Published in Cell on November 28, 2008
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol (2011) 4.63
Tumors as organs: complex tissues that interface with the entire organism. Dev Cell (2010) 3.98
Epithelial cell polarity, stem cells and cancer. Nat Rev Cancer (2011) 3.06
Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion. Nature (2010) 2.79
SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. J Clin Invest (2011) 2.60
Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter. Dev Cell (2010) 2.46
MYC regulation of a "poor-prognosis" metastatic cancer cell state. Proc Natl Acad Sci U S A (2010) 2.21
Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity. Cold Spring Harb Perspect Biol (2009) 2.01
The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nat Struct Mol Biol (2012) 1.88
The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis. Genes Dev (2009) 1.82
Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis. Cancer Cell (2012) 1.65
Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis. J Cell Sci (2013) 1.63
Multiscale modeling of form and function. Science (2009) 1.60
Bioelectric mechanisms in regeneration: Unique aspects and future perspectives. Semin Cell Dev Biol (2009) 1.56
Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Nat Cell Biol (2012) 1.53
Epithelial cell polarity: a major gatekeeper against cancer? Cell Death Differ (2011) 1.51
Epithelial cell organization suppresses Myc function by attenuating Myc expression. Cancer Res (2011) 1.44
Three-dimensional organotypic culture: experimental models of mammalian biology and disease. Nat Rev Mol Cell Biol (2014) 1.43
MYC is a metastasis gene for non-small-cell lung cancer. PLoS One (2009) 1.41
Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators. Curr Opin Genet Dev (2010) 1.40
Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development. Breast Cancer Res (2009) 1.40
dMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cells. PLoS Genet (2010) 1.38
Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex. Cell Death Differ (2009) 1.35
Cell-matrix interactions in mammary gland development and breast cancer. Cold Spring Harb Perspect Biol (2010) 1.30
A role for the TGFbeta-Par6 polarity pathway in breast cancer progression. Proc Natl Acad Sci U S A (2009) 1.29
Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. Curr Opin Cell Biol (2009) 1.28
Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss. Genes Dev (2015) 1.27
Tumor suppression by cell competition through regulation of the Hippo pathway. Proc Natl Acad Sci U S A (2011) 1.26
Three-dimensional culture of human breast epithelial cells: the how and the why. Methods Mol Biol (2013) 1.26
A pathway for the control of anoikis sensitivity by E-cadherin and epithelial-to-mesenchymal transition. Mol Cell Biol (2011) 1.23
Mechanisms and mechanics of cell competition in epithelia. Nat Rev Mol Cell Biol (2013) 1.22
A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression. Oncogene (2011) 1.20
Loss of Scribble causes cell competition in mammalian cells. J Cell Sci (2012) 1.19
The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy. BMC Biol (2010) 1.17
Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase. Breast Cancer Res (2011) 1.15
Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling. BMC Dev Biol (2011) 1.15
Role of JNK in mammary gland development and breast cancer. Cancer Res (2011) 1.14
The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble. J Virol (2010) 1.13
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res (2010) 1.13
Tissue polarity-dependent control of mammary epithelial homeostasis and cancer development: an epigenetic perspective. J Mammary Gland Biol Neoplasia (2010) 1.11
Asymmetric cell division of stem and progenitor cells during homeostasis and cancer. Cell Mol Life Sci (2013) 1.11
Drosophila cancer models. Dev Dyn (2011) 1.10
Normal morphogenesis of epithelial tissues and progression of epithelial tumors. Wiley Interdiscip Rev Syst Biol Med (2011) 1.10
Scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs. BMC Biol (2009) 1.09
The Cdc42/Par6/aPKC polarity complex regulates apoptosis-induced compensatory proliferation in epithelia. Curr Biol (2010) 1.08
Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium. Am J Pathol (2009) 1.07
