Published in J Biol Chem on March 21, 2002
Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load. J Clin Invest (2003) 1.32
Circulating prouroguanylin is processed to its active natriuretic form exclusively within the renal tubules. Endocrinology (2008) 0.94
Cure and curse: E. coli heat-stable enterotoxin and its receptor guanylyl cyclase C. Toxins (Basel) (2010) 0.94
Potassium channels in epithelial transport. Pflugers Arch (2003) 0.92
Glycosylation of the receptor guanylate cyclase C: role in ligand binding and catalytic activity. Biochem J (2004) 0.92
A novel role for uroguanylin in the regulation of sodium balance. J Clin Invest (2003) 0.91
E. coli heat-stable enterotoxin and guanylyl cyclase C: new functions and unsuspected actions. Trans Am Clin Climatol Assoc (2003) 0.88
Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors. BMC Pharmacol (2012) 0.83
Current understanding of guanylin peptides actions. ISRN Nephrol (2013) 0.82
Effect of guanylate cyclase-C activity on energy and glucose homeostasis. Diabetes (2014) 0.80
The natriuretic peptide uroguanylin elicits physiologic actions through 2 distinct topoisomers. Hypertension (2009) 0.80
The rat kidney contains high levels of prouroguanylin (the uroguanylin precursor) but does not express GC-C (the enteric uroguanylin receptor). Am J Physiol Renal Physiol (2010) 0.79
Lack of guanylate cyclase C results in increased mortality in mice following liver injury. BMC Gastroenterol (2010) 0.79
Transcriptional regulation of the pendrin gene. Cell Physiol Biochem (2011) 0.78
Mechanisms of actions of guanylin peptides in the kidney. Pflugers Arch (2005) 0.78
The pendrin anion exchanger gene is transcriptionally regulated by uroguanylin: a novel enterorenal link. Am J Physiol Renal Physiol (2011) 0.78
Defying the stereotype: non-canonical roles of the Peptide hormones guanylin and uroguanylin. Front Endocrinol (Lausanne) (2011) 0.76
Pendrin, a novel transcriptional target of the uroguanylin system. Cell Physiol Biochem (2013) 0.76
Uroguanylin inhibits H-ATPase activity and surface expression in renal distal tubules by a PKG-dependent pathway. Am J Physiol Cell Physiol (2014) 0.75
Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci U S A (2002) 3.03
Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A. J Clin Invest (2003) 2.37
Familial diarrhea syndrome caused by an activating GUCY2C mutation. N Engl J Med (2012) 2.04
Organic cation transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions. Am J Pathol (2010) 1.76
Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am J Pathol (2005) 1.73
Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I. Eur Heart J (2011) 1.67
Individual PKC-phosphorylation sites in organic cation transporter 1 determine substrate selectivity and transport regulation. J Am Soc Nephrol (2005) 1.65
Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. J Physiol (2002) 1.56
Vascular endothelium is critically involved in the hypotensive and hypovolemic actions of atrial natriuretic peptide. J Clin Invest (2005) 1.53
Translocation of aquaporin-containing vesicles to the plasma membrane is facilitated by actomyosin relaxation. Biophys J (2007) 1.47
Mechanisms of angiotensin II signaling on cytoskeleton of podocytes. J Mol Med (Berl) (2008) 1.46
Site-directed mutagenesis using a single mutagenic oligonucleotide and DpnI digestion of template DNA. Anal Biochem (2003) 1.36
Class III nucleotide cyclases in bacteria and archaebacteria: lineage-specific expansion of adenylyl cyclases and a dearth of guanylyl cyclases. FEBS Lett (2004) 1.34
New messages from old messengers: cAMP and mycobacteria. Trends Microbiol (2006) 1.33
Nephrocalcinosis (enamel renal syndrome) caused by autosomal recessive FAM20A mutations. Nephron Physiol (2013) 1.31
The Rv0805 gene from Mycobacterium tuberculosis encodes a 3',5'-cyclic nucleotide phosphodiesterase: biochemical and mutational analysis. Biochemistry (2005) 1.26
Structural and biochemical analysis of the Rv0805 cyclic nucleotide phosphodiesterase from Mycobacterium tuberculosis. J Mol Biol (2006) 1.20
cAMP-regulated protein lysine acetylases in mycobacteria. J Biol Chem (2010) 1.18
Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients. Clin Cancer Res (2012) 1.15
Essential amino acids of the hantaan virus N protein in its interaction with RNA. J Virol (2005) 1.13
Atrial natriuretic peptide modulation of albumin clearance and contrast agent permeability in mouse skeletal muscle and skin: role in regulation of plasma volume. J Physiol (2009) 1.12
Mycobacterial adenylyl cyclases: biochemical diversity and structural plasticity. FEBS Lett (2006) 1.12
