Published in J Biomol Screen on February 21, 2012
Wnt/beta-catenin signaling and small molecule inhibitors. Curr Pharm Des (2013) 1.44
Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4. PLoS One (2013) 0.88
Inhibition of poly(ADP-ribose) polymerase interferes with Trypanosoma cruzi infection and proliferation of the parasite. PLoS One (2012) 0.84
Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors. ACS Med Chem Lett (2013) 0.83
Characterization of the DNA dependent activation of human ARTD2/PARP2. Sci Rep (2016) 0.75
The DEXD/H-box RNA helicase DDX19 is regulated by an {alpha}-helical switch. J Biol Chem (2009) 1.39
Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78. PLoS One (2010) 1.33
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA. J Biol Chem (2010) 1.32
Structural basis of selective inhibition of human tankyrases. J Med Chem (2012) 1.25
Comparative structural analysis of human DEAD-box RNA helicases. PLoS One (2010) 1.21
Comparative structural analysis of lipid binding START domains. PLoS One (2011) 1.19
Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim. FEBS Lett (2008) 1.13
Structure of Streptococcus agalactiae serine/threonine phosphatase. The subdomain conformation is coupled to the binding of a third metal ion. FEBS J (2007) 1.09
Studies on the toxicity of Punica granatum L. (Punicaceae) whole fruit extracts. J Ethnopharmacol (2003) 1.08
A trimetal site and substrate distortion in a family II inorganic pyrophosphatase. J Biol Chem (2006) 1.03
Preclinical evaluation of rapeseed, raspberry, and pine bark phenolics for health related effects. J Agric Food Chem (2005) 1.03
Pros and cons of using resazurin staining for quantification of viable Staphylococcus aureus biofilms in a screening assay. J Microbiol Methods (2009) 0.99
Automating a 96-well microtitre plate model for Staphylococcus aureus biofilms: an approach to screening of natural antimicrobial compounds. Int J Antimicrob Agents (2008) 0.96
Structural studies of metal ions in family II pyrophosphatases: the requirement for a Janus ion. Biochemistry (2004) 0.93
Combining biofilm matrix measurements with biomass and viability assays in susceptibility assessments of antimicrobials against Staphylococcus aureus biofilms. J Antibiot (Tokyo) (2012) 0.92
Crystal structure of the N-terminal NC4 domain of collagen IX, a zinc binding member of the laminin-neurexin-sex hormone binding globulin (LNS) domain family. J Biol Chem (2007) 0.91
The exploration of thienothiazines as selective butyrylcholinesterase inhibitors. Eur J Pharm Sci (2012) 0.90
Benthic cyanobacteria from the Baltic Sea contain cytotoxic Anabaena, Nodularia, and Nostoc strains and an apoptosis-inducing Phormidium strain. Environ Toxicol (2005) 0.89
Activity-based assay for human mono-ADP-ribosyltransferases ARTD7/PARP15 and ARTD10/PARP10 aimed at screening and profiling inhibitors. Eur J Pharm Sci (2013) 0.89
Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4. PLoS One (2013) 0.88
HPLC micro-fractionation coupled to a cell-based assay for automated on-line primary screening of calcium antagonistic components in plant extracts. Anal Bioanal Chem (2004) 0.88
Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem (2013) 0.88
Structural studies of tri-functional human GART. Nucleic Acids Res (2010) 0.88
Evidence for conserved function of γ-glutamyltranspeptidase in Helicobacter genus. PLoS One (2012) 0.87
Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles. Arch Biochem Biophys (2004) 0.87
Interaction of (benzylidene-hydrazono)-1,4-dihydropyridines with beta-amyloid, acetylcholine, and butyrylcholine esterases. Bioorg Med Chem (2010) 0.86
Proteomic analysis of Chlamydia pneumoniae-infected HL cells reveals extensive degradation of cytoskeletal proteins. FEMS Immunol Med Microbiol (2008) 0.86
Inhibitory effect of the natural product betulin and its derivatives against the intracellular bacterium Chlamydia pneumoniae. Biochem Pharmacol (2010) 0.85
Screening and structural analysis of flavones inhibiting tankyrases. J Med Chem (2013) 0.85
Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages. Planta Med (2011) 0.85
In vivo treatment of acute Chlamydia pneumoniae infection with the flavonoids quercetin and luteolin and an alkyl gallate, octyl gallate, in a mouse model. Biochem Pharmacol (2005) 0.84
para-Substituted 2-phenyl-3,4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitors. ChemMedChem (2013) 0.84
Microarray analysis of a Chlamydia pneumoniae-infected human epithelial cell line by use of gene ontology hierarchy. J Infect Dis (2008) 0.84
Inhibition of poly(ADP-ribose) polymerase interferes with Trypanosoma cruzi infection and proliferation of the parasite. PLoS One (2012) 0.84
(+)-Dehydroabietic acid, an abietane-type diterpene, inhibits Staphylococcus aureus biofilms in vitro. Int J Mol Sci (2013) 0.84
Characterization of flavonoid--biomembrane interactions. Arch Biochem Biophys (2002) 0.83
Tailoring controlled-release oral dosage forms by combining inkjet and flexographic printing techniques. Eur J Pharm Sci (2012) 0.83
Microplate screening assay to identify inhibitors of human catechol-O-methyltransferase. Anal Biochem (2004) 0.83
Crystal morphology engineering of pharmaceutical solids: tabletting performance enhancement. AAPS PharmSciTech (2009) 0.83
Alpha- and β-casein components of host milk induce biofilm formation in the mastitis bacterium Streptococcus uberis. Vet Microbiol (2010) 0.83
Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays. Anal Biochem (2006) 0.83
