Published in BMC Pharmacol on May 03, 2012
Drug development for the irritable bowel syndrome: current challenges and future perspectives. Front Pharmacol (2013) 0.88
Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia. Am J Physiol Lung Cell Mol Physiol (2013) 0.85
Polyunsaturated Fatty Acids and Their Derivatives: Therapeutic Value for Inflammatory, Functional Gastrointestinal Disorders, and Colorectal Cancer. Front Pharmacol (2016) 0.84
Pharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis. Drug Des Devel Ther (2013) 0.79
Lubiprostone in constipation: clinical evidence and place in therapy. Ther Adv Chronic Dis (2015) 0.78
Direct interactions between ENaC gamma subunit and ClCN2 in cystic fibrosis epithelial cells. Physiol Rep (2015) 0.76
A comparison of linaclotide and lubiprostone dosing regimens on ion transport responses in human colonic mucosa. Pharmacol Res Perspect (2015) 0.76
ClC-2 regulation of intestinal barrier function: Translation of basic science to therapeutic target. Tissue Barriers (2015) 0.75
Open channels for functional bowel disorders: guanylate cyclase C agonists in IBS and CC. Dig Dis Sci (2013) 0.75
Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators. Gut (2008) 3.52
SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents. Am J Physiol Cell Physiol (2004) 2.33
Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome. Gastroenterology (2007) 2.30
Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome--results of two randomized, placebo-controlled studies. Aliment Pharmacol Ther (2008) 2.06
Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers. Am J Physiol Gastrointest Liver Physiol (2006) 1.94
Epithelial tight junctions in intestinal inflammation. Ann N Y Acad Sci (2009) 1.81
Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit. Eur J Pharmacol (2010) 1.74
Efficacy of linaclotide for patients with chronic constipation. Gastroenterology (2010) 1.71
Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton, Ontario. Aliment Pharmacol Ther (2004) 1.70
Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation. Gastroenterology (2010) 1.61
Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain. Neurogastroenterol Motil (2009) 1.58
Linaclotide, a synthetic guanylate cyclase C agonist, for the treatment of functional gastrointestinal disorders associated with constipation. Expert Rev Gastroenterol Hepatol (2011) 1.47
Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract. Life Sci (2010) 1.42
A synthetic prostone activates apical chloride channels in A6 epithelial cells. Am J Physiol Gastrointest Liver Physiol (2008) 1.35
Bacterial enterotoxins are associated with resistance to colon cancer. Proc Natl Acad Sci U S A (2003) 1.35
Intestinal permeability and irritable bowel syndrome. Neurogastroenterol Motil (2007) 1.33
Pilot study on the effect of linaclotide in patients with chronic constipation. Am J Gastroenterol (2009) 1.26
The expression and the cellular distribution of the tight junction proteins are altered in irritable bowel syndrome patients with differences according to the disease subtype. Am J Gastroenterol (2011) 1.26
Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone. Am J Physiol Gastrointest Liver Physiol (2006) 1.21
Efficacy and safety of lubiprostone in patients with chronic constipation. Dig Dis Sci (2009) 1.19
Cross-talk between enteric pathogens and the intestine. Cell Microbiol (2000) 1.10
Combination of allergic factors can worsen diarrheic irritable bowel syndrome: role of barrier defects and mast cells. Am J Gastroenterol (2011) 1.07
AMP-activated protein kinase mediates the interferon-gamma-induced decrease in intestinal epithelial barrier function. J Biol Chem (2009) 1.06
Differential effects of TNF (TNFSF2) and IFN-γ on intestinal epithelial cell morphogenesis and barrier function in three-dimensional culture. PLoS One (2011) 1.04
Interferon-gamma regulation of intestinal epithelial permeability. J Interferon Cytokine Res (2009) 1.02
Guanylin, uroguanylin, and heat-stable euterotoxin activate guanylate cyclase C and/or a pertussis toxin-sensitive G protein in human proximal tubule cells. J Biol Chem (2002) 1.02
Comparison of the chloride channel activator lubiprostone and the oral laxative Polyethylene Glycol 3350 on mucosal barrier repair in ischemic-injured porcine intestine. World J Gastroenterol (2008) 0.99
Cellular and molecular effects of unoprostone as a BK channel activator. Biochim Biophys Acta (2007) 0.95
Intestinal permeability in irritable bowel syndrome patients: effects of NSAIDs. Dig Dis Sci (2009) 0.94
Chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludin. Am J Physiol Cell Physiol (2011) 0.93
Taking a lesson from microbial diarrheagenesis in the management of chronic constipation. Gastroenterology (2010) 0.92
Lubiprostone does not influence visceral pain thresholds in patients with irritable bowel syndrome. Neurogastroenterol Motil (2011) 0.92
