Published in J Med Chem on November 11, 2010
A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells. Cell Death Dis (2015) 0.78
Lead Discovery Strategies for Identification of Chlamydia pneumoniae Inhibitors. Microorganisms (2016) 0.75
Pharmacological properties of the ubiquitous natural product betulin. Eur J Pharm Sci (2006) 2.00
Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae. Circ Res (2005) 1.50
CNS infection with Chlamydia pneumoniae complicated by multiple strokes. J Neurol (2002) 1.41
Pneumococcal septic shock is associated with the interleukin-10-1082 gene promoter polymorphism. Am J Respir Crit Care Med (2003) 1.33
Chlamydia pneumoniae multiply in neutrophil granulocytes and delay their spontaneous apoptosis. J Immunol (2004) 1.24
Genotypic differences in the Chlamydia pneumoniae tyrP locus related to vascular tropism and pathogenicity. J Infect Dis (2003) 1.16
Chlamydia pneumoniae directly interferes with HIF-1alpha stabilization in human host cells. Cell Microbiol (2007) 1.15
UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly. Drug Metab Dispos (2008) 1.13
Preclinical evaluation of rapeseed, raspberry, and pine bark phenolics for health related effects. J Agric Food Chem (2005) 1.03
Immunoproteomic identification and serological responses to novel Chlamydia pneumoniae antigens that are associated with persistent C. pneumoniae infections. J Immunol (2008) 1.01
Chlamydia pneumoniae infection promotes a proliferative phenotype in the vasculature through Egr-1 activation in vitro and in vivo. Proc Natl Acad Sci U S A (2005) 1.00
Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the rat. Anesth Analg (2006) 1.00
Isolation of Chlamydia pneumoniae clonal variants by a focus-forming assay. Infect Immun (2002) 1.00
Alveolar epithelial cells type II are major target cells for C. pneumoniae in chronic but not in acute respiratory infection. FEMS Immunol Med Microbiol (2004) 0.98
Hydroxymethylglutaryl coenzyme A reductase inhibition reduces Chlamydia pneumoniae-induced cell interaction and activation. Circulation (2003) 0.96
Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L. Bioorg Med Chem (2008) 0.94
Genetic diversity of the obligate intracellular bacterium Chlamydophila pneumoniae by genome-wide analysis of single nucleotide polymorphisms: evidence for highly clonal population structure. BMC Genomics (2007) 0.94
Bovine serum albumin decreases Km values of human UDP-glucuronosyltransferases 1A9 and 2B7 and increases Vmax values of UGT1A9. Drug Metab Dispos (2011) 0.93
The interleukin-6 -174 promoter polymorphism is associated with extrapulmonary bacterial dissemination in Streptococcus pneumoniae infection. Cytokine (2005) 0.92
Betulin-derived compounds as inhibitors of alphavirus replication. J Nat Prod (2009) 0.91
Chlamydophila pneumoniae. Mechanisms of target cell infection and activation. Thromb Haemost (2005) 0.91
Anti-leishmanial activity of betulin derivatives. J Antibiot (Tokyo) (2010) 0.91
Analysis of small molecules by ultra thin-layer chromatography-atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry. J Am Soc Mass Spectrom (2005) 0.90
The exploration of thienothiazines as selective butyrylcholinesterase inhibitors. Eur J Pharm Sci (2012) 0.90
Solid-phase synthesis of 1,2,3-triazoles via 1,3-dipolar cycloaddition. J Comb Chem (2003) 0.89
Benthic cyanobacteria from the Baltic Sea contain cytotoxic Anabaena, Nodularia, and Nostoc strains and an apoptosis-inducing Phormidium strain. Environ Toxicol (2005) 0.89
Mycobacterium bohemicum and cervical lymphadenitis in children. Emerg Infect Dis (2008) 0.89
Partitioning of pyrene-labeled phospho- and sphingolipids between ordered and disordered bilayer domains. Biophys J (2004) 0.89
Regioselective sulfonation of dopamine by SULT1A3 in vitro provides a molecular explanation for the preponderance of dopamine-3-O-sulfate in human blood circulation. Biochem Pharmacol (2007) 0.88
HPLC micro-fractionation coupled to a cell-based assay for automated on-line primary screening of calcium antagonistic components in plant extracts. Anal Bioanal Chem (2004) 0.88
