Published in Cell Mol Life Sci on March 31, 2016
Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature (2006) 24.43
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell (2002) 20.11
Cryopyrin activates the inflammasome in response to toxins and ATP. Nature (2006) 18.74
Leishmaniasis worldwide and global estimates of its incidence. PLoS One (2012) 18.07
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature (2004) 14.80
Toxoplasmosis. Lancet (2004) 13.96
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell (1997) 12.68
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem (2003) 10.79
The lineage decisions of helper T cells. Nat Rev Immunol (2002) 10.61
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 9.77
Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem (2003) 9.37
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science (2003) 7.49
Amoebiasis. Lancet (2003) 6.90
Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc Natl Acad Sci U S A (1993) 6.87
The immunology of susceptibility and resistance to Leishmania major in mice. Nat Rev Immunol (2002) 6.59
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol (2003) 6.46
Altered immune responses in mice lacking inducible nitric oxide synthase. Nature (1995) 6.20
Amebiasis. N Engl J Med (2003) 5.63
The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination. PLoS Negl Trop Dis (2008) 5.30
In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies. Science (2008) 5.09
TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science (2005) 4.86
Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature (2014) 4.69
The IL-1 family: regulators of immunity. Nat Rev Immunol (2010) 4.65
Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria. Nature (1989) 4.08
Epidemiology of and diagnostic strategies for toxoplasmosis. Clin Microbiol Rev (2012) 4.07
Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J Immunol (1992) 4.02
Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa. PLoS Pathog (2010) 3.76
Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J Exp Med (1997) 3.62
Susceptibility of beta 2-microglobulin-deficient mice to Trypanosoma cruzi infection. Nature (1992) 3.50
Toxoplasmosis: A history of clinical observations. Int J Parasitol (2009) 3.39
Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection. J Exp Med (1992) 3.34
Importance of endogenous IFN-gamma for prevention of toxoplasmic encephalitis in mice. J Immunol (1989) 3.20
In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. J Immunol (1996) 3.15
Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS One (2009) 2.93
Rat and human colonic mucins bind to and inhibit adherence lectin of Entamoeba histolytica. J Clin Invest (1987) 2.74
Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps. Proc Natl Acad Sci U S A (2009) 2.68
CD8+ cytolytic T cell clones derived against the Plasmodium yoelii circumsporozoite protein protect against malaria. Int Immunol (1991) 2.67
Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection. Nat Immunol (2011) 2.54
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell (2010) 2.49
Malaria biology and disease pathogenesis: insights for new treatments. Nat Med (2013) 2.38
Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunity. J Exp Med (1998) 2.30
NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways. Immunity (2011) 2.29
Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science (1993) 2.20
Amebiasis and mucosal IgA antibody against the Entamoeba histolytica adherence lectin in Bangladeshi children. J Infect Dis (2001) 2.20
The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell (2011) 2.18
Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains. J Immunol (2002) 2.18
CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major. J Immunol (2002) 2.16
NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK. Immunity (2011) 2.10
Cytotoxic T cells recognize a peptide from the circumsporozoite protein on malaria-infected hepatocytes. J Exp Med (1990) 2.09
Endogenous IFN-gamma is required for resistance to acute Trypanosoma cruzi infection in mice. J Immunol (1991) 2.08
Leishmania lipophosphoglycan (LPG) activates NK cells through toll-like receptor-2. Mol Biochem Parasitol (2003) 2.08
Malaria susceptibility and CD36 mutation. Nature (2000) 2.07
Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. PLoS Pathog (2009) 2.07
NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling. Immunity (2012) 2.07
Cutting edge: dendritic cells are essential for in vivo IL-12 production and development of resistance against Toxoplasma gondii infection in mice. J Immunol (2006) 2.06
Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling. Cell (2015) 2.04
