Published in Int J Nanomedicine on March 12, 2012
Protein encapsulation in polymeric microneedles by photolithography. Int J Nanomedicine (2012) 0.85
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Multifunctional particle-constituted microneedle arrays as cutaneous or mucosal vaccine adjuvant-delivery systems. Hum Vaccin Immunother (2016) 0.75
Topical Application of 0.5% Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangioma. Front Oncol (2017) 0.75
Microneedles for transdermal drug delivery. Adv Drug Deliv Rev (2004) 4.37
Dissolving polymer microneedle patches for influenza vaccination. Nat Med (2010) 3.24
Microfabricated microneedles: a novel approach to transdermal drug delivery. J Pharm Sci (1998) 2.80
Dissolving microneedles for transdermal drug delivery. Biomaterials (2008) 2.47
Polymer microneedles for controlled-release drug delivery. Pharm Res (2006) 1.72
Precise microinjection into skin using hollow microneedles. J Invest Dermatol (2006) 1.51
Minimally invasive protein delivery with rapidly dissolving polymer microneedles. Adv Mater (2008) 1.49
Mechanism of fluid infusion during microneedle insertion and retraction. J Control Release (2006) 1.46
Sugar micro needles as transdermic drug delivery system. Biomed Microdevices (2005) 1.28
Microfabricated silicon microneedles for nonviral cutaneous gene delivery. Br J Dermatol (2004) 1.25
Sustained delivery of proteins for novel therapeutic agents. Science (1998) 0.94
Multidimensional drug profiling by automated microscopy. Science (2004) 5.45
A pre-Archaeopteryx troodontid theropod from China with long feathers on the metatarsus. Nature (2009) 4.78
Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol (2007) 3.17
Maintenance rituximab after cyclophosphamide, vincristine, and prednisone prolongs progression-free survival in advanced indolent lymphoma: results of the randomized phase III ECOG1496 Study. J Clin Oncol (2009) 3.07
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest (2009) 2.52
Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am J Clin Nutr (2006) 2.52
Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. Proc Natl Acad Sci U S A (2006) 2.26
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. Nat Cell Biol (2011) 2.25
Critical regulation of CD4+ T cell survival and autoimmunity by beta-arrestin 1. Nat Immunol (2007) 2.15
CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice. Cancer Res (2003) 2.00
Human VPS34 and p150 are Rab7 interacting partners. Traffic (2003) 1.86
Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis. Crit Care Med (2010) 1.84
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. Nat Chem Biol (2005) 1.84
GM-CSF in the lung protects against lethal influenza infection. Am J Respir Crit Care Med (2011) 1.83
The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing. EMBO Rep (2004) 1.82
Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer. Mol Cancer (2011) 1.75
Hepatocellular carcinoma associated with liver-gender disruption in male mice. Cancer Res (2007) 1.56
Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis. Hepatology (2015) 1.55
Does swaddling influence developmental dysplasia of the hip?: An experimental study of the traditional straight-leg swaddling model in neonatal rats. J Bone Joint Surg Am (2012) 1.50
Total colony-forming units are a strong, independent predictor of neutrophil and platelet engraftment after unrelated umbilical cord blood transplantation: a single-center analysis of 435 cord blood transplants. Biol Blood Marrow Transplant (2011) 1.46
Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia. Crit Care Med (2012) 1.45
The Health Utilities Index 3 invalidated when completed by nurses for pediatric oncology patients. Cancer Nurs (2007) 1.43
Importance of Toll-like receptor 2 in mitochondrial dysfunction during polymicrobial sepsis. Anesthesiology (2014) 1.43
LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling. Proc Natl Acad Sci U S A (2010) 1.40
Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model. J Neurosci (2009) 1.39
Complement Factor B Production in Renal Tubular Cells and Its Role in Sodium Transporter Expression During Polymicrobial Sepsis. Crit Care Med (2016) 1.39
Appraisal of immunoglobulin free light chain as a marker of response. Blood (2008) 1.38
Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice. Infect Immun (2005) 1.36
MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene. J Biol Chem (2012) 1.33
Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis. Cell Microbiol (2007) 1.32
Bmi-1 expression predicts prognosis for patients with gastric carcinoma. J Surg Oncol (2008) 1.31
Abiraterone acetate in combination with prednisone for the treatment of patients with metastatic castration-resistant prostate cancer: U.S. Food and Drug Administration drug approval summary. Clin Cancer Res (2013) 1.31
ALK status testing in non-small cell lung carcinoma: correlation between ultrasensitive IHC and FISH. J Mol Diagn (2013) 1.30
Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men. Hum Genet (2005) 1.30
Dietary glycaemic index and glycaemic load in relation to the risk of type 2 diabetes: a meta-analysis of prospective cohort studies. Br J Nutr (2011) 1.29
Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity. Neurochem Int (2009) 1.27
Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. J Biol Chem (2011) 1.27
MiR-410 regulates MET to influence the proliferation and invasion of glioma. Int J Biochem Cell Biol (2012) 1.22
Campylobacter jejuni type VI secretion system: roles in adaptation to deoxycholic acid, host cell adherence, invasion, and in vivo colonization. PLoS One (2012) 1.21
Concurrent Helicobacter bilis infection in C57BL/6 mice attenuates proinflammatory H. pylori-induced gastric pathology. Infect Immun (2009) 1.20
Downregulation of BMI-1 enhances 5-fluorouracil-induced apoptosis in nasopharyngeal carcinoma cells. Biochem Biophys Res Commun (2008) 1.16
Immediate splenectomy decreases mortality and improves cognitive function of rats after severe traumatic brain injury. J Trauma (2011) 1.14
miR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2. Eur J Cancer (2012) 1.14
Dairy consumption and risk of breast cancer: a meta-analysis of prospective cohort studies. Breast Cancer Res Treat (2011) 1.13
Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival. Clin Cancer Res (2007) 1.13
Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. J Biol Chem (2012) 1.12
U.S. Food and Drug Administration approval: crizotinib for treatment of advanced or metastatic non-small cell lung cancer that is anaplastic lymphoma kinase positive. Clin Cancer Res (2014) 1.12
Helicobacter bilis-associated hepatitis in outbred mice. Comp Med (2004) 1.09
Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis. Sci Transl Med (2013) 1.08
Identification of a critical site in Wld(s): essential for Nmnat enzyme activity and axon-protective function. Neurosci Lett (2006) 1.08
Patterns of retropharyngeal node metastasis in nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys (2008) 1.07
Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia. Am J Obstet Gynecol (2006) 1.06
A comparative analysis of functional outcomes in adolescents and young adults with lower-extremity bone sarcoma. Pediatr Blood Cancer (2007) 1.05
The Cord Blood Apgar: a novel scoring system to optimize selection of banked cord blood grafts for transplantation (CME). Transfusion (2011) 1.05
Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131. Antimicrob Agents Chemother (2007) 1.05
G2677T and C3435T genotype and haplotype are associated with hepatic ABCB1 (MDR1) expression. J Clin Pharmacol (2006) 1.04
Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1. Structure (2004) 1.04
Single endemic genotype of measles virus continuously circulating in China for at least 16 years. PLoS One (2012) 1.03
Acute kidney injury predicts outcomes of non-critically ill patients. Mayo Clin Proc (2009) 1.03
PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling. Chem Biol (2013) 1.02
Nocturnal awakenings, sleep environment interruptions, and fatigue in hospitalized children with cancer. Oncol Nurs Forum (2007) 1.01
O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. Bioorg Med Chem Lett (2009) 1.01
Role of extracellular RNA and TLR3-Trif signaling in myocardial ischemia-reperfusion injury. J Am Heart Assoc (2014) 1.01
Polymer-based sustained-release dosage forms for protein drugs, challenges, and recent advances. AAPS PharmSciTech (2008) 1.01
A support vector machine classifier for recognizing mitotic subphases using high-content screening data. J Biomol Screen (2007) 1.01
