Oncogenic human papillomavirus imposes an instructive pattern of DNA methylation changes which parallel the natural history of cervical HPV infection in young women.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMID 22552403)

Published in Carcinogenesis on May 02, 2012

Authors

Sarah M Leonard1, Wenbin Wei, Stuart I Collins, Merlin Pereira, Afaf Diyaf, Christothea Constandinou-Williams, Lawrence S Young, Sally Roberts, Ciarán B Woodman

Author Affiliations

1: School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Articles citing this

DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns. Genome Biol (2014) 2.02

HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas. J Clin Invest (2013) 1.01

Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review). Oncol Rep (2014) 0.96

Differences in methylation profiles between HPV-positive and HPV-negative oropharynx squamous cell carcinoma: a systematic review. Epigenetics (2013) 0.96

Quantitative DNA methylation analysis of candidate genes in cervical cancer. PLoS One (2015) 0.86

Cervical neoplasia-related factors and decreased prevalence of uterine fibroids among a cohort of African American women. Fertil Steril (2013) 0.84

DNA methylation profiling across the spectrum of HPV-associated anal squamous neoplasia. PLoS One (2012) 0.83

Methylation of human papillomavirus Type 16 CpG sites at E2-binding site 1 (E2BS1), E2BS2, and the Sp1-binding site in cervical cancer samples as determined by high-resolution melting analysis-PCR. J Clin Microbiol (2013) 0.80

Human papillomavirus induced transformation in cervical and head and neck cancers. Cancers (Basel) (2014) 0.79

E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines. Oncotarget (2015) 0.79

Epigenomic characterization of locally advanced anal cancer: a radiation therapy oncology group 98-11 specimen study. Dis Colon Rectum (2014) 0.79

Tumour suppressor gene methylation and cervical cell folate concentration are determinants of high-risk human papillomavirus persistence: a nested case control study. BMC Cancer (2014) 0.78

CD66+ cells in cervical precancers are partially differentiated progenitors with neoplastic traits. Cancer Res (2014) 0.77

Evidence of disrupted high-risk human papillomavirus DNA in morphologically normal cervices of older women. Sci Rep (2016) 0.76

Hypermethylation of the tumor-suppressor cell adhesion molecule 1 in human papillomavirus-transformed cervical carcinoma cells. Int J Oncol (2015) 0.75

Methylation pattern of CDH1 promoter and its association with CDH1 gene expression in cytological cervical specimens. Oncol Lett (2016) 0.75

Procainamide Inhibits DNA Methylation and Alleviates Multiple Organ Dysfunction in Rats with Endotoxic Shock. PLoS One (2016) 0.75

Genome-Wide Epigenetic Characterization of Tissues from Three Germ Layers Isolated from Sheep Fetuses. Front Genet (2017) 0.75

Epigenetic Alterations in Human Papillomavirus-Associated Cancers. Viruses (2017) 0.75

Articles by these authors

Degeneration of the intervertebral disc. Arthritis Res Ther (2003) 4.30

The natural history of cervical HPV infection: unresolved issues. Nat Rev Cancer (2007) 3.99

A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years. J Bone Joint Surg Am (2007) 3.73

Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial. J Bone Joint Surg Am (2004) 3.59

Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis. BMC Cancer (2007) 3.16

Performance of influenza rapid point-of-care tests in the detection of swine lineage A(H1N1) influenza viruses. Influenza Other Respir Viruses (2009) 2.75

Should grade 3 endometrioid endometrial carcinoma be considered a type 2 cancer-a clinical and pathological evaluation. Gynecol Oncol (2011) 2.57

Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer--systematic review and meta-analysis of trends by time and region. Head Neck (2012) 2.40

Histological assessment of cartilage repair: a report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS). J Bone Joint Surg Am (2003) 2.24

Choroidal vessel diameter in central serous chorioretinopathy. Acta Ophthalmol (2013) 2.16

Staphylococcus aureus bacteraemia: a major cause of mortality in Australia and New Zealand. Med J Aust (2009) 2.16

Corynebacterium species isolated from patients with mastitis. Clin Infect Dis (2002) 2.12

Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling. J Biol Chem (2002) 2.08

Risk factors and immunity in a nationally representative population following the 2009 influenza A(H1N1) pandemic. PLoS One (2010) 2.04

Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling pathway. Oncogene (2003) 1.98

A new histology scoring system for the assessment of the quality of human cartilage repair: ICRS II. Am J Sports Med (2010) 1.93

Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis. Arthritis Res Ther (2012) 1.74