Cell Adhesion and Transcriptional Activity - Defining the Role of the Novel Protooncogene LPP. Transl Oncol (2009) 1.05
The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis. Oncogene (2010) 1.04
Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer. Cancer Res (2014) 1.02
Mechanical cell competition kills cells via induction of lethal p53 levels. Nat Commun (2016) 1.02
Tight junctions: a barrier to the initiation and progression of breast cancer? J Biomed Biotechnol (2009) 1.01
Zebrafish neural tube morphogenesis requires Scribble-dependent oriented cell divisions. Curr Biol (2010) 1.01
Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity. Cancer Res (2009) 1.01
Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung. Dev Biol (2012) 1.01
K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc. J Cell Biol (2012) 1.00
A novel role for 14-3-3sigma in regulating epithelial cell polarity. Genes Dev (2010) 1.00
p120-catenin is essential for terminal end bud function and mammary morphogenesis. Development (2012) 0.99
DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancer. PLoS Med (2009) 0.99
CD74-dependent deregulation of the tumor suppressor scribble in human epithelial and breast cancer cells. Neoplasia (2013) 0.97
NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo. EMBO J (2010) 0.96
miR-296 regulation of a cell polarity-cell plasticity module controls tumor progression. Oncogene (2011) 0.96
Transcriptome dynamics in the asexual cycle of the chordate Botryllus schlosseri. BMC Genomics (2016) 0.96
Emerging role for drug transporters at the blood-testis barrier. Trends Pharmacol Sci (2010) 0.95
The human PDZome: a gateway to PSD95-Disc large-zonula occludens (PDZ)-mediated functions. Mol Cell Proteomics (2013) 0.94
Maximum entropy reconstructions of dynamic signaling networks from quantitative proteomics data. PLoS One (2009) 0.93
WIF1 is a frequent target for epigenetic silencing in squamous cell carcinoma of the cervix. Carcinogenesis (2011) 0.93
S6K1 alternative splicing modulates its oncogenic activity and regulates mTORC1. Cell Rep (2012) 0.93
Putting into practice domain-linear motif interaction predictions for exploration of protein networks. PLoS One (2011) 0.92
The interdependence of the Rho GTPases and apicobasal cell polarity. Small GTPases (2014) 0.91
Aberrant overexpression of the cell polarity module scribble in human cancer. Am J Pathol (2011) 0.91
NOS1AP associates with Scribble and regulates dendritic spine development. J Neurosci (2010) 0.91
The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling. Nat Cell Biol (2014) 0.90
Human tumour viruses and the deregulation of cell polarity in cancer. Nat Rev Cancer (2012) 0.90
Role of the polarity protein Scribble for podocyte differentiation and maintenance. PLoS One (2012) 0.90
Vangl1 and Vangl2: planar cell polarity components with a developing role in cancer. Endocr Relat Cancer (2014) 0.89
Profiling and inhibiting reversible palmitoylation. Curr Opin Chem Biol (2013) 0.89
Label-free analysis of breast tissue polarity by Raman imaging of lipid phase. Biophys J (2012) 0.88
The Mammalian Blood-Testis Barrier: Its Biology and Regulation. Endocr Rev (2015) 0.88
Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells. EMBO J (2015) 0.87
Emerging role for epithelial polarity proteins of the Crumbs family as potential tumor suppressors. J Biomed Biotechnol (2011) 0.87
A new platinum(II) compound anticancer drug candidate with selective cytotoxicity for breast cancer cells. Cell Death Dis (2013) 0.87
The influenza A virus protein NS1 displays structural polymorphism. J Virol (2014) 0.86
Regulation of actin dynamics and protein trafficking during spermatogenesis--insights into a complex process. Crit Rev Biochem Mol Biol (2013) 0.86
Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland. PLoS Genet (2014) 0.86
PDZ domains and viral infection: versatile potentials of HPV-PDZ interactions in relation to malignancy. Biomed Res Int (2013) 0.86
Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse. Dev Biol (2013) 0.86
Developmental stratification of the mammary epithelium occurs through symmetry-breaking vertical divisions of apically positioned luminal cells. Development (2014) 0.86
