Published in Proc Natl Acad Sci U S A on April 16, 2012
Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation. Cell Mol Life Sci (2013) 1.08
G protein-coupled receptor kinase 2: a link between myocardial contractile function and cardiac metabolism. Circ Res (2014) 1.02
β-Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma. Proc Natl Acad Sci U S A (2012) 1.01
Cell-surface receptors transactivation mediated by g protein-coupled receptors. Int J Mol Sci (2014) 0.93
Thyrotropin and Insulin-Like Growth Factor 1 Receptor Crosstalk Upregulates Sodium-Iodide Symporter Expression in Primary Cultures of Human Thyrocytes. Thyroid (2016) 0.87
Targeting the IGF-1R: The Tale of the Tortoise and the Hare. Front Endocrinol (Lausanne) (2015) 0.87
Inhibition of G-protein-coupled receptor kinase 2 (GRK2) triggers the growth-promoting mitogen-activated protein kinase (MAPK) pathway. J Biol Chem (2013) 0.81
Antitumor effects and molecular mechanisms of figitumumab, a humanized monoclonal antibody to IGF-1 receptor, in esophageal carcinoma. Sci Rep (2014) 0.81
Increased G protein-coupled receptor kinase (GRK) expression in the anterior cingulate cortex in schizophrenia. Schizophr Res (2014) 0.81
G-protein-coupled receptor kinases in inflammation and disease. Genes Immun (2015) 0.80
Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice. J Biol Chem (2015) 0.78
IGF-1 Receptor and Adhesion Signaling: An Important Axis in Determining Cancer Cell Phenotype and Therapy Resistance. Front Endocrinol (Lausanne) (2015) 0.77
Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma. Oncogene (2017) 0.76
Feedback regulation of G protein-coupled receptor signaling by GRKs and arrestins. Semin Cell Dev Biol (2016) 0.76
Bacillus bombysepticus α-Toxin Binding to G Protein-Coupled Receptor Kinase 2 Regulates cAMP/PKA Signaling Pathway to Induce Host Death. PLoS Pathog (2016) 0.75
The human cytomegalovirus chemokine receptor homolog encoded by US27. Virus Genes (2017) 0.75
The quinic acid derivative KZ-41 prevents glucose-induced caspase-3 activation in retinal endothelial cells through an IGF-1 receptor dependent mechanism. PLoS One (2017) 0.75
Functional antagonism of β-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes. Oncogene (2017) 0.75
Transduction of receptor signals by beta-arrestins. Science (2005) 9.87
Beta-arrestins and cell signaling. Annu Rev Physiol (2007) 8.65
Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors. J Biol Chem (2000) 4.46
Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Sci Signal (2011) 2.56
Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. Proc Natl Acad Sci U S A (2005) 2.53
Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. Proc Natl Acad Sci U S A (2005) 2.48
Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis. J Biol Chem (2003) 1.76
Role of insulin-like growth factor 1 receptor signalling in cancer. Br J Cancer (2005) 1.64
Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor. Proc Natl Acad Sci U S A (2003) 1.60
beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor. J Biol Chem (1998) 1.51
Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression. J Biol Chem (2007) 1.36
{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J Biol Chem (2005) 1.31
Insulin and insulin-like growth factor I receptors utilize different G protein signaling components. J Biol Chem (2001) 1.24
Identification of the cathelicidin peptide LL-37 as agonist for the type I insulin-like growth factor receptor. Oncogene (2011) 1.09
Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins. Annu Rev Physiol (2007) 1.06
Targeting insulin and insulin-like growth factor pathways in epithelial ovarian cancer. J Oncol (2010) 1.06
The cellular distribution of fluorescently labeled arrestins provides a robust, sensitive, and universal assay for screening G protein-coupled receptors. Assay Drug Dev Technol (2002) 1.06
Insulin-like growth factor type-I receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not Akt (protein kinase B) can be induced by picropodophyllin. Mol Pharmacol (2007) 0.94
Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res (2004) 2.90
Uveal melanoma: epidemiologic aspects. Ophthalmol Clin North Am (2005) 2.24
Choroidal biopsies for intraocular tumors of indeterminate origin. Am J Ophthalmol (2005) 1.87
Photochemical damage of the retina. Surv Ophthalmol (2006) 1.83
Benefit from bevacizumab for macular edema in central retinal vein occlusion: twelve-month results of a prospective, randomized study. Ophthalmology (2012) 1.78
