Published in Toxicol Sci on March 02, 2012
Arsenite selectively inhibits mouse bone marrow lymphoid progenitor cell development in vivo and in vitro and suppresses humoral immunity in vivo. PLoS One (2014) 1.01
Environmentally Relevant Concentrations of Arsenite Induce Dose-Dependent Differential Genotoxicity Through Poly(ADP-Ribose) Polymerase Inhibition and Oxidative Stress in Mouse Thymus Cells. Toxicol Sci (2015) 0.85
Arsenite binds to the RING finger domains of RNF20-RNF40 histone E3 ubiquitin ligase and inhibits DNA double-strand break repair. J Am Chem Soc (2014) 0.85
Molecular features in arsenic-induced lung tumors. Mol Cancer (2013) 0.82
Arsenite Interacts with Dibenzo[def,p]chrysene (DBC) at Low Levels to Suppress Bone Marrow Lymphoid Progenitors in Mice. Biol Trace Elem Res (2015) 0.81
Heavy Metal Exposure Influences Double Strand Break DNA Repair Outcomes. PLoS One (2016) 0.80
Ethanol enhances arsenic-induced cyclooxygenase-2 expression via both NFAT and NF-κB signalings in colorectal cancer cells. Toxicol Appl Pharmacol (2015) 0.79
Synergistic cytotoxicity and DNA strand breaks in cells and plasmid DNA exposed to uranyl acetate and ultraviolet radiation. J Appl Toxicol (2014) 0.79
Monomethylarsonous acid (MMA+3) Inhibits IL-7 Signaling in Mouse Pre-B Cells. Toxicol Sci (2015) 0.79
Maternal arsenic exposure and DNA damage biomarkers, and the associations with birth outcomes in a general population from Taiwan. PLoS One (2014) 0.78
Nicotinamide enhances repair of arsenic and ultraviolet radiation-induced DNA damage in HaCaT keratinocytes and ex vivo human skin. PLoS One (2015) 0.77
Arsenite suppression of BMP signaling in human keratinocytes. Toxicol Appl Pharmacol (2013) 0.77
Editor's Highlight: Interactive Genotoxicity Induced by Environmentally Relevant Concentrations of Benzo(a)Pyrene Metabolites and Arsenite in Mouse Thymus Cells. Toxicol Sci (2016) 0.76
Arsenite-loaded nanoparticles inhibit PARP-1 to overcome multidrug resistance in hepatocellular carcinoma cells. Sci Rep (2016) 0.75
Poly(ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol (2006) 9.58
PARP inhibition: PARP1 and beyond. Nat Rev Cancer (2010) 6.70
Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death. Proc Natl Acad Sci U S A (2006) 3.47
Poly(ADP-ribose) (PAR) polymer is a death signal. Proc Natl Acad Sci U S A (2006) 3.41
DNA polymerases and cancer. Nat Rev Cancer (2011) 3.05
Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms. Arch Toxicol (2008) 2.75
Role of oxidative stress and DNA damage in human carcinogenesis. Mutat Res (2011) 2.54
Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene (2004) 2.52
PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration. Cell Commun Signal (2010) 2.27
Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos. Exp Neurol (2009) 2.24
Reactive oxygen species (ROS)--induced genetic and epigenetic alterations in human carcinogenesis. Mutat Res (2011) 1.90
Lung cancer in a U.S. population with low to moderate arsenic exposure. Environ Health Perspect (2009) 1.77
Evidence that arsenite acts as a cocarcinogen in skin cancer. Toxicol Appl Pharmacol (2004) 1.73
Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis. Toxicol Appl Pharmacol (2001) 1.70
Molecular mechanisms of arsenic carcinogenesis. Mol Cell Biochem (2004) 1.66
Poly ADP-ribose polymerase-1: an international molecule of mystery. DNA Repair (Amst) (2008) 1.64
Arsenite interacts selectively with zinc finger proteins containing C3H1 or C4 motifs. J Biol Chem (2011) 1.45
Inhibition of poly(ADP-ribose) polymerase-1 by arsenite interferes with repair of oxidative DNA damage. J Biol Chem (2008) 1.44
Poly(ADP-ribose) makes a date with death. Curr Opin Chem Biol (2007) 1.44
Arsenic-induced carcinogenesis--oxidative stress as a possible mode of action and future research needs for more biologically based risk assessment. Chem Res Toxicol (2010) 1.43