Cyclic AMP-dependent protein lysine acylation in mycobacteria regulates fatty acid and propionate metabolism. J Biol Chem (2013) 1.08
A mycobacterial cyclic AMP phosphodiesterase that moonlights as a modifier of cell wall permeability. J Biol Chem (2009) 1.06
Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. Basic Res Cardiol (2010) 1.05
Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases. Am J Physiol Renal Physiol (2002) 1.03
A survey of nucleotide cyclases in actinobacteria: unique domain organization and expansion of the class III cyclase family in Mycobacterium tuberculosis. Comp Funct Genomics (2004) 1.02
Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice. Circulation (2005) 1.01
Local atrial natriuretic peptide signaling prevents hypertensive cardiac hypertrophy in endothelial nitric-oxide synthase-deficient mice. J Biol Chem (2005) 1.00
The heart communicates with the endothelium through the guanylyl cyclase-A receptor: acute handling of intravascular volume in response to volume expansion. Endocrinology (2008) 0.99
Cyclic AMP in mycobacteria: characterization and functional role of the Rv1647 ortholog in Mycobacterium smegmatis. J Bacteriol (2008) 0.99
Regulation of organic cation transport. Pflugers Arch (2004) 0.98
Expression of the receptor guanylyl cyclase C and its ligands in reproductive tissues of the rat: a potential role for a novel signaling pathway in the epididymis. Biol Reprod (2002) 0.97
Non-invasive imaging of acute renal allograft rejection in rats using small animal F-FDG-PET. PLoS One (2009) 0.97
Culture and characterization of oral mucosal epithelial cells on human amniotic membrane for ocular surface reconstruction. Mol Vis (2008) 0.97
Atrial natriuretic peptide and nitric oxide signaling antagonizes vasopressin-mediated water permeability in inner medullary collecting duct cells. Am J Physiol Renal Physiol (2009) 0.96
Calcium-dependent dephosphorylation mediates the hyperosmotic and lysophosphatidic acid-dependent inhibition of natriuretic peptide receptor-B/guanylyl cyclase-B. J Biol Chem (2004) 0.96
Dynamic 18F-fluoride small animal PET to noninvasively assess renal function in rats. Eur J Nucl Med Mol Imaging (2008) 0.96
Rapid regulation of K(ATP) channel activity by 17{beta}-estradiol in pancreatic {beta}-cells involves the estrogen receptor {beta} and the atrial natriuretic peptide receptor. Mol Endocrinol (2009) 0.96
Hypervolemic hypertension in mice with systemic inactivation of the (floxed) guanylyl cyclase-A gene by alphaMHC-Cre-mediated recombination. Genesis (2004) 0.95
Renal electrolyte effects of guanylin and uroguanylin. Curr Opin Nephrol Hypertens (2007) 0.95
Deep sequencing reveals unique small RNA repertoire that is regulated during head regeneration in Hydra magnipapillata. Nucleic Acids Res (2012) 0.94
The evolution of guanylyl cyclases as multidomain proteins: conserved features of kinase-cyclase domain fusions. J Mol Evol (2009) 0.94
Characterization of phylogenetically distant members of the adenylate cyclase family from mycobacteria: Rv1647 from Mycobacterium tuberculosis and its orthologue ML1399 from M. leprae. Biochem J (2005) 0.94
The atrial natriuretic peptide and guanylyl cyclase-A system modulates pancreatic beta-cell function. Endocrinology (2010) 0.94
Potential of noninvasive serial assessment of acute renal allograft rejection by 18F-FDG PET to monitor treatment efficiency. J Nucl Med (2010) 0.94
Atrial natriuretic peptide enhances microvascular albumin permeability by the caveolae-mediated transcellular pathway. Cardiovasc Res (2011) 0.93
Receptor guanylyl cyclase C (GC-C): regulation and signal transduction. Mol Cell Biochem (2009) 0.93
Glycosylation of the receptor guanylate cyclase C: role in ligand binding and catalytic activity. Biochem J (2004) 0.92
Impact of renal transplantation on small vessel reactivity. Transplantation (2003) 0.92
Cellular effects of guanylin and uroguanylin. J Am Soc Nephrol (2005) 0.92
Acute rejection after rat renal transplantation leads to downregulation of NA+ and water channels in the collecting duct. Am J Transplant (2005) 0.92
Regulation of the human organic cation transporter hOCT1. J Cell Physiol (2004) 0.92
Increased effects of C-type natriuretic peptide on cardiac ventricular contractility and relaxation in guanylyl cyclase A-deficient mice. Cardiovasc Res (2002) 0.91
Homologous desensitization of guanylyl cyclase A, the receptor for atrial natriuretic peptide, is associated with a complex phosphorylation pattern. FEBS J (2010) 0.91
Uroguanylin and guanylin regulate transport of mouse cortical collecting duct independent of guanylate cyclase C. Kidney Int (2005) 0.91
