Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF.

PubWeight™: 0.85‹?›

🔗 View Article (PMC 3366788)

Published in J Biol Chem on March 30, 2012

Authors

Mu-Shui Dai1, Kishore B Challagundla, Xiao-Xin Sun, Lakshmi Reddy Palam, Shelya X Zeng, Ronald C Wek, Hua Lu

Author Affiliations

1: Department of Biochemistry and Molecular Biology and Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

Articles cited by this

Surfing the p53 network. Nature (2000) 35.36

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell (1992) 16.53

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science (1998) 11.90

The p53-mdm-2 autoregulatory feedback loop. Genes Dev (1993) 11.19

Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev (1998) 9.03

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell (1998) 8.99

mdm2 expression is induced by wild type p53 activity. EMBO J (1993) 8.01

Tumor suppression by Ink4a-Arf: progress and puzzles. Curr Opin Genet Dev (2003) 8.00

Nucleolar Arf sequesters Mdm2 and activates p53. Nat Cell Biol (1999) 5.78

DNA damage induces phosphorylation of the amino terminus of p53. Genes Dev (1997) 5.76

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc Natl Acad Sci U S A (1998) 5.74

Decision making by p53: life, death and cancer. Cell Death Differ (2003) 5.52

Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell (2003) 5.44

p19ARF links the tumour suppressor p53 to Ras. Nature (1998) 4.89

The INK4a/ARF network in tumour suppression. Nat Rev Mol Cell Biol (2001) 4.83

p14ARF links the tumour suppressors RB and p53. Nature (1998) 4.78

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. EMBO J (1999) 4.69

Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol (2003) 4.61

E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev (1998) 4.60

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol (2004) 4.08

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev (2001) 4.06

Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5. J Biol Chem (2004) 4.05

Signaling to p53: ribosomal proteins find their way. Cancer Cell (2009) 3.84

Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature (2000) 3.83

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2. Proc Natl Acad Sci U S A (1999) 3.78

Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation. Mol Cell (2003) 3.42

Inhibition of HDM2 and activation of p53 by ribosomal protein L23. Mol Cell Biol (2004) 3.31

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction. Nat Cell Biol (2009) 2.97

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Mol Cell (1999) 2.93

Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene (2007) 2.68

Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation. EMBO J (2004) 2.59

Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing. Mol Cell (2003) 2.54

Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. Mol Cell (2008) 2.46

Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell (2005) 2.46

Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2. Mol Cell Biol (2008) 2.45

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex. Mol Cell Biol (2000) 2.34

Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo. Oncogene (2001) 2.14

5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction. J Biol Chem (2007) 2.13

Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation. J Biol Chem (2011) 2.12

Control of p53 ubiquitination and nuclear export by MDM2 and ARF. Cell Growth Differ (2001) 2.05

Ribosomal protein S7 is both a regulator and a substrate of MDM2. Mol Cell (2009) 2.00

An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction. Cancer Cell (2010) 1.91

p53 website and analysis of p53 gene mutations in human cancer: forging a link between epidemiology and carcinogenesis. Hum Mutat (2000) 1.86

Inhibition of c-Myc activity by ribosomal protein L11. EMBO J (2007) 1.78

Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation. Mol Cell Biol (2006) 1.76

The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53? Bioessays (1993) 1.70

Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation. EMBO J (2001) 1.69

Mycophenolic acid activation of p53 requires ribosomal proteins L5 and L11. J Biol Chem (2008) 1.65

Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism. J Biol Chem (2006) 1.62

Conventional and nonconventional roles of the nucleolus. Int Rev Cytol (2002) 1.43

Ribosomal protein S27L is a direct p53 target that regulates apoptosis. Oncogene (2006) 1.28

Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26. Nucleic Acids Res (2010) 1.21

Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines. Cancer Genet Cytogenet (2002) 1.20

Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation. J Biol Chem (2010) 1.18

