Published in Proc Natl Acad Sci U S A on March 26, 2012
Next-generation proteomics: towards an integrative view of proteome dynamics. Nat Rev Genet (2012) 2.39
Quantitative phosphoproteomics identifies SnRK2 protein kinase substrates and reveals the effectors of abscisic acid action. Proc Natl Acad Sci U S A (2013) 1.60
Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules. Cancer Cell (2015) 1.52
Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros. Proc Natl Acad Sci U S A (2012) 1.30
RegPhos 2.0: an updated resource to explore protein kinase-substrate phosphorylation networks in mammals. Database (Oxford) (2014) 0.90
Salmonella modulation of host cell gene expression promotes its intracellular growth. PLoS Pathog (2013) 0.89
Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer. Biochim Biophys Acta (2014) 0.89
Encephalomyocarditis virus leader is phosphorylated by CK2 and syk as a requirement for subsequent phosphorylation of cellular nucleoporins. J Virol (2013) 0.89
A peptide-based biosensor assay to detect intracellular Syk kinase activation and inhibition. Biochemistry (2012) 0.89
Signal transduction in cerebral arteries after subarachnoid hemorrhage-a phosphoproteomic approach. J Cereb Blood Flow Metab (2013) 0.89
NANOG is multiply phosphorylated and directly modified by ERK2 and CDK1 in vitro. Stem Cell Reports (2014) 0.85
Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease. EBioMedicine (2015) 0.85
Method for identifying phosphorylated substrates of specific cyclin/cyclin-dependent kinase complexes. Proc Natl Acad Sci U S A (2014) 0.84
Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival. Mol Cell Biol (2014) 0.84
A PREVIOUSLY UNKNOWN UNIQUE CHALLENGE FOR INHIBITORS OF SYK ATP-BINDING SITE: ROLE OF SYK AS A CELL CYCLE CHECKPOINT REGULATOR. EBioMedicine (2014) 0.83
KINATEST-ID: a pipeline to develop phosphorylation-dependent terbium sensitizing kinase assays. J Am Chem Soc (2015) 0.83
Proteogenomic convergence for understanding cancer pathways and networks. Clin Proteomics (2014) 0.83
Global screening of CK2 kinase substrates by an integrated phosphoproteomics workflow. Sci Rep (2013) 0.83
Identification of direct tyrosine kinase substrates based on protein kinase assay-linked phosphoproteomics. Mol Cell Proteomics (2013) 0.82
Nanomechanical property maps of breast cancer cells as determined by multiharmonic atomic force microscopy reveal Syk-dependent changes in microtubule stability mediated by MAP1B. Biochemistry (2014) 0.82
Is phosphoproteomics ready for clinical research? Clin Chim Acta (2012) 0.81
Global phosphoproteomics of activated B cells using complementary metal ion functionalized soluble nanopolymers. Anal Chem (2014) 0.81
Identification of extracellular signal-regulated kinase 1 (ERK1) direct substrates using stable isotope labeled kinase assay-linked phosphoproteomics. Mol Cell Proteomics (2014) 0.81
Analytical challenges translating mass spectrometry-based phosphoproteomics from discovery to clinical applications. Electrophoresis (2014) 0.81
Syk inhibits the activity of protein kinase A by phosphorylating tyrosine 330 of the catalytic subunit. J Biol Chem (2013) 0.79
A C-terminal acidic domain regulates degradation of the transcriptional coactivator Bob1. Mol Cell Biol (2013) 0.79
Current technologies to identify protein kinase substrates in high throughput. Front Biol (Beijing) (2013) 0.78
Identification of nuclear phosphoproteins as novel tobacco markers in mouse lung tissue following short-term exposure to tobacco smoke. FEBS Open Bio (2014) 0.78
In-Depth Analyses of B Cell Signaling Through Tandem Mass Spectrometry of Phosphopeptides Enriched by PolyMAC. Int J Mass Spectrom (2015) 0.78
Tissue phosphoproteomics with PolyMAC identifies potential therapeutic targets in a transgenic mouse model of HER2 positive breast cancer. Electrophoresis (2014) 0.78
Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy. J Biol Chem (2015) 0.76
Reconstruction and signal propagation analysis of the Syk signaling network in breast cancer cells. PLoS Comput Biol (2017) 0.75
An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor. Elife (2016) 0.75
Estimating the Efficiency of Phosphopeptide Identification by Tandem Mass Spectrometry. J Am Soc Mass Spectrom (2017) 0.75
Enzyme kinetics for complex system enables accurate determination of specificity constants of numerous substrates in a mixture by proteomics platform. Mol Cell Proteomics (2016) 0.75
Protein networks and activation of lymphocytes. Curr Opin Immunol (2015) 0.75
H2Av facilitates H3S10 phosphorylation but is not required for heat shock-induced chromatin decondensation or transcriptional elongation. Development (2017) 0.75
Coupling functionalized cobalt ferrite nanoparticle enrichment with online LC/MS/MS for top-down phosphoproteomics. Chem Sci (2017) 0.75
