The zinc dyshomeostasis hypothesis of Alzheimer's disease.

Integrating pathways of Parkinson's disease in a molecular interaction map. Mol Neurobiol (2013) 1.34

Computational opportunities for remote collaboration and capacity building afforded by Web 2.0 and cloud computing. Biophys Rev (2012) 1.06

Oxidant/Antioxidant imbalance and the risk of Alzheimer's disease. Curr Alzheimer Res (2015) 0.92

Computational predictions of volatile anesthetic interactions with the microtubule cytoskeleton: implications for side effects of general anesthesia. PLoS One (2012) 0.86

How quantum brain biology can rescue conscious free will. Front Integr Neurosci (2012) 0.85

Zinc-induced self-association of complement C3b and Factor H: implications for inflammation and age-related macular degeneration. J Biol Chem (2013) 0.82

Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION. J Biol Chem (2015) 0.82

Nutrition and the risk of Alzheimer's disease. Biomed Res Int (2013) 0.82

Importance and management of micronutrient deficiencies in patients with Alzheimer's disease. Clin Interv Aging (2013) 0.81

Role of environmental contaminants in the etiology of Alzheimer's disease: a review. Curr Alzheimer Res (2015) 0.80

PrP overdrive: does inhibition of α-cleavage contribute to PrP(C) toxicity and prion disease? Prion (2014) 0.80

Spatial memory deficits in a mouse model of late-onset Alzheimer's disease are caused by zinc supplementation and correlate with amyloid-beta levels. Front Aging Neurosci (2014) 0.80

Alzheimer's Disease: Mechanism and Approach to Cell Therapy. Int J Mol Sci (2015) 0.79

Systems biology of complex symptom profiles: capturing interactivity across behavior, brain and immune regulation. Brain Behav Immun (2012) 0.79

Dyshomeostasis, obesity, addiction and chronic stress. Health Psychol Open (2016) 0.78

Iron is a specific cofactor for distinct oxidation- and aggregation-dependent Aβ toxicity mechanisms in a Drosophila model. Dis Model Mech (2015) 0.78

Relationship between Zinc (Zn (2+) ) and Glutamate Receptors in the Processes Underlying Neurodegeneration. Neural Plast (2015) 0.78

In vitro study on the alterations of brain tubulin structure and assembly affected by magnetite nanoparticles. J Biol Inorg Chem (2013) 0.77

Antidepressant Use in the Elderly Is Associated With an Increased Risk of Dementia. Alzheimer Dis Assoc Disord (2016) 0.77

Zinc proteome interaction network as a model to identify nutrient-affected pathways in human pathologies. Genes Nutr (2014) 0.76

Altered transition metal homeostasis in Niemann-Pick disease, type C1. Metallomics (2013) 0.76

Obesity and age-related alterations in the gene expression of zinc-transporter proteins in the human brain. Transl Psychiatry (2016) 0.76

The Kinetic Response of the Proteome in A549 Cells Exposed to ZnSO4 Stress. PLoS One (2015) 0.75

Early and Late Pathomechanisms in Alzheimer's Disease: From Zinc to Amyloid-β Neurotoxicity. Neurochem Res (2016) 0.75

The tachykinin peptide neurokinin B binds copper forming an unusual [CuII(NKB)2] complex and inhibits copper uptake into 1321N1 astrocytoma cells. ACS Chem Neurosci (2013) 0.75

The Impact of Mathematical Modeling in Understanding the Mechanisms Underlying Neurodegeneration: Evolving Dimensions and Future Directions. CPT Pharmacometrics Syst Pharmacol (2017) 0.75

Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer's Disease. J Alzheimers Dis (2017) 0.75

Oxidative species-induced excitonic transport in tubulin aromatic networks: Potential implications for neurodegenerative disease. J Photochem Photobiol B (2017) 0.75

The Protein Data Bank: a computer-based archival file for macromolecular structures. J Mol Biol (1977) 90.57

Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol (1993) 64.61

Scalable molecular dynamics with NAMD. J Comput Chem (2005) 59.49

Electrostatics of nanosystems: application to microtubules and the ribosome. Proc Natl Acad Sci U S A (2001) 42.14

Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science (1996) 19.72

PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations. Nucleic Acids Res (2004) 11.53

Structure of the alpha beta tubulin dimer by electron crystallography. Nature (1998) 11.07

Very fast empirical prediction and rationalization of protein pKa values. Proteins (2005) 8.61

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell (2005) 8.40

Refined structure of alpha beta-tubulin at 3.5 A resolution. J Mol Biol (2001) 7.08

PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations. Nucleic Acids Res (2007) 7.07

Rapid induction of Alzheimer A beta amyloid formation by zinc. Science (1994) 5.34

The neurobiology of zinc in health and disease. Nat Rev Neurosci (2005) 5.07

Differential regulation of dynein and kinesin motor proteins by tau. Science (2008) 4.29

Microtubule-based transport systems in neurons: the roles of kinesins and dyneins. Annu Rev Neurosci (2000) 3.48

Microtubule structure at 8 A resolution. Structure (2002) 3.41

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J Biol Chem (2010) 3.16

The MAP2/Tau family of microtubule-associated proteins. Genome Biol (2004) 2.80

Zn(2+): a novel ionic mediator of neural injury in brain disease. Trends Pharmacol Sci (2000) 2.34

Transcranial pulsed ultrasound stimulates intact brain circuits. Neuron (2010) 2.33

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron (2008) 2.30

A gene expression profile of Alzheimer's disease. DNA Cell Biol (2001) 2.16

Repeat motifs of tau bind to the insides of microtubules in the absence of taxol. EMBO J (2003) 2.07

Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1. J Neurosci (2007) 1.82

Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function. Prog Neurobiol (2000) 1.76

Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease? J Neurosci (2010) 1.74

Focused ultrasound modulates region-specific brain activity. Neuroimage (2011) 1.68

Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. Am J Pathol (2003) 1.66

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. Am J Pathol (2003) 1.64

The MAP1 family of microtubule-associated proteins. Genome Biol (2006) 1.60

Therapeutics for Alzheimer's disease based on the metal hypothesis. Neurotherapeutics (2008) 1.58

PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. J Alzheimers Dis (2010) 1.57

Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability. Pharmacol Ther (2006) 1.50

Molecular motors in neuronal development, intracellular transport and diseases. Curr Opin Neurobiol (2004) 1.48

The physical basis of microtubule structure and stability. Protein Sci (2003) 1.43

Molecular characterization of microtubule-associated proteins tau and MAP2. Trends Neurosci (1991) 1.43

Memory-specific temporal profiles of gene expression in the hippocampus. Proc Natl Acad Sci U S A (2002) 1.38

mTOR-dependent signalling in Alzheimer's disease. J Cell Mol Med (2008) 1.29

Successful molecular dynamics simulation of two zinc complexes bridged by a hydroxide in phosphotriesterase using the cationic dummy atom method. Proteins (2001) 1.28

Tau-focused immunotherapy for Alzheimer's disease and related tauopathies. Curr Alzheimer Res (2009) 1.26

Successful molecular dynamics simulation of the zinc-bound farnesyltransferase using the cationic dummy atom approach. Protein Sci (2000) 1.26

Quantum computation in brain microtubules: decoherence and biological feasibility. Phys Rev E Stat Nonlin Soft Matter Phys (2002) 1.25

Robust recognition of zinc binding sites in proteins. Protein Sci (2007) 1.23

Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau. J Biol Chem (2007) 1.16

The possible involvement of brain microtubules in memory fixation. J Exp Biol (1974) 1.16

Microtubule-associated protein 1B, a growth-associated and phosphorylated scaffold protein. Brain Res Bull (2006) 1.13

Zinc and disease of the brain. Mol Neurobiol (2002) 1.12

LIMK1 and CLIP-115: linking cytoskeletal defects to Williams syndrome. Bioessays (2004) 1.11

Deletion of the N-terminus of murine map2 by gene targeting disrupts hippocampal ca1 neuron architecture and alters contextual memory. Neuroscience (2003) 1.09

Microtubule-associated protein 1B function during normal development, regeneration, and pathological conditions in the nervous system. J Neurobiol (2004) 1.09