Patterns of level II node metastasis in nasopharyngeal carcinoma. Radiother Oncol (2008) 1.00
MiR-139 inhibits Mcl-1 expression and potentiates TMZ-induced apoptosis in glioma. CNS Neurosci Ther (2013) 1.00
Immunohistochemical detection of human small lymphatic vessels under normal and pathological conditions using the LYVE-1 antibody. Virchows Arch (2004) 1.00
Gene therapy for human colorectal carcinoma using human CEA promoter contro led bacterial ADP-ribosylating toxin genes human CEA: PEA & DTA gene transfer. World J Gastroenterol (1998) 1.00
Coinfection with Enterohepatic Helicobacter species can ameliorate or promote Helicobacter pylori-induced gastric pathology in C57BL/6 mice. Infect Immun (2011) 1.00
Antitumor activities of kushen: literature review. Evid Based Complement Alternat Med (2012) 0.99
Discovery of potent non-urea inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett (2008) 0.99
Active Learning Based on Locally Linear Reconstruction. IEEE Trans Pattern Anal Mach Intell (2011) 0.99
Clinical field testing of an enhanced-activity intervention in hospitalized children with cancer. J Pain Symptom Manage (2007) 0.99
A naturally occurring rabbit model of enterohemorrhagic Escherichia coli-induced disease. J Infect Dis (2002) 0.98
Preparation of protein-loaded sustained-release microspheres via 'solid-in-oil-in-hydrophilic oil-in-ethanol (S/O/hO/E)' emulsification. Colloids Surf B Biointerfaces (2010) 0.98
Californium-252 brachytherapy combined with external-beam radiotherapy for cervical cancer: long-term treatment results. Int J Radiat Oncol Biol Phys (2011) 0.98
Genome shuffling enhanced L-lactic acid production by improving glucose tolerance of Lactobacillus rhamnosus. J Biotechnol (2008) 0.97
Rare-earth metal complexes having an unusual indolyl-1,2-dianion through C-H activation with a novel η1:(μ2-η1:η1) bonding with metals. Chem Commun (Camb) (2012) 0.97
Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study. J Med Chem (2015) 0.97
Renal injury is a consistent finding in Dutch Belted rabbits experimentally infected with enterohemorrhagic Escherichia coli. J Infect Dis (2006) 0.97
Olefin-dependent discrimination between two nonheme HO-FeV=O tautomeric species in catalytic H2O2 epoxidations. Chemistry (2009) 0.97
Enhanced enzyme kinetic stability by increasing rigidity within the active site. J Biol Chem (2014) 0.96
Identification of residues in the receptor-binding domain (RBD) of the spike protein of human coronavirus NL63 that are critical for the RBD-ACE2 receptor interaction. J Gen Virol (2008) 0.96
Utility of sparse concentration sampling for citalopram in elderly clinical trial subjects. J Clin Pharmacol (2004) 0.96
Identification of RET gene fusion by exon array analyses in "pan-negative" lung cancer from never smokers. Cell Res (2012) 0.96
Endothelial glucocorticoid receptor is required for protection against sepsis. Proc Natl Acad Sci U S A (2012) 0.96
Curcumin suppresses malignant glioma cells growth and induces apoptosis by inhibition of SHH/GLI1 signaling pathway in vitro and vivo. CNS Neurosci Ther (2013) 0.95
Interaction and functional analyses of human VPS34/p150 phosphatidylinositol 3-kinase complex with Rab7. Methods Enzymol (2005) 0.95
Formulating protein therapeutics into particulate forms. Expert Opin Drug Deliv (2009) 0.95
Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase- and soluble guanylate cyclase-dependent mechanisms. Anesthesiology (2011) 0.94
Evaluation of the safety and efficacy of transcatheter aortic valve implantation in patients with a severe stenotic bicuspid aortic valve in a Chinese population. J Zhejiang Univ Sci B (2015) 0.94
Crystal structure of the hyperthermophilic inorganic pyrophosphatase from the archaeon Pyrococcus horikoshii. Biophys J (2004) 0.94
Neuroprotective effect of erythropoietin-loaded composite microspheres on retinal ganglion cells in rats. Eur J Pharm Sci (2011) 0.94
Uterine tumor resembling ovarian sex cord tumor: report of a case with t(X;6)(p22.3;q23.1) and t(4;18)(q21.1;q21.3). Diagn Mol Pathol (2003) 0.94
Formulating erythropoietin-loaded sustained-release PLGA microspheres without protein aggregation. J Control Release (2008) 0.94
Biscarbamate cross-linked low molecular weight PEI for delivering IL-1 receptor antagonist gene to synoviocytes for arthritis therapy. Biomaterials (2012) 0.93