Published in J Am Vet Med Assoc on January 01, 2015
Age-related changes of the eye in dogs. J Am Vet Med Assoc (2015) 0.96
Exceptional longevity and potential determinants of successful ageing in a cohort of 39 Labrador retrievers: results of a prospective longitudinal study. Acta Vet Scand (2016) 0.81
The authors respond. J Am Vet Med Assoc (2015) 0.75
Results of Screening of Apparently Healthy Senior and Geriatric Dogs. J Vet Intern Med (2016) 0.75
The Companion Dog as a Model for the Longevity Dividend. Cold Spring Harb Perspect Med (2016) 0.75
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med (2015) 10.12
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell (2009) 8.62
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab (2008) 6.22
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature (2012) 5.00
A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. J Cell Biol (2003) 4.38
CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion. J Mol Histol (2004) 4.08
Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts. Cell Rep (2013) 3.85
Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc Natl Acad Sci U S A (2004) 3.31
PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell (2012) 3.28
AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22
Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes (2009) 3.17
Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science (2012) 2.98
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci U S A (2003) 2.82
Metformin improves healthspan and lifespan in mice. Nat Commun (2013) 2.68
Subcellular dynamics of protein kinase A activity visualized by FRET-based reporters. Biochem Biophys Res Commun (2006) 2.66
PNPASE regulates RNA import into mitochondria. Cell (2010) 2.54
Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell (2006) 2.54
Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle. Nat Med (2004) 2.52
Calorie restriction in rhesus monkeys. Exp Gerontol (2003) 2.52
beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. J Biol Chem (2007) 2.42
Coupled ferredoxin and crotonyl coenzyme A (CoA) reduction with NADH catalyzed by the butyryl-CoA dehydrogenase/Etf complex from Clostridium kluyveri. J Bacteriol (2007) 2.38
Aging in rhesus monkeys: relevance to human health interventions. Science (2004) 2.37
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A (2008) 2.34
Biomarkers of caloric restriction may predict longevity in humans. Science (2002) 2.32
Optimizing the fMRI data-processing pipeline using prediction and reproducibility performance metrics: I. A preliminary group analysis. Neuroimage (2004) 2.19
A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults. Am J Clin Nutr (2007) 2.16
The anterior cruciate ligament remnant: to leave it or not? Arthroscopy (2013) 2.13
Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates. Proc Natl Acad Sci U S A (2006) 2.03
Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. J Biol Chem (2009) 2.02
Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell (2006) 2.01
Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy. Clin Cancer Res (2006) 1.97
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A (2008) 1.97
Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J Biol Chem (2004) 1.96
Chemical rescue of a mutant enzyme in living cells. Science (2006) 1.95
Genetically encodable fluorescent biosensors for tracking signaling dynamics in living cells. Chem Rev (2011) 1.88
Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev (2014) 1.87
Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc Natl Acad Sci U S A (2004) 1.86
Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity. Am J Physiol Endocrinol Metab (2008) 1.84
Cognitive impairment following high fat diet consumption is associated with brain inflammation. J Neuroimmunol (2009) 1.82
Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet. Neurobiol Dis (2009) 1.80
Can graphene be used as a substrate for Raman enhancement? Nano Lett (2010) 1.78
Involvement of Notch signaling in hippocampal synaptic plasticity. Proc Natl Acad Sci U S A (2004) 1.77
Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure. J Biol Chem (2009) 1.71
Emergence of a new multidrug-resistant serotype X variant in an epidemic clone of Shigella flexneri. J Clin Microbiol (2009) 1.71
The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells. Immunity (2002) 1.70
Social network and other correlates of HIV testing: findings from male sex workers and other MSM in Shanghai, China. AIDS Behav (2012) 1.69
Age and gender effects on microglia and astrocyte numbers in brains of mice. Brain Res (2002) 1.67
Imaging of cAMP levels and protein kinase A activity reveals that retinal waves drive oscillations in second-messenger cascades. J Neurosci (2006) 1.67