Cell polarity in morphogenesis and metastasis. Philos Trans R Soc Lond B Biol Sci (2013) 0.86
The predominant WT1 isoform (+KTS) encodes a DNA-binding protein targeting the planar cell polarity gene Scribble in renal podocytes. Mol Cancer Res (2010) 0.86
Paradigms lost-an emerging role for over-expression of tight junction adhesion proteins in cancer pathogenesis. Ann Transl Med (2015) 0.86
G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion. Proc Natl Acad Sci U S A (2014) 0.85
Differential regulation of cell-cell contact, invasion and anoikis by hScrib and hDlg in keratinocytes. PLoS One (2012) 0.85
Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4. Philos Trans R Soc Lond B Biol Sci (2013) 0.85
The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy. Viruses (2015) 0.84
Polarity proteins as regulators of cell junction complexes: implications for breast cancer. Pharmacol Ther (2013) 0.84
The dark side of fly TNF: an ancient developmental proof reading mechanism turned into tumor promoter. Cell Cycle (2010) 0.84
The breast cancer susceptibility gene product fibroblast growth factor receptor 2 serves as a scaffold for regulation of NF-κB signaling. Mol Cell Biol (2012) 0.84
CPEB1 promotes differentiation and suppresses EMT in mammary epithelial cells. J Cell Sci (2014) 0.83
Cyclic AMP regulates formation of mammary epithelial acini in vitro. Mol Biol Cell (2012) 0.83
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods (2003) 18.51
Induction of apoptosis in fibroblasts by c-myc protein. Cell (1992) 16.95
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A (2001) 11.06
Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci U S A (1992) 8.59
A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res (1995) 7.95
Sequence-specific DNA binding by the c-Myc protein. Science (1990) 7.75
Morphogenesis of the polarized epithelial cell phenotype. Science (1989) 7.54
The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell (2002) 7.35
A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. Proc Natl Acad Sci U S A (2003) 7.30
Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes. Cell (1984) 6.71
ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat Cell Biol (2001) 6.21
Adaptation of core mechanisms to generate cell polarity. Nature (2003) 5.64
Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature (1989) 4.65
The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation (2002) 4.64
Binding of myc proteins to canonical and noncanonical DNA sequences. Mol Cell Biol (1993) 4.08
Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev (2004) 3.86
c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations. Nat Med (2001) 3.51
Myc pathways provoking cell suicide and cancer. Oncogene (2003) 3.49
Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nat Cell Biol (2006) 3.42
Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion. Cell (1992) 3.37
Genetic variation in DLG5 is associated with inflammatory bowel disease. Nat Genet (2004) 3.19
Parsing the polarity code. Nat Rev Mol Cell Biol (2004) 3.07
Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. Mol Cell Biol (2000) 2.79
Histological and biological evolution of human premalignant breast disease. Endocr Relat Cancer (2001) 2.71
Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays (2003) 2.49
Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro. Proc Natl Acad Sci U S A (1984) 2.44
c-Myc in breast cancer. Endocr Relat Cancer (2000) 2.32
The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin. J Cell Biol (2005) 2.28
Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation. Oncogene (1999) 2.25
Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Mol Cell Biol (2005) 2.20
C-myc amplification in breast cancer: a meta-analysis of its occurrence and prognostic relevance. Br J Cancer (2000) 2.14
Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration. Curr Biol (2006) 2.03
Mammalian Scribble forms a tight complex with the betaPIX exchange factor. Curr Biol (2004) 1.89
The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge. Oncogene (2006) 1.88
Junctional recruitment of mammalian Scribble relies on E-cadherin engagement. Oncogene (2005) 1.73
Role of JNK in tumor development. Cell Cycle (2003) 1.71
