| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
|
Proc Natl Acad Sci U S A
|
2003
|
1.84
|
|
2
|
Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice.
|
J Natl Cancer Inst
|
2012
|
1.58
|
|
3
|
IKKalpha is required to maintain skin homeostasis and prevent skin cancer.
|
Cancer Cell
|
2008
|
1.38
|
|
4
|
Cyclo-oxygenase-2 plays a critical role in UV-induced skin carcinogenesis.
|
Photochem Photobiol
|
2008
|
1.38
|
|
5
|
A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas.
|
Proc Natl Acad Sci U S A
|
2006
|
1.37
|
|
6
|
Rosiglitazone, a PPAR gamma agonist: potent promoter of hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers.
|
Int J Cancer
|
2008
|
1.34
|
|
7
|
Gemfibrozil, a lipid-lowering drug, inhibits the induction of nitric-oxide synthase in human astrocytes.
|
J Biol Chem
|
2002
|
1.28
|
|
8
|
Lack of expression of the EP2 but not EP3 receptor for prostaglandin E2 results in suppression of skin tumor development.
|
Cancer Res
|
2005
|
1.27
|
|
9
|
Progressive metaplastic and dysplastic changes in mouse pancreas induced by cyclooxygenase-2 overexpression.
|
Neoplasia
|
2008
|
1.24
|
|
10
|
Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.
|
Cancer Res
|
2007
|
1.24
|
|
11
|
The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis.
|
Cancer Res
|
2005
|
1.22
|
|
12
|
Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia.
|
Sci Transl Med
|
2012
|
1.22
|
|
13
|
Quantitative high-performance liquid chromatography/electrospray ionization tandem mass spectrometric analysis of 2- and 3-series prostaglandins in cultured tumor cells.
|
Anal Biochem
|
2002
|
1.21
|
|
14
|
Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis.
|
J Natl Cancer Inst
|
2009
|
1.16
|
|
15
|
Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells.
|
J Biol Chem
|
2002
|
1.15
|
|
16
|
A role for cyclooxygenase-2 in ultraviolet light-induced skin carcinogenesis.
|
Mol Carcinog
|
2007
|
1.15
|
|
17
|
Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development.
|
Cancer Res
|
2002
|
1.14
|
|
18
|
Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells.
|
J Lipid Res
|
2004
|
1.11
|
|
19
|
Multiple signaling pathways are responsible for prostaglandin E2-induced murine keratinocyte proliferation.
|
Mol Cancer Res
|
2008
|
1.10
|
|
20
|
Molecular mechanisms of mouse skin tumor promotion.
|
Cancers (Basel)
|
2010
|
1.09
|
|
21
|
Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors.
|
Cell Microbiol
|
2003
|
1.07
|
|
22
|
GATA-6 transcriptional regulation of 15-lipoxygenase-1 during NSAID-induced apoptosis in colorectal cancer cells.
|
Cancer Res
|
2002
|
1.05
|
|
23
|
Thiazolidinediones inhibit insulin-like growth factor-i-induced activation of p70S6 kinase and suppress insulin-like growth factor-I tumor-promoting activity.
|
Cancer Res
|
2006
|
1.05
|
|
24
|
Transitional cell hyperplasia and carcinomas in urinary bladders of transgenic mice with keratin 5 promoter-driven cyclooxygenase-2 overexpression.
|
Cancer Res
|
2005
|
1.03
|
|
25
|
Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer.
|
Cancer Prev Res (Phila)
|
2011
|
1.01
|
|
26
|
The effect of cyclooxygenase-2 overexpression on skin carcinogenesis is context dependent.
|
Mol Carcinog
|
2007
|
1.00
|
|
27
|
Nonsteroidal anti-inflammatory drug-activated gene-1 expression inhibits urethane-induced pulmonary tumorigenesis in transgenic mice.
|
Cancer Prev Res (Phila)
|
2009
|
0.99
|
|
28
|
Genetic reduction of insulin-like growth factor-1 mimics the anticancer effects of calorie restriction on cyclooxygenase-2-driven pancreatic neoplasia.
