Published in J Biol Chem on May 11, 2012
hnRNP K Is a Haploinsufficient Tumor Suppressor that Regulates Proliferation and Differentiation Programs in Hematologic Malignancies. Cancer Cell (2015) 0.85
Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic acid binding proteins. J Immunol (2014) 0.82
Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation. Nucleic Acids Res (2014) 0.81
Proteomic-based approach to gain insight into reprogramming of THP-1 cells exposed to Leishmania donovani over an early temporal window. Infect Immun (2015) 0.80
Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis. Cell Death Differ (2013) 0.79
Heterogeneous nuclear ribonucleoprotein K supports vesicular stomatitis virus replication by regulating cell survival and cellular gene expression. J Virol (2013) 0.79
Type 1 diabetes cadaveric human pancreata exhibit a unique exocrine tissue proteomic profile. Proteomics (2016) 0.78
Methylthioadenosine (MTA) Regulates Liver Cells Proteome and Methylproteome: Implications in Liver Biology and Disease. Mol Cell Proteomics (2016) 0.78
Reduced serpinB9-mediated caspase-1 inhibition can contribute to autoinflammatory disease. Oncotarget (2016) 0.75
Granzyme M: behind enemy lines. Cell Death Differ (2014) 0.75
Cytotoxic T lymphocytes: all roads lead to death. Nat Rev Immunol (2002) 3.01
Death by a thousand cuts: granzyme pathways of programmed cell death. Annu Rev Immunol (2008) 2.97
hnRNP K: one protein multiple processes. Bioessays (2004) 2.96
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Nat Immunol (2003) 2.48
Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death. Cell (2008) 2.04
Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs. Mol Cell Proteomics (2008) 2.01
Inactivation of hnRNP K by expanded intronic AUUCU repeat induces apoptosis via translocation of PKCdelta to mitochondria in spinocerebellar ataxia 10. PLoS Genet (2010) 1.76
Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer. Br J Cancer (2006) 1.65
Heat shock protein 75 (TRAP1) antagonizes reactive oxygen species generation and protects cells from granzyme M-mediated apoptosis. J Biol Chem (2007) 1.64
Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis. Immunity (2005) 1.55
Heterogeneous nuclear ribonuclear protein K interacts with the enterovirus 71 5' untranslated region and participates in virus replication. J Gen Virol (2008) 1.39
Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B. Immunol Rev (2010) 1.29
Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks. J Biol Chem (2001) 1.25
HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Mol Cell Biol (2002) 1.25
Complementary positional proteomics for screening substrates of endo- and exoproteases. Nat Methods (2010) 1.25
Orphan granzymes find a home. Immunol Rev (2010) 1.05
Heterogeneous nuclear ribonucleoprotein K represses the production of pro-apoptotic Bcl-xS splice isoform. J Biol Chem (2009) 1.04
Increased expression of the heterogeneous nuclear ribonucleoprotein K in pancreatic cancer and its association with the mutant p53. Int J Cancer (2010) 1.04
Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death. J Biol Chem (2007) 1.04
Loss-of-function screening by randomized intracellular antibodies: identification of hnRNP-K as a potential target for metastasis. Proc Natl Acad Sci U S A (2007) 1.03
Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70. EMBO Rep (2006) 1.03
Heterogeneous ribonucleoprotein K is a marker of oral leukoplakia and correlates with poor prognosis of squamous cell carcinoma. Int J Cancer (2009) 1.03
Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells. Cell Death Differ (2006) 1.02
Cooperative binding of the hnRNP K three KH domains to mRNA targets. FEBS Lett (2004) 1.01
Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity. Mol Immunol (2008) 1.01
The antiapoptotic protein, FLIP, is regulated by heterogeneous nuclear ribonucleoprotein K and correlates with poor overall survival of nasopharyngeal carcinoma patients. Cell Death Differ (2010) 1.01
Granzyme M mediates a novel form of perforin-dependent cell death. J Biol Chem (2004) 1.01
NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network. J Immunol (2008) 1.00
The substrate specificity profile of human granzyme A. Biol Chem (2010) 0.98
Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A. J Biol Chem (2008) 0.97
Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program. Blood (2007) 0.96
Host heterogeneous ribonucleoprotein K (hnRNP K) as a potential target to suppress hepatitis B virus replication. PLoS Med (2005) 0.96
Heterogeneous ribonucleoprotein k and thymidine phosphorylase are independent prognostic and therapeutic markers for nasopharyngeal carcinoma. Clin Cancer Res (2008) 0.96
