Published in J Biotechnol on January 18, 2008
Genome shuffling to improve thermotolerance, ethanol tolerance and ethanol productivity of Saccharomyces cerevisiae. J Ind Microbiol Biotechnol (2008) 1.23
A genome shuffling-generated Saccharomyces cerevisiae isolate that ferments xylose and glucose to produce high levels of ethanol. J Ind Microbiol Biotechnol (2012) 0.82
Genome shuffling of Bacillus amyloliquefaciens for improving antimicrobial lipopeptide production and an analysis of relative gene expression using FQ RT-PCR. J Ind Microbiol Biotechnol (2012) 0.80
Simultaneously improving xylose fermentation and tolerance to lignocellulosic inhibitors through evolutionary engineering of recombinant Saccharomyces cerevisiae harbouring xylose isomerase. BMC Biotechnol (2014) 0.80
Betaine and beet molasses enhance L-lactic acid production by Bacillus coagulans. PLoS One (2014) 0.78
Xylose-fermenting Pichia stipitis by genome shuffling for improved ethanol production. Microb Biotechnol (2014) 0.78
Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies. J Ind Microbiol Biotechnol (2014) 0.76
Protoplast formation and regeneration in Lactobacillus delbrueckii. Indian J Microbiol (2010) 0.75
Intraspecific protoplast fusion of Brettanomyces anomalus for improved production of an extracellular β-glucosidase. Biotechnol Biotechnol Equip (2014) 0.75
Engineered biosynthesis of biodegradable polymers. J Ind Microbiol Biotechnol (2016) 0.75
Genome shuffling of Colletotrichum lini for improving 3β,7α,15α-trihydroxy-5-androsten-17-one production from dehydroepiandrosterone. J Ind Microbiol Biotechnol (2017) 0.75
Multidimensional drug profiling by automated microscopy. Science (2004) 5.45
A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. N Engl J Med (2007) 5.39
Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol (2007) 3.17
Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinib. Mol Cancer Ther (2010) 2.78
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest (2009) 2.52
Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am J Clin Nutr (2006) 2.52
Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. Proc Natl Acad Sci U S A (2006) 2.26
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. Nat Cell Biol (2011) 2.25
Critical regulation of CD4+ T cell survival and autoimmunity by beta-arrestin 1. Nat Immunol (2007) 2.15
Microsurgical treatment of symptomatic sacral perineurial cysts. Neurosurgery (2007) 2.13
CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice. Cancer Res (2003) 2.00
Human VPS34 and p150 are Rab7 interacting partners. Traffic (2003) 1.86
Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis. Crit Care Med (2010) 1.84
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. Nat Chem Biol (2005) 1.84
GM-CSF in the lung protects against lethal influenza infection. Am J Respir Crit Care Med (2011) 1.83
The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing. EMBO Rep (2004) 1.82
Elevated CO2 induces physiological, biochemical and structural changes in leaves of Arabidopsis thaliana. New Phytol (2006) 1.80
Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer. Mol Cancer (2011) 1.75
Downregulation of LRIG2 expression by RNA interference inhibits glioblastoma cell (GL15) growth, causes cell cycle redistribution, increases cell apoptosis and enhances cell adhesion and invasion in vitro. Cancer Biol Ther (2009) 1.60
Hepatocellular carcinoma associated with liver-gender disruption in male mice. Cancer Res (2007) 1.56
Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats. J Clin Invest (2008) 1.53
Metagenomic analyses of alcohol induced pathogenic alterations in the intestinal microbiome and the effect of Lactobacillus rhamnosus GG treatment. PLoS One (2013) 1.48
Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia. Crit Care Med (2012) 1.45
Importance of Toll-like receptor 2 in mitochondrial dysfunction during polymicrobial sepsis. Anesthesiology (2014) 1.43
Human cerebrospinal fluid regulates proliferation and migration of stem cells through insulin-like growth factor-1. Stem Cells Dev (2015) 1.42
LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling. Proc Natl Acad Sci U S A (2010) 1.40
Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model. J Neurosci (2009) 1.39
Complement Factor B Production in Renal Tubular Cells and Its Role in Sodium Transporter Expression During Polymicrobial Sepsis. Crit Care Med (2016) 1.39
Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice. Infect Immun (2005) 1.36
MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene. J Biol Chem (2012) 1.33
Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis. Cell Microbiol (2007) 1.32
Bmi-1 expression predicts prognosis for patients with gastric carcinoma. J Surg Oncol (2008) 1.31
ALK status testing in non-small cell lung carcinoma: correlation between ultrasensitive IHC and FISH. J Mol Diagn (2013) 1.30
Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men. Hum Genet (2005) 1.30
Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity. Neurochem Int (2009) 1.27
Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. J Biol Chem (2011) 1.27
MiR-410 regulates MET to influence the proliferation and invasion of glioma. Int J Biochem Cell Biol (2012) 1.22
A highly efficient synthetic vector: nonhydrodynamic delivery of DNA to hepatocyte nuclei in vivo. ACS Nano (2013) 1.22
Campylobacter jejuni type VI secretion system: roles in adaptation to deoxycholic acid, host cell adherence, invasion, and in vivo colonization. PLoS One (2012) 1.21
Concurrent Helicobacter bilis infection in C57BL/6 mice attenuates proinflammatory H. pylori-induced gastric pathology. Infect Immun (2009) 1.20
The type of dietary fat modulates intestinal tight junction integrity, gut permeability, and hepatic toll-like receptor expression in a mouse model of alcoholic liver disease. Alcohol Clin Exp Res (2011) 1.17
Downregulation of BMI-1 enhances 5-fluorouracil-induced apoptosis in nasopharyngeal carcinoma cells. Biochem Biophys Res Commun (2008) 1.16
miR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2. Eur J Cancer (2012) 1.14
Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival. Clin Cancer Res (2007) 1.13
Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. J Biol Chem (2012) 1.12
MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma. Cancer Res (2011) 1.09
Prevalence of dementia and major dementia subtypes in the Chinese populations: a meta-analysis of dementia prevalence surveys, 1980-2010. J Clin Neurosci (2012) 1.09
Helicobacter bilis-associated hepatitis in outbred mice. Comp Med (2004) 1.09
The utility and limitations of neurosphere assay, CD133 immunophenotyping and side population assay in glioma stem cell research. Brain Pathol (2010) 1.08
Multifunctional nanoparticles co-delivering Trp2 peptide and CpG adjuvant induce potent cytotoxic T-lymphocyte response against melanoma and its lung metastasis. J Control Release (2013) 1.08
Identification of a critical site in Wld(s): essential for Nmnat enzyme activity and axon-protective function. Neurosci Lett (2006) 1.08
The prevalence of mild cognitive impairment about elderly population in China: a meta-analysis. Int J Geriatr Psychiatry (2010) 1.08
Patterns of retropharyngeal node metastasis in nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys (2008) 1.07
Lipid-coated Cisplatin nanoparticles induce neighboring effect and exhibit enhanced anticancer efficacy. ACS Nano (2013) 1.07
Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia. Am J Obstet Gynecol (2006) 1.06
Expression of 15-PGDH is downregulated by COX-2 in gastric cancer. Carcinogenesis (2008) 1.05
Disruption of actin filaments by latrunculin B affects cell wall construction in Picea meyeri pollen tube by disturbing vesicle trafficking. Plant Cell Physiol (2006) 1.05
MicroRNA-187, down-regulated in clear cell renal cell carcinoma and associated with lower survival, inhibits cell growth and migration though targeting B7-H3. Biochem Biophys Res Commun (2013) 1.04
Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1. Structure (2004) 1.04
Single endemic genotype of measles virus continuously circulating in China for at least 16 years. PLoS One (2012) 1.03
Acute kidney injury predicts outcomes of non-critically ill patients. Mayo Clin Proc (2009) 1.03
Role of transcription factor NFAT in glucose and insulin homeostasis. Mol Cell Biol (2006) 1.02
PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling. Chem Biol (2013) 1.02
Quantitative MR phase-corrected imaging to investigate increased brain iron deposition of patients with Alzheimer disease. Radiology (2009) 1.02
siRNA and shRNA screens advance key understanding of host factors required for HIV-1 replication. Retrovirology (2009) 1.01
O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. Bioorg Med Chem Lett (2009) 1.01
Role of extracellular RNA and TLR3-Trif signaling in myocardial ischemia-reperfusion injury. J Am Heart Assoc (2014) 1.01
A support vector machine classifier for recognizing mitotic subphases using high-content screening data. J Biomol Screen (2007) 1.01
Patterns of level II node metastasis in nasopharyngeal carcinoma. Radiother Oncol (2008) 1.00
Gene therapy for human colorectal carcinoma using human CEA promoter contro led bacterial ADP-ribosylating toxin genes human CEA: PEA & DTA gene transfer. World J Gastroenterol (1998) 1.00
Nanoparticle delivery of pooled siRNA for effective treatment of non-small cell lung cancer. Mol Pharm (2012) 1.00
Coinfection with Enterohepatic Helicobacter species can ameliorate or promote Helicobacter pylori-induced gastric pathology in C57BL/6 mice. Infect Immun (2011) 1.00
MiR-139 inhibits Mcl-1 expression and potentiates TMZ-induced apoptosis in glioma. CNS Neurosci Ther (2013) 1.00
Biosynthesis and characterization of a novel genetically engineered polymer for targeted gene transfer to cancer cells. J Control Release (2009) 1.00
Discovery of potent non-urea inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett (2008) 0.99
Upregulation of LRIG1 suppresses malignant glioma cell growth by attenuating EGFR activity. J Neurooncol (2009) 0.99
A naturally occurring rabbit model of enterohemorrhagic Escherichia coli-induced disease. J Infect Dis (2002) 0.98
Californium-252 brachytherapy combined with external-beam radiotherapy for cervical cancer: long-term treatment results. Int J Radiat Oncol Biol Phys (2011) 0.98
Expression of HAb18G is associated with tumor progression and prognosis of breast carcinoma. Breast Cancer Res Treat (2010) 0.97
Nanoparticle-delivered transforming growth factor-β siRNA enhances vaccination against advanced melanoma by modifying tumor microenvironment. ACS Nano (2014) 0.97
Renal injury is a consistent finding in Dutch Belted rabbits experimentally infected with enterohemorrhagic Escherichia coli. J Infect Dis (2006) 0.97
Olefin-dependent discrimination between two nonheme HO-FeV=O tautomeric species in catalytic H2O2 epoxidations. Chemistry (2009) 0.97
Azaborine compounds for organic field-effect transistors: efficient synthesis, remarkable stability, and BN dipole interactions. Angew Chem Int Ed Engl (2013) 0.96
Identification of RET gene fusion by exon array analyses in "pan-negative" lung cancer from never smokers. Cell Res (2012) 0.96
Endothelial glucocorticoid receptor is required for protection against sepsis. Proc Natl Acad Sci U S A (2012) 0.96
Utility of sparse concentration sampling for citalopram in elderly clinical trial subjects. J Clin Pharmacol (2004) 0.96
Identification of residues in the receptor-binding domain (RBD) of the spike protein of human coronavirus NL63 that are critical for the RBD-ACE2 receptor interaction. J Gen Virol (2008) 0.96
Enhanced enzyme kinetic stability by increasing rigidity within the active site. J Biol Chem (2014) 0.96
Identification and characterization of cold-responsive microRNAs in tea plant (Camellia sinensis) and their targets using high-throughput sequencing and degradome analysis. BMC Plant Biol (2014) 0.96
Curcumin suppresses malignant glioma cells growth and induces apoptosis by inhibition of SHH/GLI1 signaling pathway in vitro and vivo. CNS Neurosci Ther (2013) 0.95
Interaction and functional analyses of human VPS34/p150 phosphatidylinositol 3-kinase complex with Rab7. Methods Enzymol (2005) 0.95
Evaluation of the effect of vector architecture on DNA condensation and gene transfer efficiency. J Control Release (2008) 0.95
Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase- and soluble guanylate cyclase-dependent mechanisms. Anesthesiology (2011) 0.94