Human tumor suppressor p14ARF negatively regulates rRNA transcription and inhibits UBF1 transcription factor phosphorylation. Oncogene (2006) 1.14

The nucleolus and transcription of ribosomal genes. Biol Cell (2004) 1.13

The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I. Mol Cell (2010) 1.13

Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene. Cell Death Differ (2005) 1.11

Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator. Oncogene (2010) 1.09

Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress. J Biol Chem (2011) 1.06

Multiple interacting domains contribute to p14ARF mediated inhibition of MDM2. Oncogene (2002) 1.01

A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function. Mol Cell Biol (2007) 1.00

Hydrophilic residues are crucial for ribosomal protein L11 (RPL11) interaction with zinc finger domain of MDM2 and p53 protein activation. J Biol Chem (2011) 0.89

RNA polymerase III transcription is repressed in response to the tumour suppressor ARF. Nucleic Acids Res (2007) 0.84

Articles by these authors

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci U S A (2004) 7.03

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol (2004) 4.08

Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5. J Biol Chem (2004) 4.05

Signaling to p53: ribosomal proteins find their way. Cancer Cell (2009) 3.84

Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Neuron (2003) 3.62

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol (2004) 3.57

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol (2002) 3.22

Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Mol Cell Biol (2003) 3.01

Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition. J Biol Chem (2005) 2.53

Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science (2005) 2.51

Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2. Mol Cell Biol (2008) 2.45

Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism. Adv Nutr (2012) 2.27

Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions. J Biol Chem (2008) 2.25

Ceramides modulate programmed cell death in plants. Genes Dev (2003) 2.22

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress. J Biol Chem (2002) 2.16

5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction. J Biol Chem (2007) 2.13

MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation. EMBO J (2003) 2.13

Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation. J Biol Chem (2011) 2.12

Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. J Biol Chem (2004) 2.00

Inhibition of c-Myc activity by ribosomal protein L11. EMBO J (2007) 1.78

Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer. J Cell Biochem (2008) 1.77

A systematic review of the management of hangman's fractures. Eur Spine J (2005) 1.74

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress. Mol Biol Cell (2011) 1.73

Nucleophosmin is essential for ribosomal protein L5 nuclear export. Mol Cell Biol (2006) 1.72

Mycophenolic acid activation of p53 requires ribosomal proteins L5 and L11. J Biol Chem (2008) 1.65

Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p. J Biol Chem (2009) 1.64

Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism. J Biol Chem (2006) 1.62

Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response. J Biol Chem (2010) 1.51

Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity. Diabetes (2004) 1.50

GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation. Biochem J (2005) 1.48

Prescription pattern and its influencing factors in Chinese county hospitals: a retrospective cross-sectional study. PLoS One (2013) 1.46

A plasmodesmata-localized protein mediates crosstalk between cell-to-cell communication and innate immunity in Arabidopsis. Plant Cell (2011) 1.45

DNA Methyltransferase protein synthesis is reduced in CXXC finger protein 1-deficient embryonic stem cells. DNA Cell Biol (2009) 1.44

Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2alpha phosphorylation and translation of a small upstream open reading frame. J Biol Chem (2001) 1.41

14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J (2006) 1.40

The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells. Mol Immunol (2007) 1.39

SSRP1 functions as a co-activator of the transcriptional activator p63. EMBO J (2002) 1.39

Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. EMBO J (2011) 1.38

A key role for ALD1 in activation of local and systemic defenses in Arabidopsis. Plant J (2004) 1.35

Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondii. J Biol Chem (2008) 1.34

Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-Myc. Neoplasia (2006) 1.34

MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2. Mol Cell Biol (2007) 1.33

A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation. Biochem J (2007) 1.32

Vital signs: communication between health professionals and their patients about alcohol use--44 states and the District of Columbia, 2011. MMWR Morb Mortal Wkly Rep (2014) 1.32

