Published in Genes Dev on April 14, 2014
MicroRNA biogenesis pathways in cancer. Nat Rev Cancer (2015) 2.67
Aberrant regulation and function of microRNAs in cancer. Curr Biol (2014) 1.72
The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs. PLoS Genet (2015) 1.46
A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor. Nat Genet (2017) 1.38
MicroRNA Processing and Human Cancer. J Clin Med (2015) 1.23
Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors. Cancer Cell (2015) 1.18
Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours. Nat Commun (2014) 1.12
Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway. Nature (2014) 1.04
A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis. Cancer Cell (2015) 0.97
Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma. Nature (2016) 0.96
The yin and yang of kidney development and Wilms' tumors. Genes Dev (2015) 0.95
LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans. Genes Dev (2015) 0.91
Trim25 Is an RNA-Specific Activator of Lin28a/TuT4-Mediated Uridylation. Cell Rep (2014) 0.90
The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy. Leukemia (2015) 0.85
Identification of small molecule inhibitors of Zcchc11 TUTase activity. RNA Biol (2015) 0.84
The IGF signalling pathway in Wilms tumours--a report from the ENCCA Renal Tumours Biology-driven drug development workshop. Oncotarget (2014) 0.82
A Single Let-7 MicroRNA Bypasses LIN28-Mediated Repression. Cell Rep (2015) 0.82
A role of uridylation pathway for blockade of let-7 microRNA biogenesis by Lin28B. Cancer Sci (2015) 0.81
The epigenetic landscape of renal cancer. Nat Rev Nephrol (2016) 0.81
Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations. Elife (2016) 0.80
MicroRNA expression patterns and signalling pathways in the development and progression of childhood solid tumours. Mol Cancer (2017) 0.79
The LIN28/let-7 Pathway in Cancer. Front Genet (2017) 0.79
MicroRNAs in the pathogenesis of cystic kidney disease. Curr Opin Pediatr (2015) 0.79
Dissecting Stages of Human Kidney Development and Tumorigenesis with Surface Markers Affords Simple Prospective Purification of Nephron Stem Cells. Sci Rep (2016) 0.78
The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea. Proc Natl Acad Sci U S A (2015) 0.77
Bistable switch in let-7 miRNA biogenesis pathway involving Lin28. Int J Mol Sci (2014) 0.77
Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis. J Exp Med (2016) 0.77
Lin28 and let-7 in cell metabolism and cancer. Transl Pediatr (2015) 0.76
Engineering Hematopoietic Stem Cells: Lessons from Development. Cell Stem Cell (2016) 0.76
A Rapid Induction Mechanism for Lin28a in Trophic Responses. Mol Cell (2017) 0.75
LINking microRNAs, kidney development, and Wilms tumors. Genes Dev (2014) 0.75
Re: Lin28 sustains early renal progenitors and induces Wilms tumor. J Urol (2014) 0.75
microRNA-dependent temporal gene expression in the ureteric bud epithelium during mammalian kidney development. Dev Dyn (2014) 0.75
Repair after nephron ablation reveals limitations of neonatal neonephrogenesis. JCI Insight (2017) 0.75
Preface to the column "Metabolism of Childhood Cancer". Transl Pediatr (2015) 0.75
The LIN28B/let-7 axis is a novel therapeutic pathway in multiple myeloma. Leukemia (2016) 0.75
Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis. Nat Struct Mol Biol (2017) 0.75
Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50
RAS is regulated by the let-7 microRNA family. Cell (2005) 30.24
Selective blockade of microRNA processing by Lin28. Science (2008) 14.39
The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell (1997) 12.87
Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science (2007) 12.42
The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev (2007) 10.15
Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med (2008) 8.77
Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol Cell (2008) 8.32
Recent advances in neuroblastoma. N Engl J Med (2010) 7.86
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol (2008) 7.35
Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol (2009) 7.34
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature (2008) 7.03
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA (2008) 6.86
Heterochronic mutants of the nematode Caenorhabditis elegans. Science (1984) 6.85
Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet (2009) 6.35
Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell (2008) 5.76
MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells. Cancer Res (2007) 5.25
The Lin28/let-7 axis regulates glucose metabolism. Cell (2011) 4.65
Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem (2008) 4.40
Mutation and cancer: a model for Wilms' tumor of the kidney. J Natl Cancer Inst (1972) 3.78
Testicular germ-cell tumours in a broader perspective. Nat Rev Cancer (2005) 3.75
Lin28: A microRNA regulator with a macro role. Cell (2010) 3.39
Epithelial-specific Cre/lox recombination in the developing kidney and genitourinary tract. J Am Soc Nephrol (2002) 3.28
Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell (2013) 3.08
Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2. Genes Dev (1996) 3.01
A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature (2009) 2.88
Trans-filter induction of tubules in mouse metanephrogenic mesenchyme. Exp Cell Res (1956) 2.77