Efficacy and safety of oral lubiprostone in constipated patients with or without irritable bowel syndrome: a randomized, placebo-controlled and dose-finding study. Neurogastroenterol Motil (2011) 0.91
ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunum. Exp Cell Res (2008) 0.91
Lubiprostone for the treatment of adults with constipation and irritable bowel syndrome. Dig Dis Sci (2011) 0.91
Tumor necrosis factor alpha increases epithelial barrier permeability by disrupting tight junctions in Caco-2 cells. Braz J Med Biol Res (2010) 0.89
Lubiprostone: evaluation of the newest medication for the treatment of adult women with constipation-predominant irritable bowel syndrome. Int J Womens Health (2010) 0.85
Optimized Fmoc solid-phase synthesis of the cysteine-rich peptide linaclotide. Biopolymers (2010) 0.79
SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents. Am J Physiol Cell Physiol (2004) 2.33
Early weaning stress impairs development of mucosal barrier function in the porcine intestine. Am J Physiol Gastrointest Liver Physiol (2009) 1.49
Analysis of sodium carboxymethylcellulose administration and related factors associated with postoperative colic and survival in horses with small intestinal disease. Vet Surg (2008) 1.42
Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs. Am J Physiol Gastrointest Liver Physiol (2007) 1.31
Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone. Am J Physiol Gastrointest Liver Physiol (2006) 1.21
Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig. Am J Physiol Gastrointest Liver Physiol (2006) 1.20
Effects of continuous rate intravenous infusion of butorphanol on physiologic and outcome variables in horses after celiotomy. J Vet Intern Med (2004) 1.11
TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium. J Immunol (2010) 1.07
Sonic hedgehog is associated with H+-K+-ATPase-containing membranes in gastric parietal cells and secreted with histamine stimulation. Am J Physiol Gastrointest Liver Physiol (2008) 1.05
Effects of lubiprostone on human uterine smooth muscle cells. Prostaglandins Other Lipid Mediat (2008) 1.05
Can homeopathic arsenic remedy combat arsenic poisoning in humans exposed to groundwater arsenic contamination?: a preliminary report on first human trial. Evid Based Complement Alternat Med (2005) 1.03
ClC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum. Gastroenterology (2004) 1.03
PI3K signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum. Am J Physiol Gastrointest Liver Physiol (2002) 1.01
Mice lacking the Na+/H+ exchanger 2 have impaired recovery of intestinal barrier function. Am J Physiol Gastrointest Liver Physiol (2008) 0.95
Cellular and molecular effects of unoprostone as a BK channel activator. Biochim Biophys Acta (2007) 0.95
Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration. PLoS One (2013) 0.94
Chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludin. Am J Physiol Cell Physiol (2011) 0.93
ClC-2 regulates mucosal barrier function associated with structural changes to the villus and epithelial tight junction. Am J Physiol Gastrointest Liver Physiol (2010) 0.93
Methadone but not morphine inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents. Cell Biochem Biophys (2013) 0.92
Gastrointestinal tract perforation in dogs treated with a selective cyclooxygenase-2 inhibitor: 29 cases (2002-2003). J Am Vet Med Assoc (2005) 0.91
ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunum. Exp Cell Res (2008) 0.91
Effect of curcumin on gelatinase A (MMP-2) activity in B16F10 melanoma cells. Cancer Lett (2004) 0.90
Prostaglandin-mediated inhibition of Na+/H+ exchanger isoform 2 stimulates recovery of barrier function in ischemia-injured intestine. Am J Physiol Gastrointest Liver Physiol (2006) 0.89
Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum. Am J Vet Res (2009) 0.89
PG-mediated closure of paracellular pathway and not restitution is the primary determinant of barrier recovery in acutely injured porcine ileum. Am J Physiol Gastrointest Liver Physiol (2003) 0.89
Mechanisms of porcine diarrheal disease. J Am Vet Med Assoc (2007) 0.88
Astrovirus infection induces sodium malabsorption and redistributes sodium hydrogen exchanger expression. Virology (2010) 0.87
Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs. Am J Vet Res (2008) 0.86
Sites of protein kinase A activation of the human ClC-2 Cl(-) channel. J Biol Chem (2004) 0.86
Binding of alpha5 monoclonal antibody to cell surface alpha5beta1 integrin modulates MMP-2 and MMP-7 activity in B16F10 melanoma cells. J Environ Pathol Toxicol Oncol (2003) 0.86
Red maple (Acer rubrum) leaf toxicosis in horses: a retrospective study of 32 cases. J Vet Intern Med (2006) 0.85
Arginine activates intestinal p70(S6k) and protein synthesis in piglet rotavirus enteritis. J Nutr (2008) 0.84
Curcumin, a potential inhibitor of MMP-2 in human laryngeal squamous carcinoma cells HEp2. J Environ Pathol Toxicol Oncol (2006) 0.84
Culture of human cervical cancer cells, SiHa, in the presence of fibronectin activates MMP-2. J Cancer Res Clin Oncol (2006) 0.84