Structure of the Streptococcus agalactiae family II inorganic pyrophosphatase at 2.80 A resolution. Acta Crystallogr D Biol Crystallogr (2007) 0.82
Staphylococcus aureus biofilm susceptibility to small and potent β(2,2)-amino acid derivatives. Biofouling (2013) 0.82
Antimicrobial and antioxidative enrichment of oak (Quercus robur) bark by rotation planar extraction using ExtraChrom. Int J Food Microbiol (2004) 0.81
Structural determination of functional domains in early B-cell factor (EBF) family of transcription factors reveals similarities to Rel DNA-binding proteins and a novel dimerization motif. J Biol Chem (2010) 0.81
Computer-assisted, high-performance liquid chromatography with mass spectrometric detection for the analysis of coumarins in Peucedanum palustre and Angelica archangelica. Phytochem Anal (2004) 0.81
Living cells of Staphylococcus aureus immobilized onto the capillary surface in electrochromatography: a tool for screening of biofilms. Anal Chem (2008) 0.81
Crystallization and preliminary crystallographic analysis of two Streptococcus agalactiae proteins: the family II inorganic pyrophosphatase and the serine/threonine phosphatase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.80
The crystal structure of the Dachshund domain of human SnoN reveals flexibility in the putative protein interaction surface. PLoS One (2010) 0.80
Substrate specificity and oligomerization of human GMP synthetase. J Mol Biol (2013) 0.79
Development and validation of a time-resolved fluorometric immunoassay for screening of antichlamydial activity using a genus-specific europium-conjugated antibody. Anal Biochem (2004) 0.78
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorg Med Chem (2012) 0.78
Systematic exploration of natural and synthetic flavonoids for the inhibition of Staphylococcus aureus biofilms. Int J Mol Sci (2013) 0.78
Discovery of dual binding site acetylcholinesterase inhibitors identified by pharmacophore modeling and sequential virtual screening techniques. Bioorg Med Chem Lett (2011) 0.78
Design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against Chlamydia pneumoniae. J Med Chem (2010) 0.78
Phototoxic activity of a thiophene polyacetylene from Leuzea carthamoides. Fitoterapia (2006) 0.77
1,4-Substituted 4-(1H)-pyridylene-hydrazone-type inhibitors of AChE, BuChE, and amyloid-β aggregation crossing the blood-brain barrier. Eur J Pharm Sci (2013) 0.77
Transport properties of bovine and reindeer beta-lactoglobulin in the Caco-2 cell model. Int J Pharm (2007) 0.77
The structure of Pseudomonas P51 Cl-muconate lactonizing enzyme: co-evolution of structure and dynamics with the dehalogenation function. Protein Sci (2003) 0.77
Structure and function of the 3-carboxy-cis,cis-muconate lactonizing enzyme from the protocatechuate degradative pathway of Agrobacterium radiobacter S2. FEBS J (2006) 0.77
Miniaturization and validation of the Ellman's reaction based acetylcholinesterase inhibitory assay into 384-well plate format and screening of a chemical library. Comb Chem High Throughput Screen (2010) 0.77
Effect of high concentration of Co (II) on Enterobacter liquefaciens strain C-1: a bacterium highly resistant to heavy metals with an unknown genome. Proteomics (2004) 0.77
Anthranoid laxatives influence the absorption of poorly permeable drugs in human intestinal cell culture model (Caco-2). Eur J Pharm Biopharm (2006) 0.77
Identification and characterization of diarylimidazoles as hybrid inhibitors of butyrylcholinesterase and amyloid beta fibril formation. Eur J Pharm Sci (2011) 0.76
Conformation study of 2-arylbenzimidazoles as inhibitors of Chlamydia pneumoniae growth. Bioorg Med Chem Lett (2012) 0.76
Potency determinations of acetylcholinesterase inhibitors using Ellman's reaction-based assay in screening: Effect of assay variants. Anal Biochem (2010) 0.75
Microplate screening assay for binding of ligands to bovine or reindeer beta-lactoglobulins. J Biochem Biophys Methods (2006) 0.75
Application of centrifugal force to the extraction and separation of parasorboside and gerberin from Gerbera hybrida. Phytochem Anal (2002) 0.75
Evaluation of antibacterial and anti-biofilm activities of cinchona alkaloid derivatives against Staphylococcus aureus. Nat Prod Commun (2012) 0.75
Rotation planar extraction and rotation planar chromatography of oak (Quercus robur L.) bark. J Chromatogr A (2003) 0.75
Chemical modifications of cinchona alkaloids lead to enhanced inhibition of human butyrylcholinesterase. Nat Prod Commun (2014) 0.75
Nature still provides us with a vast amount of useful molecules. Planta Med (2014) 0.75
Miniaturisation and validation of a cell-based assay for screening of Ca2+ channel modulators. J Biochem Biophys Methods (2004) 0.75
Revisiting an agar-based plate method: what the static biofilm method can offer for biofilm research. J Microbiol Methods (2014) 0.75
In-vitro mutagenic potential and effect on permeability of co-administered drugs across Caco-2 cell monolayers of Rubus idaeus and its fortified fractions. J Pharm Pharmacol (2006) 0.75
Coumarins permeability in Caco-2 cell model. J Pharm Pharmacol (2009) 0.75
High-throughput screening with a miniaturized radioligand competition assay identifies new modulators of human α2-adrenoceptors. Eur J Pharm Sci (2012) 0.75
Discovering protein kinase C active plants growing in Finland utilizing automated bioassay combined to LC/MS. Nat Prod Commun (2009) 0.75
Tailored beads made of dissolved cellulose--investigation of their drug release properties. Int J Pharm (2013) 0.75