Revised International Society of Paediatric Oncology (SIOP) working classification of renal tumors of childhood. Med Pediatr Oncol (2002) 2.76
Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nat Genet (2010) 2.72
A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Nature (2013) 2.34
Lin28: primal regulator of growth and metabolism in stem cells. Cell Stem Cell (2013) 2.27
Wilms' tumour: connecting tumorigenesis and organ development in the kidney. Nat Rev Cancer (2005) 2.19
Generation of a germ cell-specific mouse transgenic Cre line, Vasa-Cre. Genesis (2007) 2.08
Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene. Nat Rev Cancer (2011) 2.02
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. Nat Genet (2012) 1.96
Cessation of renal morphogenesis in mice. Dev Biol (2007) 1.94
Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. Nat Genet (2012) 1.74
Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and Cavalieri principle. Lab Invest (1991) 1.72
let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts. J Biol Chem (2009) 1.65
Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun (2012) 1.35
Constitutional translocation breakpoint mapping by genome-wide paired-end sequencing identifies HACE1 as a putative Wilms tumour susceptibility gene. J Med Genet (2009) 1.35
Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network. Cell Stem Cell (2010) 1.34
Expression and interdependencies of pluripotency factors LIN28, OCT3/4, NANOG and SOX2 in human testicular germ cells and tumours of the testis. Int J Androl (2011) 1.26
Concise review: Kidney stem/progenitor cells: differentiate, sort out, or reprogram? Stem Cells (2010) 1.23
Nephron formation adopts a novel spatial topology at cessation of nephrogenesis. Dev Biol (2011) 1.21
Childhood solid tumours: a developmental disorder. Nat Rev Cancer (2005) 1.20
Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation. J Clin Invest (2010) 1.17
The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets. EMBO Mol Med (2012) 1.15
Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells (2013) 1.09
miRNA processing and human cancer: DICER1 cuts the mustard. Sci Transl Med (2011) 1.01
A genome-wide association study identifies susceptibility loci for Wilms tumor. Nat Genet (2012) 0.97
LIN28 Expression in malignant germ cell tumors downregulates let-7 and increases oncogene levels. Cancer Res (2013) 0.92
Lin28a regulates germ cell pool size and fertility. Stem Cells (2013) 0.88
Focus on embryonal malignancies. Cancer Cell (2002) 0.84
Clinical features of molecular pathology of solid tumours in childhood. Lancet Oncol (2005) 0.80
Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84
Disease-specific induced pluripotent stem cells. Cell (2008) 16.95
Selective blockade of microRNA processing by Lin28. Science (2008) 14.39
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell (2010) 14.18
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol (2009) 11.18
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet (2009) 10.54
Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med (2015) 10.12
Somatic coding mutations in human induced pluripotent stem cells. Nature (2011) 9.50
Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells. Cell Stem Cell (2009) 8.97
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell (2009) 8.62
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell (2005) 7.99
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature (2007) 7.55
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature (2011) 7.43
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell (2011) 7.41
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. Nat Biotechnol (2009) 6.76
Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet (2009) 6.35
Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature (2010) 6.06
HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell (2002) 5.71
Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell (2003) 5.71
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. Nat Genet (2010) 5.37
The promise of induced pluripotent stem cells in research and therapy. Nature (2012) 5.05
Fusion gene-negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma. J Clin Oncol (2010) 4.93
Generation of induced pluripotent stem cells from human blood. Blood (2009) 4.92
Generation of human-induced pluripotent stem cells. Nat Protoc (2008) 4.85
In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. Mayo Clin Proc (2015) 4.70
Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell (2009) 4.69
The Lin28/let-7 axis regulates glucose metabolism. Cell (2011) 4.65
Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature (2003) 4.56
Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell (2002) 4.56
Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem (2008) 4.40
A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol (2003) 4.38
Chromatin-modifying enzymes as modulators of reprogramming. Nature (2012) 4.22
BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res (2003) 4.17
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature (2009) 4.14
CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion. J Mol Histol (2004) 4.08
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature (2009) 3.93
Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts. Cell Rep (2013) 3.85