Prediction of zinc-binding sites in proteins from sequence. Bioinformatics (2008) 1.08

Low micromolar zinc accelerates the fibrillization of human tau via bridging of Cys-291 and Cys-322. J Biol Chem (2009) 1.08

A chemical kinetics model for microtubule oscillations J Theor Biol (1999) 1.06

Altered expression of MAP-2, GAP-43, and synaptophysin in the hippocampus of rats with chronic cerebral hypoperfusion correlates with cognitive impairment. Brain Res Mol Brain Res (2005) 1.06

Phosphorylation of tubulin by a calmodulin-dependent protein kinase. J Biol Chem (1986) 1.06

Facilitate insight by non-invasive brain stimulation. PLoS One (2011) 1.06

Isolation rearing induces recognition memory deficits accompanied by cytoskeletal alterations in rat hippocampus. Eur J Neurosci (2006) 1.05

Tau induces cooperative Taxol binding to microtubules. Proc Natl Acad Sci U S A (2004) 1.05

Cytoskeletal signaling: is memory encoded in microtubule lattices by CaMKII phosphorylation? PLoS Comput Biol (2012) 1.03

Conduction pathways in microtubules, biological quantum computation, and consciousness. Biosystems (2002) 1.00

Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells. J Neurochem (2005) 0.99

p70 S6 kinase and tau in Alzheimer's disease. J Alzheimers Dis (2008) 0.99

Damaged microtubules can inactivate BCL-2 by means of the mTOR kinase. Oncogene (2001) 0.99

The immunosuppressant rapamycin exacerbates neurotoxicity of Abeta peptide. J Neurosci Res (2006) 0.94

Solution structure of GDP-tubulin double rings to 3 nm resolution and comparison with microtubules. J Mol Biol (1994) 0.92

CaM kinase II in long-term potentiation. Neurochem Int (1996) 0.92

Temperature dependence of the nucleation constant rate in beta amyloid fibrillogenesis. Int J Biol Macromol (2005) 0.92

A quantitative study of frontal cortex dendritic microtubules in patients with Alzheimer's disease. Brain Res (1987) 0.91

Cerebral developmental disorders. Curr Opin Pediatr (2006) 0.91

Hippocampal microtubule-associated protein-2 alterations with contextual memory. Brain Res (1999) 0.91

Information processing in microtubules. J Theor Biol (1982) 0.91

Microtubule-associated proteins (MAPs) in the peripheral nervous system during development and regeneration. J Mol Neurosci (1997) 0.91

Transcranial magnetic stimulation in the management of mood disorders. Neuropsychobiology (2011) 0.90

Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold. Mol Neurodegener (2011) 0.89

Structural diversity and dynamics of microtubules and polymorphic tubulin assemblies. Electron Microsc Rev (1990) 0.88

Hippocampal protein-protein interactions in spatial memory. Hippocampus (2004) 0.88

Zinc-stimulated microtubule assembly and evidence for zinc binding to tubulin. Int J Biochem (1982) 0.87

Apical vulnerability to dendritic retraction in prefrontal neurones of ageing SAMP10 mouse: a model of cerebral degeneration. Neuropathol Appl Neurobiol (2006) 0.86

A structural basis for memory storage in mammals. Prog Neurobiol (1998) 0.86

Impaired hippocampal long-term potentiation in microtubule-associated protein 1B-deficient mice. J Neurosci Res (2005) 0.85

The "conscious pilot"-dendritic synchrony moves through the brain to mediate consciousness. J Biol Phys (2010) 0.85

Thermodynamics of tubulin polymerization into zinc sheets: assembly is not regulated by GTP hydrolysis. Biochemistry (1993) 0.84

Effects of marginal zinc deficiency on microtubule polymerization in the developing rat brain. Biol Trace Elem Res (1990) 0.84

Increased expression of dendritic mRNA following the induction of long-term potentiation. Brain Res Mol Brain Res (1998) 0.84

Tubulin assembly in the presence of calcium ions and taxol: microtubule bundling and formation of macrotubule-ring complexes. Cell Motil Cytoskeleton (1997) 0.84

