Published in Protein Sci on June 05, 2012
Light-mediated kinetic control reveals the temporal effect of the Raf/MEK/ERK pathway in PC12 cell neurite outgrowth. PLoS One (2014) 1.07
Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin. Elife (2014) 0.89
Disentangling biological signaling networks by dynamic coupling of signaling lipids to modifying enzymes. Adv Biol Regul (2013) 0.84
IGFBP2 potentiates nuclear EGFR-STAT3 signaling. Oncogene (2015) 0.82
Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution. Nat Methods (2017) 0.78
Quantitative analysis of receptor tyrosine kinase-effector coupling at functionally relevant stimulus levels. J Biol Chem (2015) 0.77
Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci (2005) 28.08
Cardiac excitation-contraction coupling. Nature (2002) 18.48
Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science (1993) 17.63
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. Nat Methods (2009) 13.39
A high signal-to-noise Ca(2+) probe composed of a single green fluorescent protein. Nat Biotechnol (2001) 8.45
A genetically encoded photoactivatable Rac controls the motility of living cells. Nature (2009) 7.25
Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science (2000) 6.93
Coordination of Rho GTPase activities during cell protrusion. Nature (2009) 6.54
MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science (2002) 6.29
Channelrhodopsin-1: a light-gated proton channel in green algae. Science (2002) 5.73
Defining network topologies that can achieve biochemical adaptation. Cell (2009) 5.49
Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature (2010) 5.27
Calcium sparks and [Ca2+]i waves in cardiac myocytes. Am J Physiol (1996) 5.18
Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression. Nature (1994) 5.17
Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circ Res (2001) 5.08
An expanded palette of genetically encoded Ca²⁺ indicators. Science (2011) 5.05
Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. J Cell Biol (2004) 5.02
Novel single chain cAMP sensors for receptor-induced signal propagation. J Biol Chem (2004) 5.00
Design principles of biochemical oscillators. Nat Rev Mol Cell Biol (2008) 4.55
A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol (2003) 4.38
Physicochemical modelling of cell signalling pathways. Nat Cell Biol (2006) 4.34
An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways. Nat Methods (2005) 4.23
Bright and stable near-infrared fluorescent protein for in vivo imaging. Nat Biotechnol (2011) 4.14
Temporally precise in vivo control of intracellular signalling. Nature (2009) 4.14
Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks. Cell (2008) 3.79
Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient. Nature (2008) 3.77
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proc Natl Acad Sci U S A (2001) 3.77
Activation of CaMKII in single dendritic spines during long-term potentiation. Nature (2009) 3.76
Spatio-temporal regulation of Rac1 localization and lamellipodia dynamics during epithelial cell-cell adhesion. Dev Cell (2002) 3.60
Caged compounds: photorelease technology for control of cellular chemistry and physiology. Nat Methods (2007) 3.22
A model for circadian oscillations in the Drosophila period protein (PER). Proc Biol Sci (1995) 3.09
Bistability in the JNK cascade. Curr Biol (2001) 2.93
Direct measurement of SR release flux by tracking 'Ca2+ spikes' in rat cardiac myocytes. J Physiol (1998) 2.78
Crystal structures of the GCaMP calcium sensor reveal the mechanism of fluorescence signal change and aid rational design. J Biol Chem (2008) 2.76
Designing customized cell signalling circuits. Nat Rev Mol Cell Biol (2010) 2.64
Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science (1993) 2.51
A CHEMICAL MECHANISM FOR OSCILLATION OF GLYCOLYTIC INTERMEDIATES IN YEAST CELLS. Proc Natl Acad Sci U S A (1964) 2.45
A genetically encoded fluorescent sensor of ERK activity. Proc Natl Acad Sci U S A (2008) 2.34
A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia. Curr Biol (2011) 2.34
A simple model of circadian rhythms based on dimerization and proteolysis of PER and TIM. Biophys J (2008) 2.19
Light modulation of cellular cAMP by a small bacterial photoactivated adenylyl cyclase, bPAC, of the soil bacterium Beggiatoa. J Biol Chem (2010) 1.94
How amoeboids self-organize into a fruiting body: multicellular coordination in Dictyostelium discoideum. Proc Natl Acad Sci U S A (2001) 1.86
Spatiotemporal development and distribution of intercellular junctions in adult rat cardiomyocytes in culture. Circ Res (1999) 1.66
Decoding cytosolic Ca2+ oscillations. Trends Biochem Sci (2010) 1.63
Protein kinase A type I and type II define distinct intracellular signaling compartments. Circ Res (2008) 1.62
Modelling the Bicoid gradient. Development (2010) 1.61
