Published in Trends Parasitol on June 19, 2014
The physiology of protein S-acylation. Physiol Rev (2015) 1.03
A Single Protein S-acyl Transferase Acts through Diverse Substrates to Determine Cryptococcal Morphology, Stress Tolerance, and Pathogenic Outcome. PLoS Pathog (2015) 0.81
Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei. ACS Infect Dis (2016) 0.77
N-terminal region of the catalytic domain of human N-myristoyltransferase 1 acts as an inhibitory module. PLoS One (2015) 0.77
All about that fat: Lipid modification of proteins in Cryptococcus neoformans. J Microbiol (2016) 0.76
Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi. PLoS Negl Trop Dis (2016) 0.75
Dynamic protein S-palmitoylation mediates parasite life cycle progression and diverse mechanisms of virulence. Crit Rev Biochem Mol Biol (2017) 0.75
AID-ing Signaling in Toxoplasma gondii. MBio (2017) 0.75
Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat of Trypanosoma brucei. Parasitology (1975) 7.22
Palmitoylation: policing protein stability and traffic. Nat Rev Mol Cell Biol (2007) 6.15
Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation. Nature (2008) 4.52
Global analysis of protein palmitoylation in yeast. Cell (2006) 4.43
Identification of PSD-95 palmitoylating enzymes. Neuron (2004) 4.37
Palmitoylation of intracellular signaling proteins: regulation and function. Annu Rev Biochem (2004) 4.34
Glycosyl-sn-1,2-dimyristylphosphatidylinositol is covalently linked to Trypanosoma brucei variant surface glycoprotein. J Biol Chem (1985) 3.64
The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase. J Cell Biol (2002) 3.48
Glycosyl-phosphatidylinositol moiety that anchors Trypanosoma brucei variant surface glycoprotein to the membrane. Science (1988) 3.41
Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae. J Biol Chem (2002) 3.27
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature (2010) 2.90
CSS-Palm 2.0: an updated software for palmitoylation sites prediction. Protein Eng Des Sel (2008) 2.86
Hydrodynamic flow-mediated protein sorting on the cell surface of trypanosomes. Cell (2007) 2.84
Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Biochim Biophys Acta (2006) 2.49
Protein palmitoylation by a family of DHHC protein S-acyltransferases. J Lipid Res (2006) 2.45
Genetic and biochemical studies of protein N-myristoylation. Annu Rev Biochem (1994) 2.30
DHHC palmitoyl transferases: substrate interactions and (patho)physiology. Trends Biochem Sci (2011) 2.28
Signalling functions of protein palmitoylation. Biochim Biophys Acta (1998) 2.24
Fatty acid synthesis by elongases in trypanosomes. Cell (2006) 2.18
Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae. Mol Cell Biol (1999) 2.14
Doubly-lipid-modified protein sequence motifs exhibit long-lived anchorage to lipid bilayer membranes. Biochemistry (1995) 2.12
Myristoyl-CoA:protein N-myristoyltransferase, an essential enzyme and potential drug target in kinetoplastid parasites. J Biol Chem (2002) 2.08
The trypanosome flagellar pocket. Nat Rev Microbiol (2009) 2.07
SMP-1, a member of a new family of small myristoylated proteins in kinetoplastid parasites, is targeted to the flagellum membrane in Leishmania. Mol Biol Cell (2004) 1.95
Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization. J Biol Chem (1994) 1.90
Fatty acid remodeling: a novel reaction sequence in the biosynthesis of trypanosome glycosyl phosphatidylinositol membrane anchors. Cell (1990) 1.83
Acylation-dependent protein export in Leishmania. J Biol Chem (2000) 1.77
Membrane targeting of lipid modified signal transduction proteins. Subcell Biochem (2004) 1.73
Autoacylation of G protein alpha subunits. J Biol Chem (1996) 1.64
Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics. Mol Biochem Parasitol (2003) 1.61
Flagellar protein localization mediated by a calcium-myristoyl/palmitoyl switch mechanism. EMBO J (1999) 1.59
Protein myristoylation in health and disease. J Chem Biol (2009) 1.57