|
Cancer Prev Res (Phila)
|
2011
|
0.97
|
|
29
|
Selective cyclooxygenase-2 inhibitors inhibit growth and induce apoptosis of bladder cancer.
|
Oncol Rep
|
2006
|
0.95
|
|
30
|
Chemoprevention of skin carcinogenesis by phenylretinamides: retinoid receptor-independent tumor suppression.
|
Clin Cancer Res
|
2006
|
0.95
|
|
31
|
SAGE profiling of UV-induced mouse skin squamous cell carcinomas, comparison with acute UV irradiation effects.
|
Mol Carcinog
|
2005
|
0.94
|
|
32
|
Mutation frequencies in murine keratinocytes as a function of carcinogenic status.
|
Mol Carcinog
|
2004
|
0.92
|
|
33
|
Overexpression of cyclooxygenase-2 (COX-2) in the mouse urinary bladder induces the expression of immune- and cell proliferation-related genes.
|
Mol Carcinog
|
2009
|
0.92
|
|
34
|
An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis.
|
Oncogene
|
2005
|
0.92
|
|
35
|
The chemopreventive efficacies of nonsteroidal anti-inflammatory drugs: the relationship of short-term biomarkers to long-term skin tumor outcome.
|
Cancer Prev Res (Phila)
|
2013
|
0.92
|
|
36
|
Prostaglandin receptor EP2 is responsible for cyclooxygenase-2 induction by prostaglandin E2 in mouse skin.
|
Carcinogenesis
|
2007
|
0.91
|
|
37
|
Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors.
|
Biochem J
|
2002
|
0.91
|
|
38
|
Modulation of UVB-induced and basal cyclooxygenase-2 (COX-2) expression by apigenin in mouse keratinocytes: role of USF transcription factors.
|
Mol Carcinog
|
2007
|
0.90
|
|
39
|
Combined targeting of STAT3/NF-κB/COX-2/EP4 for effective management of pancreatic cancer.
|
Clin Cancer Res
|
2014
|
0.90
|
|
40
|
A dose-finding study of aspirin for chemoprevention utilizing rectal mucosal prostaglandin E(2) levels as a biomarker.
|
Cancer Epidemiol Biomarkers Prev
|
2002
|
0.90
|
|
41
|
Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma.
|
Cancer Res
|
2003
|
0.90
|
|
42
|
Critical role of IkappaB kinase alpha in embryonic skin development and skin carcinogenesis.
|
Histol Histopathol
|
2009
|
0.89
|
|
43
|
In vivo functional studies of tumor-specific retrogene NanogP8 in transgenic animals.
|
Cell Cycle
|
2013
|
0.89
|
|
44
|
Cyclooxygenase-2 deficiency increases epidermal apoptosis and impairs recovery following acute UVB exposure.
|
Mol Carcinog
|
2007
|
0.88
|
|
45
|
Changes in cancer cell metabolism revealed by direct sample analysis with MALDI mass spectrometry.
|
PLoS One
|
2013
|
0.88
|
|
46
|
UVB radiation-induced β-catenin signaling is enhanced by COX-2 expression in keratinocytes.
|
Mol Carcinog
|
2011
|
0.87
|
|
47
|
Targeted disruption of glutathione peroxidase 4 in mouse skin epithelial cells impairs postnatal hair follicle morphogenesis that is partially rescued through inhibition of COX-2.
|
J Invest Dermatol
|
2013
|
0.87
|
|
48
|
Loss of 15-hydroxyprostaglandin dehydrogenase expression disrupts urothelial differentiation.
|
Urology
|
2008
|
0.86
|
|
49
|
Protective role of cathepsin L in mouse skin carcinogenesis.
|
Mol Carcinog
|
2011
|
0.86
|
|
50
|
Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal human prostate epithelial cells.
|
Oncogene
|
2004
|
0.86
|
|
51
|
Protein expression profiles in the epidermis of cyclooxygenase-2 transgenic mice by 2-dimensional gel electrophoresis and mass spectrometry.
