Molecular mechanisms of arsenic carcinogenesis.

Arsenic exposure and toxicology: a historical perspective. Toxicol Sci (2011) 2.63

Environmental chemical exposures and human epigenetics. Int J Epidemiol (2011) 1.97

Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium. Metallomics (2009) 1.96

Lung cancer in a U.S. population with low to moderate arsenic exposure. Environ Health Perspect (2009) 1.77

Long term low-dose arsenic exposure induces loss of DNA methylation. Biochem Biophys Res Commun (2006) 1.59

Effects of arsenic exposure on DNA methylation and epigenetic gene regulation. Epigenomics (2010) 1.56

Arsenite alters global histone H3 methylation. Carcinogenesis (2008) 1.53

Trace elements in hemodialysis patients: a systematic review and meta-analysis. BMC Med (2009) 1.21

Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity. Toxicol Appl Pharmacol (2008) 1.11

PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation. Environ Health Perspect (2008) 1.06

Environmental chemicals and microRNAs. Mutat Res (2011) 1.05

Enhanced ROS production and redox signaling with combined arsenite and UVA exposure: contribution of NADPH oxidase. Free Radic Biol Med (2009) 1.05

Cyclooxygenase-2 induction by arsenite through the IKKbeta/NFkappaB pathway exerts an antiapoptotic effect in mouse epidermal Cl41 cells. Environ Health Perspect (2006) 1.04

Low levels of arsenite activates nuclear factor-kappaB and activator protein-1 in immortalized mesencephalic cells. J Biochem Mol Toxicol (2005) 1.03

Dual actions involved in arsenite-induced oxidative DNA damage. Chem Res Toxicol (2008) 1.02

As(III) inhibits ultraviolet radiation-induced cyclobutane pyrimidine dimer repair via generation of nitric oxide in human keratinocytes. Free Radic Biol Med (2008) 0.99

Poly(ADP-ribose) polymerase-1 inhibition by arsenite promotes the survival of cells with unrepaired DNA lesions induced by UV exposure. Toxicol Sci (2012) 0.97

Neoplastic transformation of human small airway epithelial cells induced by arsenic. Mol Med (2008) 0.95

Phosphorylation of the eukaryotic translation initiation factor 4E-transporter (4E-T) by c-Jun N-terminal kinase promotes stress-dependent P-body assembly. Mol Cell Biol (2012) 0.94

Role and mechanism of arsenic in regulating angiogenesis. PLoS One (2011) 0.94

The effects of arsenic trioxide on DNA synthesis and genotoxicity in human colon cancer cells. Int J Environ Res Public Health (2010) 0.93

A genome-wide screen in Saccharomyces cerevisiae reveals pathways affected by arsenic toxicity. Genomics (2009) 0.93

Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/β-catenin signaling pathway. Toxicol Appl Pharmacol (2012) 0.92

Quantitative Mass Spectrometry Reveals Changes in Histone H2B Variants as Cells Undergo Inorganic Arsenic-Mediated Cellular Transformation. Mol Cell Proteomics (2016) 0.92

Chronic arsenic exposure and angiogenesis in human bronchial epithelial cells via the ROS/miR-199a-5p/HIF-1α/COX-2 pathway. Environ Health Perspect (2014) 0.90

Effects of arsenic on zebrafish innate immune system. Mar Biotechnol (NY) (2005) 0.89

Arsenic levels in ground water and cancer incidence in Idaho: an ecologic study. Int Arch Occup Environ Health (2008) 0.89

The ETS family transcription factor ELK-1 regulates induction of the cell cycle-regulatory gene p21(Waf1/Cip1) and the BAX gene in sodium arsenite-exposed human keratinocyte HaCaT cells. J Biol Chem (2011) 0.87

Inhibition of transforming growth factor beta/SMAD signal by MiR-155 is involved in arsenic trioxide-induced anti-angiogenesis in prostate cancer. Cancer Sci (2014) 0.85

GSTM1 and APE1 genotypes affect arsenic-induced oxidative stress: a repeated measures study. Environ Health (2007) 0.85

