Published in Anal Biochem on December 28, 2006
Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening. Chem Res Toxicol (2008) 1.25
Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features. Toxicol Sci (2009) 1.05
Modeling to optimize terminal stem cell differentiation. Scientifica (Cairo) (2013) 0.75
Pharmacological properties of the ubiquitous natural product betulin. Eur J Pharm Sci (2006) 2.00
Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays. PLoS One (2011) 1.37
UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly. Drug Metab Dispos (2008) 1.13
Preclinical evaluation of rapeseed, raspberry, and pine bark phenolics for health related effects. J Agric Food Chem (2005) 1.03
Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the rat. Anesth Analg (2006) 1.00
Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade. PLoS One (2011) 0.99
Aggregating behavior of phenolic compounds--a source of false bioassay results? Molecules (2012) 0.98
Synthesis, metabolism and cellular permeability of enzymatically stable dipeptide prodrugs of acyclovir. Int J Pharm (2008) 0.94
Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L. Bioorg Med Chem (2008) 0.94
Bovine serum albumin decreases Km values of human UDP-glucuronosyltransferases 1A9 and 2B7 and increases Vmax values of UGT1A9. Drug Metab Dispos (2011) 0.93
Betulin-derived compounds as inhibitors of alphavirus replication. J Nat Prod (2009) 0.91
Anti-leishmanial activity of betulin derivatives. J Antibiot (Tokyo) (2010) 0.91
Effect of pmt gene overexpression on tropane alkaloid production in transformed root cultures of Datura metel and Hyoscyamus muticus. J Exp Bot (2003) 0.90
Analysis of small molecules by ultra thin-layer chromatography-atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry. J Am Soc Mass Spectrom (2005) 0.90
The exploration of thienothiazines as selective butyrylcholinesterase inhibitors. Eur J Pharm Sci (2012) 0.90
Solid-phase synthesis of 1,2,3-triazoles via 1,3-dipolar cycloaddition. J Comb Chem (2003) 0.89
Benthic cyanobacteria from the Baltic Sea contain cytotoxic Anabaena, Nodularia, and Nostoc strains and an apoptosis-inducing Phormidium strain. Environ Toxicol (2005) 0.89
HPLC micro-fractionation coupled to a cell-based assay for automated on-line primary screening of calcium antagonistic components in plant extracts. Anal Bioanal Chem (2004) 0.88
Regioselective sulfonation of dopamine by SULT1A3 in vitro provides a molecular explanation for the preponderance of dopamine-3-O-sulfate in human blood circulation. Biochem Pharmacol (2007) 0.88
Brain-derived neurotrophic factor controls activity-dependent maturation of CA1 synapses by downregulating tonic activation of presynaptic kainate receptors. J Neurosci (2009) 0.87
Synthesis and anti-leishmanial activity of heterocyclic betulin derivatives. Bioorg Med Chem (2010) 0.87
Development and characterization of nanoparticulate formulation of a water soluble prodrug of dexamethasone by HIP complexation. J Microencapsul (2010) 0.87
Evidence for conserved function of γ-glutamyltranspeptidase in Helicobacter genus. PLoS One (2012) 0.87
Permeability characteristics and membrane affinity of flavonoids and alkyl gallates in Caco-2 cells and in phospholipid vesicles. Arch Biochem Biophys (2004) 0.87
Interaction of (benzylidene-hydrazono)-1,4-dihydropyridines with beta-amyloid, acetylcholine, and butyrylcholine esterases. Bioorg Med Chem (2010) 0.86
Proteomic analysis of Chlamydia pneumoniae-infected HL cells reveals extensive degradation of cytoskeletal proteins. FEMS Immunol Med Microbiol (2008) 0.86
Inhibitory effect of the natural product betulin and its derivatives against the intracellular bacterium Chlamydia pneumoniae. Biochem Pharmacol (2010) 0.85
Targeted lipid based drug conjugates: a novel strategy for drug delivery. Int J Pharm (2012) 0.85
Stereochemical sensitivity of the human UDP-glucuronosyltransferases 2B7 and 2B17. J Med Chem (2006) 0.85