Down-regulation of BLIMP1α by the EBV oncogene, LMP-1, disrupts the plasma cell differentiation program and prevents viral replication in B cells: implications for the pathogenesis of EBV-associated B-cell lymphomas. Blood (2011) 1.64

Tissue engineering and the intervertebral disc: the challenges. Eur Spine J (2008) 1.56

The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC). Semin Cancer Biol (2012) 1.56

Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer. J Clin Oncol (2004) 1.54

Transmission of pandemic A/H1N1 2009 influenza on passenger aircraft: retrospective cohort study. BMJ (2010) 1.52

Prognostic impact of tumour-infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma. Hematol Oncol (2009) 1.50

Three days of intravenous benzyl penicillin treatment of meningococcal disease in adults. Clin Infect Dis (2003) 1.49

Mechanisms of recurrence of Ta/T1 bladder cancer. Ann R Coll Surg Engl (2010) 1.48

Cells from different regions of the intervertebral disc: effect of culture system on matrix expression and cell phenotype. Spine (Phila Pa 1976) (2002) 1.48

A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma. Hepatology (2009) 1.46

Human papillomavirus type 18 and rapidly progressing cervical intraepithelial neoplasia. Lancet (2003) 1.42

Increased nerve and blood vessel ingrowth associated with proteoglycan depletion in an ovine anular lesion model of experimental disc degeneration. Spine (Phila Pa 1976) (2002) 1.39

The excess cost associated with healthcare-associated bloodstream infections at Auckland City Hospital. N Z Med J (2010) 1.39

Elastic fibre organization in the intervertebral discs of the bovine tail. J Anat (2002) 1.38

Microfibrils, elastin fibres and collagen fibres in the human intervertebral disc and bovine tail disc. J Anat (2007) 1.38

High incidence of cervical human papillomavirus infection in women during their first sexual relationship. BJOG (2002) 1.33

Modulation of the cell growth regulator mTOR by Epstein-Barr virus-encoded LMP2A. J Virol (2005) 1.33

Epstein-Barr virus-encoded LMP2A regulates viral and cellular gene expression by modulation of the NF-kappaB transcription factor pathway. Proc Natl Acad Sci U S A (2004) 1.32

A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival. Blood (2005) 1.32

Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells. Blood (2007) 1.32

Role of the Epstein-Barr virus-encoded latent membrane protein-1, LMP1, in the pathogenesis of nasopharyngeal carcinoma. Future Oncol (2009) 1.31

Activity of the human papillomavirus E6 PDZ-binding motif correlates with an enhanced morphological transformation of immortalized human keratinocytes. J Cell Sci (2003) 1.31

The elastic fiber network of the anulus fibrosus of the normal and scoliotic human intervertebral disc. Spine (Phila Pa 1976) (2005) 1.29

Microfracture for acetabular chondral defects in patients with femoroacetabular impingement: results at second-look arthroscopic surgery. Am J Sports Med (2012) 1.29

Epstein-Barr virus (EBV) and its associated human cancers--genetics, epigenetics, pathobiology and novel therapeutics. Front Biosci (2006) 1.29

Implementation of RCGP guidelines for acute low back pain: a cluster randomised controlled trial. Br J Gen Pract (2004) 1.29

Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates Up-regulation of CCL20 and the migration of regulatory T cells. Am J Pathol (2008) 1.29

Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR. J Pathol (2005) 1.27

Australasian Society for Infectious Diseases guidelines for the diagnosis and treatment of Clostridium difficile infection. Med J Aust (2011) 1.22

Proximity of first intercourse to menarche and the risk of human papillomavirus infection: a longitudinal study. Int J Cancer (2005) 1.20

Overexpression of Slug is associated with malignant progression of esophageal adenocarcinoma. World J Gastroenterol (2008) 1.20

The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: implications for degenerative disc disease. Arthritis Res Ther (2008) 1.20

Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway. J Virol (2008) 1.18

Reactivity with A monoclonal antibody to Epstein-Barr virus (EBV) nuclear antigen 1 defines a subset of aggressive breast cancers in the absence of the EBV genome. Cancer Res (2003) 1.17

A phase I/II clinical trial in localized prostate cancer of an adenovirus expressing nitroreductase with CB1954 [correction of CB1984]. Mol Ther (2009) 1.16

Changes in expression of the human homologue of the Drosophila discs large tumour suppressor protein in high-grade premalignant cervical neoplasias. Carcinogenesis (2002) 1.12

Disruption of the E2 gene is a common and early event in the natural history of cervical human papillomavirus infection: a longitudinal cohort study. Cancer Res (2009) 1.11

Absence of Epstein-Barr virus DNA in the tumor cells of European hepatocellular carcinoma. Virology (2003) 1.10