Structure of the glycosyl-phosphatidylinositol membrane anchor of the Leishmania major promastigote surface protease. J Biol Chem (1990) 1.56
The DHHC domain: a new highly conserved cysteine-rich motif. Mol Cell Biochem (1999) 1.55
Flagellar membrane localization via association with lipid rafts. J Cell Sci (2009) 1.49
CAP5.5, a life-cycle-regulated, cytoskeleton-associated protein is a member of a novel family of calpain-related proteins in Trypanosoma brucei. Mol Biochem Parasitol (2001) 1.49
Very long-chain fatty acids: elongation, physiology and related disorders. J Biochem (2012) 1.49
Rab5 and Rab11 mediate transferrin and anti-variant surface glycoprotein antibody recycling in Trypanosoma brucei. Biochem J (2003) 1.45
A fatty-acid synthesis mechanism specialized for parasitism. Nat Rev Microbiol (2007) 1.44
Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs. PLoS Negl Trop Dis (2012) 1.36
Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors. J Med Chem (2011) 1.33
Erf4p and Erf2p form an endoplasmic reticulum-associated complex involved in the plasma membrane localization of yeast Ras proteins. J Biol Chem (2002) 1.31
Functional analysis of TbARL1, an N-myristoylated Golgi protein essential for viability in bloodstream trypanosomes. J Cell Sci (2005) 1.30
Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major. Biochem J (2006) 1.30
N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis. J Mol Biol (2009) 1.28
A second mammalian N-myristoyltransferase. J Biol Chem (1998) 1.28
Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects. Mol Biochem Parasitol (2009) 1.28
Post-translational myristoylation: Fat matters in cellular life and death. Biochimie (2010) 1.25
Mitochondrial fatty acid synthesis in Trypanosoma brucei. J Biol Chem (2006) 1.25
Identification of a palmitoyl acyltransferase required for protein sorting to the flagellar membrane. J Cell Sci (2009) 1.24
What does S-palmitoylation do to membrane proteins? FEBS J (2013) 1.23
An analog of myristic acid with selective toxicity for African trypanosomes. Science (1991) 1.22
Kinetoplastid PPEF phosphatases: dual acylated proteins expressed in the endomembrane system of Leishmania. Mol Biochem Parasitol (2006) 1.21
A fluorescence-based assay for N-myristoyltransferase activity. Anal Biochem (2011) 1.20
DHHC protein S-acyltransferases use similar ping-pong kinetic mechanisms but display different acyl-CoA specificities. J Biol Chem (2012) 1.17
Trypanosome variant surface glycoprotein transfer to target membranes: a model for the pathogenesis of trypanosomiasis. Proc Natl Acad Sci U S A (1990) 1.16
N-myristoylation regulates the SnRK1 pathway in Arabidopsis. Plant Cell (2007) 1.16
N-myristoyltransferase 1 is essential in early mouse development. J Biol Chem (2005) 1.14
Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis. Curr Opin Investig Drugs (2005) 1.14
Trypanosome metabolism of myristate, the fatty acid required for the variant surface glycoprotein membrane anchor. J Biol Chem (1993) 1.13
Discovery and characterization of inhibitors of human palmitoyl acyltransferases. Mol Cancer Ther (2006) 1.13
Antifungals targeted to protein modification: focus on protein N-myristoyltransferase. Expert Opin Investig Drugs (2002) 1.12
Glycosylphosphatidylinositol-dependent secretory transport in Trypanosoma brucei. Biochem J (1998) 1.11
Amino acid residue penultimate to the amino-terminal gly residue strongly affects two cotranslational protein modifications, N-myristoylation and N-acetylation. J Biol Chem (2000) 1.10
Fatty acid synthesis in African trypanosomes: a solution to the myristate mystery. Trends Parasitol (2001) 1.09
A Toxoplasma palmitoyl acyl transferase and the palmitoylated armadillo repeat protein TgARO govern apical rhoptry tethering and reveal a critical role for the rhoptries in host cell invasion but not egress. PLoS Pathog (2013) 1.08
Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. Mol Biol Cell (2012) 1.07
A proteomic approach identifies many novel palmitoylated proteins in Arabidopsis. New Phytol (2012) 1.06
Calflagin inhibition prolongs host survival and suppresses parasitemia in Trypanosoma brucei infection. Eukaryot Cell (2010) 1.05
Mutational analysis of the variant surface glycoprotein GPI-anchor signal sequence in Trypanosoma brucei. J Cell Sci (2002) 1.05
Mitochondrial fatty acid synthesis is required for normal mitochondrial morphology and function in Trypanosoma brucei. Mol Microbiol (2008) 1.05
A lipid-modified phosphoinositide-specific phospholipase C (TcPI-PLC) is involved in differentiation of trypomastigotes to amastigotes of Trypanosoma cruzi. J Biol Chem (2005) 1.03
Member of the membrane-bound O-acyltransferase (MBOAT) family encodes a lysophospholipid acyltransferase with broad substrate specificity. Genes Cells (2008) 1.03
Streamlined architecture and glycosylphosphatidylinositol-dependent trafficking in the early secretory pathway of African trypanosomes. Mol Biol Cell (2009) 1.03
S-myristoylation of a glycosylphosphatidylinositol-specific phospholipase C in Trypanosoma brucei. J Biol Chem (1999) 1.02
Global analysis of apicomplexan protein S-acyl transferases reveals an enzyme essential for invasion. Traffic (2013) 1.01
Glycosylphosphatidylinositol-dependent protein trafficking in bloodstream stage Trypanosoma brucei. Eukaryot Cell (2003) 1.00
Trypanosoma brucei metacaspase 4 is a pseudopeptidase and a virulence factor. J Biol Chem (2011) 0.99
Characterization of human palmitoyl-acyl transferase activity using peptides that mimic distinct palmitoylation motifs. Biochem J (2003) 0.99
Toxicity of myristic acid analogs toward African trypanosomes. Proc Natl Acad Sci U S A (1994) 0.99
Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes. J Biol Chem (2010) 0.98
Macromolecular trafficking and immune evasion in african trypanosomes. Int Rev Cell Mol Biol (2009) 0.97
Myristate exchange on the Trypanosoma brucei variant surface glycoprotein. Proc Natl Acad Sci U S A (1996) 0.97
Direct transport across the plasma membrane of mammalian cells of Leishmania HASPB as revealed by a CHO export mutant. J Cell Sci (2005) 0.97
Global analysis of protein palmitoylation in African trypanosomes. Eukaryot Cell (2010) 0.97
Surface coat remodeling during differentiation of Trypanosoma brucei. J Biol Chem (2003) 0.97
A fluorescence-based high performance liquid chromatographic method for the characterization of palmitoyl acyl transferase activity. Anal Biochem (2002) 0.96
Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: protein N-myristoyltransferase: a new approach to antifungal therapy. Biopolymers (1997) 0.96
Cell morphogenesis of Trypanosoma brucei requires the paralogous, differentially expressed calpain-related proteins CAP5.5 and CAP5.5V. Protist (2009) 0.94
GPI valence and the fate of secretory membrane proteins in African trypanosomes. J Cell Sci (2005) 0.94
Expression and cellular localisation of calpain-like proteins in Trypanosoma brucei. Mol Biochem Parasitol (2009) 0.93
Molecular determinants of ciliary membrane localization of Trypanosoma cruzi flagellar calcium-binding protein. J Biol Chem (2011) 0.93
The leishmania ARL-1 and Golgi traffic. PLoS One (2008) 0.89
Trafficking and release of Leishmania metacyclic HASPB on macrophage invasion. Cell Microbiol (2012) 0.88
Homology modeling and molecular dynamics simulation of N-myristoyltransferase from protozoan parasites: active site characterization and insights into rational inhibitor design. J Comput Aided Mol Des (2009) 0.88
Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase. Biochem J (2014) 0.87
Membrane protein SMP-1 is required for normal flagellum function in Leishmania. J Cell Sci (2010) 0.87
Immunocytochemical characterization and subcellular localization of human myristoyl-CoA: protein N-myristoyltransferase in HeLa cells. Exp Cell Res (1996) 0.85