Heterogeneous nuclear ribonucleoprotein K: altered pattern of expression associated with diagnosis and prognosis of prostate cancer. Br J Cancer (2009) 0.96
Evidence for heterogeneous nuclear ribonucleoprotein K overexpression in oral squamous cell carcinoma. Br J Cancer (2007) 0.95
Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage. Mol Immunol (2007) 0.92
Probing the efficiency of proteolytic events by positional proteomics. Mol Cell Proteomics (2010) 0.91
Protein kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction. Exp Cell Res (2009) 0.90
The heterogeneous nuclear ribonucleoprotein K is important for Herpes simplex virus-1 propagation. FEBS Lett (2010) 0.89
Valosin-containing protein cleavage by granzyme K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target tumor cells. J Immunol (2010) 0.88
Ignition of p53 bomb sensitizes tumor cells to granzyme K-mediated cytolysis. J Immunol (2009) 0.87
FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade. Cell Death Differ (2011) 0.85
Human and mouse granzyme M display divergent and species-specific substrate specificities. Biochem J (2011) 0.84
Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing. J Biol Chem (2008) 0.83
Proteomic profiling of proteases: tools for granzyme degradomics. Expert Rev Proteomics (2010) 0.80
Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem (2006) 3.20
Proteomic profiling of the human failing heart after left ventricular assist device support. J Heart Lung Transplant (2011) 1.47
CTGF inhibits BMP-7 signaling in diabetic nephropathy. J Am Soc Nephrol (2008) 1.19
NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network. J Immunol (2008) 1.00
Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A. J Biol Chem (2008) 0.97
Accessory cells of the microenvironment protect multiple myeloma from T-cell cytotoxicity through cell adhesion-mediated immune resistance. Clin Cancer Res (2013) 0.96
Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol. Blood (2004) 0.90
Biology of granzyme M: a serine protease with unique features. Crit Rev Immunol (2009) 0.88
Identification by phage display of single-domain antibody fragments specific for the ODD domain in hypoxia-inducible factor 1alpha. Lab Invest (2006) 0.87
Cleavage of von Willebrand factor by granzyme M destroys its factor VIII binding capacity. PLoS One (2011) 0.87
Intracellular serine protease inhibitor SERPINB4 inhibits granzyme M-induced cell death. PLoS One (2011) 0.86
Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice. J Lipid Res (2005) 0.86
Granzyme K synergistically potentiates LPS-induced cytokine responses in human monocytes. Proc Natl Acad Sci U S A (2014) 0.86
Hemizygous deletion of CTGF/CCN2 does not suffice to prevent fibrosis of the severely injured kidney. Matrix Biol (2012) 0.85
Human and mouse granzyme M display divergent and species-specific substrate specificities. Biochem J (2011) 0.84
Cleavage of Notch1 by granzyme B disables its transcriptional activity. Biochem J (2011) 0.83
Regulation of vitamin D receptor function in MEN1-related parathyroid adenomas. Mol Cell Endocrinol (2009) 0.83
Cell death-independent functions of granzymes: hit viruses where it hurts. Rev Med Virol (2011) 0.83
The cytotoxic protease granzyme M is expressed by lymphocytes of both the innate and adaptive immune system. Mol Immunol (2009) 0.83
Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71. J Immunol (2010) 0.82
Downregulation of SERPINB13 expression in head and neck squamous cell carcinomas associates with poor clinical outcome. Int J Cancer (2009) 0.81
The granzyme B inhibitor proteinase inhibitor 9 (PI9) is expressed by human mast cells. Eur J Immunol (2005) 0.80
Proteomic profiling of proteases: tools for granzyme degradomics. Expert Rev Proteomics (2010) 0.80
Post-transcriptional regulation of α-1-antichymotrypsin by microRNA-137 in chronic heart failure and mechanical support. Circ Heart Fail (2013) 0.80
Granzyme M cannot induce cell death via cleavage of mouse FADD. Apoptosis (2013) 0.79
Urinary connective tissue growth factor is associated with human renal allograft fibrogenesis. Transplantation (2013) 0.77
Compensatory growth of congenital solitary kidneys in pigs reflects increased nephron numbers rather than hypertrophy. PLoS One (2012) 0.77
Phospholipid vesicles interfere with the binding of antibody fragments to the light chain of factor VIII. Thromb Haemost (2005) 0.76
Dendrimer-based macromolecular conjugate for the kidney-directed delivery of a multitargeted sunitinib analogue. Macromol Biosci (2011) 0.75
Cytosolic beta-glycosidases for activation of glycoside prodrugs of daunorubicin. Biochem Pharmacol (2003) 0.75
Serine protease inhibitor 8 is a novel immunohistochemical marker for neuroendocrine tumors of the pancreas. Pancreas (2009) 0.75