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proc Natl Acad Sci U S A (2006) 1.59
Systems biology of Caulobacter. Annu Rev Genet (2007) 1.58
Spatiotemporal analysis of differential Akt regulation in plasma membrane microdomains. Mol Biol Cell (2008) 1.57
Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nat Cell Biol (2011) 1.51
Selective activation of particulate cAMP-dependent protein kinase by isoproterenol and prostaglandin E1. J Biol Chem (1980) 1.46
Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit. Nat Chem Biol (2010) 1.35
A microprobe for parallel optical and electrical recordings from single neurons in vivo. Nat Methods (2011) 1.34
Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell (2008) 1.32
Spatiotemporal dynamics of CREB phosphorylation: transient versus sustained phosphorylation in the developing striatum. Neuron (1996) 1.31
High content cell screening in a microfluidic device. Mol Cell Proteomics (2008) 1.29
Bistability by multiple phosphorylation of regulatory proteins. Prog Biophys Mol Biol (2009) 1.28
Bidirectional regulation of Ca2+ sparks by mitochondria-derived reactive oxygen species in cardiac myocytes. Cardiovasc Res (2007) 1.26
Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development. Cancer Res (2009) 1.25
Birhythmicity, chaos, and other patterns of temporal self-organization in a multiply regulated biochemical system. Proc Natl Acad Sci U S A (1982) 1.21
Visualization of JNK activity dynamics with a genetically encoded fluorescent biosensor. Proc Natl Acad Sci U S A (2010) 1.20
SNARE membrane trafficking dynamics in vivo. J Cell Biol (1999) 1.17
Hormonally specific phosphorylation of cardiac troponin I and activation of glycogen phosphorylase. Nature (1979) 1.15
Competing docking interactions can bring about bistability in the MAPK cascade. Biophys J (2007) 1.13
Predicting local SR Ca(2+) dynamics during Ca(2+) wave propagation in ventricular myocytes. Biophys J (2010) 1.10
Human insulin vesicle dynamics during pulsatile secretion. Diabetes (2007) 1.09
Subcellular calcium dynamics in a whole-cell model of an atrial myocyte. Proc Natl Acad Sci U S A (2012) 1.07
Normal heart rhythm is initiated and regulated by an intracellular calcium clock within pacemaker cells. Heart Lung Circ (2007) 1.06
Inducible membrane recruitment of small GTP-binding proteins by rapamycin-based system in living cells. Methods Enzymol (2000) 1.03
Fluorescent biosensors for real-time tracking of post-translational modification dynamics. Curr Opin Chem Biol (2009) 1.00
Prostaglandin E1 activation of heart cAMP-dependent protein kinase: apparent dissociation of protein kinase activation from increases in phosphorylase activity and contractile force. Mol Pharmacol (1979) 0.99
Constitutive beta2-adrenergic signalling enhances sarcoplasmic reticulum Ca2+ cycling to augment contraction in mouse heart. J Physiol (1999) 0.98
Quantifying calcium fluxes underlying calcium puffs in Xenopus laevis oocytes. Cell Calcium (2010) 0.98
Glucose induces oscillatory Ca2+ signalling and insulin release in human pancreatic beta cells. Diabetologia (1994) 0.96
A synthetic-natural hybrid oscillator in human cells. Proc Natl Acad Sci U S A (2010) 0.92
Oscillatory signaling processes: the how, the why and the where. Curr Opin Genet Dev (2010) 0.92
Tuning caged calcium: photolabile analogues of EGTA with improved optical and chelation properties. Cell Calcium (2005) 0.92
Dynamic visualization of signal transduction in living cells: from second messengers to kinases. IUBMB Life (2009) 0.90
Spatiotemporally regulated protein kinase A activity is a critical regulator of growth factor-stimulated extracellular signal-regulated kinase signaling in PC12 cells. Mol Cell Biol (2011) 0.90
Calcium sparks in human ventricular cardiomyocytes from patients with terminal heart failure. Cell Calcium (2002) 0.89
What's wrong with correlative experiments? Nat Cell Biol (2011) 0.89
The design of Förster (fluorescence) resonance energy transfer (FRET)-based molecular sensors for Ran GTPase. Methods (2010) 0.88
The glycolytic oscillator. J Exp Biol (1979) 0.82
Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med (2015) 10.12
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell (2009) 8.62
A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol (2003) 4.38
CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion. J Mol Histol (2004) 4.08
Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts. Cell Rep (2013) 3.85
Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc Natl Acad Sci U S A (2004) 3.31
PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell (2012) 3.28
Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes (2009) 3.17
Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science (2012) 2.98
Subcellular dynamics of protein kinase A activity visualized by FRET-based reporters. Biochem Biophys Res Commun (2006) 2.66
