Published in PLoS Negl Trop Dis on April 24, 2012
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach. Nat Chem (2013) 1.95
Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani. Chem Biol (2015) 1.47
Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery. J Med Chem (2012) 1.03
Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors. J Med Chem (2014) 0.95
Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase. J Med Chem (2012) 0.95
Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors. IUCrJ (2014) 0.90
Acylation in trypanosomatids: an essential process and potential drug target. Trends Parasitol (2014) 0.88
Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase. Biochem J (2014) 0.87
Kinases as Druggable Targets in Trypanosomatid Protozoan Parasites. Chem Rev (2014) 0.83
Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes. PLoS Negl Trop Dis (2014) 0.82
N-myristoyltransferase is a cell wall target in Aspergillus fumigatus. ACS Chem Biol (2015) 0.78
In vitro and in vivo activities of 2-aminopyrazines and 2-aminopyridines in experimental models of human African trypanosomiasis. Antimicrob Agents Chemother (2012) 0.78
Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei. ACS Infect Dis (2016) 0.77
Pharmacological Inhibition of Protein Lipidation. J Membr Biol (2015) 0.76
Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase. Medchemcomm (2015) 0.76
Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase. Medchemcomm (2015) 0.76
The N-myristoylome of Trypanosoma cruzi. Sci Rep (2016) 0.75
Pattern recognition techniques applied to the study of leishmanial glyceraldehyde-3-phosphate dehydrogenase inhibition. Int J Mol Sci (2014) 0.75
Multiple chemical scaffolds inhibit a promising Leishmania drug target. IUCrJ (2014) 0.75
N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells. ACS Chem Biol (2016) 0.75
Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase. Medchemcomm (2016) 0.75
A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J Biomol Screen (1999) 32.67
Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet (2012) 17.62
Vivax malaria: neglected and not benign. Am J Trop Med Hyg (2007) 10.16
Ligand efficiency: a useful metric for lead selection. Drug Discov Today (2004) 6.60
Global mapping of pharmacological space. Nat Biotechnol (2006) 4.99
Chloroquine-resistant malaria. J Infect Dis (2001) 4.58
Antimalarial drug discovery: efficacy models for compound screening. Nat Rev Drug Discov (2004) 3.90
The maximal affinity of ligands. Proc Natl Acad Sci U S A (1999) 3.24
Drug resistance in Indian visceral leishmaniasis. Trop Med Int Health (2001) 3.08
Delaying antimalarial drug resistance with combination chemotherapy. Parassitologia (1999) 3.00
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature (2010) 2.90
Myristoyl-CoA:protein N-myristoyltransferase, an essential enzyme and potential drug target in kinetoplastid parasites. J Biol Chem (2002) 2.08
Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum. Biochem J (2007) 1.75
Leishmaniasis impact and treatment access. Clin Microbiol Infect (2011) 1.72
Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics. Mol Biochem Parasitol (2003) 1.61
Protein myristoylation in health and disease. J Chem Biol (2009) 1.57
CAP5.5, a life-cycle-regulated, cytoskeleton-associated protein is a member of a novel family of calpain-related proteins in Trypanosoma brucei. Mol Biochem Parasitol (2001) 1.49
Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem (2008) 1.34
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors. J Med Chem (2011) 1.33
N-myristoyltransferase: a prospective drug target for protozoan parasites. ChemMedChem (2008) 1.33
Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major. Biochem J (2006) 1.30
A second mammalian N-myristoyltransferase. J Biol Chem (1998) 1.28
N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis. J Mol Biol (2009) 1.28
Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects. Mol Biochem Parasitol (2009) 1.28
Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs. Nat Struct Biol (1998) 1.27
Developments in the treatment of visceral leishmaniasis. Expert Opin Emerg Drugs (2009) 1.23
A fluorescence-based assay for N-myristoyltransferase activity. Anal Biochem (2011) 1.20
N-myristoyltransferase 1 is essential in early mouse development. J Biol Chem (2005) 1.14
Drug to genome to drug: discovery of new antiplasmodial compounds. J Med Chem (2011) 1.02
Characterization of N-myristoyltransferase from Plasmodium falciparum. Biochem J (2000) 1.00
Enhanced HTS hit selection via a local hit rate analysis. J Chem Inf Model (2009) 1.00
Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors. Chem Biol (2002) 0.98
Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads. PLoS Negl Trop Dis (2011) 0.95
Novel biologically active nonpeptidic inhibitors of myristoylCoA:protein N-myristoyltransferase. J Med Chem (1998) 0.94
Enrichment of extremely noisy high-throughput screening data using a naïve Bayes classifier. J Biomol Screen (2004) 0.94
Synthesis of potent and selective inhibitors of Candida albicans N-myristoyltransferase based on the benzothiazole structure. Bioorg Med Chem (2005) 0.92
Scanning alanine mutagenesis and de-peptidization of a Candida albicans myristoyl-CoA:protein N-myristoyltransferase octapeptide substrate reveals three elements critical for molecular recognition. J Biol Chem (1997) 0.90
Genomics, systems biology and drug development for infectious diseases. Mol Biosyst (2007) 0.88
A proteomic view of the Plasmodium falciparum life cycle. Nature (2002) 10.65
Discovery of gene function by expression profiling of the malaria parasite life cycle. Science (2003) 10.57
The genome of the kinetoplastid parasite, Leishmania major. Science (2005) 8.64
Comparative genomic analysis of three Leishmania species that cause diverse human disease. Nat Genet (2007) 4.58
Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis. Science (2012) 4.41
TriTrypDB: a functional genomic resource for the Trypanosomatidae. Nucleic Acids Res (2009) 3.79
Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. Genome Res (2004) 3.63
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature (2010) 2.90
A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites. J Biol Chem (2005) 2.50
Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism. Science (2012) 2.38
Fine specificity of serum antibodies to Plasmodium falciparum merozoite surface protein, PfMSP-1(19), predicts protection from malaria infection and high-density parasitemia. Infect Immun (2004) 2.31
Profiling the antibody immune response against blood stage malaria vaccine candidates. Clin Chem (2007) 2.23
A role for the protease falcipain 1 in host cell invasion by the human malaria parasite. Science (2002) 2.20
Conserved arginine residues implicated in ATP hydrolysis, nucleotide-sensing, and inter-subunit interactions in AAA and AAA+ ATPases. J Struct Biol (2004) 2.15
The motor complex of Plasmodium falciparum: phosphorylation by a calcium-dependent protein kinase. J Biol Chem (2008) 2.14
Myristoyl-CoA:protein N-myristoyltransferase, an essential enzyme and potential drug target in kinetoplastid parasites. J Biol Chem (2002) 2.08
Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania. Genome Res (2011) 1.90
GeneDB--an annotation database for pathogens. Nucleic Acids Res (2011) 1.82
The isomerase active site of cyclophilin A is critical for hepatitis C virus replication. J Biol Chem (2009) 1.79
Effective induction of high-titer antibodies by viral vector vaccines. Nat Med (2008) 1.76
Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum. Biochem J (2007) 1.75
Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses. Nat Med (2003) 1.75
Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major. Infect Immun (2004) 1.65
Variation in the expression of a Plasmodium falciparum protein family implicated in erythrocyte invasion. Infect Immun (2002) 1.64
Epigenetic silencing of Plasmodium falciparum genes linked to erythrocyte invasion. PLoS Pathog (2007) 1.63
Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics. Mol Biochem Parasitol (2003) 1.61
The importance of human FcgammaRI in mediating protection to malaria. PLoS Pathog (2007) 1.61
Protein myristoylation in health and disease. J Chem Biol (2009) 1.57
The human immune response to Plasmodium falciparum includes both antibodies that inhibit merozoite surface protein 1 secondary processing and blocking antibodies. Infect Immun (2002) 1.56
Malaria parasite actin filaments are very short. J Mol Biol (2005) 1.56
Novel small-molecule inhibitors of RNA polymerase III. Eukaryot Cell (2003) 1.56
Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites. PLoS Genet (2012) 1.55
The structure of CodY, a GTP- and isoleucine-responsive regulator of stationary phase and virulence in gram-positive bacteria. J Biol Chem (2006) 1.54
Dual acylation of the 45 kDa gliding-associated protein (GAP45) in Plasmodium falciparum merozoites. Mol Biochem Parasitol (2006) 1.53
Ether phospholipids and glycosylinositolphospholipids are not required for amastigote virulence or for inhibition of macrophage activation by Leishmania major. J Biol Chem (2003) 1.52
Function of region I and II adhesive motifs of Plasmodium falciparum circumsporozoite protein in sporozoite motility and infectivity. J Biol Chem (2002) 1.50