Oncogenic kinase signalling. Nature (2001) 16.30
Signaling--2000 and beyond. Cell (2000) 11.78
A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nat Biotechnol (2001) 6.50
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell (1998) 6.15
An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data sets. Nat Biotechnol (2005) 5.93
MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J (1997) 4.39
The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol (2010) 4.26
Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates. Proc Natl Acad Sci U S A (1997) 3.59
A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. EMBO J (2001) 2.60
BLNK: a central linker protein in B cell activation. Immunity (1998) 2.59
The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells. Nature (2000) 2.17
B-cell-specific coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation. Nature (1996) 2.10
Hitting the target: emerging technologies in the search for kinase substrates. Sci STKE (2002) 1.91
Early events in B cell activation. Annu Rev Immunol (2010) 1.86
In-depth analyses of kinase-dependent tyrosine phosphoproteomes based on metal ion-functionalized soluble nanopolymers. Mol Cell Proteomics (2010) 1.62
Syk and pTyr'd: Signaling through the B cell antigen receptor. Biochim Biophys Acta (2009) 1.55
Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling. J Immunol (1998) 1.50
Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. Mol Cell Biol (1996) 1.40
Peptide and protein phosphorylation by protein tyrosine kinase Csk: insights into specificity and mechanism. Biochemistry (1998) 1.39
Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine. J Biol Chem (1996) 1.37
Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. EMBO J (2011) 1.34
BLNK mediates Syk-dependent Btk activation. Proc Natl Acad Sci U S A (2001) 1.32
Applications of one-bead one-compound combinatorial libraries and chemical microarrays in signal transduction research. Acc Chem Res (2003) 1.29
Neurotransmitters drive combinatorial multistate postsynaptic density networks. Sci Signal (2009) 1.24
Sensitive multiplexed analysis of kinase activities and activity-based kinase identification. Nat Biotechnol (2009) 1.21
Retracted The IL-15R alpha chain signals through association with Syk in human B cells. J Immunol (2001) 1.20
Catalytic specificity of phosphotyrosine kinases Blk, Lyn, c-Src and Syk as assessed by phage display. J Mol Biol (1996) 1.20
Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells. Mol Cancer Res (2009) 1.13
KESTREL: a powerful method for identifying the physiological substrates of protein kinases. Biochem J (2006) 1.09
A systematic MS-based approach for identifying in vitro substrates of PKA and PKG in rat uteri. J Proteome Res (2007) 1.07
Searching for biomarkers of Aurora-A kinase activity: identification of in vitro substrates through a modified KESTREL approach. J Proteome Res (2005) 1.06
Identification of c-Src tyrosine kinase substrates using mass spectrometry and peptide microarrays. J Proteome Res (2008) 1.06
The Syk tyrosine kinase localizes to the centrosomes and negatively affects mitotic progression. Cancer Res (2005) 1.05
B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1. J Exp Med (2001) 1.00
Studies of a germinal centre B-cell expressed gene, GCET2, suggest its role as a membrane associated adapter protein. Br J Haematol (2007) 0.97
Thrombin-induced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the protein. J Biol Chem (2005) 0.97
Quantitative analysis of protein phosphorylation on a system-wide scale by mass spectrometry-based proteomics. Methods Enzymol (2010) 0.96
Syk-dependent phosphorylation of microtubules in activated B-lymphocytes. J Cell Sci (2000) 0.96
Phosphoproteomic analysis of Syk kinase signaling in human cancer cells reveals its role in cell-cell adhesion. Oncogene (2009) 0.95
QIKS--Quantitative identification of kinase substrates. Proteomics (2010) 0.91
Global identification of protein kinase substrates by protein microarray analysis. Nat Protoc (2009) 0.90
Polo-like-kinase 1 (PLK1) as a molecular target to overcome SYK-mediated resistance of B-lineage acute lymphoblastic leukaemia cells to oxidative stress. Br J Haematol (2009) 0.86
PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet (2007) 4.09
Profiling constitutive proteolytic events in vivo. Biochem J (2007) 1.78
Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt. Proc Natl Acad Sci U S A (2004) 1.66
In-depth analyses of kinase-dependent tyrosine phosphoproteomes based on metal ion-functionalized soluble nanopolymers. Mol Cell Proteomics (2010) 1.62
Quantitative phosphoproteomics identifies SnRK2 protein kinase substrates and reveals the effectors of abscisic acid action. Proc Natl Acad Sci U S A (2013) 1.60