A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development. PLoS Biol (2004) 1.64
Inhibition of mammary gland involution is associated with transforming growth factor alpha but not c-myc-induced tumorigenesis in transgenic mice. Cancer Res (1995) 1.60
Isolation of mouse mammary epithelial progenitor cells with basal characteristics from the Comma-Dbeta cell line. Dev Biol (2006) 1.59
Pro-apoptotic Bim induction in response to nerve growth factor deprivation requires simultaneous activation of three different death signaling pathways. J Biol Chem (2007) 1.51
Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression. Int J Cancer (2006) 1.50
Apicobasal polarity complexes. J Cell Sci (2005) 1.48
Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble. J Cell Biol (2004) 1.41
Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription. EMBO J (1988) 1.41
Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice. Oncogene (1997) 1.30
Using three-dimensional acinar structures for molecular and cell biological assays. Methods Enzymol (2006) 1.26
The PIX-GIT complex: a G protein signaling cassette in control of cell shape. Semin Cell Dev Biol (2008) 1.16
Synergistic interaction of transforming growth factor alpha and c-myc in mouse mammary and salivary gland tumorigenesis. Cell Growth Differ (1995) 1.10
Of mice and Myc: c-Myc and mammary tumorigenesis. J Mammary Gland Biol Neoplasia (2004) 1.07
Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells. Exp Cell Res (2003) 1.00
Defining a role for c-Myc in breast tumorigenesis. Breast Cancer Res Treat (1997) 0.97
Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling. J Cell Biol (2004) 0.92
Cooperation of TGF alpha and c-Myc in mouse mammary tumorigenesis: coordinated stimulation of growth and suppression of apoptosis. Oncogene (1996) 0.92
What is Drosophila telling us about cancer? Cancer Metastasis Rev (1999) 0.90
p53 mutations in COMMA-D cells. In Vitro Cell Dev Biol Anim (1994) 0.88
Regulation of Myc-dependent apoptosis by p53, c-Jun N-terminal kinases/stress-activated protein kinases, and Mdm-2. Cell Growth Differ (1997) 0.86
Spontaneous conversion to estrogen receptor expression by the human breast epithelial cell line, MCF-10A. Oncol Rep (1999) 0.86
Conditional mouse models demonstrate oncogene-dependent differences in tumor maintenance and recurrence. Breast Cancer Res (2003) 0.84
Cultured mouse mammary epithelial cells: normal phenotype after implantation. J Natl Cancer Inst (1987) 0.84
Junction genetics. Dev Genet (1997) 0.84
Viral Ha-ras mediated mammary tumor progression. Oncogene (1991) 0.83
Bax regulates c-Myc-induced mammary tumour apoptosis but not proliferation in MMTV-c-myc transgenic mice. Br J Cancer (2004) 0.83
Tissue reconstitution, or transgenic mammary gland, technique for modeling breast cancer development. Cancer Treat Res (1996) 0.82
Elevated expression of the myc gene in human benign and malignant breast lesions compared to normal tissue. Anticancer Res (1988) 0.80
Using quality scores and longer reads improves accuracy of Solexa read mapping. BMC Bioinformatics (2008) 39.08
Genome-wide in situ exon capture for selective resequencing. Nat Genet (2007) 19.97
A microRNA component of the p53 tumour suppressor network. Nature (2007) 19.25
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods (2003) 18.51
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc Natl Acad Sci U S A (2010) 7.77
The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev (2002) 7.61
Sensitive and accurate detection of copy number variants using read depth of coverage. Genome Res (2009) 7.42
The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell (2002) 7.35
Revision of the American Joint Committee on Cancer staging system for breast cancer. J Clin Oncol (2002) 6.51
Design of a genome-wide siRNA library using an artificial neural network. Nat Biotechnol (2005) 5.60
Regulating gene expression through RNA nuclear retention. Cell (2005) 5.58
A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci U S A (2007) 5.16
Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells. Sci Transl Med (2013) 4.74
Regulation of in situ to invasive breast carcinoma transition. Cancer Cell (2008) 4.46
Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing. Nat Protoc (2009) 4.45