Parasite-specific eIF2 (eukaryotic initiation factor-2) kinase required for stress-induced translation control. Biochem J (2004) 1.31

UV Induces p21 rapid turnover independently of ubiquitin and Skp2. J Biol Chem (2006) 1.30

GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase. J Biol Chem (2009) 1.29

Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest. J Biol Chem (2006) 1.29

Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase. J Biol Chem (2006) 1.29

Novel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein−protein interactions. J Am Chem Soc (2011) 1.29

Binge drinking - United States, 2011. MMWR Surveill Summ (2013) 1.28

Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses. Mol Cell Biol (2002) 1.28

The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death. Diabetes (2007) 1.28

p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. J Biol Chem (2002) 1.27

Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice. Biochem J (2006) 1.27

p53 downregulates Down syndrome-associated DYRK1A through miR-1246. EMBO Rep (2011) 1.25

Upregulation of endothelial and inducible nitric oxide synthase expression by reactive oxygen species. Am J Hypertens (2008) 1.25

Divergent roles in Arabidopsis thaliana development and defense of two homologous genes, aberrant growth and death2 and AGD2-LIKE DEFENSE RESPONSE PROTEIN1, encoding novel aminotransferases. Plant Cell (2004) 1.25

Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility. Cell Rep (2012) 1.24

Versatile multi-wavelength ultrafast fiber laser mode-locked by carbon nanotubes. Sci Rep (2013) 1.24

SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection. Neoplasia (2006) 1.24

Multilevel regression and poststratification for small-area estimation of population health outcomes: a case study of chronic obstructive pulmonary disease prevalence using the behavioral risk factor surveillance system. Am J Epidemiol (2014) 1.23

Reactive and bioactive cationic α-helical polypeptide template for nonviral gene delivery. Angew Chem Int Ed Engl (2011) 1.21

Phosphorylation of eukaryotic initiation factor-2{alpha} promotes the extracellular survival of obligate intracellular parasite Toxoplasma gondii. Proc Natl Acad Sci U S A (2010) 1.21

Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions. J Biol Chem (2004) 1.20

Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast. J Biol Chem (2010) 1.20

Plasmodesmata: the battleground against intruders. Trends Plant Sci (2011) 1.20

MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation. J Biol Chem (2002) 1.20

Crosstalk between the circadian clock and innate immunity in Arabidopsis. PLoS Pathog (2013) 1.19

A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53. EMBO Mol Med (2012) 1.18

Methods for analyzing eIF2 kinases and translational control in the unfolded protein response. Methods Enzymol (2011) 1.17

Salicylic acid regulates Plasmodesmata closure during innate immune responses in Arabidopsis. Plant Cell (2013) 1.17

Differential activation of eIF2 kinases in response to cellular stresses in Schizosaccharomyces pombe. Genetics (2004) 1.17

Autoregulatory suppression of c-Myc by miR-185-3p. J Biol Chem (2011) 1.16

Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress. Mol Cell Biol (2011) 1.13

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis. Mol Biol Cell (2013) 1.13

Modeling spatial accessibility to parks: a national study. Int J Health Geogr (2011) 1.12

Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication. PLoS One (2008) 1.10

Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-β to promote proliferation. J Clin Invest (2013) 1.10

Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth. Cancer Biol Ther (2012) 1.09

BAG3 gene silencing sensitizes leukemic cells to Bortezomib-induced apoptosis. FEBS Lett (2008) 1.08

Multiple roles of WIN3 in regulating disease resistance, cell death, and flowering time in Arabidopsis. Plant Physiol (2011) 1.07

Prevalence of Healthy Sleep Duration among Adults - United States, 2014. MMWR Morb Mortal Wkly Rep (2016) 1.07

Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress. J Biol Chem (2011) 1.06

Stress-activated protein kinase pathway functions to support protein synthesis and translational adaptation in response to environmental stress in fission yeast. Eukaryot Cell (2005) 1.04