A novel quantitative proteomics strategy to study phosphorylation-dependent peptide-protein interactions. J Proteome Res (2007) 1.44
In vivo analysis of intracellular amino acid labelings by GC/MS. Anal Biochem (2002) 1.37
Regulation of hemolysin expression and virulence of Staphylococcus aureus by a serine/threonine kinase and phosphatase. PLoS One (2010) 1.34
Glial cells are born with synapses. FASEB J (2008) 1.32
Identification of proteolytic cleavage sites by quantitative proteomics. J Proteome Res (2007) 1.32
Nucleocytoplasmic trafficking of the Syk protein tyrosine kinase. Mol Cell Biol (2006) 1.26
Plk1-mediated phosphorylation of Topors regulates p53 stability. J Biol Chem (2009) 1.26
An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells. Mol Biosyst (2007) 1.26
Hepatitis B virus X protein differentially regulates cell cycle progression in X-transforming versus nontransforming hepatocyte (AML12) cell lines. J Biol Chem (2001) 1.26
Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase. J Mol Biol (2005) 1.23
Aptamer in bioanalytical applications. Anal Chem (2011) 1.21
Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase. J Biol Chem (2004) 1.13
Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells. Mol Cancer Res (2009) 1.13
Cloning, expression, and hemostatic activities of a disintegrin, r-mojastin 1, from the mohave rattlesnake (Crotalus scutulatus scutulatus). Thromb Res (2010) 1.11
Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase. J Biol Chem (2002) 1.10
Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression. J Cell Biol (2013) 1.08
Tyr130 phosphorylation triggers Syk release from antigen receptor by long-distance conformational uncoupling. Proc Natl Acad Sci U S A (2008) 1.04
The tig1 histone deacetylase complex regulates infectious growth in the rice blast fungus Magnaporthe oryzae. Plant Cell (2010) 1.03
Rapid ambient mass spectrometric profiling of intact, untreated bacteria using desorption electrospray ionization. Chem Commun (Camb) (2006) 1.01
Chemical visualization of phosphoproteomes on membrane. Mol Cell Proteomics (2012) 1.01
Recent development of monolithic stationary phases with emphasis on microscale chromatographic separation. J Chromatogr A (2007) 1.00
Design and synthesis of phosphotyrosine peptidomimetic prodrugs. J Med Chem (2006) 0.98
Dynamics of intracellular metabolites of glycolysis and TCA cycle during cell-cycle-related oscillation in Saccharomyces cerevisiae. Biotechnol Bioeng (2005) 0.97
Phosphorylation assay based on multifunctionalized soluble nanopolymer. Anal Chem (2011) 0.97
Hepatitis B virus X protein increases the Cdt1-to-geminin ratio inducing DNA re-replication and polyploidy. J Biol Chem (2008) 0.96
The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling. Biochim Biophys Acta (2002) 0.95
Hyperpolarizing inhibition develops without trophic support by GABA in cultured rat midbrain neurons. J Physiol (2003) 0.95
Quantitative measurement of phosphoproteome response to osmotic stress in arabidopsis based on Library-Assisted eXtracted Ion Chromatogram (LAXIC). Mol Cell Proteomics (2013) 0.95
Identification of serine/threonine kinase substrates in the human pathogen group B streptococcus. J Proteome Res (2009) 0.94
Detection of kinase translocation using microfluidic electroporative flow cytometry. Anal Chem (2007) 0.94
The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl. J Biol Chem (2001) 0.94
Homeodomain transcription factor Phox2a, via cyclic AMP-mediated activation, induces p27Kip1 transcription, coordinating neural progenitor cell cycle exit and differentiation. Mol Cell Biol (2006) 0.93
Identification of the components of a glycolytic enzyme metabolon on the human red blood cell membrane. J Biol Chem (2012) 0.93
Playing tag with quantitative proteomics. Anal Bioanal Chem (2008) 0.92
Polo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidy. J Biol Chem (2010) 0.92
Polo-like kinase 1 inhibition suppresses hepatitis B virus X protein-induced transformation in an in vitro model of liver cancer progression. Hepatology (2009) 0.92
Regulation of parkin and PINK1 by neddylation. Hum Mol Genet (2012) 0.90
Distinct roles for the linker region tyrosines of Syk in FcepsilonRI signaling in primary mast cells. J Biol Chem (2004) 0.90
A peptide-based biosensor assay to detect intracellular Syk kinase activation and inhibition. Biochemistry (2012) 0.89
Synthesis of a phosphoserine mimetic prodrug with potent 14-3-3 protein inhibitory activity. Chem Biol (2012) 0.89
Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav. Mol Cell Biol (2011) 0.88
The cAMP pathway in combination with BMP2 regulates Phox2a transcription via cAMP response element binding sites. J Biol Chem (2005) 0.88
