Selection pressure on HIV-1 envelope by broadly neutralizing antibodies to the conserved CD4-binding site.

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Published in J Virol on March 14, 2012

Authors

Xueling Wu1, Charlene Wang, Sijy O'Dell, Yuxing Li, Brandon F Keele, Zhongjia Yang, Hiromi Imamichi, Nicole Doria-Rose, James A Hoxie, Mark Connors, George M Shaw, Richard T Wyatt, John R Mascola

Author Affiliations

1: Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, USA.

Associated clinical trials:

Study of the Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRC-HIVMAB060-00-AB (VRC01), Administered Intravenously or Subcutaneously to Healthy Adults | NCT01993706

VRC 601: A Phase I, Open-Label, Dose-Escalation Study of the Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRC HIVMAB060-00-AB (VRC01), With Broad HIV-1 Neutralizing Activity, Administered Intravenously or Subcutaneously to HIV-Infected... | NCT01950325

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