Published in Neurobiol Aging on February 24, 2012
Neural mechanisms of brain plasticity with complex cognitive training in healthy seniors. Cereb Cortex (2013) 1.06
Integration and relative value of biomarkers for prediction of MCI to AD progression: spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers. Neuroimage Clin (2013) 0.99
BrainAGE in Mild Cognitive Impaired Patients: Predicting the Conversion to Alzheimer's Disease. PLoS One (2013) 0.98
Nonlinear Association Between Cerebrospinal Fluid and Florbetapir F-18 β-Amyloid Measures Across the Spectrum of Alzheimer Disease. JAMA Neurol (2015) 0.96
Is amyloid-β harmful to the brain? Insights from human imaging studies. Brain (2015) 0.88
Longitudinal assessment of global and regional rate of grey matter atrophy in 1,172 healthy older adults: modulation by sex and age. PLoS One (2014) 0.88
Application of a MRI based index to longitudinal atrophy change in Alzheimer disease, mild cognitive impairment and healthy older individuals in the AddNeuroMed cohort. Front Aging Neurosci (2014) 0.84
Memory decline shows stronger associations with estimated spatial patterns of amyloid deposition progression than total amyloid burden. Neurobiol Aging (2013) 0.84
Gender-specific impact of personal health parameters on individual brain aging in cognitively unimpaired elderly subjects. Front Aging Neurosci (2014) 0.81
Resting state FMRI reveals diminished functional connectivity in a mouse model of amyloidosis. PLoS One (2013) 0.80
Memory, executive, and multidomain subtle cognitive impairment: clinical and biomarker findings. Neurology (2015) 0.78
Exploring the use of shape and texture descriptors of positron emission tomography tracer distribution in imaging studies of neurodegenerative disease. J Cereb Blood Flow Metab (2015) 0.78
Quinolinic acid injection in mouse medial prefrontal cortex affects reversal learning abilities, cortical connectivity and hippocampal synaptic plasticity. Sci Rep (2016) 0.76
Visceral fat is associated with brain structure independent of human immunodeficiency virus infection status. J Neurovirol (2016) 0.75
AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res (1996) 53.52
A default mode of brain function. Proc Natl Acad Sci U S A (2001) 50.73
Voxel-based morphometry--the methods. Neuroimage (2000) 34.79
The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement (2011) 24.26
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement (2011) 24.02
A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging (1998) 23.54
The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement (2011) 21.80
Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci U S A (2004) 19.84
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol (2010) 19.42
The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry (1968) 18.69
Common Blood Flow Changes across Visual Tasks: II. Decreases in Cerebral Cortex. J Cogn Neurosci (1997) 14.97
HAMMER: hierarchical attribute matching mechanism for elastic registration. IEEE Trans Med Imaging (2002) 12.71
The medial temporal lobe and recognition memory. Annu Rev Neurosci (2007) 10.37
Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain. J Neurosci (2003) 7.26
Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain (2009) 7.20
Automatic classification of MR scans in Alzheimer's disease. Brain (2008) 6.71
Prevalence of cognitive impairment without dementia in the United States. Ann Intern Med (2008) 5.34
Reduced resting-state brain activity in the "default network" in normal aging. Cereb Cortex (2007) 5.28
Selective changes of resting-state networks in individuals at risk for Alzheimer's disease. Proc Natl Acad Sci U S A (2007) 5.16
One-year age changes in MRI brain volumes in older adults. Cereb Cortex (2000) 5.16
A prospective study of physical activity and cognitive decline in elderly women: women who walk. Arch Intern Med (2001) 4.87
Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. Int Psychogeriatr (1997) 4.87
Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Arch Neurol (2010) 4.78
Voxel-based morphometry using the RAVENS maps: methods and validation using simulated longitudinal atrophy. Neuroimage (2001) 4.58
Adaptive fuzzy segmentation of magnetic resonance images. IEEE Trans Med Imaging (1999) 4.52
Alzheimer's disease diagnosis in individual subjects using structural MR images: validation studies. Neuroimage (2007) 4.41
Baseline and longitudinal patterns of brain atrophy in MCI patients, and their use in prediction of short-term conversion to AD: results from ADNI. Neuroimage (2008) 3.74
COMPARE: classification of morphological patterns using adaptive regional elements. IEEE Trans Med Imaging (2007) 3.72
An image-processing system for qualitative and quantitative volumetric analysis of brain images. J Comput Assist Tomogr (1998) 3.49
Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease. J Int Neuropsychol Soc (2008) 3.21
Longitudinal pattern of regional brain volume change differentiates normal aging from MCI. Neurology (2009) 2.84
Very high-resolution morphometry using mass-preserving deformations and HAMMER elastic registration. Neuroimage (2003) 2.70