Clinical and pathologic characteristics of biopsy-proven iris melanoma: a multicenter international study. Arch Ophthalmol (2011) 1.78
Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor. Proc Natl Acad Sci U S A (2003) 1.60
Ligneous conjunctivitis. Surv Ophthalmol (2003) 1.59
The use of resonance energy transfer in high-throughput screening: BRET versus FRET. Trends Pharmacol Sci (2002) 1.48
Age-related maculopathy and the impact of blue light hazard. Acta Ophthalmol Scand (2006) 1.47
Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression. J Biol Chem (2007) 1.36
High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer. Eur J Cancer (2012) 1.34
Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target. Invest Ophthalmol Vis Sci (2002) 1.33
Ruthenium brachytherapy for uveal melanoma, 1979-2003: survival and functional outcomes in the Swedish population. Ophthalmology (2005) 1.32
{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J Biol Chem (2005) 1.31
IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells. Blood (2005) 1.29
Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis. Cancer Res (2008) 1.28
O-glycosylation of FoxO1 increases its transcriptional activity towards the glucose 6-phosphatase gene. FEBS Lett (2008) 1.21
Sunlight exposure and pathogenesis of uveal melanoma. Surv Ophthalmol (2004) 1.20
Molecular and clinical spectrum of type I plasminogen deficiency: A series of 50 patients. Blood (2006) 1.20
MicroRNA-143 functions as a tumor suppressor in human esophageal squamous cell carcinoma. Gene (2012) 1.19
O-GlcNAcylation: A New Cancer Hallmark? Front Endocrinol (Lausanne) (2013) 1.16
Bevacizumab for macular edema in central retinal vein occlusion: a prospective, randomized, double-masked clinical study. Ophthalmology (2012) 1.15
Reduced choroidal neovascular membrane formation in matrix metalloproteinase-2-deficient mice. Invest Ophthalmol Vis Sci (2003) 1.14
The cut-and-paste method for primary pterygium surgery: long-term follow-up. Acta Ophthalmol Scand (2005) 1.12
Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model. Blood (2005) 1.11
The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells. Clin Cancer Res (2006) 1.09
Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation. Cell Mol Life Sci (2013) 1.08
Dynamics of the interaction between the insulin receptor and protein tyrosine-phosphatase 1B in living cells. EMBO Rep (2003) 1.08
Incidence of uveal melanoma in Sweden from 1960 to 1998. Invest Ophthalmol Vis Sci (2002) 1.08
Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastoma. Neuro Oncol (2009) 1.05
Role of ubiquitination in IGF-1 receptor signaling and degradation. PLoS One (2007) 1.04
Effect of insulin analogues on insulin/IGF1 hybrid receptors: increased activation by glargine but not by its metabolites M1 and M2. PLoS One (2012) 1.03
A comparison of Twist and E-cadherin protein expression in primary non-small-cell lung carcinoma and corresponding metastases. Eur J Cardiothorac Surg (2011) 1.02
β-Arrestin-biased agonism as the central mechanism of action for insulin-like growth factor 1 receptor-targeting antibodies in Ewing's sarcoma. Proc Natl Acad Sci U S A (2012) 1.01
Insulin-like growth factor type 1 receptor expression correlates to good prognosis in highly malignant soft tissue sarcoma. Clin Cancer Res (2005) 1.00
Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor. Invest Ophthalmol Vis Sci (2008) 0.99
Intratumoral forkhead box P3-positive regulatory T cells predict poor survival in cyclooxygenase-2-positive uveal melanoma. Cancer (2010) 0.98
Molecular determinants of Grb14-mediated inhibition of insulin signaling. Mol Endocrinol (2009) 0.97
A prospective study on intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration of different durations. Acta Ophthalmol (2007) 0.96
Expression and prognostic significance of iNOS in uveal melanoma. Int J Cancer (2010) 0.96
Delayed inflammation-associated corneal neovascularization in MMP-2-deficient mice. Exp Eye Res (2005) 0.95
Effect of acid suppression on molecular predictors for esophageal cancer. Cancer Epidemiol Biomarkers Prev (2006) 0.95
c-Kit-dependent growth of uveal melanoma cells: a potential therapeutic target? Invest Ophthalmol Vis Sci (2004) 0.95
Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor. EMBO Rep (2006) 0.95
Insulin-like growth factor type-I receptor-dependent phosphorylation of extracellular signal-regulated kinase 1/2 but not Akt (protein kinase B) can be induced by picropodophyllin. Mol Pharmacol (2007) 0.94