Sphingolipid-free Leishmania are defective in membrane trafficking, differentiation and infectivity. Mol Microbiol (2004) 1.45
The fine specificity, but not the invasion inhibitory activity, of 19-kilodalton merozoite surface protein 1-specific antibodies is associated with resistance to malarial parasitemia in a cross-sectional survey in The Gambia. Infect Immun (2004) 1.44
HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors. J Hepatol (2010) 1.43
Crystal structure of dihydrodipicolinate synthase (BA3935) from Bacillus anthracis at 1.94 A resolution. Proteins (2006) 1.40
Lipid spirals in Bacillus subtilis and their role in cell division. Mol Microbiol (2008) 1.40
The protozoan inositol phosphorylceramide synthase: a novel drug target that defines a new class of sphingolipid synthase. J Biol Chem (2006) 1.39
The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony. Eukaryot Cell (2009) 1.39
Crystal structure of foot-and-mouth disease virus 3C protease. New insights into catalytic mechanism and cleavage specificity. J Biol Chem (2005) 1.38
Protein engineering 20 years on. Nat Rev Mol Cell Biol (2002) 1.34
N-myristoyltransferase: a prospective drug target for protozoan parasites. ChemMedChem (2008) 1.33
Dynamic imaging of experimental Leishmania donovani-induced hepatic granulomas detects Kupffer cell-restricted antigen presentation to antigen-specific CD8 T cells. PLoS Pathog (2010) 1.32
A comprehensive evaluation of rodent malaria parasite genomes and gene expression. BMC Biol (2014) 1.31
Functional analysis of TbARL1, an N-myristoylated Golgi protein essential for viability in bloodstream trypanosomes. J Cell Sci (2005) 1.30
Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major. Biochem J (2006) 1.30
The crystal structure of YloQ, a circularly permuted GTPase essential for Bacillus subtilis viability. J Mol Biol (2004) 1.29
N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis. J Mol Biol (2009) 1.28
Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects. Mol Biochem Parasitol (2009) 1.28
Identification of a stomatin orthologue in vacuoles induced in human erythrocytes by malaria parasites. A role for microbial raft proteins in apicomplexan vacuole biogenesis. J Biol Chem (2003) 1.27
Dimer formation and transcription activation in the sporulation response regulator Spo0A. J Mol Biol (2002) 1.27
Trypanosoma brucei ARF1 plays a central role in endocytosis and golgi-lysosome trafficking. Mol Biol Cell (2006) 1.26
Apical expression of three RhopH1/Clag proteins as components of the Plasmodium falciparum RhopH complex. Mol Biochem Parasitol (2005) 1.26
Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry. Chem Commun (Camb) (2007) 1.25
Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes. Proc Natl Acad Sci U S A (2012) 1.24
Identification of new PNEPs indicates a substantial non-PEXEL exportome and underpins common features in Plasmodium falciparum protein export. PLoS Pathog (2013) 1.24
Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides. Org Biomol Chem (2008) 1.24
Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5. J Immunol (2013) 1.22
The crystal structure of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli at 1.5 A resolution. Structure (2002) 1.22
Transgene optimization, immunogenicity and in vitro efficacy of viral vectored vaccines expressing two alleles of Plasmodium falciparum AMA1. PLoS One (2011) 1.22
Kinetoplastid PPEF phosphatases: dual acylated proteins expressed in the endomembrane system of Leishmania. Mol Biochem Parasitol (2006) 1.21
N-Myristoyl transferase-mediated protein labelling in vivo. Org Biomol Chem (2008) 1.21
The MTIP-myosin A complex in blood stage malaria parasites. J Mol Biol (2005) 1.20
PSLAP, a protein with multiple adhesive motifs, is expressed in Plasmodium falciparum gametocytes. Mol Biochem Parasitol (2002) 1.20
A fluorescence-based assay for N-myristoyltransferase activity. Anal Biochem (2011) 1.20
Protective immune responses to the 42-kilodalton (kDa) region of Plasmodium yoelii merozoite surface protein 1 are induced by the C-terminal 19-kDa region but not by the adjacent 33-kDa region. Infect Immun (2002) 1.19
The structure of the oligopeptide-binding protein, AppA, from Bacillus subtilis in complex with a nonapeptide. J Mol Biol (2005) 1.19
Formation of the food vacuole in Plasmodium falciparum: a potential role for the 19 kDa fragment of merozoite surface protein 1 (MSP1(19)). PLoS One (2008) 1.18
Activity-based probes: discovering new biology and new drug targets. Chem Soc Rev (2010) 1.18
Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry. Nat Protoc (2011) 1.17
The Plasmodium falciparum clag9 gene encodes a rhoptry protein that is transferred to the host erythrocyte upon invasion. Mol Microbiol (2004) 1.17