Age-related changes in brain activity across the adult lifespan. J Cogn Neurosci (2006) 2.68
Past adult lead exposure is linked to neurodegeneration measured by brain MRI. Neurology (2006) 2.52
Individual patient diagnosis of AD and FTD via high-dimensional pattern classification of MRI. Neuroimage (2008) 2.36
Use of neuroanatomical pattern classification to identify subjects in at-risk mental states of psychosis and predict disease transition. Arch Gen Psychiatry (2009) 2.17
Age differences in deactivation: a link to cognitive control? J Cogn Neurosci (2007) 2.14
Linear regression with spatial constraint to generate parametric images of ligand-receptor dynamic PET studies with a simplified reference tissue model. Neuroimage (2003) 2.09
Longitudinal progression of Alzheimer's-like patterns of atrophy in normal older adults: the SPARE-AD index. Brain (2009) 2.05
Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease. Neuroimage (2007) 1.67
Early intervention for cognitive decline: is there a role for multiple medical or behavioural interventions? Early Interv Psychiatry (2009) 1.64
High-dimensional pattern regression using machine learning: from medical images to continuous clinical variables. Neuroimage (2010) 1.60
MRI-based automated computer classification of probable AD versus normal controls. IEEE Trans Med Imaging (2008) 1.58
Hippocampus volume loss due to chronic heavy drinking. Alcohol Clin Exp Res (2006) 1.51
Longitudinal changes in verbal memory in older adults: distinguishing the effects of age from repeat testing. Neurology (2003) 1.38
Improvement of brain segmentation accuracy by optimizing non-uniformity correction using N3. Neuroimage (2009) 1.26
Longitudinal cerebral blood flow and amyloid deposition: an emerging pattern? J Nucl Med (2008) 1.22
Hypercortisolism in alcohol dependence and its relation to hippocampal volume loss. J Stud Alcohol (2006) 1.21
Prefrontal modulation of working memory performance in brain injury and disease. Hum Brain Mapp (2006) 1.12
I. Longitudinal changes in aging brain function. Neurobiol Aging (2006) 1.12
Stability Of Default-Mode Network Activity In The Aging Brain. Brain Imaging Behav (2009) 1.11
Prevalence of ageing-associated cognitive decline in an elderly population. Age Ageing (1996) 1.10
Imaging and biomarkers in early Alzheimer's disease and mild cognitive impairment. Clin Pharmacol Ther (2009) 1.06
Early intervention for cognitive decline: can cognitive training be used as a selective prevention technique? Int Psychogeriatr (2010) 1.05
Relationship between quality of life and cognitive decline in dementia. Dement Geriatr Cogn Disord (2008) 0.89
Impact of place of residence on relationship between quality of life and cognitive decline in dementia. Alzheimer Dis Assoc Disord (2009) 0.79
Prevalence of aging-associated cognitive decline in an Italian elderly population: results from cross-sectional phase of Italian PRoject on Epidemiology of Alzheimer's disease (IPREA). Aging Clin Exp Res (2010) 0.78
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Gait speed and survival in older adults. JAMA (2011) 15.01
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
HAMMER: hierarchical attribute matching mechanism for elastic registration. IEEE Trans Med Imaging (2002) 12.71
Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci (2004) 12.46
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab (2007) 11.79
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet (2010) 8.74
Phenotype of frailty: characterization in the women's health and aging studies. J Gerontol A Biol Sci Med Sci (2006) 8.00
Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain. J Neurosci (2003) 7.26
Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc (2006) 6.81
Effects of Testosterone Treatment in Older Men. N Engl J Med (2016) 6.66
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66
Detection of life-threatening prostate cancer with prostate-specific antigen velocity during a window of curability. J Natl Cancer Inst (2006) 6.02
Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood (2004) 5.86
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. J Appl Physiol (1985) (2003) 5.73
New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58
Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med (2010) 5.20
Frailty: an emerging research and clinical paradigm--issues and controversies. J Gerontol A Biol Sci Med Sci (2007) 4.98
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87
A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet (2008) 4.75
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet (2008) 4.69
Hearing loss and incident dementia. Arch Neurol (2011) 4.65
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28
Functional decline in peripheral arterial disease: associations with the ankle brachial index and leg symptoms. JAMA (2004) 4.27
Hearing loss and cognitive decline in older adults. JAMA Intern Med (2013) 4.25
Hearing loss prevalence in the United States. Arch Intern Med (2011) 4.22
Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. JAMA (2011) 4.09