Solid-phase synthesis of amino acid derived N-unsubstituted pyrazoles via sydnones. Org Lett (2009) 0.85
Determination of neutral carbohydrates by CZE with direct UV detection. Electrophoresis (2007) 0.85
Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages. Planta Med (2011) 0.85
In vivo treatment of acute Chlamydia pneumoniae infection with the flavonoids quercetin and luteolin and an alkyl gallate, octyl gallate, in a mouse model. Biochem Pharmacol (2005) 0.84
Microarray analysis of a Chlamydia pneumoniae-infected human epithelial cell line by use of gene ontology hierarchy. J Infect Dis (2008) 0.84
(+)-Dehydroabietic acid, an abietane-type diterpene, inhibits Staphylococcus aureus biofilms in vitro. Int J Mol Sci (2013) 0.84
Characterization of flavonoid--biomembrane interactions. Arch Biochem Biophys (2002) 0.83
Crystal morphology engineering of pharmaceutical solids: tabletting performance enhancement. AAPS PharmSciTech (2009) 0.83
Alpha- and β-casein components of host milk induce biofilm formation in the mastitis bacterium Streptococcus uberis. Vet Microbiol (2010) 0.83
Tailoring controlled-release oral dosage forms by combining inkjet and flexographic printing techniques. Eur J Pharm Sci (2012) 0.83
Homogeneous screening assay for human tankyrase. J Biomol Screen (2012) 0.83
Current status and future prospects of C1 domain ligands as drug candidates. Curr Top Med Chem (2011) 0.83
Microplate screening assay to identify inhibitors of human catechol-O-methyltransferase. Anal Biochem (2004) 0.83
UDP-glucuronic acid binds first and the aglycone substrate binds second to form a ternary complex in UGT1A9-catalyzed reactions, in both the presence and absence of bovine serum albumin. Drug Metab Dispos (2012) 0.82
Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma. PLoS One (2013) 0.82
Total synthesis of bistramide A and its 36(Z) isomers: differential effect on cell division, differentiation, and apoptosis. Chemistry (2012) 0.82
γ-Aminobutyric acid type A (GABAA) receptor activation modulates tau phosphorylation. J Biol Chem (2012) 0.81
Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. J Med Chem (2009) 0.81
Computer-assisted, high-performance liquid chromatography with mass spectrometric detection for the analysis of coumarins in Peucedanum palustre and Angelica archangelica. Phytochem Anal (2004) 0.81
Albumin stimulates the activity of the human UDP-glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the effects are enzyme and substrate dependent. PLoS One (2013) 0.81
Methadone increases intracellular calcium in SH-SY5Y and SH-EP1-halpha7 cells by activating neuronal nicotinic acetylcholine receptors. J Neurochem (2005) 0.81
Antimicrobial and antioxidative enrichment of oak (Quercus robur) bark by rotation planar extraction using ExtraChrom. Int J Food Microbiol (2004) 0.81
A new insight into solid-state conformation of macrolide antibiotics. Bioorg Med Chem (2007) 0.80
HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition. Eur J Pharm Sci (2010) 0.80
C1 Domain-targeted isophthalate derivatives induce cell elongation and cell cycle arrest in HeLa cells. PLoS One (2011) 0.79
Benzo[cd]azulene skeleton: azulene, heptafulvene, and tropone derivatives. Org Lett (2009) 0.79
Development and validation of a time-resolved fluorometric immunoassay for screening of antichlamydial activity using a genus-specific europium-conjugated antibody. Anal Biochem (2004) 0.78
Design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against Chlamydia pneumoniae. J Med Chem (2010) 0.78
Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors. ChemMedChem (2011) 0.78
Chiral distinction between the enantiomers of bicyclic alcohols by UDP-glucuronosyltransferases 2B7 and 2B17. Biol Chem (2006) 0.78
Recent advances in 1,3-dipolar cycloaddition reactions on solid supports. Mol Divers (2005) 0.78
Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease. Bioorg Med Chem Lett (2011) 0.78
