MicroRNAs, new effectors and regulators of NF-κB.

PubWeight™: 1.61‹?› | Rank: Top 4%

🔗 View Article (PMID 22435557)

Published in Immunol Rev on March 01, 2012

Authors

Mark P Boldin1, David Baltimore

Author Affiliations

1: Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA.

Articles citing this

A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics. Elife (2013) 1.63

Inflammation and colorectal cancer: colitis-associated neoplasia. Semin Immunopathol (2012) 1.61

Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes. Glia (2013) 1.37

MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice. Elife (2013) 1.36

Hypoxia: a master regulator of microRNA biogenesis and activity. Free Radic Biol Med (2013) 1.30

Celebrating 25 years of NF-κB research. Immunol Rev (2012) 1.19

Differential regulation of microRNA-146a and microRNA-146b-5p in human retinal pigment epithelial cells by interleukin-1β, tumor necrosis factor-α, and interferon-γ. Mol Vis (2013) 1.16

Obesity-associated oxidative stress: strategies finalized to improve redox state. Int J Mol Sci (2013) 1.15

Intermittent or sustained systemic inflammation and the preterm brain. Pediatr Res (2013) 1.08

Circulating inflamma-miRs in aging and age-related diseases. Front Genet (2013) 1.06

Regulation of nuclear factor-κB in autoimmunity. Trends Immunol (2013) 1.05

MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice. Gastroenterology (2015) 1.01

Regulation of miRNA biogenesis and turnover in the immune system. Immunol Rev (2013) 1.00

Short-term memory of danger signals and environmental stimuli in immune cells. Nat Immunol (2013) 0.99

Antagonism of NF-κB-up-regulated micro RNAs (miRNAs) in sporadic Alzheimer's disease (AD)-anti-NF-κB vs. anti-miRNA strategies. Front Genet (2013) 0.99

The Yin and Yang of microRNAs: leukemia and immunity. Immunol Rev (2013) 0.98

MiR-155 induction in microglial cells suppresses Japanese encephalitis virus replication and negatively modulates innate immune responses. J Neuroinflammation (2014) 0.97

Targeted regulation of PI3K/Akt/mTOR/NF-κB signaling by indole compounds and their derivatives: mechanistic details and biological implications for cancer therapy. Anticancer Agents Med Chem (2013) 0.96

NF-κB-mediated miR-124 suppresses metastasis of non-small-cell lung cancer by targeting MYO10. Oncotarget (2015) 0.96

Neuroprotection by astrocytes in brain ischemia: importance of microRNAs. Neurosci Lett (2013) 0.94

Interleukin-1β and tumor necrosis factor-α: reliable targets for protective therapies in Parkinson's Disease? Front Cell Neurosci (2013) 0.93

Functional significance of macrophage-derived exosomes in inflammation and pain. Pain (2014) 0.92

Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer. Oncogene (2015) 0.91

Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b in Alzheimer's disease (AD) and in primary human neuronal-glial (HNG) cells. Mol Neurobiol (2013) 0.91

Combination therapy with VELCADE and tissue plasminogen activator is neuroprotective in aged rats after stroke and targets microRNA-146a and the toll-like receptor signaling pathway. Arterioscler Thromb Vasc Biol (2012) 0.91

Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation. Front Genet (2014) 0.89

NF-κB-regulated, proinflammatory miRNAs in Alzheimer's disease. Alzheimers Res Ther (2012) 0.87

Unraveling regulatory programs for NF-kappaB, p53 and microRNAs in head and neck squamous cell carcinoma. PLoS One (2013) 0.86

Down-regulation of miR-301a suppresses pro-inflammatory cytokines in Toll-like receptor-triggered macrophages. Immunology (2013) 0.85

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. J Cereb Blood Flow Metab (2014) 0.85

MicroRNAs--mediators of myometrial contractility during pregnancy and labour. Nat Rev Endocrinol (2013) 0.84

Resolution of Inflammation: What Controls Its Onset? Front Immunol (2016) 0.84

MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer's Disease (AD)-Novel and Unique Pathological Features. Int J Mol Sci (2015) 0.83

Persistence of smoking-induced dysregulation of miRNA expression in the small airway epithelium despite smoking cessation. PLoS One (2015) 0.83

