporosis: clinical and therapeutic aspects. Arq Bras Endocrinol Metabol (2007) 0.78
Hypomyelination and congenital cataract: broadening the clinical phenotype. Arch Neurol (2011) 0.78
Management of glucocorticoid induced osteoporosis in premenopausal women with autoimmune disease. Autoimmun Rev (2003) 0.78
Nephroblastoma overexpressed (Nov) induces gremlin in ST-2 stromal cell lines by post-transcriptional mechanisms. J Cell Biochem (2011) 0.76
11beta-hydroxysteroid dehydrogenase, an amplifier of glucocorticoid action in osteoblasts. J Bone Miner Res (2002) 0.76
Treatment of glucocorticoid-induced osteoporsis. Ther Adv Musculoskelet Dis (2009) 0.76
Transcriptional regulation of collagenase-3 by interleukin-1 alpha in osteoblasts. J Cell Biochem (2003) 0.76
Connective tissue growth factor (CTGF) transactivates nuclear factor of activated T-cells (NFAT) in cells of the osteoblastic lineage. J Cell Biochem (2010) 0.75
Transgenic overexpression of gremlin results in developmental defects in enamel and dentin in mice. Connect Tissue Res (2008) 0.75
Bone Morphogenetic Proteins Induce Gremlin, a Protein That Limits Their Activity in Osteoblasts* *This work was supported by NIAMSD Grant AR-21707. Endocrinology (2000) 0.75
Hypomyelination and congenital cataract: identification of novel mutations in two unrelated families. Eur J Paediatr Neurol (2012) 0.75