Arsenic carcinogenesis in the skin. J Biomed Sci (2006) 1.39
The expanding role of poly(ADP-ribose) metabolism: current challenges and new perspectives. Curr Opin Cell Biol (2006) 1.35
Arsenic-induced enhancement of ultraviolet radiation carcinogenesis in mouse skin: a dose-response study. Environ Health Perspect (2004) 1.29
Modulation of DNA repair processes by arsenic and selenium compounds. Toxicology (2003) 1.25
Oxidative stress and apoptosis in metal ion-induced carcinogenesis. Free Radic Biol Med (2004) 1.25
Damage of zinc fingers in DNA repair proteins, a novel molecular mechanism in carcinogenesis. Toxicol Lett (2005) 1.23
Low level, long-term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: potential role in skin co-carcinogenesis. Int J Cancer (2005) 1.21
Early events in UV carcinogenesis--DNA damage, target cells and mutant p53 foci. Photochem Photobiol (2008) 1.20
Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity. Toxicol Appl Pharmacol (2008) 1.11
Arsenic co-exposure potentiates benzo[a]pyrene genotoxicity. Mutat Res (2002) 1.04
Coordination of altered DNA repair and damage pathways in arsenite-exposed keratinocytes. Toxicol Sci (2002) 1.04
Opening the doors to cytochrome c: changes in mitochondrial shape and apoptosis. Int J Biochem Cell Biol (2009) 1.03
Dual actions involved in arsenite-induced oxidative DNA damage. Chem Res Toxicol (2008) 1.02
Insights into the carcinogenic mode of action of arsenic. Toxicol Appl Pharmacol (2006) 1.01
As(III) inhibits ultraviolet radiation-induced cyclobutane pyrimidine dimer repair via generation of nitric oxide in human keratinocytes. Free Radic Biol Med (2008) 0.99
Ultraviolet radiation and cutaneous carcinogenesis. Curr Probl Dermatol (2007) 0.99
The molecular "Jekyll and Hyde" duality of PARP1 in cell death and cell survival. Front Biosci (Landmark Ed) (2009) 0.99
NAD+ depletion or PAR polymer formation: which plays the role of executioner in ischaemic cell death? Acta Physiol (Oxf) (2011) 0.94
Arsenite-induced alterations of DNA photodamage repair and apoptosis after solar-simulation UVR in mouse keratinocytes in vitro. Environ Health Perspect (2005) 0.84
Metal ions and carcinogenesis. EXS (2006) 0.84
Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J Cereb Blood Flow Metab (2006) 4.19
Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes. J Cell Physiol (2005) 2.91
Oxidative mechanism of arsenic toxicity and carcinogenesis. Mol Cell Biochem (2004) 2.07
Normobaric hyperoxia reduces the neurovascular complications associated with delayed tissue plasminogen activator treatment in a rat model of focal cerebral ischemia. Stroke (2009) 1.90
Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells. Cancer Res (2007) 1.90
Side population cells and Bcrp1 expression in lung. Am J Physiol Lung Cell Mol Physiol (2003) 1.90
Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage. J Neurosci (2012) 1.89
G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells. Am J Physiol Cell Physiol (2004) 1.85
Translational physiology: origin and phenotype of lung side population cells. Am J Physiol Lung Cell Mol Physiol (2004) 1.64
Interstitial pO2 in ischemic penumbra and core are differentially affected following transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab (2004) 1.60
Enhanced radical scavenging activity by antioxidant-functionalized gold nanoparticles: a novel inspiration for development of new artificial antioxidants. Free Radic Biol Med (2007) 1.59
Electron paramagnetic resonance-guided normobaric hyperoxia treatment protects the brain by maintaining penumbral oxygenation in a rat model of transient focal cerebral ischemia. J Cereb Blood Flow Metab (2006) 1.54
Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia. J Neurochem (2009) 1.53
Matrix metalloproteinase 9 is a mediator of epidermal growth factor-dependent e-cadherin loss in ovarian carcinoma cells. Cancer Res (2008) 1.51