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol (2003) 4.25
Critical roles for Dicer in the female germline. Genes Dev (2007) 4.23
Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer. Sci Transl Med (2010) 3.90
Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell (2006) 3.73
Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nat Cell Biol (2006) 3.42
YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nat Cell Biol (2009) 3.26
Relationship between quantitative estrogen and progesterone receptor expression and human epidermal growth factor receptor 2 (HER-2) status with recurrence in the Arimidex, Tamoxifen, Alone or in Combination trial. J Clin Oncol (2008) 3.23
Updates to the RMAP short-read mapping software. Bioinformatics (2009) 3.18
A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression. EMBO J (2010) 3.18
High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. Genome Res (2009) 3.08
Staging system for breast cancer: revisions for the 6th edition of the AJCC Cancer Staging Manual. Surg Clin North Am (2003) 2.82
Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells. Proc Natl Acad Sci U S A (2004) 2.81
TRED: a Transcriptional Regulatory Element Database and a platform for in silico gene regulation studies. Nucleic Acids Res (2005) 2.73
Pharmaceutical supply chain in China: current issues and implications for health system reform. Health Policy (2010) 2.63
A complete sequence of the T. tengcongensis genome. Genome Res (2002) 2.60
Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell (2009) 2.54
Targeted investigation of the Neandertal genome by array-based sequence capture. Science (2010) 2.49
A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells. Genes Dev (2007) 2.48
DNA motifs in human and mouse proximal promoters predict tissue-specific expression. Proc Natl Acad Sci U S A (2006) 2.38
Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Mol Cell Biol (2005) 2.20
TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers. Cell (2012) 2.08
High-resolution human core-promoter prediction with CoreBoost_HM. Genome Res (2008) 1.88
The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nat Struct Mol Biol (2012) 1.88
Computational prediction of methylation status in human genomic sequences. Proc Natl Acad Sci U S A (2006) 1.83
Breast cancer, version 3.2013: featured updates to the NCCN guidelines. J Natl Compr Canc Netw (2013) 1.79
Cyfip1 is a putative invasion suppressor in epithelial cancers. Cell (2009) 1.77
ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. Cell Stem Cell (2011) 1.75
Chaperonins facilitate KNOTTED1 cell-to-cell trafficking and stem cell function. Science (2011) 1.73
Molecular characterization of Brassica napus NAC domain transcriptional activators induced in response to biotic and abiotic stress. Plant Mol Biol (2003) 1.73
Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis. J Neuropathol Exp Neurol (2002) 1.70
The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer. Cancer Res (2008) 1.59
Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Nat Cell Biol (2012) 1.53
Associations of ACE gene insertion/deletion polymorphism, ACE activity, and ACE mRNA expression with hypertension in a Chinese population. PLoS One (2013) 1.52
Conservation of small RNA pathways in platypus. Genome Res (2008) 1.51
Aryl Hydrocarbon Receptor Activation Down-Regulates IL-7 and Reduces Inflammation in a Mouse Model of DSS-Induced Colitis. Dig Dis Sci (2015) 1.50
The survey of birth defects rate based on birth registration system. Chin Med J (Engl) (2015) 1.47
Mutations in TUBB8 and Human Oocyte Meiotic Arrest. N Engl J Med (2016) 1.46
Association of TLR4 gene non-missense single nucleotide polymorphisms with rheumatoid arthritis in Chinese Han population. Rheumatol Int (2012) 1.45
Epithelial cell organization suppresses Myc function by attenuating Myc expression. Cancer Res (2011) 1.44
Poly A- transcripts expressed in HeLa cells. PLoS One (2008) 1.42
Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells. Mol Cell Biol (2004) 1.40
Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators. Curr Opin Genet Dev (2010) 1.40
Epithelial-mesenchymal transition. Cancer Res (2008) 1.37
Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors. Cancer Res (2006) 1.37