Brain-derived neurotrophic factor controls activity-dependent maturation of CA1 synapses by downregulating tonic activation of presynaptic kainate receptors. J Neurosci (2009) 0.87
Alterations in the phenotype of CMV-specific and total CD8+ T-cell populations in Wegener's granulomatosis. Cell Immunol (2003) 0.87
Chlamydophila pneumoniae induces expression of toll-like receptor 4 and release of TNF-alpha and MIP-2 via an NF-kappaB pathway in rat type II pneumocytes. Respir Res (2005) 0.87
Evidence for conserved function of γ-glutamyltranspeptidase in Helicobacter genus. PLoS One (2012) 0.87
Synthesis and anti-leishmanial activity of heterocyclic betulin derivatives. Bioorg Med Chem (2010) 0.87
An isotope dilution gas chromatographic-mass spectrometric method for the simultaneous assay of estrogens and phytoestrogens in urine. J Steroid Biochem Mol Biol (2005) 0.87
Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles. Arch Biochem Biophys (2004) 0.87
Interaction of (benzylidene-hydrazono)-1,4-dihydropyridines with beta-amyloid, acetylcholine, and butyrylcholine esterases. Bioorg Med Chem (2010) 0.86
Proteomic analysis of Chlamydia pneumoniae-infected HL cells reveals extensive degradation of cytoskeletal proteins. FEMS Immunol Med Microbiol (2008) 0.86
Inhibitory effect of the natural product betulin and its derivatives against the intracellular bacterium Chlamydia pneumoniae. Biochem Pharmacol (2010) 0.85
Detection of Chlamydia pneumoniae but not of Helicobacter pylori in symptomatic atherosclerotic carotids associated with enhanced serum antibodies, inflammation and apoptosis rate. Atherosclerosis (2003) 0.85
Transmission of Chlamydia pneumoniae infection from blood monocytes to vascular cells in a novel transendothelial migration model. FEMS Microbiol Lett (2005) 0.85
Solid-phase synthesis of amino acid derived N-unsubstituted pyrazoles via sydnones. Org Lett (2009) 0.85
Stereochemical sensitivity of the human UDP-glucuronosyltransferases 2B7 and 2B17. J Med Chem (2006) 0.85
Determination of neutral carbohydrates by CZE with direct UV detection. Electrophoresis (2007) 0.85
Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages. Planta Med (2011) 0.85
In vivo treatment of acute Chlamydia pneumoniae infection with the flavonoids quercetin and luteolin and an alkyl gallate, octyl gallate, in a mouse model. Biochem Pharmacol (2005) 0.84
High-resolution melting analysis of the single nucleotide polymorphism hot-spot region in the rpoB gene as an indicator of reduced susceptibility to rifaximin in Clostridium difficile. J Med Microbiol (2012) 0.84
Microarray analysis of a Chlamydia pneumoniae-infected human epithelial cell line by use of gene ontology hierarchy. J Infect Dis (2008) 0.84
Mechanisms of Chlamydophila pneumoniae-mediated GM-CSF release in human bronchial epithelial cells. Am J Respir Cell Mol Biol (2005) 0.84
(+)-Dehydroabietic acid, an abietane-type diterpene, inhibits Staphylococcus aureus biofilms in vitro. Int J Mol Sci (2013) 0.84
Characterization of flavonoid--biomembrane interactions. Arch Biochem Biophys (2002) 0.83
Cox-2 inhibition abrogates Chlamydia pneumoniae-induced PGE2 and MMP-1 expression. Biochem Biophys Res Commun (2004) 0.83
Homogeneous screening assay for human tankyrase. J Biomol Screen (2012) 0.83
Tailoring controlled-release oral dosage forms by combining inkjet and flexographic printing techniques. Eur J Pharm Sci (2012) 0.83
Current status and future prospects of C1 domain ligands as drug candidates. Curr Top Med Chem (2011) 0.83
Microplate screening assay to identify inhibitors of human catechol-O-methyltransferase. Anal Biochem (2004) 0.83
Alpha- and β-casein components of host milk induce biofilm formation in the mastitis bacterium Streptococcus uberis. Vet Microbiol (2010) 0.83
Crystal morphology engineering of pharmaceutical solids: tabletting performance enhancement. AAPS PharmSciTech (2009) 0.83
Chlamydia pneumoniae infection acts as an endothelial stressor with the potential to initiate the earliest heat shock protein 60-dependent inflammatory stage of atherosclerosis. Cell Stress Chaperones (2012) 0.83
Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays. Anal Biochem (2006) 0.83
Asymptomatic carotid atherosclerosis is associated with circulating chlamydia pneumoniae DNA in younger normotensive subjects in a general population survey. Arterioscler Thromb Vasc Biol (2004) 0.83
UDP-glucuronic acid binds first and the aglycone substrate binds second to form a ternary complex in UGT1A9-catalyzed reactions, in both the presence and absence of bovine serum albumin. Drug Metab Dispos (2012) 0.82
Absence of Clostridium difficile in asymptomatic hospital staff. Am J Infect Control (2012) 0.82
Similarity based virtual screening: a tool for targeted library design. J Med Chem (2006) 0.82
Total synthesis of bistramide A and its 36(Z) isomers: differential effect on cell division, differentiation, and apoptosis. Chemistry (2012) 0.82
Chlamydia pneumoniae adversely modulates vascular cell properties by direct interaction with signalling cascades. Thromb Haemost (2009) 0.82
Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma. PLoS One (2013) 0.82
Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. J Med Chem (2009) 0.81
Antimicrobial and antioxidative enrichment of oak (Quercus robur) bark by rotation planar extraction using ExtraChrom. Int J Food Microbiol (2004) 0.81
Albumin stimulates the activity of the human UDP-glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the effects are enzyme and substrate dependent. PLoS One (2013) 0.81
Methadone increases intracellular calcium in SH-SY5Y and SH-EP1-halpha7 cells by activating neuronal nicotinic acetylcholine receptors. J Neurochem (2005) 0.81
Computer-assisted, high-performance liquid chromatography with mass spectrometric detection for the analysis of coumarins in Peucedanum palustre and Angelica archangelica. Phytochem Anal (2004) 0.81
Chlamydia pneumoniae-induced pathological signaling in the vasculature. FEMS Immunol Med Microbiol (2009) 0.80
A new insight into solid-state conformation of macrolide antibiotics. Bioorg Med Chem (2007) 0.80
HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition. Eur J Pharm Sci (2010) 0.80
Construction of a highly flexible and comprehensive gene collection representing the ORFeome of the human pathogen Chlamydia pneumoniae. BMC Genomics (2012) 0.80
Serine-to-asparagine substitution in the GyrA gene leads to quinolone resistance in moxifloxacin-exposed Chlamydia pneumoniae. Antimicrob Agents Chemother (2005) 0.80
Benzo[cd]azulene skeleton: azulene, heptafulvene, and tropone derivatives. Org Lett (2009) 0.79
Investigation of bacterial and viral agents and immune status in Behcet's disease patients from Iran. Int J Rheum Dis (2011) 0.79
C1 Domain-targeted isophthalate derivatives induce cell elongation and cell cycle arrest in HeLa cells. PLoS One (2011) 0.79
The resveratrol tetramer (-)-hopeaphenol inhibits type III secretion in the gram-negative pathogens Yersinia pseudotuberculosis and Pseudomonas aeruginosa. PLoS One (2013) 0.79
Endothelial Chlamydia pneumoniae infection promotes oxidation of LDL. Biochem Biophys Res Commun (2004) 0.79
Development and validation of a time-resolved fluorometric immunoassay for screening of antichlamydial activity using a genus-specific europium-conjugated antibody. Anal Biochem (2004) 0.78
Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors. ChemMedChem (2011) 0.78
Systematic exploration of natural and synthetic flavonoids for the inhibition of Staphylococcus aureus biofilms. Int J Mol Sci (2013) 0.78
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorg Med Chem (2012) 0.78
Recent advances in 1,3-dipolar cycloaddition reactions on solid supports. Mol Divers (2005) 0.78
Tricyclic Benzo[cd]azulenes selectively inhibit activities of Pim kinases and restrict growth of Epstein-Barr virus-transformed cells. PLoS One (2013) 0.78
Micromanipulation of the Chlamydia pneumoniae inclusion: implications for cloning and host-pathogen interactions. FEMS Microbiol Lett (2003) 0.78