Evidence that bone marrow cells do not contribute to the alveolar epithelium. Am J Respir Cell Mol Biol (2005) 1.47
Arsenite interacts selectively with zinc finger proteins containing C3H1 or C4 motifs. J Biol Chem (2011) 1.45
Inhibition of poly(ADP-ribose) polymerase-1 by arsenite interferes with repair of oxidative DNA damage. J Biol Chem (2008) 1.44
Vanadate-induced expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species. J Biol Chem (2002) 1.41
Cyclooxygenase-2 functions as a downstream mediator of lysophosphatidic acid to promote aggressive behavior in ovarian carcinoma cells. Cancer Res (2005) 1.39
Benzo(a)pyrene quinones increase cell proliferation, generate reactive oxygen species, and transactivate the epidermal growth factor receptor in breast epithelial cells. Cancer Res (2003) 1.39
Arsenite causes DNA damage in keratinocytes via generation of hydroxyl radicals. Chem Res Toxicol (2004) 1.37
Oxidative stress and apoptosis in metal ion-induced carcinogenesis. Free Radic Biol Med (2004) 1.25
Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke. J Neurochem (2008) 1.24
Characterization of a Cdc42 protein inhibitor and its use as a molecular probe. J Biol Chem (2013) 1.24
PUMA overexpression induces reactive oxygen species generation and proteasome-mediated stathmin degradation in colorectal cancer cells. Cancer Res (2005) 1.23
The epidermal growth factor receptor responsive miR-125a represses mesenchymal morphology in ovarian cancer cells. Neoplasia (2009) 1.20
Inorganic arsenic compounds cause oxidative damage to DNA and protein by inducing ROS and RNS generation in human keratinocytes. Mol Cell Biochem (2005) 1.19
Use of 3-acetoxymethoxycarbonyl-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl as an EPR oximetry probe: potential for in vivo measurement of tissue oxygenation in mouse brain. Magn Reson Med (2006) 1.18
Cdc42 regulates arsenic-induced NADPH oxidase activation and cell migration through actin filament reorganization. J Biol Chem (2004) 1.15
Generation of hydrogen peroxide during brief oxygen-glucose deprivation induces preconditioning neuronal protection in primary cultured neurons. J Neurosci Res (2005) 1.14
PEA3 is necessary for optimal epidermal growth factor receptor-stimulated matrix metalloproteinase expression and invasion of ovarian tumor cells. Mol Cancer Res (2007) 1.13
Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair. J Biol Chem (2012) 1.13
Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity. Toxicol Appl Pharmacol (2008) 1.11
Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury. J Neurochem (2011) 1.10
Specific inhibition of hypoxia inducible factor 1 exaggerates cell injury induced by in vitro ischemia through deteriorating cellular redox environment. J Neurochem (2009) 1.10
Antioxidant activities of oleanolic acid in vitro: possible role of Nrf2 and MAP kinases. Chem Biol Interact (2010) 1.09
Down-regulation of integrin alpha2 surface expression by mutant epidermal growth factor receptor (EGFRvIII) induces aberrant cell spreading and focal adhesion formation. Cancer Res (2005) 1.09
Direct visualization of mouse brain oxygen distribution by electron paramagnetic resonance imaging: application to focal cerebral ischemia. J Cereb Blood Flow Metab (2009) 1.08
Glucose up-regulates HIF-1 alpha expression in primary cortical neurons in response to hypoxia through maintaining cellular redox status. J Neurochem (2008) 1.08
The skinny on Slug. Mol Carcinog (2010) 1.06
Integrin regulation of beta-catenin signaling in ovarian carcinoma. J Biol Chem (2011) 1.06
Enhanced ROS production and redox signaling with combined arsenite and UVA exposure: contribution of NADPH oxidase. Free Radic Biol Med (2009) 1.05
Application of in vivo EPR in brain research: monitoring tissue oxygenation, blood flow, and oxidative stress. NMR Biomed (2004) 1.05