Anti-Inflammatory Role of MicroRNA-146a in the Pathogenesis of Diabetic Nephropathy. J Am Soc Nephrol (2015) 0.82

MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi. PLoS Pathog (2014) 0.82

The use of microRNAs to modulate redox and immune response to stroke. Antioxid Redox Signal (2015) 0.81

MiR-23b is a safeguard against autoimmunity. Nat Med (2012) 0.80

MicroRNA Regulation of Epithelial to Mesenchymal Transition. J Clin Med (2016) 0.80

The epigenetic dimension of Alzheimer's disease: causal, consequence, or curiosity? Dialogues Clin Neurosci (2014) 0.80

Overexpression of heat shock protein 72 attenuates NF-κB activation using a combination of regulatory mechanisms in microglia. PLoS Comput Biol (2014) 0.80

Switching off key signaling survival molecules to switch on the resolution of inflammation. Mediators Inflamm (2014) 0.80

Unique microRNA Expression in the Colonic Mucosa During Chronic HIV-1 Infection. AIDS (2017) 0.80

Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock. Inflamm Res (2014) 0.79

Signaling Networks of Activated Oncogenic and Altered Tumor Suppressor Genes in Head and Neck Cancer. J Carcinog Mutagen (2013) 0.78

miRNA-133 augments coelomocyte phagocytosis in bacteria-challenged Apostichopus japonicus via targeting the TLR component of IRAK-1 in vitro and in vivo. Sci Rep (2015) 0.78

Inflammatory cytokine-mediated evasion of virus-induced tumors from NK cell control. J Immunol (2013) 0.78

Cancer Cachexia and MicroRNAs. Mediators Inflamm (2015) 0.78

MicroRNA-381 Negatively Regulates TLR4 Signaling in A549 Cells in Response to LPS Stimulation. Biomed Res Int (2015) 0.78

MicroRNA expression shows inflammatory dysregulation and tumor-like proliferative responses in joints of patients with post-infectious Lyme arthritis. Arthritis Rheumatol (2017) 0.78

Molecular Background of miRNA Role in Asthma and COPD: An Updated Insight. Biomed Res Int (2016) 0.77

Transcriptional regulation of microRNA-100, -146a, and -150 genes by p53 and NFκB p65/RelA in mouse striatal STHdh(Q7)/ Hdh(Q7) cells and human cervical carcinoma HeLa cells. RNA Biol (2015) 0.77

miR-155 targets Caspase-3 mRNA in activated macrophages. RNA Biol (2016) 0.77

Experimental reduction of miR-92a mimics arterial aging. Exp Gerontol (2016) 0.76

A step-by-step microRNA guide to cancer development and metastasis. Cell Oncol (Dordr) (2017) 0.75

The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6. PLoS One (2015) 0.75

Potentiated DNA Damage Response in Circulating Breast Tumor Cells Confers Resistance to Chemotherapy. J Biol Chem (2015) 0.75

Widespread Shortening of 3' Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection. PLoS Genet (2016) 0.75

Significance of Polymorphism and Expression of miR-146a and NFkB1 Genetic Variants in Patients with Rheumatoid Arthritis. Arch Immunol Ther Exp (Warsz) (2017) 0.75

Regulation of proinflammatory genes by the circulating microRNA hsa-miR-939. Sci Rep (2016) 0.75

The Role of the Phylogenetically Conserved Cochaperone Protein Droj2/DNAJA3 in NF-κB Signaling. J Biol Chem (2015) 0.75

Reciprocal Feedback Between miR-181a and E2/ERα in Myometrium Enhances Inflammation Leading to Labor. J Clin Endocrinol Metab (2016) 0.75

Histone modifications induced by MDV infection at early cytolytic and latency phases. BMC Genomics (2015) 0.75

Expression of MicroRNAs in the Eyes of Lewis Rats with Experimental Autoimmune Anterior Uveitis. Mediators Inflamm (2015) 0.75

An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses. Nat Commun (2017) 0.75

NeurimmiRs and Postoperative Delirium in Elderly Patients Undergoing Total Hip/Knee Replacement: A Pilot Study. Front Aging Neurosci (2017) 0.75

miR-146a-Traf6 regulatory axis controls autoimmunity and myelopoiesis, but is dispensable for hematopoietic stem cell homeostasis and tumor suppression. Proc Natl Acad Sci U S A (2017) 0.75