O-GlcNAc modification of FoxO1 increases its transcriptional activity: a role in the glucotoxicity phenomenon? Biochimie (2008) 0.93
Age-related maculopathy: pathogenetic features and new treatment modalities. Acta Ophthalmol Scand (2002) 0.93
Uveal melanoma: a study on incidence of additional cancers in the Swedish population. Invest Ophthalmol Vis Sci (2006) 0.92
Oncocytoma of the lacrimal gland. Acta Ophthalmol Scand (2007) 0.91
Intraoperative mitomycin C versus autologous conjunctival autograft in surgery of primary pterygium with four-year follow-up. Acta Ophthalmol (2010) 0.91
Association between circulating levels of IGF-1 and IGFBP-3 and lung cancer risk: a meta-analysis. PLoS One (2012) 0.91
Interaction of the insulin receptor with the receptor-like protein tyrosine phosphatases PTPalpha and PTPepsilon in living cells. Mol Pharmacol (2005) 0.90
To biopsy or not to biopsy? Acta Ophthalmol (2009) 0.90
Structure and function of the N-cadherin/catenin complex in retinoblastoma. Invest Ophthalmol Vis Sci (2002) 0.89
Receptors for the liver synthesized growth factors IGF-1 and HGF/SF in uveal melanoma: intercorrelation and prognostic implications. Invest Ophthalmol Vis Sci (2005) 0.89
Oral picropodophyllin (PPP) is well tolerated in vivo and inhibits IGF-1R expression and growth of uveal melanoma. Invest Ophthalmol Vis Sci (2008) 0.89
Subthreshold transpupillary thermotherapy reduces experimental choroidal neovascularization in the mouse without collateral damage to the neural retina. Invest Ophthalmol Vis Sci (2004) 0.88
Fine-needle aspiration cytology and immunocytochemistry of orbital masses. Diagn Cytopathol (2006) 0.88
Positive regulation of insulin signaling by neuraminidase 1. Diabetes (2013) 0.88
A prospective study of children treated for retinoblastoma: cognitive and visual outcomes in relation to treatment. Acta Ophthalmol Scand (2002) 0.88
Topical chemotherapy for ocular surface squamous neoplasia: current status. Br J Ophthalmol (2009) 0.87
Characterization of IRA/IRB hybrid insulin receptors using bioluminescence resonance energy transfer. Biochem Pharmacol (2008) 0.86
Mantle cell lymphoma of the iris. Acta Ophthalmol Scand (2007) 0.86
Uveal melanoma survival in Sweden from 1960 to 1998. Invest Ophthalmol Vis Sci (2003) 0.86
Prognostic role of Twist or Snail in various carcinomas: a systematic review and meta-analysis. Eur J Clin Invest (2014) 0.85
Implication of protein tyrosine phosphatase 1B in MCF-7 cell proliferation and resistance to 4-OH tamoxifen. Biochem Biophys Res Commun (2009) 0.85
Receptors for the liver synthesized growth factors IGF-1 and HGF/SF in uveal melanoma: intercorrelation and prognostic implications. Acta Ophthalmol (2008) 0.85
Administration of embryonic stem cells generates effective antitumor immunity in mice with minor and heavy tumor load. Cancer Immunol Immunother (2010) 0.85
Leptin is a hypoxia-inducible gene. Obes Res (2002) 0.84
Expression and growth dependency of the insulin-like growth factor I receptor in craniopharyngioma cells: a novel therapeutic approach. Clin Cancer Res (2005) 0.84
Gene expression profile by blocking the SYT-SSX fusion gene in synovial sarcoma cells. Identification of XRCC4 as a putative SYT-SSX target gene. Oncogene (2003) 0.84
The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling. J Vasc Surg (2007) 0.84
Monitoring the activation state of insulin/insulin-like growth factor-1 hybrid receptors using bioluminescence resonance energy transfer. Mol Pharmacol (2006) 0.84
Photodynamic therapy for circumscribed choroidal haemangioma. Acta Ophthalmol Scand (2002) 0.83
Interaction between the insulin receptor and Grb14: a dynamic study in living cells using BRET. Biochem Pharmacol (2006) 0.83
Transpupillary thermotherapy of predominantly occult choroidal neovascularization in age-related macular degeneration with 12 months follow-up. Acta Ophthalmol Scand (2003) 0.83
Association of ERCC2/XPD polymorphisms and interaction with tobacco smoking in lung cancer susceptibility: a systemic review and meta-analysis. Mol Biol Rep (2011) 0.83
Monitoring the activation state of the insulin-like growth factor-1 receptor and its interaction with protein tyrosine phosphatase 1B using bioluminescence resonance energy transfer. Mol Pharmacol (2005) 0.83
High expression of PRDM14 correlates with cell differentiation and is a novel prognostic marker in resected non-small cell lung cancer. Med Oncol (2013) 0.83
IGF-1R tyrosine kinase expression and dependency in clones of IGF-1R knockout cells (R-). Biochem Biophys Res Commun (2006) 0.82