Published in Nat Chem Biol on November 20, 2005
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JNK-mediated phosphorylation of paxillin in adhesion assembly and tension-induced cell death by the adenovirus death factor E4orf4. J Biol Chem (2008) 0.84
Trifunctional norrisolide probes for the study of Golgi vesiculation. Bioorg Med Chem Lett (2006) 0.83
R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis. Mol Cancer Ther (2015) 0.81
The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells. Biochem Pharmacol (2006) 0.81
β3 integrin-mediated spreading induced by matrix-bound BMP-2 controls Smad signaling in a stiffness-independent manner. J Cell Biol (2016) 0.81
The necrotic signal induced by mycophenolic acid overcomes apoptosis-resistance in tumor cells. PLoS One (2009) 0.81
Protein kinase C δ regulates the release of collagen type I from vascular smooth muscle cells via regulation of Cdc42. Mol Biol Cell (2012) 0.80
Rho GTPase Cdc42 is essential for human T-cell development. Haematologica (2010) 0.80
Chemical biology studies on norrisolide. Bioorg Med Chem (2010) 0.80
The small molecule dispergo tubulates the endoplasmic reticulum and inhibits export. Mol Biol Cell (2013) 0.80
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Neurobiological applications of small molecule screening. Chem Rev (2008) 0.77
Deregulation of Rho GTPases in cancer. Small GTPases (2016) 0.76
Dual effects of Ral-activated pathways on p27 localization and TGF-β signaling. Mol Biol Cell (2013) 0.75
Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell (2006) 13.15
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Multidimensional drug profiling by automated microscopy. Science (2004) 5.45
Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature (2004) 4.48
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Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol (2007) 3.17
Itinerant exosomes: emerging roles in cell and tissue polarity. Trends Cell Biol (2008) 2.93
Endosomal recycling controls plasma membrane area during mitosis. Proc Natl Acad Sci U S A (2007) 2.86
Distinct dynamics of endocytic clathrin-coated pits and coated plaques. PLoS Biol (2009) 2.83
Clathrin is a key regulator of basolateral polarity. Nature (2008) 2.67
Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis. Methods Enzymol (2008) 2.61
Invasive and adherent bacterial pathogens co-Opt host clathrin for infection. Cell Host Microbe (2007) 2.53
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest (2009) 2.52
Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am J Clin Nutr (2006) 2.52
Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells. Nat Cell Biol (2003) 2.50
Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin. Immunity (2009) 2.50
Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport. Nat Cell Biol (2005) 2.50
Actin dynamics counteract membrane tension during clathrin-mediated endocytosis. Nat Cell Biol (2011) 2.48
Crystal structure of the clathrin adaptor protein 1 core. Proc Natl Acad Sci U S A (2004) 2.28
Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. Proc Natl Acad Sci U S A (2006) 2.26
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. Nat Cell Biol (2011) 2.25
Polarization-dependent selective transport to the apical membrane by KIF5B in MDCK cells. Dev Cell (2007) 2.19
The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium. Proc Natl Acad Sci U S A (2002) 2.18
Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly. J Mol Biol (2006) 2.17
The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane. Nat Cell Biol (2002) 2.16
Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton. J Cell Biol (2004) 2.16
Critical regulation of CD4+ T cell survival and autoimmunity by beta-arrestin 1. Nat Immunol (2007) 2.15
A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating. Proc Natl Acad Sci U S A (2006) 2.12
Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis. Immunity (2005) 2.11
Apical trafficking in epithelial cells: signals, clusters and motors. J Cell Sci (2009) 2.08
Role of lipids and actin in the formation of clathrin-coated pits. Exp Cell Res (2006) 2.01
CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice. Cancer Res (2003) 2.00
Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling. Dev Cell (2007) 1.99
CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. Mol Cell (2008) 1.94
Specificity profiling of Pak kinases allows identification of novel phosphorylation sites. J Biol Chem (2007) 1.92
AP1B sorts basolateral proteins in recycling and biosynthetic routes of MDCK cells. Proc Natl Acad Sci U S A (2007) 1.92
Human VPS34 and p150 are Rab7 interacting partners. Traffic (2003) 1.86
Differential evanescence nanometry: live-cell fluorescence measurements with 10-nm axial resolution on the plasma membrane. Biophys J (2007) 1.85
Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis. Crit Care Med (2010) 1.84