Articles by these authors

(truncated to the top 100)

NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A (2006) 21.58

Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science (2002) 17.71

The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86

Chimeric nucleases stimulate gene targeting in human cells. Science (2003) 12.12

MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci U S A (2007) 11.42

Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol (2010) 7.75

Circuitry of nuclear factor kappaB signaling. Immunol Rev (2006) 6.49

Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci U S A (2002) 6.09

Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. J Exp Med (2008) 5.97

Permissive secondary mutations enable the evolution of influenza oseltamivir resistance. Science (2010) 5.94

Inositol phosphatase SHIP1 is a primary target of miR-155. Proc Natl Acad Sci U S A (2009) 5.30

Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science (2005) 4.83

Medicine. The need for a global HIV vaccine enterprise. Science (2003) 4.70

MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity (2010) 4.65

Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell (2010) 4.57

One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers. Cell (2004) 4.53

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev (2003) 4.40

Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities. EMBO J (2003) 3.93

The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules. Nat Immunol (2009) 3.85

Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature (2011) 3.80

miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J Exp Med (2011) 3.78

microRNA regulation of inflammatory responses. Annu Rev Immunol (2012) 3.47

NF-kappa B functions in synaptic signaling and behavior. Nat Neurosci (2003) 3.40

Two pathways to NF-kappaB. Mol Cell (2002) 3.12

Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy. Nature (2011) 3.08

MicroRNAs and immunity: tiny players in a big field. Immunity (2007) 3.01

CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex. EMBO J (2002) 2.90

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell (2004) 2.79

NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies. Proc Natl Acad Sci U S A (2011) 2.74

Long-term in vivo provision of antigen-specific T cell immunity by programming hematopoietic stem cells. Proc Natl Acad Sci U S A (2005) 2.68

MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output. Proc Natl Acad Sci U S A (2010) 2.40

Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates. Proc Natl Acad Sci U S A (2007) 2.30

Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20. Genes Dev (2008) 2.29

Essential role for STAT5 signaling in CD25+CD4+ regulatory T cell homeostasis and the maintenance of self-tolerance. J Immunol (2003) 2.13

Regulation of NF-kappaB activity through lysine monomethylation of p65. Proc Natl Acad Sci U S A (2009) 2.10

Engineered lentivector targeting of dendritic cells for in vivo immunization. Nat Biotechnol (2008) 2.05

Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks. Mol Cell Biol (2003) 2.01

Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors. Mol Ther (2006) 1.99

Physiological functions for brain NF-kappaB. Trends Neurosci (2005) 1.85

Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Immunity (2013) 1.83

miR-146a controls the resolution of T cell responses in mice. J Exp Med (2012) 1.81

Sam68 is required for both NF-κB activation and apoptosis signaling by the TNF receptor. Mol Cell (2011) 1.73

Targeting lentiviral vectors to specific cell types in vivo. Proc Natl Acad Sci U S A (2006) 1.71

Broad protection against influenza infection by vectored immunoprophylaxis in mice. Nat Biotechnol (2013) 1.71

MicroRNA-34a perturbs B lymphocyte development by repressing the forkhead box transcription factor Foxp1. Immunity (2010) 1.70

MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways. EMBO Mol Med (2013) 1.70

Multifunctional T-cell analyses to study response and progression in adoptive cell transfer immunotherapy. Cancer Discov (2013) 1.68

IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response. Nature (2010) 1.68

Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation. Nat Immunol (2002) 1.63

Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells. Proc Natl Acad Sci U S A (2011) 1.61

The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells. Proc Natl Acad Sci U S A (2002) 1.59

MicroRNA-125b potentiates macrophage activation. J Immunol (2011) 1.47

Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunity. Cell Rep (2012) 1.46

Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways. Proc Natl Acad Sci U S A (2004) 1.39

MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice. Elife (2013) 1.36

Reconstruction of the 1918 influenza virus: unexpected rewards from the past. MBio (2012) 1.34

Requirement for the NF-kappaB family member RelA in the development of secondary lymphoid organs. J Exp Med (2002) 1.32

Pregnancy induces a fetal antigen-specific maternal T regulatory cell response that contributes to tolerance. Proc Natl Acad Sci U S A (2010) 1.26

Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A. Proc Natl Acad Sci U S A (2012) 1.22

Generation of functional antigen-specific T cells in defined genetic backgrounds by retrovirus-mediated expression of TCR cDNAs in hematopoietic precursor cells. Proc Natl Acad Sci U S A (2002) 1.22

Regulation of monocyte functional heterogeneity by miR-146a and Relb. Cell Rep (2012) 1.19

A computational-experimental approach identifies mutations that enhance surface expression of an oseltamivir-resistant influenza neuraminidase. PLoS One (2011) 1.16

Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes. Blood (2008) 1.14

Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes. Proc Natl Acad Sci U S A (2002) 1.13

Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations. PLoS One (2010) 1.13

Steering a course to an AIDS vaccine. Science (2002) 1.12

Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice. Blood (2012) 1.11

MicroRNAs and hematopoietic cell development. Curr Top Dev Biol (2012) 1.11

RNA splicing regulates the temporal order of TNF-induced gene expression. Proc Natl Acad Sci U S A (2013) 1.01

Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma. Clin Cancer Res (2014) 1.01

Allelic exclusion and peripheral reconstitution by TCR transgenic T cells arising from transduced human hematopoietic stem/progenitor cells. Mol Ther (2013) 1.00

The Yin and Yang of microRNAs: leukemia and immunity. Immunol Rev (2013) 0.98

HIV-1 Gag-specific immunity induced by a lentivector-based vaccine directed to dendritic cells. Proc Natl Acad Sci U S A (2009) 0.98

Dimeric 2G12 as a potent protection against HIV-1. PLoS Pathog (2010) 0.98

Activation of the transcriptional function of the NF-κB protein c-Rel by O-GlcNAc glycosylation. Sci Signal (2013) 0.97

Inhibition of DNA binding by NF-kappa B with pyrrole-imidazole polyamides. Biochemistry (2002) 0.97

Targeting lentiviral vectors to antigen-specific immunoglobulins. Hum Gene Ther (2008) 0.96

As good as it gets? The problem of HIV persistence despite antiretroviral drugs. Cell Host Microbe (2012) 0.94

Uncovering the V(D)J recombinase. Cell (2004) 0.93

Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection. J Virol (2015) 0.91

Homeostatic cytokines orchestrate the segregation of CD4 and CD8 memory T-cell reservoirs in mice. Blood (2011) 0.91

CD4+CD25- T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model. J Immunol (2008) 0.90

Regulation of stress-induced hematopoiesis. Curr Opin Hematol (2015) 0.84

EHMT1 protein binds to nuclear factor-κB p50 and represses gene expression. J Biol Chem (2012) 0.82

A TLR4 agonist synergizes with dendritic cell-directed lentiviral vectors for inducing antigen-specific immune responses. Vaccine (2012) 0.79

Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986. 46: 705-716. J Immunol (2006) 0.78

Use of mutated self-cleaving 2A peptides as a molecular rheostat to direct simultaneous formation of membrane and secreted anti-HIV immunoglobulins. PLoS One (2012) 0.78

Exploring the limits of ultrafast polymerase chain reaction using liquid for thermal heat exchange: A proof of principle. Appl Phys Lett (2010) 0.78

Retraction. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity (2009) 0.77

Regulation of APC development, immune response, and autoimmunity by Bach1/HO-1 pathway in mice. Blood (2012) 0.77

Overcoming barriers to programming a therapeutic cellular immune response to fight melanoma. Pigment Cell Melanoma Res (2010) 0.77

Limiting science: a biologist's perspective. Daedalus (1978) 0.76

Vaccine trial provided valuable information. Nature (2008) 0.75

Pillars article: the V(D)J recombination activating gene, RAG-1. 1989. J Immunol (2008) 0.75

Legal aids: Science primers in the courtroom. Nature (2016) 0.75

QnAs with David Baltimore. Interview by Prashant Nair. Proc Natl Acad Sci U S A (2011) 0.75

An interview with David Baltimore. [Interview by Joseph Glorioso and Jenny Jacoby]. Gene Ther (2005) 0.75

Science for the globe. Science (2008) 0.75

Will cloning beget disaster? Wall St J (East Ed) (1997) 0.75

Retraction. Autoimmunity as a consequence of retrovirus-mediated expression of C-FLIP in lymphocytes. Immunity (2009) 0.75