Published in J Cell Sci on February 28, 2012
Exosomes Mediate LTB4 Release during Neutrophil Chemotaxis. PLoS Biol (2016) 1.42
Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors. J Leukoc Biol (2013) 0.91
Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1. Blood (2015) 0.88
A role for Rab27 in neutrophil chemotaxis and lung recruitment. BMC Cell Biol (2014) 0.79
Congenital defects in neutrophil dynamics. J Immunol Res (2014) 0.76
Genetic deletion of Rab27B in pancreatic acinar cells affects granules size and has inhibitory effects on amylase secretion. Biochem Biophys Res Commun (2016) 0.75
Rab GTPases in Immunity and Inflammation. Front Cell Infect Microbiol (2017) 0.75
Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol (2006) 12.29
Neutrophil serine proteases: specific regulators of inflammation. Nat Rev Immunol (2006) 4.01
Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest (2008) 2.77
Regulation of secretory vesicle traffic by Rab small GTPases. Cell Mol Life Sci (2008) 2.71
Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat Immunol (2010) 2.09
The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation. Blood (2007) 1.99
Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes. Mol Biol Cell (2001) 1.88
Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J Clin Invest (2002) 1.81
A general role for Rab27a in secretory cells. Mol Biol Cell (2003) 1.76
Leukocyte elastase: physiological functions and role in acute lung injury. Am J Respir Crit Care Med (2001) 1.72
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. J Natl Cancer Inst (2010) 1.65
Neutrophil-mediated mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice. Infect Immun (2002) 1.52
Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. J Leukoc Biol (2005) 1.43
Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase. Nat Genet (2003) 1.36
Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors. J Exp Med (2005) 1.23
The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules. Traffic (2008) 1.22
Physiological roles of Rab27 effectors in regulated exocytosis. Endocr J (2007) 1.19
Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes. Biochem J (2007) 1.17
Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis. Blood (2011) 0.99
Griscelli syndrome: report of a case and review of the literature. Pediatr Int (2001) 0.80
Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol (2009) 5.44
NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. Cell (2006) 5.35
Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence. Immunity (2003) 3.55
Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes. J Cell Biol (2006) 2.79
Rab GTPases, intracellular traffic and disease. Trends Mol Med (2002) 2.72
A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport. J Biol Chem (2002) 2.69
Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes. Nat Cell Biol (2007) 2.69
Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria. J Immunol (2006) 2.65
Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. Cancer Res (2012) 2.55
Neutrophil kinetics in health and disease. Trends Immunol (2010) 2.47
The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA. J Cell Biol (2008) 2.39
Differential mobilization of subsets of progenitor cells from the bone marrow. Cell Stem Cell (2009) 2.10
The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation. Blood (2007) 1.99
Neutrophil mobilization and clearance in the bone marrow. Immunology (2008) 1.87
Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J Clin Invest (2002) 1.81
A general role for Rab27a in secretory cells. Mol Biol Cell (2003) 1.76
Rab27b regulates number and secretion of platelet dense granules. Proc Natl Acad Sci U S A (2007) 1.66
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. J Natl Cancer Inst (2010) 1.65
Gene therapy for choroideremia: in vitro rescue mediated by recombinant adenovirus. Vision Res (2003) 1.63
Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases. J Lipid Res (2006) 1.60
The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes. Traffic (2002) 1.59
Membrane targeting of Rab GTPases is influenced by the prenylation motif. Mol Biol Cell (2003) 1.57
MT1-MMP-dependent invasion is regulated by TI-VAMP/VAMP7. Curr Biol (2008) 1.55
VEGFR1 stimulates a CXCR4-dependent translocation of megakaryocytes to the vascular niche, enhancing platelet production in mice. Blood (2012) 1.55
Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis. Mol Biol Cell (2007) 1.50
Fatty acylation and prenylation of proteins: what's hot in fat. Curr Opin Cell Biol (2005) 1.50