Low-dose synergistic immunosuppression of T-dependent antibody responses by polycyclic aromatic hydrocarbons and arsenic in C57BL/6J murine spleen cells. Toxicol Appl Pharmacol (2010) 1.02
Dual actions involved in arsenite-induced oxidative DNA damage. Chem Res Toxicol (2008) 1.02
Slug/Snai2 is a downstream mediator of epidermal growth factor receptor-stimulated reepithelialization. J Invest Dermatol (2008) 1.02
Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species. Arch Biochem Biophys (2005) 1.01
Activated epidermal growth factor receptor induces integrin alpha2 internalization via caveolae/raft-dependent endocytic pathway. J Biol Chem (2006) 1.00
Stem cell antigen-1 expression in the pulmonary vascular endothelium. Am J Physiol Lung Cell Mol Physiol (2003) 1.00
Cerebral tissue oxygenation and oxidative brain injury during ischemia and reperfusion. Front Biosci (2007) 1.00
As(III) inhibits ultraviolet radiation-induced cyclobutane pyrimidine dimer repair via generation of nitric oxide in human keratinocytes. Free Radic Biol Med (2008) 0.99
Microenvironmental regulation of ovarian cancer metastasis. Cancer Treat Res (2009) 0.99
Hydroxyl radical formation is greater in striatal core than in penumbra in a rat model of ischemic stroke. J Neurosci Res (2003) 0.99
Contributions of reactive oxygen species and mitogen-activated protein kinase signaling in arsenite-stimulated hemeoxygenase-1 production. Toxicol Appl Pharmacol (2006) 0.99
Normobaric hyperoxia protects the blood brain barrier through inhibiting Nox2 containing NADPH oxidase in ischemic stroke. Med Gas Res (2011) 0.98
Mesenchymal transformation in epithelial ovarian tumor cells expressing epidermal growth factor receptor variant III. Mol Carcinog (2006) 0.98
Reduction of arsenite-enhanced ultraviolet radiation-induced DNA damage by supplemental zinc. Toxicol Appl Pharmacol (2013) 0.97
Acetoxymethoxycarbonyl nitroxides as electron paramagnetic resonance proimaging agents to measure O2 levels in mouse brain: a pharmacokinetic and pharmacodynamic study. J Pharmacol Exp Ther (2006) 0.97
Differential binding of monomethylarsonous acid compared to arsenite and arsenic trioxide with zinc finger peptides and proteins. Chem Res Toxicol (2014) 0.96
Targeting the EGF receptor for ovarian cancer therapy. J Oncol (2009) 0.96
AUF-1 mediates inhibition by nitric oxide of lipopolysaccharide-induced matrix metalloproteinase-9 expression in cultured astrocytes. J Neurosci Res (2006) 0.96
Role of polyethylene glycol integrity in specific receptor targeting of carbon nanotubes to cancer cells. Nano Lett (2009) 0.96
Roles of mitogen activated protein kinases and EGF receptor in arsenite-stimulated matrix metalloproteinase-9 production. Toxicol Appl Pharmacol (2004) 0.95
Ultrasensitive detection of protein using an aptamer-based exonuclease protection assay. Anal Chem (2004) 0.95
Immunotoxicity and biodistribution analysis of arsenic trioxide in C57Bl/6 mice following a 2-week inhalation exposure. Toxicol Appl Pharmacol (2009) 0.94
Microarray analysis demonstrates a role for Slug in epidermal homeostasis. J Invest Dermatol (2007) 0.93
Spatiotemporal evolution of blood brain barrier damage and tissue infarction within the first 3h after ischemia onset. Neurobiol Dis (2012) 0.92
Embryonic lung side population cells are hematopoietic and vascular precursors. Am J Respir Cell Mol Biol (2005) 0.91
Nitric oxide down-regulates caveolin-1 expression in rat brains during focal cerebral ischemia and reperfusion injury. J Neurochem (2006) 0.91
Effects of glucose concentration on redox status in rat primary cortical neurons under hypoxia. Neurosci Lett (2006) 0.91
Development and psychometric evaluation of the Dialysis patient-perceived Exercise Benefits and Barriers Scale. Int J Nurs Stud (2009) 0.91
Polymorphisms in the DNA repair gene XPD and susceptibility to esophageal squamous cell carcinoma. Cancer Genet Cytogenet (2004) 0.90