GM-CSF in the lung protects against lethal influenza infection. Am J Respir Crit Care Med (2011) 1.83
The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing. EMBO Rep (2004) 1.82
Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature (2004) 1.81
Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer. Mol Cancer (2011) 1.75
Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI. Proc Natl Acad Sci U S A (2002) 1.67
Macropinocytosis: regulated coordination of endocytic and exocytic membrane traffic events. J Cell Sci (2006) 1.64
PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal. Mol Biol Cell (2007) 1.63
Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nat Immunol (2011) 1.57
Hepatocellular carcinoma associated with liver-gender disruption in male mice. Cancer Res (2007) 1.56
The delta region of outer-capsid protein micro 1 undergoes conformational change and release from reovirus particles during cell entry. J Virol (2003) 1.56
Exo1: a new chemical inhibitor of the exocytic pathway. Proc Natl Acad Sci U S A (2003) 1.55
Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells. Mol Biol Cell (2002) 1.54
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The clathrin adaptor AP-1A mediates basolateral polarity. Dev Cell (2012) 1.47
The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells. Proc Natl Acad Sci U S A (2007) 1.45
Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia. Crit Care Med (2012) 1.45
Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia. Proc Natl Acad Sci U S A (2005) 1.44
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Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation. J Biol Chem (2007) 1.42
Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly. J Cell Biol (2011) 1.41
LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling. Proc Natl Acad Sci U S A (2010) 1.40
Roles of AP-2 in clathrin-mediated endocytosis. PLoS One (2010) 1.40
The length of vesicular stomatitis virus particles dictates a need for actin assembly during clathrin-dependent endocytosis. PLoS Pathog (2010) 1.40
Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model. J Neurosci (2009) 1.39
Complement Factor B Production in Renal Tubular Cells and Its Role in Sodium Transporter Expression During Polymicrobial Sepsis. Crit Care Med (2016) 1.39
An ACAP1-containing clathrin coat complex for endocytic recycling. J Cell Biol (2007) 1.38
Enantioselective synthesis of (+)-cortistatin a, a potent and selective inhibitor of endothelial cell proliferation. J Am Chem Soc (2008) 1.38
The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes. J Biol Chem (2005) 1.37
Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice. Infect Immun (2005) 1.36
An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently. Mol Cancer Ther (2009) 1.36
Antibody to AP1B adaptor blocks biosynthetic and recycling routes of basolateral proteins at recycling endosomes. Mol Biol Cell (2007) 1.35
Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell (2012) 1.34
Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs. Structure (2007) 1.34
MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene. J Biol Chem (2012) 1.33
Cholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways. Mol Biol Cell (2004) 1.32
Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis. Cell Microbiol (2007) 1.32
Bmi-1 expression predicts prognosis for patients with gastric carcinoma. J Surg Oncol (2008) 1.31
Natural products reveal cancer cell dependence on oxysterol-binding proteins. Nat Chem Biol (2011) 1.31
ALK status testing in non-small cell lung carcinoma: correlation between ultrasensitive IHC and FISH. J Mol Diagn (2013) 1.30
Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men. Hum Genet (2005) 1.30
Golgi vesicle proteins are linked to the assembly of an actin complex defined by mAbp1. Mol Biol Cell (2002) 1.29
Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration. J Cell Biol (2011) 1.28
Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells. EMBO Rep (2004) 1.28
Kinetic studies of the Arf activator Arno on model membranes in the presence of Arf effectors suggest control by a positive feedback loop. J Biol Chem (2010) 1.28
Regulating cytoskeleton-based vesicle motility. FEBS Lett (2007) 1.28
Mammalian cells change volume during mitosis. PLoS One (2008) 1.28
The basolateral targeting signal of CD147 (EMMPRIN) consists of a single leucine and is not recognized by retinal pigment epithelium. Mol Biol Cell (2004) 1.27
Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity. Neurochem Int (2009) 1.27
Enantioselective synthesis of the central ring system of lomaiviticin A in the form of an unusually stable cyclic hydrate. Angew Chem Int Ed Engl (2008) 1.27
The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites. Traffic (2002) 1.27
The transcription factor NFAT3 mediates neuronal survival. J Biol Chem (2004) 1.27