Interleukin-8 (IL-8) over-production and autocrine cell activation are key factors in monomethylarsonous acid [MMA(III)]-induced malignant transformation of urothelial cells. Toxicol Appl Pharmacol (2011) 0.85

The role of reactive oxygen species in arsenite and monomethylarsonous acid-induced signal transduction in human bladder cells: acute studies. Toxicology (2008) 0.84

Reactive oxygen species regulate properties of transformation in UROtsa cells exposed to monomethylarsonous acid by modulating MAPK signaling. Toxicology (2008) 0.83

Arsenic-induced changes in the gene expression of lung epithelial L2 cells: implications in carcinogenesis. BMC Genomics (2008) 0.83

Role of reactive oxygen species in arsenic-induced transformation of human lung bronchial epithelial (BEAS-2B) cells. Biochem Biophys Res Commun (2014) 0.83

Comparative genomic analyses identify common molecular pathways modulated upon exposure to low doses of arsenic and cadmium. BMC Genomics (2011) 0.82

Melanocytes and keratinocytes have distinct and shared responses to ultraviolet radiation and arsenic. Toxicol Lett (2013) 0.81

Inhibition by methylated organo-arsenicals of the respiratory 2-oxo-acid dehydrogenases. J Organomet Chem (2009) 0.81

Filamin A phosphorylation by Akt promotes cell migration in response to arsenic. Oncotarget (2015) 0.81

Feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1 are involved in arsenite-induced cell malignant transformation. PLoS One (2013) 0.81

p27 suppresses cyclooxygenase-2 expression by inhibiting p38β and p38δ-mediated CREB phosphorylation upon arsenite exposure. Biochim Biophys Acta (2013) 0.81

Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene. Biochim Biophys Acta (2015) 0.80

Arsenic transformation predisposes human skin keratinocytes to UV-induced DNA damage yet enhances their survival apparently by diminishing oxidant response. Toxicol Appl Pharmacol (2011) 0.80

CD44v6 expression in human skin keratinocytes as a possible mechanism for carcinogenesis associated with chronic arsenic exposure. Eur J Histochem (2013) 0.80

Plant extracts of the family Lauraceae: a potential resource for chemopreventive agents that activate the nuclear factor-erythroid 2-related factor 2/antioxidant response element pathway. Planta Med (2014) 0.78

mot-2-Mediated cross talk between nuclear factor-B and p53 is involved in arsenite-induced tumorigenesis of human embryo lung fibroblast cells. Environ Health Perspect (2010) 0.78

Human AP endonuclease 1: a potential marker for the prediction of environmental carcinogenesis risk. Oxid Med Cell Longev (2014) 0.78

Global analysis of posttranscriptional gene expression in response to sodium arsenite. Environ Health Perspect (2014) 0.76

Oxidative stress, epigenetics, and cancer stem cells in arsenic carcinogenesis and prevention. Curr Pharmacol Rep (2016) 0.75

Impairment of antioxidant defenses as a contributor to arsenite-induced cell transformation. Biometals (2012) 0.75

Genome-wide DNA methylation reprogramming in response to inorganic arsenic links inhibition of CTCF binding, DNMT expression and cellular transformation. Sci Rep (2017) 0.75

Metabolism, toxicity and anticancer activities of arsenic compounds. Oncotarget (2017) 0.75

Correlation between heavy metal exposure and GSTM1 polymorphism in Iranian multiple sclerosis patients. Neurol Sci (2017) 0.75

Uptake of arsenic by alkaline soils near alkaline coal fly ash disposal facilities. Environ Monit Assess (2013) 0.75

SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab (2007) 4.75

Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol (2006) 4.71

Oxidative mechanism of arsenic toxicity and carcinogenesis. Mol Cell Biochem (2004) 2.07

Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium. Metallomics (2009) 1.96

Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses. Biochem Biophys Res Commun (2003) 1.91

AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway. Cancer Res (2007) 1.85

G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells. Am J Physiol Cell Physiol (2004) 1.85

Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer. Biochem Biophys Res Commun (2003) 1.82

Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res (2006) 1.78

Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity. J Biol Chem (2006) 1.78

Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Mol Cell Biol (2006) 1.77

Metal-induced oxidative stress and signal transduction. Free Radic Biol Med (2004) 1.59

Constructing molecular classifiers for the accurate prognosis of lung adenocarcinoma. Clin Cancer Res (2006) 1.55

Arsenite alters global histone H3 methylation. Carcinogenesis (2008) 1.53

Cytoplasm-localized SIRT1 enhances apoptosis. J Cell Physiol (2007) 1.52

Confirmation of gene expression-based prediction of survival in non-small cell lung cancer. Clin Cancer Res (2008) 1.49

PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration. Am J Physiol Cell Physiol (2003) 1.49

The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia. Mol Cell Biol (2002) 1.48

Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer. Mol Pharmacol (2005) 1.47

Epigenetics and the environment. Ann N Y Acad Sci (2003) 1.47

NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states. Carcinogenesis (2007) 1.47

ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling. Oncogene (2005) 1.46

A Shope Fibroma virus PYRIN-only protein modulates the host immune response. Virus Genes (2007) 1.41

Vanadate-induced expression of hypoxia-inducible factor 1 alpha and vascular endothelial growth factor through phosphatidylinositol 3-kinase/Akt pathway and reactive oxygen species. J Biol Chem (2002) 1.41

Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling. Part Fibre Toxicol (2009) 1.41

Predicting cancer drug response by proteomic profiling. Clin Cancer Res (2006) 1.39

Arsenite causes DNA damage in keratinocytes via generation of hydroxyl radicals. Chem Res Toxicol (2004) 1.37

Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1alpha expression through activation of AKT and P70S6K1 in human ovarian cancer cells. Free Radic Biol Med (2006) 1.32

Alterations of histone modifications and transgene silencing by nickel chloride. Carcinogenesis (2006) 1.32

Phosphorylation of H3S10 blocks the access of H3K9 by specific antibodies and histone methyltransferase. Implication in regulating chromatin dynamics and epigenetic inheritance during mitosis. J Biol Chem (2008) 1.27

Occupational toxicology of nickel and nickel compounds. J Environ Pathol Toxicol Oncol (2009) 1.27

The potential protective effects of taurine on coronary heart disease. Atherosclerosis (2009) 1.27

Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (2002) 1.26

Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions. Cancer Res (2008) 1.26

Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression. Carcinogenesis (2006) 1.25

Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer. J Hepatol (2008) 1.25

Nucleolin links to arsenic-induced stabilization of GADD45alpha mRNA. Nucleic Acids Res (2006) 1.23

Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation. Infect Immun (2006) 1.23

Effects of nickel, chromate, and arsenite on histone 3 lysine methylation. Toxicol Appl Pharmacol (2009) 1.23

Antioxidant properties of fruit and vegetable juices: more to the story than ascorbic acid. Ann Clin Lab Sci (2002) 1.22

Ethanol promotes mammary tumor growth and angiogenesis: the involvement of chemoattractant factor MCP-1. Breast Cancer Res Treat (2011) 1.21

Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells. Carcinogenesis (2004) 1.21

Diseases caused by silica: mechanisms of injury and disease development. Int Immunopharmacol (2002) 1.20

Global levels of histone modifications in peripheral blood mononuclear cells of subjects with exposure to nickel. Environ Health Perspect (2011) 1.20

Nickel carcinogenesis: epigenetics and hypoxia signaling. Mutat Res (2005) 1.19

Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis. J Biol Chem (2003) 1.19

Reactive oxygen species-activated Akt/ASK1/p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cells. Chem Res Toxicol (2010) 1.19

DMT1: which metals does it transport? Biol Res (2006) 1.19

trans-3,4,5'-Trihydroxystibene inhibits hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in human ovarian cancer cells. Clin Cancer Res (2004) 1.18

Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase. Cancer Res (2010) 1.18

JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70. Cancer Res (2010) 1.18

Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers. J Biol Chem (2009) 1.17

Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells. Mol Carcinog (2006) 1.17

miR-190-mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesis. Toxicol Sci (2011) 1.16