Time-dependent activation of Phox2a by the cyclic AMP pathway modulates onset and duration of p27Kip1 transcription. Mol Cell Biol (2009) 0.88
Hormesis phenomena under Cd stress in a hyperaccumulator--Lonicera japonica Thunb. Ecotoxicology (2013) 0.87
Bisphenol A inhibits voltage-activated Ca(2+) channels in vitro: mechanisms and structural requirements. Mol Pharmacol (2012) 0.87
Generation of an analog-sensitive Syk tyrosine kinase for the study of signaling dynamics from the B cell antigen receptor. J Biol Chem (2007) 0.87
Contact killing of bacteria on copper is suppressed if bacterial-metal contact is prevented and is induced on iron by copper ions. Appl Environ Microbiol (2013) 0.86
Phosphatase of regenerating liver 3 (PRL3) provokes a tyrosine phosphoproteome to drive prometastatic signal transduction. Mol Cell Proteomics (2013) 0.86
The microtubule-associated protein tau is phosphorylated by Syk. Biochim Biophys Acta (2007) 0.86
Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap. J Am Soc Mass Spectrom (2011) 0.86
Functionalized soluble nanopolymers for phosphoproteome analysis. Methods Mol Biol (2011) 0.86
Identification of cytoskeletal elements enclosing the ATP pools that fuel human red blood cell membrane cation pumps. Proc Natl Acad Sci U S A (2012) 0.85
Anti-sulfonylbenzoate antibodies as a tool for the detection of nucleotide-binding proteins for functional proteomics. J Proteome Res (2004) 0.85
Total internal reflection fluorescence flow cytometry. Anal Chem (2008) 0.84
A novel quantitative proteomics reagent based on soluble nanopolymers. Chem Commun (Camb) (2007) 0.84
Identification of drug targets in vitro and in living cells by soluble-nanopolymer-based proteomics. Angew Chem Int Ed Engl (2011) 0.84
One-step extraction of subcellular proteins from eukaryotic cells. Lab Chip (2010) 0.84
PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac. Blood (2002) 0.83
Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility. Mol Cell Biol (2013) 0.83
CD44 and hyaluronan promote invasive growth of B35 neuroblastoma cells into the brain. Biochim Biophys Acta (2010) 0.83
Facile determination of double bond position in unsaturated fatty acids and esters by low temperature plasma ionization mass spectrometry. Anal Chem (2011) 0.83
Effect of phosphorylation of ovalbumin on adsorption by aluminum-containing adjuvants and elution upon exposure to interstitial fluid. Vaccine (2005) 0.82
Identification of direct tyrosine kinase substrates based on protein kinase assay-linked phosphoproteomics. Mol Cell Proteomics (2013) 0.82
Kinetics of NF-κB nucleocytoplasmic transport probed by single-cell screening without imaging. Lab Chip (2010) 0.82
Characterization of the in vivo sites of serine phosphorylation on Lck identifying serine 59 as a site of mitotic phosphorylation. J Biol Chem (2002) 0.82
Quantitative analysis of snake venoms using soluble polymer-based isotope labeling. Mol Cell Proteomics (2007) 0.82
Nanomechanical property maps of breast cancer cells as determined by multiharmonic atomic force microscopy reveal Syk-dependent changes in microtubule stability mediated by MAP1B. Biochemistry (2014) 0.82
Selective extraction of peptides from human plasma by highly ordered mesoporous silica particles for peptidome analysis. Angew Chem Int Ed Engl (2007) 0.82
Is phosphoproteomics ready for clinical research? Clin Chim Acta (2012) 0.81
Global phosphoproteomics of activated B cells using complementary metal ion functionalized soluble nanopolymers. Anal Chem (2014) 0.81
The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2. Biochim Biophys Acta (2011) 0.81
Modulation of voltage-dependent sodium channels by the delta-agonist SNC80 in acutely isolated rat hippocampal neurons. Neuropharmacology (2004) 0.81
Multiplexed quantitation of protein expression and phosphorylation based on functionalized soluble nanopolymers. J Am Chem Soc (2012) 0.81
ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling. J Biol Chem (2013) 0.81
Selective enrichment of endogenous peptides by chemically modified porous nanoparticles for peptidome analysis. J Chromatogr A (2008) 0.80
Biological fingerprinting analysis of the traditional Chinese prescription Longdan Xiegan Decoction by on/off-line comprehensive two-dimensional biochromatography. J Chromatogr B Analyt Technol Biomed Life Sci (2007) 0.80
Quantitative analysis of protein translocations by microfluidic total internal reflection fluorescence flow cytometry. Lab Chip (2010) 0.80
The SH3 domain of Lck modulates T-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of Raf-1. Mol Cell Biol (2007) 0.80
Determination of landiolol, an ultra-short-acting β₁-receptor antagonist, in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2011) 0.80