Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia.

PubWeight™: 1.22‹?› | Rank: Top 10%

🔗 View Article (PMC 3319975)

Published in Sci Transl Med on March 21, 2012

Authors

Luis A Garza1, Yaping Liu, Zaixin Yang, Brinda Alagesan, John A Lawson, Scott M Norberg, Dorothy E Loy, Tailun Zhao, Hanz B Blatt, David C Stanton, Lee Carrasco, Gurpreet Ahluwalia, Susan M Fischer, Garret A FitzGerald, George Cotsarelis

Author Affiliations

1: Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Articles citing this

Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche. Neuron (2014) 2.25

A Guide to Studying Human Hair Follicle Cycling In Vivo. J Invest Dermatol (2016) 1.46

Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms. J Invest Dermatol (2014) 1.36

Macroenvironmental regulation of hair cycling and collective regenerative behavior. Cold Spring Harb Perspect Med (2014) 1.11

Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44. J Invest Dermatol (2012) 1.01

Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering. Expert Opin Biol Ther (2013) 0.95

Human gene correlation analysis (HGCA): a tool for the identification of transcriptionally co-expressed genes. BMC Res Notes (2012) 0.86

Female Pattern Hair Loss: a clinical and pathophysiological review. An Bras Dermatol (2015) 0.83

The Modulatable Stem Cell Niche: Tissue Interactions during Hair and Feather Follicle Regeneration. J Mol Biol (2015) 0.83

The role of androgen and androgen receptor in skin-related disorders. Arch Dermatol Res (2012) 0.83

Resting no more: re-defining telogen, the maintenance stage of the hair growth cycle. Biol Rev Camb Philos Soc (2014) 0.81

Hair restoration surgery: challenges and solutions. Clin Cosmet Investig Dermatol (2015) 0.81

Does prostaglandin D2 hold the cure to male pattern baldness? Exp Dermatol (2014) 0.81

Minoxidil may suppress androgen receptor-related functions. Oncotarget (2014) 0.78

Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase. J Lipid Res (2013) 0.77

An overview of alopecias. Cold Spring Harb Perspect Med (2014) 0.76

Expression and Function of Group IIE Phospholipase A2 in Mouse Skin. J Biol Chem (2016) 0.76

A new target for squamous cell skin cancer? Exp Dermatol (2015) 0.75

Bad Hair Day: Testosterone and Wnts. J Invest Dermatol (2015) 0.75

Similar response patterns to topical minoxidil foam 5% in frontal and vertex scalp of men with androgenetic alopecia: a microarray analysis. Br J Dermatol (2014) 0.75

Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease. Thromb Res (2015) 0.75

Advances in Understanding Hair Growth. F1000Res (2016) 0.75

Investigating the effects of metabolic dysregulation on hair follicles: a comparison of HIV-infected women with and without central lipohypertrophy. Int J Dermatol (2013) 0.75

Regulation of inflammation by lipid mediators in oral diseases. Oral Dis (2016) 0.75

Drug discovery for alopecia: gone today, hair tomorrow. Expert Opin Drug Discov (2015) 0.75

Study on the Efficacy of Platelet-rich Fibrin Matrix in Hair Follicular Unit Transplantation in Androgenetic Alopecia Patients. J Clin Aesthet Dermatol (2016) 0.75

Conventional and novel stem cell based therapies for androgenic alopecia. Stem Cells Cloning (2017) 0.75

Comprehensive Transcriptome Profiling of Balding and Non-Balding Scalps in Trichorhinophalangeal Syndrome Type I Patient. Ann Dermatol (2017) 0.75

15-deoxy prostaglandin J2, the nonenzymatic metabolite of prostaglandin D2, induces apoptosis in keratinocytes of human hair follicles: a possible explanation for prostaglandin D2-mediated inhibition of hair growth. Naunyn Schmiedebergs Arch Pharmacol (2016) 0.75

Articles cited by this

Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell (1990) 12.13

P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev (2002) 6.14

A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol (2001) 6.12

The biology of hair follicles. N Engl J Med (1999) 4.46

Prostaglandin D2 as a mediator of allergic asthma. Science (2000) 3.19

Induction of PGE2 by estradiol mediates developmental masculinization of sex behavior. Nat Neurosci (2004) 3.11

FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. Cell (1994) 3.10

The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci (1998) 2.58

Treatment of hair loss. N Engl J Med (1999) 2.43

Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma. J Clin Invest (2003) 2.27

Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia. J Invest Dermatol (2008) 2.23

WNT signaling in the control of hair growth and structure. Dev Biol (1999) 2.13

Minoxidil: mechanisms of action on hair growth. Br J Dermatol (2004) 2.05

Male-pattern baldness susceptibility locus at 20p11. Nat Genet (2008) 1.87

Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. J Clin Invest (2011) 1.81

Involvement of Propionibacterium acnes in the augmentation of lipogenesis in hamster sebaceous glands in vivo and in vitro. J Invest Dermatol (2009) 1.67

Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis. Proc Natl Acad Sci U S A (2002) 1.61

Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor. J Immunol (2006) 1.54

Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice. Proc Natl Acad Sci U S A (1999) 1.41

Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia. Am J Hum Genet (2005) 1.35

Lipocalin-type and hematopoietic prostaglandin D synthases as a novel example of functional convergence. Prostaglandins Other Lipid Mediat (2002) 1.32

Prostanoid receptor antagonists: development strategies and therapeutic applications. Br J Pharmacol (2009) 1.31

Prostaglandin-induced hair growth. Surv Ophthalmol (2002) 1.28

Srcasm modulates EGF and Src-kinase signaling in keratinocytes. J Biol Chem (2004) 1.26

Human hair growth in vitro: a model for the study of hair follicle biology. J Dermatol Sci (1994) 1.18

Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development. Cancer Res (2002) 1.14

Characterization of inflammatory infiltrates in male pattern alopecia: implications for pathogenesis. Br J Dermatol (1992) 1.12

Association of benign prostatic hyperplasia with male pattern baldness. Urology (1998) 1.11

Influence of prostaglandin F2alpha and its analogues on hair regrowth and follicular melanogenesis in a murine model. Exp Dermatol (2005) 1.07

Mast cell involvement in murine hair growth. Dev Biol (1994) 1.06

Prostaglandin metabolism in human hair follicle. Exp Dermatol (2007) 1.00

Prostanoid receptors in anagen human hair follicles. Exp Dermatol (2007) 0.98

Estrogen-induced production of a peroxisome proliferator-activated receptor (PPAR) ligand in a PPARgamma-expressing tissue. J Biol Chem (1998) 0.93

Male pattern alopecia a histopathologic and histochemical study. J Cutan Pathol (1975) 0.93

Influence of androgens on gene expression in the BALB/c mouse submandibular gland. J Dent Res (2005) 0.89

Topical or systemic 16, 16 dm prostaglandin E2 or WR-2721 (WR-1065) protects mice from alopecia after fractionated irradiation. Int J Radiat Biol (1992) 0.88

Expression of cyclooxygenase isozymes during morphogenesis and cycling of pelage hair follicles in mouse skin: precocious onset of the first catagen phase and alopecia upon cyclooxygenase-2 overexpression. J Invest Dermatol (2003) 0.88

Specific regulation of lipocalin-type prostaglandin D synthase in mouse heart by estrogen receptor beta. Mol Endocrinol (2003) 0.86

Expression and regulation of lipocalin-type prostaglandin d synthase in rat testis and epididymis. Biol Reprod (2003) 0.84

Androgens and hair loss. Curr Opin Endocrinol Diabetes Obes (2009) 0.83

Agonist and antagonist effects of 15R-prostaglandin (PG) D2 and 11-methylene-PGD2 on human eosinophils and basophils. J Pharmacol Exp Ther (2006) 0.80

DP(2) receptor antagonists in development. Expert Opin Investig Drugs (2010) 0.80

Selective inhibition by minoxidil of prostacyclin production by cells in culture. Biochem Pharmacol (1988) 0.79

Genetic mechanisms underlying male sex determination in mammals. J Appl Genet (2009) 0.79

Articles by these authors

Capturing and profiling adult hair follicle stem cells. Nat Biotechnol (2004) 10.35

Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med (2005) 8.01

Cardiovascular outcomes with etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison. Lancet (2006) 6.42

Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest (2006) 6.12

Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell (2007) 6.02

A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron (2004) 5.71

Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains. Nat Genet (2011) 5.70

VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol (2005) 5.56

Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. J Invest Dermatol (2003) 5.28

Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature (2007) 5.19

Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol (2011) 4.67

Role of prostacyclin in the cardiovascular response to thromboxane A2. Science (2002) 4.59

Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. J Clin Invest (2006) 4.50

Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr Biol (2005) 4.04

Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge. J Invest Dermatol (2003) 3.72

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature (2010) 3.55

RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis. Nature (2012) 3.40

COX-2-derived prostacyclin confers atheroprotection on female mice. Science (2004) 2.87

Oxidative stress and cardiovascular injury: Part II: animal and human studies. Circulation (2003) 2.77

Drug resistance and pseudoresistance: an unintended consequence of enteric coating aspirin. Circulation (2012) 2.76

Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS. Circulation (2003) 2.69

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53

The longest telomeres: a general signature of adult stem cell compartments. Genes Dev (2008) 2.38

Hair follicle stem cells in the lower bulge form the secondary germ, a biochemically distinct but functionally equivalent progenitor cell population, at the termination of catagen. Differentiation (2004) 2.34

Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma. J Clin Invest (2003) 2.27

Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med (2012) 2.13

Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. J Biol Chem (2007) 2.10

Prostanoids in health and disease. J Lipid Res (2008) 2.06

Bis-SNP: combined DNA methylation and SNP calling for Bisulfite-seq data. Genome Biol (2012) 2.02

Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest (2004) 1.97

Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules. Genome Res (2012) 1.95

Decreased serum ferritin is associated with alopecia in women. J Invest Dermatol (2003) 1.87

The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. Proc Natl Acad Sci U S A (2003) 1.84

Identification and characterization of novel amphioxus microRNAs by Solexa sequencing. Genome Biol (2009) 1.82

Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. J Clin Invest (2011) 1.81

COX-2 inhibitors and cardiovascular risk. J Cardiovasc Pharmacol (2007) 1.77

Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J Biol Chem (2003) 1.77

COX-2-dependent cardiac failure in Gh/tTG transgenic mice. Circ Res (2003) 1.72

Review of hair follicle dermal cells. J Dermatol Sci (2010) 1.72

Vascular COX-2 modulates blood pressure and thrombosis in mice. Sci Transl Med (2012) 1.71

12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress. Am J Pathol (2004) 1.71

Genetic components of the circadian clock regulate thrombogenesis in vivo. Circulation (2008) 1.62

Effects of gut-targeted 15-LOX-1 transgene expression on colonic tumorigenesis in mice. J Natl Cancer Inst (2012) 1.58

CD34 expression by hair follicle stem cells is required for skin tumor development in mice. Cancer Res (2007) 1.55

Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis. Proc Natl Acad Sci U S A (2006) 1.52

Circadian clocks and vascular function. Circ Res (2010) 1.52

4-Des-oxy-4β-[(5-meth-oxy-1H-indol-3-yl)oxalylamino]podophyllotoxin methanol solvate. Acta Crystallogr Sect E Struct Rep Online (2008) 1.51

Parecoxib, valdecoxib, and cardiovascular risk. Circulation (2005) 1.51

Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation. Circulation (2008) 1.50

Cyclooxygenases and prostaglandins: shaping up the immune response. Int Immunopharmacol (2002) 1.49

Developmental expression of functional cyclooxygenases in zebrafish. Proc Natl Acad Sci U S A (2002) 1.48

The malagarasi river does not form an absolute barrier to chimpanzee movement in Western Tanzania. PLoS One (2013) 1.44

Summary of North American Hair Research Society (NAHRS)-sponsored Workshop on Cicatricial Alopecia, Duke University Medical Center, February 10 and 11, 2001. J Am Acad Dermatol (2003) 1.42

Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function. Proc Natl Acad Sci U S A (2009) 1.41

Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell (2013) 1.41

Cyclooxygenases, thromboxane, and atherosclerosis: plaque destabilization by cyclooxygenase-2 inhibition combined with thromboxane receptor antagonism. Circulation (2005) 1.40

Bioinformatic analysis of circadian gene oscillation in mouse aorta. Circulation (2005) 1.40

Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors. Cancer Res (2006) 1.39

IKKalpha is required to maintain skin homeostasis and prevent skin cancer. Cancer Cell (2008) 1.38

Cyclo-oxygenase-2 plays a critical role in UV-induced skin carcinogenesis. Photochem Photobiol (2008) 1.38

A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas. Proc Natl Acad Sci U S A (2006) 1.37

COX-2-derived prostacyclin modulates vascular remodeling. Circ Res (2005) 1.37

The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans. J Am Coll Cardiol (2008) 1.36

EBP, a program for protein identification using multiple tandem mass spectrometry datasets. Mol Cell Proteomics (2006) 1.36

Epithelial stem cells and implications for wound repair. Semin Cell Dev Biol (2012) 1.35

Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy. Mol Cancer Ther (2013) 1.35

Rosiglitazone, a PPAR gamma agonist: potent promoter of hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers. Int J Cancer (2008) 1.34

Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding. Nat Med (2013) 1.33

F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases. Chem Phys Lipids (2004) 1.31

Gemfibrozil, a lipid-lowering drug, inhibits the induction of nitric-oxide synthase in human astrocytes. J Biol Chem (2002) 1.28

Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2. Gastroenterology (2006) 1.27

Lack of expression of the EP2 but not EP3 receptor for prostaglandin E2 results in suppression of skin tumor development. Cancer Res (2005) 1.27

Progressive metaplastic and dysplastic changes in mouse pancreas induced by cyclooxygenase-2 overexpression. Neoplasia (2008) 1.24

Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas. Cancer Res (2007) 1.24

The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis. Cancer Res (2005) 1.22

Quantitative high-performance liquid chromatography/electrospray ionization tandem mass spectrometric analysis of 2- and 3-series prostaglandins in cultured tumor cells. Anal Biochem (2002) 1.21

Peripheral circadian clocks in the vasculature. Arterioscler Thromb Vasc Biol (2007) 1.20

Training translators for smart drug discovery. Sci Transl Med (2010) 1.19

Recalibrating intellectual property rights to enhance translational research collaborations. Sci Transl Med (2012) 1.18

Prostaglandin E synthases in zebrafish. Arterioscler Thromb Vasc Biol (2004) 1.16

Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice. Nat Med (2005) 1.16