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Spatial patterns of brain atrophy in MCI patients, identified via high-dimensional pattern classification, predict subsequent cognitive decline. Neuroimage (2007) 4.07
Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol A Biol Sci Med Sci (2004) 3.96
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76
Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75
Baseline and longitudinal patterns of brain atrophy in MCI patients, and their use in prediction of short-term conversion to AD: results from ADNI. Neuroimage (2008) 3.74
COMPARE: classification of morphological patterns using adaptive regional elements. IEEE Trans Med Imaging (2007) 3.72
Red blood cell distribution width and the risk of death in middle-aged and older adults. Arch Intern Med (2009) 3.71
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68
Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking. Magn Reson Med (2002) 3.67
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry (2010) 3.64
Hearing loss prevalence and risk factors among older adults in the United States. J Gerontol A Biol Sci Med Sci (2011) 3.63
Sarcopenic obesity: definition, cause and consequences. Curr Opin Clin Nutr Metab Care (2008) 3.54
Anemia is associated with disability and decreased physical performance and muscle strength in the elderly. J Am Geriatr Soc (2004) 3.48
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Genome-wide association study of plasma polyunsaturated fatty acids in the InCHIANTI Study. PLoS Genet (2009) 3.38
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Handgrip strength and cause-specific and total mortality in older disabled women: exploring the mechanism. J Am Geriatr Soc (2003) 3.30
Detection of prodromal Alzheimer's disease via pattern classification of magnetic resonance imaging. Neurobiol Aging (2006) 3.26
Computer-assisted imaging to assess brain structure in healthy and diseased brains. Lancet Neurol (2003) 3.26
Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia. N Engl J Med (2014) 3.25
Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy. Lancet Neurol (2011) 3.25
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease. J Int Neuropsychol Soc (2008) 3.21
The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet (2007) 3.21
Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci (2009) 3.14
Morphological classification of brains via high-dimensional shape transformations and machine learning methods. Neuroimage (2004) 3.13
Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes. JAMA (2012) 3.10
Proton pump inhibitors and risk of 1-year mortality and rehospitalization in older patients discharged from acute care hospitals. JAMA Intern Med (2013) 3.08
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04
Hypercortisolemic depression is associated with the metabolic syndrome in late-life. Psychoneuroendocrinology (2007) 2.98
Structural and functional biomarkers of prodromal Alzheimer's disease: a high-dimensional pattern classification study. Neuroimage (2008) 2.93
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study. Arch Intern Med (2007) 2.88
Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci (2006) 2.85
The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci (2014) 2.84
Searching for an operational definition of frailty: a Delphi method based consensus statement: the frailty operative definition-consensus conference project. J Gerontol A Biol Sci Med Sci (2012) 2.82
Uric acid and inflammatory markers. Eur Heart J (2006) 2.81
A prospective evaluation of a protocol for magnetic resonance imaging of patients with implanted cardiac devices. Ann Intern Med (2011) 2.81
Inflammatory markers and depressed mood in older persons: results from the Health, Aging and Body Composition study. Biol Psychiatry (2003) 2.77
Seventy-five genetic loci influencing the human red blood cell. Nature (2012) 2.77
Executive function correlates with walking speed in older persons: the InCHIANTI study. J Am Geriatr Soc (2005) 2.75
Longitudinal changes in cerebral blood flow in the older hypertensive brain. Stroke (2007) 2.75
Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging. J Am Coll Cardiol (2008) 2.75
Physical performance in peripheral arterial disease: a slower rate of decline in patients who walk more. Ann Intern Med (2006) 2.73
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med (2013) 2.73
In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18). J Nucl Med (2010) 2.72
Very high-resolution morphometry using mass-preserving deformations and HAMMER elastic registration. Neuroimage (2003) 2.70
CUBN is a gene locus for albuminuria. J Am Soc Nephrol (2011) 2.70
Spatial normalization of diffusion tensor fields. Magn Reson Med (2003) 2.70
Simple paradigm for extra-cerebral tissue removal: algorithm and analysis. Neuroimage (2011) 2.69
Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly. Ann Neurol (2006) 2.68
Measures of physical performance and risk for progressive and catastrophic disability: results from the Women's Health and Aging Study. J Gerontol A Biol Sci Med Sci (2005) 2.59
Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nat Genet (2009) 2.58