The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse. FASEB J (2008) 1.44
Thousands of rab GTPases for the cell biologist. PLoS Comput Biol (2011) 1.44
Melanosomes at a glance. J Cell Sci (2008) 1.36
Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms. Traffic (2009) 1.35
The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells. Mol Biol Cell (2004) 1.30
Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia. J Clin Invest (2006) 1.29
The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium. Traffic (2007) 1.27
Multiple regions contribute to membrane targeting of Rab GTPases. J Cell Sci (2004) 1.26
Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia. Invest Ophthalmol Vis Sci (2010) 1.23
Rab27b regulates mast cell granule dynamics and secretion. Traffic (2007) 1.22
Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation. J Biol Chem (2006) 1.20
Chemokines in allergic airway disease. Curr Opin Pharmacol (2003) 1.20
The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner. Blood (2004) 1.20
Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell type. J Cell Sci (2003) 1.19
A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes. Mol Biol Cell (2006) 1.18
A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood (2003) 1.11
Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. Blood (2009) 1.11
Eotaxin-2 generation is differentially regulated by lipopolysaccharide and IL-4 in monocytes and macrophages. J Immunol (2002) 1.11
The melanosome as a model to study organelle motility in mammals. Pigment Cell Res (2004) 1.09
Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo. J Mol Med (Berl) (2013) 1.09
Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts. Pigment Cell Res (2004) 1.08
Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes. J Biol Chem (2008) 1.07
Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases. J Biol Chem (2003) 1.07
CXCR2 mediates the recruitment of endothelial progenitor cells during allergic airways remodeling. Stem Cells (2009) 1.05
Rab27a and MyoVa are the primary Mlph interactors regulating melanosome transport in melanocytes. J Cell Sci (2007) 1.04
Novel functions for Rab GTPases in multiple aspects of tumour progression. Biochem Soc Trans (2012) 1.04
Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation. Curr Biol (2010) 1.03
Migration across the sinusoidal endothelium regulates neutrophil mobilization in response to ELR + CXC chemokines. Br J Haematol (2008) 1.01
Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease. Hum Mol Genet (2008) 0.98
The allele encoding the mycobacterial Erp protein affects lung disease in mice. Cell Microbiol (2003) 0.98
Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion. FEBS J (2013) 0.97
Effects of mouse strain, position of integration and tetracycline analogue on the tetracycline conditional system in transgenic mice. Gene (2002) 0.97
ER-associated protein degradation is a common mechanism underpinning numerous monogenic diseases including Robinow syndrome. Hum Mol Genet (2005) 0.97
V-ATPase: a potential pH sensor. Nat Cell Biol (2006) 0.96
Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase. J Biol Chem (2008) 0.96
Melanosomes on the move: a model to understand organelle dynamics. Biochem Soc Trans (2011) 0.95
The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase. Biochem J (2005) 0.95
Exosome signaling in mammary gland development and cancer. Int J Dev Biol (2011) 0.95
Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium. PLoS One (2013) 0.94
CHM/REP1 cDNA delivery by lentiviral vectors provides functional expression of the transgene in the retinal pigment epithelium of choroideremia mice. J Gene Med (2012) 0.94
Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. Am J Physiol Cell Physiol (2011) 0.94
Rapid multilabel detection of geranylgeranylated proteins by using bioorthogonal ligation chemistry. Chembiochem (2010) 0.93
Myosin Va acts in concert with Rab27a and MyRIP to regulate acute von-Willebrand factor release from endothelial cells. Traffic (2011) 0.93
PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils. Blood (2010) 0.91
Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models. BMC Cell Biol (2002) 0.90
Are prenyl groups on proteins sticky fingers or greasy handles? Biochem J (2003) 0.89
Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow. FASEB J (2011) 0.87
Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport. Pigment Cell Melanoma Res (2009) 0.87
The host endocytic pathway is essential for Plasmodium berghei late liver stage development. Traffic (2012) 0.87