Zinc stimulates tau S214 phosphorylation by the activation of Raf/mitogen-activated protein kinase-kinase/extracellular signal-regulated kinase pathway. Neuroreport (2011) 0.83

Neuropil threads are collinear with MAP2 immunostaining in neuronal dendrites of Alzheimer brain. J Neuropathol Exp Neurol (1998) 0.82

Influence of maternal dietary zinc intake on in vitro tubulin polymerization in fetal rat brain. Teratology (1990) 0.82

Abnormal tubulin aggregates induced by zinc sulfate in organotypic cultures of nerve tissue. Neuroscience (1978) 0.81

"Memory bytes" - molecular match for CaMKII phosphorylation encoding of microtubule lattices. J Integr Neurosci (2010) 0.80

Microtubule assembly in rat brain extracts. Further characterization of the effects of zinc on assembly and cold stability. Int J Biochem (1984) 0.80

Pavlovian conditioning alters cortical microtubule-associated protein-2. Neuroreport (1994) 0.79

[Mechanism of impairment to microtubule polymerization resulting from zinc deficiency during pregnancy and lactation in mice]. Wei Sheng Yan Jiu (2000) 0.79

Information processing mechanisms in microtubules at physiological temperature: Model predictions for experimental tests. Biosystems (2009) 0.79

In vitro microtubule assembly regulation by divalent cations and nucleotides. Biochemistry (1981) 0.78

Cholinoceptive cells in rat cerebral cortex: somatodendritic immunoreactivity for muscarinic receptor and cytoskeletal proteins. J Chem Neuroanat (1994) 0.78

Passive avoidance training induces enhanced levels of immunoreactivity for muscarinic acetylcholine receptor and coexpressed PKC gamma and MAP-2 in rat cortical neurons. Cereb Cortex (1994) 0.78

Zinc binding to tubulin. Int J Biochem (1983) 0.76

Effects of zinc on the cytoskeletal proteins in the central nervous system of the rat. Brain Res (1981) 0.76

Small amounts of zinc stimulate rapid axonal transport in vitro. Brain Res (1975) 0.76

Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med (2008) 19.71

Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet (2007) 14.05

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet (2007) 12.13

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet (2008) 6.71

Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med (2012) 6.27

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci U S A (2003) 5.44

The spectrum of disease in chronic traumatic encephalopathy. Brain (2012) 5.10

The genetics of Alzheimer disease: back to the future. Neuron (2010) 4.91

Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet (2008) 4.66

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nat Rev Neurosci (2008) 4.64

Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med (2005) 4.34

Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet (2012) 4.27

Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron (2007) 3.98

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol (2003) 3.58

Clinical presentation of chronic traumatic encephalopathy. Neurology (2013) 3.53

Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron (2013) 3.43

Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. Am J Pathol (2004) 3.24

Results of a high-resolution genome screen of 437 Alzheimer's disease families. Hum Mol Genet (2003) 3.00

Alzheimer's disease: the cholesterol connection. Nat Neurosci (2003) 2.99

The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide. PLoS One (2010) 2.78

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science (2011) 2.66

The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo. Ann Neurol (2008) 2.54

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell (2010) 2.46

The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. J Neurosci (2007) 2.42

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron (2008) 2.30

The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology (2006) 2.26

Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron (2010) 2.20

Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08

The genetic epidemiology of neurodegenerative disease. J Clin Invest (2005) 2.08

Review and application of group theory to molecular systems biology. Theor Biol Med Model (2011) 2.00

An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. J Biol Chem (2002) 2.00

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2). J Biol Chem (2002) 1.99

Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease. Lancet (2003) 1.91

The effects of isoflurane and desflurane on cognitive function in humans. Anesth Analg (2011) 1.88

Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. J Gerontol A Biol Sci Med Sci (2006) 1.83

Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol (2012) 1.76

Genome-wide association studies in Alzheimer's disease. Hum Mol Genet (2009) 1.70

The synaptic Abeta hypothesis of Alzheimer disease. Nat Neurosci (2005) 1.68

The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β. Neurobiol Aging (2010) 1.62

Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia. Arch Neurol (2008) 1.60

Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. J Neurosci (2010) 1.58

Therapeutics for Alzheimer's disease based on the metal hypothesis. Neurotherapeutics (2008) 1.58

PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses. J Alzheimers Dis (2010) 1.57

The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels. Arch Neurol (2009) 1.56

The current status of Alzheimer's disease genetics: what do we tell the patients? Pharmacol Res (2004) 1.53

BACE is degraded via the lysosomal pathway. J Biol Chem (2005) 1.53

Alzheimer's disease: one disorder, too many genes? Hum Mol Genet (2004) 1.48

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. Hum Mol Genet (2009) 1.46

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (2013) 1.45

Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. J Neurosci (2008) 1.44

Alzheimer's disease and post-operative cognitive dysfunction. Exp Gerontol (2006) 1.41

Tetra-kis-μ-l-alanine-κO:O'-bis-[tetra-aqua-terbium(III)] hexa-perchlorate. Acta Crystallogr Sect E Struct Rep Online (2010) 1.39

The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions. J Biol Chem (2008) 1.31

No association between CALHM1 and Alzheimer's disease risk. Cell (2008) 1.30

Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Ann N Y Acad Sci (2004) 1.28

The genetics of Alzheimer's disease. Prog Mol Biol Transl Sci (2012) 1.28

Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP). J Biol Chem (2003) 1.26

Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem (2006) 1.26

ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function. Neuron (2013) 1.25

Assessment of Alzheimer's disease case-control associations using family-based methods. Neurogenetics (2008) 1.23

Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome. PLoS One (2010) 1.23

An AICD-based functional screen to identify APP metabolism regulators. Mol Neurodegener (2007) 1.22

Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. J Biol Chem (2007) 1.22

2-[(E)-(4-Chlorophenyl)methyleneamino]-N-(X-methylphenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, where X = 2 and 3. Acta Crystallogr C (2004) 1.21

Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides. J Biol Inorg Chem (2004) 1.21

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. J Alzheimers Dis (2010) 1.19

The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels. Arch Gen Psychiatry (2011) 1.16

Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease. Hum Mol Genet (2007) 1.16

Analytic theories of allometric scaling. J Exp Biol (2011) 1.14

Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer disease. Alzheimer Dis Assoc Disord (2010) 1.14

Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein. J Biol Chem (2010) 1.14

GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results. Arch Neurol (2009) 1.13

Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection. Proc Natl Acad Sci U S A (2003) 1.13

Molecular signaling network complexity is correlated with cancer patient survivability. Proc Natl Acad Sci U S A (2012) 1.13

Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease. Am J Epidemiol (2008) 1.13

Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1. J Biol Chem (2003) 1.12

Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy-Weinberg equilibrium. Eur J Hum Genet (2009) 1.12

TREM2 and neurodegenerative disease. N Engl J Med (2013) 1.12

RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing. J Biol Chem (2005) 1.11

Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects. PLoS One (2011) 1.10

HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. J Biol Chem (2007) 1.09

Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy. Circulation (2010) 1.08

GENETICS. The Human Variome Project. Science (2008) 1.07

Isoflurane decreases self-renewal capacity of rat cultured neural stem cells. Anesthesiology (2011) 1.06

Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples. Am J Hum Genet (2006) 1.06

δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes. PLoS One (2012) 1.05

RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation. J Biol Chem (2006) 1.05

A biopolymer transistor: electrical amplification by microtubules. Biophys J (2006) 1.05

The galvanization of beta-amyloid in Alzheimer's disease. Proc Natl Acad Sci U S A (2002) 1.05

Ethyl 4-(4-chloro-phen-yl)-6-methyl-2-thioxo-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate. Acta Crystallogr Sect E Struct Rep Online (2009) 1.05

Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients. J Biol Chem (2005) 1.04

Cytoskeletal signaling: is memory encoded in microtubule lattices by CaMKII phosphorylation? PLoS Comput Biol (2012) 1.03

Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic (2011) 1.02

Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice. J Biol Chem (2011) 1.01

Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein. J Biol Chem (2010) 1.01

Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Hum Mol Genet (2003) 1.01