Effect of earlier initiation of antiretroviral treatment and increased treatment coverage on HIV-related mortality in China: a national observational cohort study. Lancet Infect Dis (2011) 3.85
Glycogen storage diseases presenting as hypertrophic cardiomyopathy. N Engl J Med (2005) 3.71
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature (2010) 3.39
Lin28: A microRNA regulator with a macro role. Cell (2010) 3.39
Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology (2010) 3.36
Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy. J Clin Invest (2002) 3.33
Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc Natl Acad Sci U S A (2004) 3.31
PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell (2012) 3.28
Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells. Nat Biotechnol (2011) 3.25
Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat Struct Mol Biol (2008) 3.18
Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes (2009) 3.17
Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. Cell Stem Cell (2010) 3.08
Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell (2013) 3.08
Concentration-QT relationships play a key role in the evaluation of proarrhythmic risk during regulatory review. J Clin Pharmacol (2008) 3.06
Broader implications of defining standards for the pluripotency of iPSCs. Cell Stem Cell (2009) 3.03
Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome. Nature (2013) 3.02
Biomechanical forces promote embryonic haematopoiesis. Nature (2009) 2.99
Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science (2012) 2.98
Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell (2011) 2.98
Reprogramming of T cells from human peripheral blood. Cell Stem Cell (2010) 2.93
Midline carcinoma of children and young adults with NUT rearrangement. J Clin Oncol (2004) 2.92
A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature (2009) 2.88
Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice. PLoS One (2011) 2.86
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development (2011) 2.82
A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells. PLoS Genet (2009) 2.78
High-efficiency RNA interference in human embryonic stem cells. Stem Cells (2005) 2.76
Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nat Genet (2010) 2.72
Impact of pharmacometric analyses on new drug approval and labelling decisions: a review of 198 submissions between 2000 and 2008. Clin Pharmacokinet (2011) 2.67
Subcellular dynamics of protein kinase A activity visualized by FRET-based reporters. Biochem Biophys Res Commun (2006) 2.66
Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat Cell Biol (2011) 2.65
Analysis of thrombocyte development in CD41-GFP transgenic zebrafish. Blood (2005) 2.65
New ISSCR guidelines underscore major principles for responsible translational stem cell research. Cell Stem Cell (2008) 2.61
Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells (2009) 2.59
Induced pluripotent stem cells--opportunities for disease modelling and drug discovery. Nat Rev Drug Discov (2011) 2.58
Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera. Cell Stem Cell (2007) 2.56
PNPASE regulates RNA import into mitochondria. Cell (2010) 2.54
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell (2011) 2.53
Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle. Nat Med (2004) 2.52
DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome. J Med Genet (2011) 2.52
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat Med (2010) 2.50
Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature (2011) 2.42
beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. J Biol Chem (2007) 2.42
Immediate nephrectomy versus preoperative chemotherapy in the management of non-metastatic Wilms' tumour: results of a randomised trial (UKW3) by the UK Children's Cancer Study Group. Eur J Cancer (2006) 2.39
Coupled ferredoxin and crotonyl coenzyme A (CoA) reduction with NADH catalyzed by the butyryl-CoA dehydrogenase/Etf complex from Clostridium kluyveri. J Bacteriol (2007) 2.38
LIF/STAT3 signaling fails to maintain self-renewal of human embryonic stem cells. Stem Cells (2004) 2.37
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature (2010) 2.36
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A (2008) 2.34
Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells. Nature (2012) 2.32
PAX3/FOXO1 fusion gene status is the key prognostic molecular marker in rhabdomyosarcoma and significantly improves current risk stratification. J Clin Oncol (2012) 2.29
Nephron sparing surgery (NSS) for unilateral wilms tumor (UWT): the SIOP 2001 experience. Pediatr Blood Cancer (2014) 2.28
Embryonic stem cell-derived hematopoietic stem cells. Proc Natl Acad Sci U S A (2005) 2.28
Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy. Circulation (2003) 2.28
Lin28: primal regulator of growth and metabolism in stem cells. Cell Stem Cell (2013) 2.27
Constitutional 11p15 abnormalities, including heritable imprinting center mutations, cause nonsyndromic Wilms tumor. Nat Genet (2008) 2.24
Optimizing the fMRI data-processing pipeline using prediction and reproducibility performance metrics: I. A preliminary group analysis. Neuroimage (2004) 2.19
BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway. Cell Stem Cell (2008) 2.17
cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature (2003) 2.16