|
J Proteome Res
|
2007
|
0.86
|
|
52
|
Anticancer activity of fish oils against human lung cancer is associated with changes in formation of PGE2 and PGE3 and alteration of Akt phosphorylation.
|
Mol Carcinog
|
2013
|
0.85
|
|
53
|
The effect of PPARgamma ligands on UV- or chemically-induced carcinogenesis in mouse skin.
|
Mol Carcinog
|
2005
|
0.85
|
|
54
|
Dietary energy balance modulation of Kras- and Ink4a/Arf+/--driven pancreatic cancer: the role of insulin-like growth factor-I.
|
Cancer Prev Res (Phila)
|
2013
|
0.85
|
|
55
|
Reduction of IKKalpha expression promotes chronic ultraviolet B exposure-induced skin inflammation and carcinogenesis.
|
Am J Pathol
|
2010
|
0.84
|
|
56
|
Black tea polyphenols inhibit IGF-I-induced signaling through Akt in normal prostate epithelial cells and Du145 prostate carcinoma cells.
|
Carcinogenesis
|
2002
|
0.84
|
|
57
|
Mouse Genetic Models Reveal Surprising Functions of IkB Kinase Alpha in Skin Development and Skin Carcinogenesis.
|
Cancers (Basel)
|
2013
|
0.84
|
|
58
|
Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways.
|
Mol Cancer Ther
|
2008
|
0.83
|
|
59
|
Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesis.
|
Mol Oncol
|
2010
|
0.82
|
|
60
|
SKHIN/Sprd, a new genetically defined inbred hairless mouse strain for UV-induced skin carcinogenesis studies.
|
Exp Dermatol
|
2012
|
0.81
|
|
61
|
Upregulation of the EP1 receptor for prostaglandin E2 promotes skin tumor progression.
|
Mol Carcinog
|
2011
|
0.81
|
|
62
|
Suppression of 15-hydroxyprostaglandin dehydrogenase messenger RNA concentration, protein expression, and enzymatic activity during human ureteral obstruction.
|
J Pharmacol Exp Ther
|
2004
|
0.81
|
|
63
|
Troglitazone inhibits cyclin D1 expression and cell cycling independently of PPARgamma in normal mouse skin keratinocytes.
|
J Invest Dermatol
|
2004
|
0.80
|
|
64
|
The EP1 receptor for prostaglandin E2 promotes the development and progression of malignant murine skin tumors.
|
Mol Carcinog
|
2011
|
0.80
|
|
65
|
Troglitazone induction of COX-2 expression is dependent on ERK activation in keratinocytes.
|
Prostaglandins Leukot Essent Fatty Acids
|
2006
|
0.79
|
|
66
|
Transgenic insulin-like growth factor-1 stimulates activation of COX-2 signaling in mammary glands.
|
Mol Carcinog
|
2011
|
0.79
|
|
67
|
Identification and characterization of a phorbol ester-responsive element in the murine 8S-lipoxygenase gene.
|
J Biol Chem
|
2004
|
0.78
|
|
68
|
Evidence for downregulation of calcium signaling proteins in advanced mouse adenocarcinoma.
|
Prostate
|
2005
|
0.78
|
|
69
|
Molecular profiling of the epidermis: a proteomics approach.
|
Methods Mol Biol
|
2010
|
0.78
|
|
70
|
The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissue.
|
Carcinogenesis
|
2007
|
0.78
|
|
71
|
Regulation of transcription of the intracellular interleukin-1 receptor antagonist gene by AP-1 in mouse carcinoma cells.
|
Mol Carcinog
|
2002
|
0.78
|
|
72
|
Chemopreventive efficacy of Targretin in rodent models of urinary bladder, colon/intestine, head and neck and mammary cancers.
|
Oncol Rep
|
2012
|
0.77
|
|
73
|
Vitamin E analog, alpha-tocopherol ether-linked acetic acid analog, alone and in combination with celecoxib, reduces multiplicity of ultraviolet-induced skin cancers in mice.
|
Anticancer Drugs
|
2008
|
0.76
|