The linker region in receptor guanylyl cyclases is a key regulatory module: mutational analysis of guanylyl cyclase C. J Biol Chem (2009) 0.90
Ventricular arrhythmias, increased cardiac calmodulin kinase II expression, and altered repolarization kinetics in ANP receptor deficient mice. J Mol Cell Cardiol (2004) 0.90
Activation of counter-regulatory mechanisms in a rat renal acute rejection model. BMC Genomics (2008) 0.89
New clues for nephrotoxicity induced by ifosfamide: preferential renal uptake via the human organic cation transporter 2. Mol Pharm (2010) 0.89
Characterization of an evolutionarily conserved metallophosphoesterase that is expressed in the fetal brain and associated with the WAGR syndrome. J Biol Chem (2008) 0.89
Tyrphostins are inhibitors of guanylyl and adenylyl cyclases. Biochemistry (2004) 0.89
The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization. FASEB J (2011) 0.89
Mutational analysis of the Mycobacterium tuberculosis Rv1625c adenylyl cyclase: residues that confer nucleotide specificity contribute to dimerization. FEBS Lett (2003) 0.89
The multiple and enigmatic roles of guanylyl cyclase C in intestinal homeostasis. FEBS Lett (2012) 0.89
Modeling and mutational analysis of the GAF domain of the cGMP-binding, cGMP-specific phosphodiesterase, PDE5. FEBS Lett (2003) 0.89
Signalling mechanisms in Mycobacteria. Tuberculosis (Edinb) (2011) 0.89
Guanylin and uroguanylin regulate electrolyte transport in isolated human cortical collecting ducts. Kidney Int (2005) 0.88
Protective role of NHE-3 inhibition in rat renal transplantation undergoing acute rejection. Pflugers Arch (2008) 0.88
Cyclic AMP-induced conformational changes in mycobacterial protein acetyltransferases. J Biol Chem (2012) 0.88
A polymorphism in the CYP1B1 promoter is functionally associated with primary congenital glaucoma. Hum Mol Genet (2010) 0.87
Increased effects of C-type natriuretic peptide on contractility and calcium regulation in murine hearts overexpressing cyclic GMP-dependent protein kinase I. Br J Pharmacol (2003) 0.86
Hydroxyfasudil-mediated inhibition of ROCK1 and ROCK2 improves kidney function in rat renal acute ischemia-reperfusion injury. PLoS One (2011) 0.86
Left but not right cardiac hypertrophy in atrial natriuretic peptide receptor-deficient mice is prevented by angiotensin type 1 receptor antagonist losartan. J Cardiovasc Pharmacol (2002) 0.86
ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport. EMBO J (2008) 0.86
Acute rejection modulates gene expression in the collecting duct. J Am Soc Nephrol (2008) 0.86
Characterization of regulatory mechanisms and states of human organic cation transporter 2. Am J Physiol Cell Physiol (2006) 0.85
The GAF domain of the cGMP-binding, cGMP-specific phosphodiesterase (PDE5) is a sensor and a sink for cGMP. Biochemistry (2008) 0.85
Cross talk between receptor guanylyl cyclase C and c-src tyrosine kinase regulates colon cancer cell cytostasis. Mol Cell Biol (2009) 0.85
Direct aldosterone action on mouse cardiomyocytes detected with atomic force microscopy. Cell Physiol Biochem (2006) 0.85
A structural basis for the role of nucleotide specifying residues in regulating the oligomerization of the Rv1625c adenylyl cyclase from M. tuberculosis. J Mol Biol (2005) 0.84
Local actions of atrial natriuretic peptide counteract angiotensin II stimulated cardiac remodeling. Endocrinology (2007) 0.84
Intestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21. J Biol Chem (2013) 0.84
CaMKII-mediated increased lusitropic responses to beta-adrenoreceptor stimulation in ANP-receptor deficient mice. Cardiovasc Res (2006) 0.84
Distinct allostery induced in the cyclic GMP-binding, cyclic GMP-specific phosphodiesterase (PDE5) by cyclic GMP, sildenafil, and metal ions. J Biol Chem (2010) 0.83
An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities. J Clin Endocrinol Metab (2013) 0.83
Advantage of the ether linkage between the positive charge and the cholesteryl skeleton in cholesterol-based amphiphiles as vectors for gene delivery. Bioconjug Chem (2002) 0.83
Increased sensitivity to endothelial nitric oxide (NO) contributes to arterial normotension in mice with vascular smooth muscle-selective deletion of the atrial natriuretic peptide (ANP) receptor. J Biol Chem (2003) 0.83
The kinase homology domain of receptor guanylyl cyclase C: ATP binding and identification of an adenine nucleotide sensitive site. Biochemistry (2006) 0.83
Mechanisms of action of uroguanylin and guanylin and their role in salt handling. Nephrol Dial Transplant (2006) 0.83