Determination of minimum alveolar concentration of sevoflurane in juvenile swine. Res Vet Sci (2007) 0.84
Enrichment of intestinal mucosal phospholipids with arachidonic and eicosapentaenoic acids fed to suckling piglets is dose and time dependent. J Nutr (2008) 0.83
Dietary long-chain PUFA enhance acute repair of ischemia-injured intestine of suckling pigs. J Nutr (2012) 0.83
Mitogen-activated protein kinases regulate COX-2 and mucosal recovery in ischemic-injured porcine ileum. Am J Physiol Gastrointest Liver Physiol (2004) 0.82
Physiological concentrations of bile salts inhibit recovery of ischemic-injured porcine ileum. Am J Physiol Gastrointest Liver Physiol (2004) 0.82
Emergence of a nephropathogenic avian infectious bronchitis virus with a novel genotype in India. J Clin Microbiol (2005) 0.82
Life in the gut without oxygen: adaptive mechanisms and inflammatory bowel disease. Gastroenterology (2008) 0.82
Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infection. Comp Immunol Microbiol Infect Dis (2011) 0.81
Preferential and non-selective cyclooxygenase inhibitors reduce inflammation during lipopolysaccharide-induced synovitis. Res Vet Sci (2005) 0.81
Unoprostone isopropyl and metabolite M1 activate BK channels and prevent ET-1-induced [Ca²⁺]i increases in human trabecular meshwork and smooth muscle. Invest Ophthalmol Vis Sci (2012) 0.80
Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets. World J Gastroenterol (2013) 0.80
Membrane-associated MMP-2 in human cervical cancer. J Environ Pathol Toxicol Oncol (2003) 0.80
Use of systemically administered lidocaine in horses with gastrointestinal tract disease. J Am Vet Med Assoc (2008) 0.80
Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum. Am J Vet Res (2007) 0.79
Effects of ischemia and the cyclooxygenase inhibitor flunixin on in vitro passage of lipopolysaccharide across equine jejunum. Am J Vet Res (2004) 0.79
Cyclooxygenase (COX) inhibitors and the intestine. J Vet Intern Med (2007) 0.78
Binding of alpha2 monoclonal antibody to human cervical tumor cell (SiHa) surface alpha2beta1 integrin modulates MMP-2 activity. Gynecol Oncol (2004) 0.78
A retrospective analysis of hepatic injury in horses with proximal enteritis (1984-2002). J Vet Intern Med (2003) 0.78
Effect of a zinc L-carnosine compound on acid-induced injury in canine gastric mucosa ex vivo. Am J Vet Res (2012) 0.78
The use of nonsteroidal anti-inflammatory drugs in critically ill horses. J Vet Emerg Crit Care (San Antonio) (2014) 0.77
Neutrophils augment recovery of porcine ischemia-injured ileal mucosa by an IL-1beta- and COX-2-dependent mechanism. Am J Physiol Gastrointest Liver Physiol (2004) 0.77
Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses. Am J Vet Res (2009) 0.77
The effect of lidocaine on in vitro adhesion and migration of equine neutrophils. Vet Immunol Immunopathol (2008) 0.77
Neutrophils increase paracellular permeability of restituted ischemic-injured porcine ileum. Surgery (2002) 0.77
Cell membrane-associated MT1-MMP dependent activation of MMP-2 in SiHa (human cervical cancer) cells. J Environ Pathol Toxicol Oncol (2006) 0.77
Effects of flunixin meglumine or etodolac treatment on mucosal recovery of equine jejunum after ischemia. Am J Vet Res (2004) 0.77
Interactions between lipopolysaccharide and the intestinal epithelium. J Am Vet Med Assoc (2004) 0.76
Expression of cyclooxygenase-1 and -2 in the left dorsal colon after different durations of ischemia and reperfusion in horses. Am J Vet Res (2009) 0.76
Pharmaceutical Activation or Genetic Absence of ClC-2 Alters Tight Junctions During Experimental Colitis. Inflamm Bowel Dis (2015) 0.76
Characterization of discrete equine intestinal epithelial cell lineages. Am J Vet Res (2015) 0.75
Performance of the 808-nm diode laser on equine upper airway tissue is enhanced by intravenous administration of indocyanine green. Photomed Laser Surg (2007) 0.75
Evaluation of the cyclooxygenase selectivity of robenacoxib and its effect on recovery of ischemia-injured jejunal mucosa in horses. Am J Vet Res (2011) 0.75
Evaluation of the relationship between lesions in the gastroduodenal region and cyclooxygenase expression in clinically normal dogs. Am J Vet Res (2010) 0.75
Endoscopy via a gastric cannula to monitor the development of ulcers in the pars esophagea in pigs after consumption of a finely ground feed combined with a period of withholding of feed. Am J Vet Res (2002) 0.75
Demographic characteristics of horses donated to the North Carolina State University Equine Health Center, 1996-2008. J Am Vet Med Assoc (2010) 0.75
Predisposing factors for small colon impaction in horses and outcome of medical and surgical treatment: 44 cases (1999-2004). J Am Vet Med Assoc (2006) 0.75
Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogs. Am J Vet Res (2009) 0.75
Expression of cyclooxygenase-1 and -2 in naturally occurring squamous cell carcinomas in horses. Am J Vet Res (2007) 0.75
Role of the enteric nervous system in the pathophysiology of secretory diarrhea. J Vet Intern Med (2002) 0.75