Published in Science on July 31, 2003
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Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors. PLoS Pathog (2009) 1.67
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A sporozoite asparagine-rich protein controls initiation of Plasmodium liver stage development. PLoS Pathog (2008) 1.65
Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum. Nat Biotechnol (2009) 1.64
Epigenetic silencing of Plasmodium falciparum genes linked to erythrocyte invasion. PLoS Pathog (2007) 1.63
A calpain unique to alveolates is essential in Plasmodium falciparum and its knockdown reveals an involvement in pre-S-phase development. Proc Natl Acad Sci U S A (2009) 1.62
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A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation. Proc Natl Acad Sci U S A (2004) 1.52
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In silico discovery of transcription regulatory elements in Plasmodium falciparum. BMC Genomics (2008) 1.48
Regulatory hotspots in the malaria parasite genome dictate transcriptional variation. PLoS Biol (2008) 1.47
H2A.Z demarcates intergenic regions of the plasmodium falciparum epigenome that are dynamically marked by H3K9ac and H3K4me3. PLoS Pathog (2010) 1.47
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The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony. Eukaryot Cell (2009) 1.39
A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates. PLoS Pathog (2008) 1.37
Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. Mol Syst Biol (2010) 1.37
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Transcription and expression of Plasmodium falciparum histidine-rich proteins in different stages and strains: implications for rapid diagnostic tests. PLoS One (2011) 1.35
cDNA sequences reveal considerable gene prediction inaccuracy in the Plasmodium falciparum genome. BMC Genomics (2007) 1.35
Statistical estimation of cell-cycle progression and lineage commitment in Plasmodium falciparum reveals a homogeneous pattern of transcription in ex vivo culture. Proc Natl Acad Sci U S A (2009) 1.35
Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites. Proc Natl Acad Sci U S A (2004) 1.34
piggyBac is an effective tool for functional analysis of the Plasmodium falciparum genome. BMC Microbiol (2009) 1.34
A new Apicomplexa-specific protein kinase family: multiple members in Plasmodium falciparum, all with an export signature. BMC Genomics (2005) 1.34
Reverse genetics screen identifies six proteins important for malaria development in the mosquito. Mol Microbiol (2008) 1.33
A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. Genome Biol (2011) 1.32
Transcribed var genes associated with placental malaria in Malawian women. Infect Immun (2006) 1.32
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PfGCN5-mediated histone H3 acetylation plays a key role in gene expression in Plasmodium falciparum. Eukaryot Cell (2007) 1.31
An unusual ERAD-like complex is targeted to the apicoplast of Plasmodium falciparum. Eukaryot Cell (2009) 1.31
PfeIK1, a eukaryotic initiation factor 2alpha kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation. Malar J (2009) 1.31
A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81
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Functional profiling of the Saccharomyces cerevisiae genome. Nature (2002) 36.10
BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol (2009) 11.17
A proteomic view of the Plasmodium falciparum life cycle. Nature (2002) 10.65
Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature (2002) 8.92
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A gene wiki for community annotation of gene function. PLoS Biol (2008) 6.60
A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses. Science (2005) 5.99
Spiroindolones, a potent compound class for the treatment of malaria. Science (2010) 5.94
Human host factors required for influenza virus replication. Nature (2010) 5.28
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci U S A (2008) 4.80
Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening. Mol Cell (2003) 4.25
Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse. PLoS Biol (2004) 4.08
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. Proc Natl Acad Sci U S A (2003) 3.93
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Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS One (2008) 3.59
A probability-based approach for the analysis of large-scale RNAi screens. Nat Methods (2007) 3.34
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol (2008) 3.23
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (2011) 3.07
The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification. Mol Biochem Parasitol (2005) 3.02
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Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science (2005) 2.81
Mouse proteome analysis. Genome Res (2003) 2.69
Genetic diversity in yeast assessed with whole-genome oligonucleotide arrays. Genetics (2003) 2.68
An efficient rapid system for profiling the cellular activities of molecular libraries. Proc Natl Acad Sci U S A (2006) 2.51
A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites. J Biol Chem (2005) 2.50
Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Nature (2002) 2.49
Transcript annotation in FANTOM3: mouse gene catalog based on physical cDNAs. PLoS Genet (2006) 2.48
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The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites. PLoS Med (2012) 2.42
Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data. Proc Natl Acad Sci U S A (2003) 2.38
Purification, characterization, and immunogenicity of the refolded ectodomain of the Plasmodium falciparum apical membrane antigen 1 expressed in Escherichia coli. Infect Immun (2002) 2.37
Gene set enrichment in eQTL data identifies novel annotations and pathway regulators. PLoS Genet (2008) 2.32
Fine specificity of serum antibodies to Plasmodium falciparum merozoite surface protein, PfMSP-1(19), predicts protection from malaria infection and high-density parasitemia. Infect Immun (2004) 2.31
Genome-wide functional analysis of human cell-cycle regulators. Proc Natl Acad Sci U S A (2006) 2.31
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol (2009) 2.23
Profiling the antibody immune response against blood stage malaria vaccine candidates. Clin Chem (2007) 2.23
A role for the protease falcipain 1 in host cell invasion by the human malaria parasite. Science (2002) 2.20
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Invasion-inhibitory antibodies inhibit proteolytic processing of apical membrane antigen 1 of Plasmodium falciparum merozoites. Proc Natl Acad Sci U S A (2003) 2.01
Proteomics approach reveals novel proteins on the surface of malaria-infected erythrocytes. Mol Biochem Parasitol (2004) 1.96
Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum. J Biol Chem (2005) 1.95
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Effective induction of high-titer antibodies by viral vector vaccines. Nat Med (2008) 1.76
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Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design. Proc Natl Acad Sci U S A (2009) 1.72
Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites. Antimicrob Agents Chemother (2011) 1.67
Complement receptor 1 is a sialic acid-independent erythrocyte receptor of Plasmodium falciparum. PLoS Pathog (2010) 1.65
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