Published in Immunity on April 12, 2012
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The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling. Oncotarget (2014) 0.85
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Gemifloxacin, a fluoroquinolone antimicrobial drug, inhibits migration and invasion of human colon cancer cells. Biomed Res Int (2013) 0.82
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Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation. Nat Commun (2014) 0.82
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How Mouse Macrophages Sense What Is Going On. Front Immunol (2016) 0.78
Anti-cancer IAP antagonists promote bone metastasis: a cautionary tale. J Bone Miner Metab (2013) 0.78
The expanding spectrum of rare monogenic autoinflammatory diseases. Orphanet J Rare Dis (2013) 0.78
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The inflammasome adaptor ASC contributes to multiple innate immune processes in the resolution of otitis media. Innate Immun (2014) 0.78
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Holding the inflammatory system in check: NLRs keep it cool. F1000Prime Rep (2015) 0.77
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The nod-like receptor, Nlrp12, plays an anti-inflammatory role in experimental autoimmune encephalomyelitis. J Neuroinflammation (2015) 0.77
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NLRP12 provides a critical checkpoint for osteoclast differentiation. Proc Natl Acad Sci U S A (2015) 0.76
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The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis. Nat Commun (2016) 0.76
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The non-canonical NF-κB pathway in immunity and inflammation. Nat Rev Immunol (2017) 0.75
Identification of Key Candidate Genes and Pathways in Colorectal Cancer by Integrated Bioinformatical Analysis. Int J Mol Sci (2017) 0.75
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NLRP12 in autoimmune diseases. Oncotarget (2015) 0.75
Enhanced Mucosal Defense and Reduced Tumor Burden in Mice with the Compromised Negative Regulator IRAK-M. EBioMedicine (2016) 0.75
Flavonoids Extracted from Licorice Prevents Colitis-Associated Carcinogenesis in AOM/DSS Mouse Model. Int J Mol Sci (2016) 0.75
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Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors. Cell Mol Life Sci (2016) 0.75
Targeting inflammasome/IL-1 pathways for cancer immunotherapy. Sci Rep (2016) 0.75
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Inflammasome-independent role of NLRP12 in suppressing colonic inflammation regulated by Blimp-1. Oncotarget (2016) 0.75
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NLRP12 negatively regulates proinflammatory cytokine production and host defense against Brucella abortus. Eur J Immunol (2016) 0.75
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Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell (2005) 18.20
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell (2004) 15.82
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science (2005) 11.31
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Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell (2007) 7.24
Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell (2007) 7.10
NLRX1 is a regulator of mitochondrial antiviral immunity. Nature (2008) 4.55
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NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways. Immunity (2011) 2.29
The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals. J Biol Chem (2005) 2.21
The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell (2011) 2.18
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Mutations in NALP12 cause hereditary periodic fever syndromes. Proc Natl Acad Sci U S A (2008) 2.06
Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation. Sci Signal (2010) 2.05
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Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes. J Immunol (2007) 1.97
A novel NF-kappa B-inducing kinase-MAPK signaling pathway up-regulates NF-kappa B activity in melanoma cells. J Biol Chem (2001) 1.94
The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis. Cancer Res (2008) 1.78
IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. J Immunol (2010) 1.77
Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells. J Immunol (2007) 1.60
Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity. J Immunol (2010) 1.59
A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses. J Biol Chem (2010) 1.55
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The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. J Biol Chem (2011) 1.27
ATP binding by monarch-1/NLRP12 is critical for its inhibitory function. Mol Cell Biol (2007) 1.25
IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway. PLoS One (2010) 1.22
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Adenoviral gene transfer of stromal cell-derived factor-1 to murine tumors induces the accumulation of dendritic cells and suppresses tumor growth. Cancer Res (2006) 1.01
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Animal models of inflammatory bowel disease at the dawn of the new genetics era. PLoS Med (2008) 0.89
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Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol (2011) 6.53
The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity (2009) 6.37
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Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J Immunol (2008) 4.60
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Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC. Cell Host Microbe (2007) 3.52
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Discovery of a viral NLR homolog that inhibits the inflammasome. Science (2011) 2.36
NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways. Immunity (2011) 2.29
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Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways. J Immunol (2006) 1.84
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Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains. Infect Immun (2004) 1.74
NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses. J Immunol (2010) 1.73
Epigenetic regulation of MHC-II and CIITA genes. Trends Immunol (2006) 1.73
In vitro and in vivo characterization of Helicobacter hepaticus cytolethal distending toxin mutants. Infect Immun (2004) 1.72
Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific. Cancer Res (2003) 1.69
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol (2008) 1.68
MAVS-mediated apoptosis and its inhibition by viral proteins. PLoS One (2009) 1.67
Cutting edge: NLRC5-dependent activation of the inflammasome. J Immunol (2010) 1.66
Pumpless extracorporeal lung assist for protective mechanical ventilation in experimental lung injury. Crit Care Med (2007) 1.66
Reduced polyp detection as endoscopy shift progresses: experience with screening colonoscopy at a tertiary-care hospital. J Clin Gastroenterol (2011) 1.66
Criteria for effective design, construction, and gene knockdown by shRNA vectors. BMC Biotechnol (2006) 1.60
Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity. J Immunol (2010) 1.59
STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells. Blood (2004) 1.58
Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice. Cancer Res (2007) 1.58
De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis. J Immunol (2002) 1.58
Differential induction of type I interferon responses in myeloid dendritic cells by mosquito and mammalian-cell-derived alphaviruses. J Virol (2006) 1.57
Dual-association of gnotobiotic IL-10-/- mice with 2 nonpathogenic commensal bacteria induces aggressive pancolitis. Inflamm Bowel Dis (2007) 1.55
Chromosomal clustering of genes controlled by the aire transcription factor. Proc Natl Acad Sci U S A (2005) 1.49
TLR2/MyD88/NF-κB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection. PLoS One (2012) 1.48
IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines. J Biol Chem (2002) 1.48
Monocytic microparticles activate endothelial cells in an IL-1β-dependent manner. Blood (2011) 1.48
Inflammasome inhibition as a pathogenic stealth mechanism. Cell Host Microbe (2010) 1.47
The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat Immunol (2012) 1.45
Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1. PLoS One (2010) 1.44
Regulation of mitochondrial antiviral signaling pathways. Immunity (2008) 1.44