Swift development of protective effector functions in naive CD8(+) T cells against malaria liver stages. J Exp Med (2001) 1.99
Host cell traversal is important for progression of the malaria parasite through the dermis to the liver. Cell Host Microbe (2008) 1.92
Neutrophil depletion during Toxoplasma gondii infection leads to impaired immunity and lethal systemic pathology. Infect Immun (2001) 1.92
Genetically resistant mice lacking MyD88-adapter protein display a high susceptibility to Leishmania major infection associated with a polarized Th2 response. J Immunol (2003) 1.91
NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc Natl Acad Sci U S A (2010) 1.90
Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase. Infect Immun (1998) 1.89
Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines. J Immunol (1991) 1.89
The receptor NLRP3 is a transcriptional regulator of TH2 differentiation. Nat Immunol (2015) 1.89
Chemokines, inflammation and Trypanosoma cruzi infection. Trends Parasitol (2002) 1.88
IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages. Nat Med (2002) 1.86
Cellular bases of experimental amebic liver abscess formation. Am J Pathol (1984) 1.83
MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll-like receptor 2 signaling. Eur J Immunol (2003) 1.82
B cell-deficient mice are highly resistant to Leishmania donovani infection, but develop neutrophil-mediated tissue pathology. J Immunol (2000) 1.73
Attribution of malnutrition to cause-specific diarrheal illness: evidence from a prospective study of preschool children in Mirpur, Dhaka, Bangladesh. Am J Trop Med Hyg (2009) 1.71
The NLRP12 inflammasome recognizes Yersinia pestis. Immunity (2012) 1.70
Entamoeba histolytica trophozoites induce an inflammatory cytokine response by cultured human cells through the paracrine action of cytolytically released interleukin-1 alpha. J Clin Invest (1995) 1.68
T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii. Nat Immunol (2009) 1.67
Class II transactivator: mastering the art of major histocompatibility complex expression. Mol Cell Biol (2000) 1.66
The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells. Immunity (2015) 1.66
NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature (2012) 1.63
Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease). Prog Cardiovasc Dis (2009) 1.60
Toxoplasmosis--a global threat. Correlation of latent toxoplasmosis with specific disease burden in a set of 88 countries. PLoS One (2014) 1.57
NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J Exp Med (2007) 1.57
Haemozoin formation. Mol Biochem Parasitol (2007) 1.56
Toxoplasmosis in nude mice. J Parasitol (1977) 1.52
CD4+ cytolytic T cell clone confers protection against murine malaria. J Exp Med (1990) 1.51
Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88. J Immunol (2004) 1.50
Susceptibility of different strains of mice to hepatic infection with Plasmodium berghei. Infect Immun (1994) 1.49
Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid. J Immunol (2009) 1.48
NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondii-infected monocytic cells. Infect Immun (2010) 1.46
Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania. Nat Med (2013) 1.46
TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasis. Eur J Immunol (2007) 1.46
Involvement of specific Lyt-2+ T cells in the immunological control of experimentally induced murine cutaneous leishmaniasis. Eur J Immunol (1987) 1.46
Chagas disease: changes in knowledge and management. Lancet Infect Dis (2010) 1.46
The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat Immunol (2012) 1.45
Murine cutaneous leishmaniasis: resistance in reconstituted nude mice and several F1 hybrids infected with Leishmania tropica major. J Immunogenet (1983) 1.45
Entamoeba histolytica cysteine proteinases with interleukin-1 beta converting enzyme (ICE) activity cause intestinal inflammation and tissue damage in amoebiasis. Mol Microbiol (2000) 1.43
Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease. Int Immunol (1996) 1.43
Neutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection. J Immunol (2009) 1.41
The immunopathogenesis of Entamoeba histolytica. Exp Parasitol (2010) 1.38
Role of nitric oxide in the regulation of T cell functions. Ann Rheum Dis (2006) 1.38
CD36 mediates the phagocytosis of Plasmodium falciparum-infected erythrocytes by rodent macrophages. J Infect Dis (2004) 1.36
IL-4 is protective against development of toxoplasmic encephalitis. J Immunol (1996) 1.34
Protection against malaria by Plasmodium yoelii sporozoite surface protein 2 linear peptide induction of CD4+ T cell- and IFN-gamma-dependent elimination of infected hepatocytes. J Immunol (1996) 1.34