PNPASE regulates RNA import into mitochondria. Cell (2010) 2.54
Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle. Nat Med (2004) 2.52
beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. J Biol Chem (2007) 2.42
Coupled ferredoxin and crotonyl coenzyme A (CoA) reduction with NADH catalyzed by the butyryl-CoA dehydrogenase/Etf complex from Clostridium kluyveri. J Bacteriol (2007) 2.38
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A (2008) 2.34
Optimizing the fMRI data-processing pipeline using prediction and reproducibility performance metrics: I. A preliminary group analysis. Neuroimage (2004) 2.19
The anterior cruciate ligament remnant: to leave it or not? Arthroscopy (2013) 2.13
Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. J Biol Chem (2009) 2.02
Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J Biol Chem (2004) 1.96
Chemical rescue of a mutant enzyme in living cells. Science (2006) 1.95
Genetically encodable fluorescent biosensors for tracking signaling dynamics in living cells. Chem Rev (2011) 1.88
Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev (2014) 1.87
Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity. Am J Physiol Endocrinol Metab (2008) 1.84
Can graphene be used as a substrate for Raman enhancement? Nano Lett (2010) 1.78
Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure. J Biol Chem (2009) 1.71
Emergence of a new multidrug-resistant serotype X variant in an epidemic clone of Shigella flexneri. J Clin Microbiol (2009) 1.71
The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells. Immunity (2002) 1.70
Social network and other correlates of HIV testing: findings from male sex workers and other MSM in Shanghai, China. AIDS Behav (2012) 1.69
Imaging of cAMP levels and protein kinase A activity reveals that retinal waves drive oscillations in second-messenger cascades. J Neurosci (2006) 1.67
GJB2 mutation spectrum in 2,063 Chinese patients with nonsyndromic hearing impairment. J Transl Med (2009) 1.66
Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation. Endocrinology (2010) 1.65
Quantitative analysis of HBV DNA level and HBeAg titer in hepatitis B surface antigen positive mothers and their babies: HBeAg passage through the placenta and the rate of decay in babies. J Med Virol (2003) 1.63
Construction of human activity-based phosphorylation networks. Mol Syst Biol (2013) 1.59
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proc Natl Acad Sci U S A (2006) 1.59
Spatiotemporal analysis of differential Akt regulation in plasma membrane microdomains. Mol Biol Cell (2008) 1.57
C-reactive protein (CRP) gene polymorphisms, CRP levels and risk of incident essential hypertension: findings from an observational cohort of Han Chinese. Hypertens Res (2012) 1.54
Reading dynamic kinase activity in living cells for high-throughput screening. ACS Chem Biol (2006) 1.54
Mobilization of mesenchymal stem cells by granulocyte colony-stimulating factor in rats with acute myocardial infarction. Cardiovasc Drugs Ther (2008) 1.53
MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells. J Biol Chem (2011) 1.52
Effect of remote ischaemic preconditioning on renal protection in patients undergoing laparoscopic partial nephrectomy: a 'blinded' randomised controlled trial. BJU Int (2013) 1.51
Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. Genes Dev (2008) 1.51
Visualization of PKA activity in plasma membrane microdomains. Mol Biosyst (2010) 1.51
Diagnostic accuracy and safety of CT-guided fine needle aspiration biopsy in cavitary pulmonary lesions. Eur J Radiol (2012) 1.50
Cytotoxicity of local anesthetics in human neuronal cells. Anesth Analg (2009) 1.45
How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension. Am J Physiol Heart Circ Physiol (2011) 1.43
Downregulation of miR-195 correlates with lymph node metastasis and poor prognosis in colorectal cancer. Med Oncol (2011) 1.42
Creation of nanostructures with poly(methyl methacrylate)-mediated nanotransfer printing. J Am Chem Soc (2008) 1.41
Localizer: fast, accurate, open-source, and modular software package for superresolution microscopy. J Biomed Opt (2012) 1.41
Defining healthy aging in older dogs and differentiating healthy aging from disease. J Am Vet Med Assoc (2015) 1.40
Common physical and functional changes associated with aging in dogs. J Am Vet Med Assoc (2015) 1.40
Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia. Am J Physiol Endocrinol Metab (2011) 1.39
Ca2+-sensing transgenic mice: postsynaptic signaling in smooth muscle. J Biol Chem (2004) 1.39
Widely accessible method for superresolution fluorescence imaging of living systems. Proc Natl Acad Sci U S A (2012) 1.39
PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains. Proc Natl Acad Sci U S A (2011) 1.39
DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. J Biol Chem (2007) 1.37
Identification of chemokines important for leukocyte recruitment to the human endometrium at the times of embryo implantation and menstruation. J Clin Endocrinol Metab (2004) 1.37
Surface enhanced Raman spectroscopy on a flat graphene surface. Proc Natl Acad Sci U S A (2012) 1.36
How does salt retention raise blood pressure? Am J Physiol Regul Integr Comp Physiol (2006) 1.36
Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit. Nat Chem Biol (2010) 1.35
Half-time image reconstruction in thermoacoustic tomography. IEEE Trans Med Imaging (2005) 1.34
Signal propagation from membrane messengers to nuclear effectors revealed by reporters of phosphoinositide dynamics and Akt activity. Proc Natl Acad Sci U S A (2005) 1.34
RNPC1 modulates the RNA-binding activity of, and cooperates with, HuR to regulate p21 mRNA stability. Nucleic Acids Res (2010) 1.34
Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. J Biol Chem (2011) 1.33
L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol Cell (2011) 1.32
Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell (2008) 1.32
Dynamics of protein kinase A signaling at the membrane, in the cytosol, and in the nucleus of neurons in mouse brain slices. J Neurosci (2007) 1.32
The pump, the exchanger, and endogenous ouabain: signaling mechanisms that link salt retention to hypertension. Hypertension (2008) 1.32
Analyzing protein kinase dynamics in living cells with FRET reporters. Methods (2006) 1.31
Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators. Exp Hematol (2002) 1.31
Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction. Circ Res (2009) 1.31
Genome sequence of the model medicinal mushroom Ganoderma lucidum. Nat Commun (2012) 1.30
p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway. J Cell Biol (2007) 1.30
Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function. Circulation (2006) 1.30
Reporting from the field: genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems. Annu Rev Biochem (2011) 1.30
MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth. PLoS One (2012) 1.30
Risk factors influencing postoperative outcomes of major hepatic resection of hepatocellular carcinoma for patients with underlying liver diseases. World J Surg (2011) 1.29
Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive. Prog Nucleic Acid Res Mol Biol (2002) 1.29
Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria. J Biomed Sci (2002) 1.29
The spatiotemporal pattern of Src activation at lipid rafts revealed by diffusion-corrected FRET imaging. PLoS Comput Biol (2008) 1.27
Graphene: a platform for surface-enhanced Raman spectroscopy. Small (2013) 1.27
Guidelines on the diagnosis and treatment of breast cancer (2011 edition). Gland Surg (2012) 1.25
Arthroscopic prevalence of ramp lesion in 868 patients with anterior cruciate ligament injury. Am J Sports Med (2011) 1.25
MAPKs (ERK1/2, p38) and AKT can be phosphorylated by shear stress independently of platelet endothelial cell adhesion molecule-1 (CD31) in vascular endothelial cells. J Biol Chem (2005) 1.25
Surgical treatment of xanthogranulomatous cholecystitis: experience in 33 cases. Hepatobiliary Pancreat Dis Int (2007) 1.25
Molecular characterization and antimicrobial susceptibility of Salmonella isolates from infections in humans in Henan Province, China. J Clin Microbiol (2008) 1.25
Controllable synthesis of conducting polypyrrole nanostructures. J Phys Chem B (2006) 1.24
Analysis of miR-205 and miR-155 expression in the blood of breast cancer patients. Chin J Cancer Res (2013) 1.23
Correcting human mitochondrial mutations with targeted RNA import. Proc Natl Acad Sci U S A (2012) 1.23
Hepatectomy for bilateral primary hepatolithiasis: a cohort study. Ann Surg (2010) 1.23
Prevalence and characterization of human Shigella infections in Henan Province, China, in 2006. J Clin Microbiol (2010) 1.22
The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes. J Biol Chem (2007) 1.21
The epidemiological, clinical, and laboratory features of sporadic Creutzfeldt-Jakob disease patients in China: surveillance data from 2006 to 2010. PLoS One (2011) 1.21
Opaque1 encodes a myosin XI motor protein that is required for endoplasmic reticulum motility and protein body formation in maize endosperm. Plant Cell (2012) 1.21
Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP. Nat Chem Biol (2012) 1.20
The induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes. PLoS One (2011) 1.20
Visualization of JNK activity dynamics with a genetically encoded fluorescent biosensor. Proc Natl Acad Sci U S A (2010) 1.20
The role of membrane microdomains in shaping beta2-adrenergic receptor-mediated cAMP dynamics. Mol Biosyst (2009) 1.19
Visualization of Src activity at different compartments of the plasma membrane by FRET imaging. Chem Biol (2009) 1.18