GJB2 mutation spectrum in 2,063 Chinese patients with nonsyndromic hearing impairment. J Transl Med (2009) 1.66
Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation. Endocrinology (2010) 1.65
Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization. Exp Gerontol (2004) 1.64
Quantitative analysis of HBV DNA level and HBeAg titer in hepatitis B surface antigen positive mothers and their babies: HBeAg passage through the placenta and the rate of decay in babies. J Med Virol (2003) 1.63
Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proc Natl Acad Sci U S A (2005) 1.61
Effects of long-term diet restriction on aging and longevity in primates remain uncertain. J Gerontol A Biol Sci Med Sci (2004) 1.60
Construction of human activity-based phosphorylation networks. Mol Syst Biol (2013) 1.59
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proc Natl Acad Sci U S A (2006) 1.59
Spatiotemporal analysis of differential Akt regulation in plasma membrane microdomains. Mol Biol Cell (2008) 1.57
Age-associated learning and memory deficits in two mouse versions of the Stone T-maze. Neurobiol Aging (2012) 1.55
C-reactive protein (CRP) gene polymorphisms, CRP levels and risk of incident essential hypertension: findings from an observational cohort of Han Chinese. Hypertens Res (2012) 1.54
Reading dynamic kinase activity in living cells for high-throughput screening. ACS Chem Biol (2006) 1.54
Mobilization of mesenchymal stem cells by granulocyte colony-stimulating factor in rats with acute myocardial infarction. Cardiovasc Drugs Ther (2008) 1.53
MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells. J Biol Chem (2011) 1.52
Effect of remote ischaemic preconditioning on renal protection in patients undergoing laparoscopic partial nephrectomy: a 'blinded' randomised controlled trial. BJU Int (2013) 1.51
Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity. Genes Dev (2008) 1.51
Visualization of PKA activity in plasma membrane microdomains. Mol Biosyst (2010) 1.51
Diagnostic accuracy and safety of CT-guided fine needle aspiration biopsy in cavitary pulmonary lesions. Eur J Radiol (2012) 1.50
Evaluation of a routine diagnostic fecal panel for dogs with diarrhea. J Am Vet Med Assoc (2002) 1.50
Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice. Neurobiol Aging (2004) 1.46
Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging. Cell Metab (2013) 1.45
Cytotoxicity of local anesthetics in human neuronal cells. Anesth Analg (2009) 1.45
High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling. J Neurochem (2010) 1.43
Effects of caloric restriction on inflammatory periodontal disease. Nutrition (2008) 1.43
How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension. Am J Physiol Heart Circ Physiol (2011) 1.43
Downregulation of miR-195 correlates with lymph node metastasis and poor prognosis in colorectal cancer. Med Oncol (2011) 1.42
Creation of nanostructures with poly(methyl methacrylate)-mediated nanotransfer printing. J Am Chem Soc (2008) 1.41
Localizer: fast, accurate, open-source, and modular software package for superresolution microscopy. J Biomed Opt (2012) 1.41
Common physical and functional changes associated with aging in dogs. J Am Vet Med Assoc (2015) 1.40
Ca2+-sensing transgenic mice: postsynaptic signaling in smooth muscle. J Biol Chem (2004) 1.39
Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia. Am J Physiol Endocrinol Metab (2011) 1.39
Widely accessible method for superresolution fluorescence imaging of living systems. Proc Natl Acad Sci U S A (2012) 1.39
PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains. Proc Natl Acad Sci U S A (2011) 1.39
Effect of age and caloric restriction on circadian adrenal steroid rhythms in rhesus macaques. Neurobiol Aging (2007) 1.39
DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. J Biol Chem (2007) 1.37
Identification of chemokines important for leukocyte recruitment to the human endometrium at the times of embryo implantation and menstruation. J Clin Endocrinol Metab (2004) 1.37
Surface enhanced Raman spectroscopy on a flat graphene surface. Proc Natl Acad Sci U S A (2012) 1.36
How does salt retention raise blood pressure? Am J Physiol Regul Integr Comp Physiol (2006) 1.36
Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit. Nat Chem Biol (2010) 1.35
Half-time image reconstruction in thermoacoustic tomography. IEEE Trans Med Imaging (2005) 1.34
Signal propagation from membrane messengers to nuclear effectors revealed by reporters of phosphoinositide dynamics and Akt activity. Proc Natl Acad Sci U S A (2005) 1.34
RNPC1 modulates the RNA-binding activity of, and cooperates with, HuR to regulate p21 mRNA stability. Nucleic Acids Res (2010) 1.34