Alcohol-induced oxidative stress and cell responses. J Gastroenterol Hepatol (2006) 1.16

Covalent modifications of histones during mitosis and meiosis. Cell Cycle (2009) 1.16

Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3. Cell Cycle (2009) 1.16

The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer. Oncogene (2005) 1.16

Histone modifications and cancer: biomarkers of prognosis? Am J Cancer Res (2012) 1.15

Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells. Mol Cell Biochem (2004) 1.15

Autophagy is a protective response to ethanol neurotoxicity. Autophagy (2012) 1.15

Cdc42 regulates arsenic-induced NADPH oxidase activation and cell migration through actin filament reorganization. J Biol Chem (2004) 1.15

Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells. J Immunol (2006) 1.15

Reduced reactive oxygen species-generating capacity contributes to the enhanced cell growth of arsenic-transformed epithelial cells. Cancer Res (2010) 1.14

Nickel compounds induce phosphorylation of histone H3 at serine 10 by activating JNK-MAPK pathway. Carcinogenesis (2008) 1.14

Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells. Carcinogenesis (2010) 1.14

Reactive oxygen species regulate insulin-induced VEGF and HIF-1alpha expression through the activation of p70S6K1 in human prostate cancer cells. Carcinogenesis (2006) 1.14

Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Cancer Res (2004) 1.13

Arsenic promotes angiogenesis in vitro via a heme oxygenase-1-dependent mechanism. Toxicol Appl Pharmacol (2010) 1.12

Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium. Metallomics (2012) 1.12

Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic. Cancer Res (2003) 1.12

Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium. Toxicol Appl Pharmacol (2009) 1.12

New perspectives in arsenic-induced cell signal transduction. J Inorg Biochem (2003) 1.12

Cadmium induces carcinogenesis in BEAS-2B cells through ROS-dependent activation of PI3K/AKT/GSK-3β/β-catenin signaling. Toxicol Appl Pharmacol (2012) 1.11

Soluble nickel interferes with cellular iron homeostasis. Mol Cell Biochem (2005) 1.11

Regulation of angiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression. J Cell Physiol (2006) 1.10

Oxidative stress and metal carcinogenesis. Free Radic Biol Med (2012) 1.09

MMP-2 mediates ethanol-induced invasion of mammary epithelial cells over-expressing ErbB2. Int J Cancer (2006) 1.09

Molecular mechanisms of Cr(VI)-induced carcinogenesis. Mol Cell Biochem (2002) 1.09

Ultraviolet-induced phosphorylation of p70(S6K) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C. Cancer Res (2002) 1.09

Role of reactive oxygen species and MAPKs in vanadate-induced G(2)/M phase arrest. Free Radic Biol Med (2003) 1.08

Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure. Toxicol Appl Pharmacol (2003) 1.08

Identification of a critical site in Wld(s): essential for Nmnat enzyme activity and axon-protective function. Neurosci Lett (2006) 1.08

Metal-induced toxicity, carcinogenesis, mechanisms and cellular responses. Mol Cell Biochem (2004) 1.08

The control of histone methylation and gene expression by oxidative stress, hypoxia, and metals. Free Radic Biol Med (2012) 1.08

Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells. Toxicol Appl Pharmacol (2004) 1.07

Carcinogenic effect of nickel compounds. Mol Cell Biochem (2005) 1.07

JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma. Mol Cancer (2009) 1.07

Egr-1 mediates hypoxia-inducible transcription of the NDRG1 gene through an overlapping Egr-1/Sp1 binding site in the promoter. Cancer Res (2007) 1.07

Ethanol promotes endoplasmic reticulum stress-induced neuronal death: involvement of oxidative stress. J Neurosci Res (2008) 1.06

PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation. Environ Health Perspect (2008) 1.06

Arsenite induces a cell stress-response gene, RTP801, through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer-binding protein. Biochem J (2005) 1.06

Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS One (2012) 1.05

Insulin-like growth factor-I (IGF-I) induces epidermal growth factor receptor transactivation and cell proliferation through reactive oxygen species. Free Radic Biol Med (2007) 1.05