Brk is coamplified with ErbB2 to promote proliferation in breast cancer. Proc Natl Acad Sci U S A (2008) 1.36
Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. Curr Opin Cell Biol (2009) 1.28
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis. J Cell Biol (2003) 1.28
NCCN task force report: positron emission tomography (PET)/computed tomography (CT) scanning in cancer. J Natl Compr Canc Netw (2007) 1.26
Noggin is required for normal lobe patterning and ductal budding in the mouse prostate. Dev Biol (2007) 1.26
Using three-dimensional acinar structures for molecular and cell biological assays. Methods Enzymol (2006) 1.26
Quantitative fitness analysis shows that NMD proteins and many other protein complexes suppress or enhance distinct telomere cap defects. PLoS Genet (2011) 1.26
A clustering property of highly-degenerate transcription factor binding sites in the mammalian genome. Nucleic Acids Res (2006) 1.21
A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration. Genes Dev (2010) 1.21
A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. Elife (2013) 1.20
Biopolymer system for cell recovery from microfluidic cell capture devices. Anal Chem (2012) 1.20
Alcohol consumption in 0.5 million people from 10 diverse regions of China: prevalence, patterns and socio-demographic and health-related correlates. Int J Epidemiol (2013) 1.20
ErbB receptors and cell polarity: new pathways and paradigms for understanding cell migration and invasion. Exp Cell Res (2008) 1.19
Rotational motion during three-dimensional morphogenesis of mammary epithelial acini relates to laminin matrix assembly. Proc Natl Acad Sci U S A (2012) 1.17
Expression of anthocyanins and proanthocyanidins after transformation of alfalfa with maize Lc. Plant Physiol (2003) 1.14
Scanning the human genome at kilobase resolution. Genome Res (2008) 1.13
Moving towards universal health insurance in China: performance, issues and lessons from Thailand. Soc Sci Med (2011) 1.12
Association between socioeconomic status and obesity in a Chinese adult population. BMC Public Health (2013) 1.10
Complete genome analysis of three Acinetobacter baumannii clinical isolates in China for insight into the diversification of drug resistance elements. PLoS One (2013) 1.10
An archived activation tagged population of Arabidopsis thaliana to facilitate forward genetics approaches. BMC Plant Biol (2009) 1.08
Boosting with stumps for predicting transcription start sites. Genome Biol (2007) 1.08
Quantification of human immunodeficiency virus type 1 proviral DNA by using TaqMan technology. J Clin Microbiol (2002) 1.08
X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy. J Biol Chem (2007) 1.07
Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Genes Dev (2011) 1.06
Prevalence of major chronic conditions among older Chinese adults: the Study on Global AGEing and adult health (SAGE) wave 1. PLoS One (2013) 1.05
p130Cas is an essential transducer element in ErbB2 transformation. FASEB J (2010) 1.05
[Epidemiological survey of mental illnesses in the people aged 15 and older in Zhejiang Province, China]. Zhonghua Yu Fang Yi Xue Za Zhi (2005) 1.04
Long non-coding RNAs and complex human diseases. Int J Mol Sci (2013) 1.03
Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis. J Mammary Gland Biol Neoplasia (2006) 1.03
A brake becomes an accelerator: PTP1B--a new therapeutic target for breast cancer. Cancer Cell (2007) 1.03
Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives. Bioorg Med Chem Lett (2005) 1.02
Pentoxifylline attenuates the development of hyperalgesia in a rat model of neuropathic pain. Neurosci Lett (2006) 1.00
Predictors and outcome of patients with acute respiratory distress syndrome caused by miliary tuberculosis: a retrospective study in Chongqing, China. BMC Infect Dis (2012) 1.00
Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity. J Biol Chem (2011) 0.99
Polypurine-repeat-containing RNAs: a novel class of long non-coding RNA in mammalian cells. J Cell Sci (2010) 0.99
Systematic review and meta-analysis of comparative studies reporting early outcomes after robot-assisted radical cystectomy versus open radical cystectomy. Cancer Treat Rev (2012) 0.98
The transcriptome of human CD34+ hematopoietic stem-progenitor cells. Proc Natl Acad Sci U S A (2009) 0.98