Human paralogs of KIAA0187 were created through independent pericentromeric-directed and chromosome-specific duplication mechanisms. Genome Res (2002) 1.10

Autologous chondrocyte implantation with bone grafting for osteochondral defect due to posttraumatic osteonecrosis of the hip--a case report. Acta Orthop (2006) 1.09

Optical coherence tomography-assisted enhanced depth imaging of central serous chorioretinopathy. Invest Ophthalmol Vis Sci (2013) 1.07

Human intervertebral disc aggrecan inhibits nerve growth in vitro. Arthritis Rheum (2002) 1.07

Characterisation of pncA mutations in clinical Mycobacterium tuberculosis isolates in New Zealand. Pathology (2009) 1.05

Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells. Blood (2005) 1.04

Interleukin 6 expression by Hodgkin/Reed-Sternberg cells is associated with the presence of 'B' symptoms and failure to achieve complete remission in patients with advanced Hodgkin's disease. Br J Haematol (2002) 1.04

Epigenetic and transcriptional changes which follow Epstein-Barr virus infection of germinal center B cells and their relevance to the pathogenesis of Hodgkin's lymphoma. J Virol (2011) 1.04

Epstein-Barr virus-encoded EBNA1 modulates the AP-1 transcription factor pathway in nasopharyngeal carcinoma cells and enhances angiogenesis in vitro. J Gen Virol (2008) 1.04

The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2. J Virol (2002) 1.03

Intervertebral disc cells as competent phagocytes in vitro: implications for cell death in disc degeneration. Arthritis Res Ther (2008) 1.03

Comparative in vitro activity of carbapenems against major Gram-negative pathogens: results of Asia-Pacific surveillance from the COMPACT II study. Int J Antimicrob Agents (2012) 1.02

CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2. Cell Signal (2005) 1.02

The Epstein-Barr virus and the pathogenesis of lymphoma. J Pathol (2015) 1.02

TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells. Mol Cell Biol (2005) 1.01

The full-length E1E4 protein of human papillomavirus type 18 modulates differentiation-dependent viral DNA amplification and late gene expression. Virology (2007) 1.01

Cigarette smoking is an independent risk factor for cervical intraepithelial neoplasia in young women: a longitudinal study. Eur J Cancer (2009) 1.01

The role of the CD40 pathway in the pathogenesis and treatment of cancer. Curr Opin Pharmacol (2004) 1.01

Prognostic biomarkers of survival in oropharyngeal squamous cell carcinoma: systematic review and meta-analysis. Head Neck (2012) 1.00

TRAF1 is a critical regulator of JNK signaling by the TRAF-binding domain of the Epstein-Barr virus-encoded latent infection membrane protein 1 but not CD40. J Virol (2003) 1.00

Aggrecan turnover in human intervertebral disc as determined by the racemization of aspartic acid. J Biol Chem (2006) 0.99

Human intervertebral disc aggrecan inhibits endothelial cell adhesion and cell migration in vitro. Spine (Phila Pa 1976) (2005) 0.99

Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells. J Biol Chem (2003) 0.99

Nitroreductase: a prodrug-activating enzyme for cancer gene therapy. Clin Exp Pharmacol Physiol (2004) 0.99

The Epstein-Barr virus-encoded LMP2A and LMP2B proteins promote epithelial cell spreading and motility. J Virol (2005) 0.98

Constitutive activation of the CD40 pathway promotes cell transformation and neoplastic growth. Oncogene (2005) 0.98

Is human papillomavirus viral load a clinically useful predictive marker? A longitudinal study. Cancer Epidemiol Biomarkers Prev (2010) 0.98

Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc. Eur Spine J (2013) 0.98

Pituitary tumor transforming gene binding factor: a novel transforming gene in thyroid tumorigenesis. J Clin Endocrinol Metab (2005) 0.98

Expression of mitochondrial non-coding RNAs (ncRNAs) is modulated by high risk human papillomavirus (HPV) oncogenes. J Biol Chem (2012) 0.98

Proteomic profiling of urine for the detection of colon cancer. Proteome Sci (2008) 0.97

The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma. J Pathol (2009) 0.97

Differential induction of nuclear factor-kappaB and activator protein-1 activity after CD40 ligation is associated with primary human hepatocyte apoptosis or intrahepatic endothelial cell proliferation. Mol Biol Cell (2003) 0.97

Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-kappaB survival pathway signaling. Blood (2004) 0.97

A global view of the oncogenic landscape in nasopharyngeal carcinoma: an integrated analysis at the genetic and expression levels. PLoS One (2012) 0.97