Tricyclic Benzo[cd]azulenes selectively inhibit activities of Pim kinases and restrict growth of Epstein-Barr virus-transformed cells. PLoS One (2013) 0.78
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorg Med Chem (2012) 0.78
Systematic exploration of natural and synthetic flavonoids for the inhibition of Staphylococcus aureus biofilms. Int J Mol Sci (2013) 0.78
Polyketide derivatives active against Botrytis cinerea in Gerbera hybrida. Planta (2010) 0.78
Microwave-assisted synthesis of imidazoles: reaction of p-toluenesulfonylmethyl isocyanide and polymer-bound imines. Bioorg Med Chem Lett (2005) 0.77
Isoform-selective inhibition of the human UDP-glucuronosyltransferase 2B7 by isolongifolol derivatives. J Med Chem (2007) 0.77
Transport properties of bovine and reindeer beta-lactoglobulin in the Caco-2 cell model. Int J Pharm (2007) 0.77
Anthranoid laxatives influence the absorption of poorly permeable drugs in human intestinal cell culture model (Caco-2). Eur J Pharm Biopharm (2006) 0.77
Phototoxic activity of a thiophene polyacetylene from Leuzea carthamoides. Fitoterapia (2006) 0.77
Synthesis and tautomerization of benzo[cd]azulen-3-ones. Org Lett (2011) 0.77
Solid-phase synthesis of pyrazolopyridines from polymer-bound alkyne and azomethine imines. J Comb Chem (2006) 0.77
1,4-Substituted 4-(1H)-pyridylene-hydrazone-type inhibitors of AChE, BuChE, and amyloid-β aggregation crossing the blood-brain barrier. Eur J Pharm Sci (2013) 0.77
Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases. Drug Metab Dispos (2009) 0.76
The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells. Pharmacol Res (2013) 0.76
Conformation study of 2-arylbenzimidazoles as inhibitors of Chlamydia pneumoniae growth. Bioorg Med Chem Lett (2012) 0.76
Identification and characterization of diarylimidazoles as hybrid inhibitors of butyrylcholinesterase and amyloid beta fibril formation. Eur J Pharm Sci (2011) 0.76
Exploring the scope of the 29G12 antibody catalyzed 1,3-dipolar cycloaddition reaction. J Org Chem (2005) 0.75
Tailored beads made of dissolved cellulose--investigation of their drug release properties. Int J Pharm (2013) 0.75
On the hydrolytic behavior of tinidazole, metronidazole, and ornidazole. J Pharm Sci (2003) 0.75
Nature still provides us with a vast amount of useful molecules. Planta Med (2014) 0.75
Potency determinations of acetylcholinesterase inhibitors using Ellman's reaction-based assay in screening: Effect of assay variants. Anal Biochem (2010) 0.75
Structural Isosteres of Phosphate Groups in the Protein Data Bank. J Chem Inf Model (2017) 0.75
Miniaturisation and validation of a cell-based assay for screening of Ca2+ channel modulators. J Biochem Biophys Methods (2004) 0.75
[Pyrophosphate in medicine]. Duodecim (2016) 0.75
Application of centrifugal force to the extraction and separation of parasorboside and gerberin from Gerbera hybrida. Phytochem Anal (2002) 0.75
Revisiting an agar-based plate method: what the static biofilm method can offer for biofilm research. J Microbiol Methods (2014) 0.75
Mechanism of the Oxidation of Heptafulvenes to Tropones Studied by Online Mass Spectrometry and Density Functional Theory Calculations. J Org Chem (2019) 0.75
Synthesis, structure characterization, and enzyme screening of clenbuterol glucuronides. Eur J Pharm Sci (2009) 0.75
High-throughput screening with a miniaturized radioligand competition assay identifies new modulators of human α2-adrenoceptors. Eur J Pharm Sci (2012) 0.75
Rotation planar extraction and rotation planar chromatography of oak (Quercus robur L.) bark. J Chromatogr A (2003) 0.75
Chemical modifications of cinchona alkaloids lead to enhanced inhibition of human butyrylcholinesterase. Nat Prod Commun (2014) 0.75
Stereochemical and steric control of the UDP-glucuronosyltransferase-catalyzed conjugation reaction: a rational approach for the design of inhibitors for the human UGT2B7. ChemMedChem (2007) 0.75