Published in Proc Natl Acad Sci U S A on May 04, 2007
Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) promotes tumor metastasis by induction of genes involved in extracellular matrix, cell movement, and angiogenesis. J Biol Chem (2013) 1.03
Heterogeneous nuclear ribonucleoprotein K is a novel regulator of androgen receptor translation. Cancer Res (2009) 1.02
An adaptor role for cytoplasmic Sam68 in modulating Src activity during cell polarization. Mol Cell Biol (2009) 0.99
Heterogeneous nuclear ribonucleoprotein K: altered pattern of expression associated with diagnosis and prognosis of prostate cancer. Br J Cancer (2009) 0.96
Identification and functional characterization of nuclear mortalin in human carcinogenesis. J Biol Chem (2014) 0.94
Comprehensive analysis of the palindromic motif TCTCGCGAGA: a regulatory element of the HNRNPK promoter. DNA Res (2010) 0.90
All human granzymes target hnRNP K that is essential for tumor cell viability. J Biol Chem (2012) 0.90
Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes. J Cell Biol (2015) 0.90
Identification of a Sam68 ribonucleoprotein complex regulated by epidermal growth factor. J Biol Chem (2009) 0.87
Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation. Nucleic Acids Res (2014) 0.81
EtpE Binding to DNase X Induces Ehrlichial Entry via CD147 and hnRNP-K Recruitment, Followed by Mobilization of N-WASP and Actin. MBio (2015) 0.78
Meta-analysis and gene set analysis of archived microarrays suggest implication of the spliceosome in metastatic and hypoxic phenotypes. PLoS One (2014) 0.76
Bortezomib inhibits Burkitt's lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression. Oncotarget (2015) 0.76
Functional Characterisation of Anticancer Activity in the Aqueous Extract of Helicteres angustifolia L. Roots. PLoS One (2016) 0.76
DC - SIGNR by influencing the lncRNA HNRNPKP2 upregulates the expression of CXCR4 in gastric cancer liver metastasis. Mol Cancer (2017) 0.76
Single domain antibodies for the knockdown of cytosolic and nuclear proteins. Protein Sci (2017) 0.75
Cytoplasmic Accumulation of Heterogeneous Nuclear Ribonucleoprotein K Strongly Promotes Tumor Invasion in Renal Cell Carcinoma Cells. PLoS One (2015) 0.75
Embelin inhibits TNF-α converting enzyme and cancer cell metastasis: molecular dynamics and experimental evidence. BMC Cancer (2014) 0.75
Role and molecular mechanism of heterogeneous nuclear ribonucleoprotein K in tumor development and progression. Biomed Rep (2016) 0.75
Regulation of PLK1 through competition between hnRNPK, miR-149-3p and miR-193b-5p. Cell Death Differ (2017) 0.75
Rho GTPases in cell biology. Nature (2002) 22.81
A molecular signature of metastasis in primary solid tumors. Nat Genet (2002) 21.36
Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature (2000) 15.53
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A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res (1987) 7.43
Naturally occurring antibodies devoid of light chains. Nature (1993) 7.35
Metastasis: a question of life or death. Nat Rev Cancer (2006) 6.26
New signals from the invasive front. Nature (2006) 5.51
hnRNP complexes: composition, structure, and function. Curr Opin Cell Biol (1999) 5.27
Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease. Nat Genet (2001) 4.48
The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein. EMBO J (1997) 3.46
hnRNP K: one protein multiple processes. Bioessays (2004) 2.96
Axis of evil: molecular mechanisms of cancer metastasis. Oncogene (2003) 2.81
RNA and RNA binding proteins participate in early stages of cell spreading through spreading initiation centers. Cell (2004) 2.57
Diverse molecular interactions of the hnRNP K protein. FEBS Lett (1997) 2.35
Single-domain antibody fragments with high conformational stability. Protein Sci (2002) 2.31
ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation. Nat Cell Biol (2001) 2.14
Immunomodulation of enzyme function in plants by single-domain antibody fragments. Nat Biotechnol (2002) 1.88
The roles of heterogeneous nuclear ribonucleoproteins (hnRNP) in RNA metabolism. Bioessays (1996) 1.63
The actin cytoskeleton in normal and pathological cell motility. Int J Biochem Cell Biol (2004) 1.53
Tumor invasion as dysregulated cell motility. Semin Cancer Biol (2001) 1.31
Antibody repertoire development in camelids. Dev Comp Immunol (2006) 1.23
Nuclear shift of hnRNP K protein in neoplasms and other states of enhanced cell proliferation. Br J Cancer (2003) 1.19
Antigen specificity and high affinity binding provided by one single loop of a camel single-domain antibody. J Biol Chem (2001) 1.15
Landscape of the hnRNP K protein-protein interactome. Proteomics (2006) 1.12
Biology of colorectal liver metastases: A review. J Surg Oncol (2006) 1.11
Intracellular antibodies and challenges facing their use as therapeutic agents. Trends Mol Med (2003) 1.09
Identification of genes involved in cell invasion by using a library of randomized hybrid ribozymes. Proc Natl Acad Sci U S A (2003) 1.06
Inhibition of PKA blocks fibroblast migration in response to growth factors. Exp Cell Res (2001) 1.05
Intracellular antibodies as specific reagents for functional ablation: future therapeutic molecules. Curr Mol Med (2004) 0.97
Compartmentalization of hnRNP-K during cell cycle progression and its interaction with calponin in the cytoplasm. J Cell Biochem (2005) 0.90
PDGF regulates the actin cytoskeleton through hnRNP-K-mediated activation of the ubiquitin E3-ligase MIR. EMBO J (2006) 0.88
Rapid chemokinetic movement and the invasive potential of lung cancer cells; a functional molecular study. BMC Cancer (2006) 0.87
The role of tumor metastasis suppressors in cancers of breast and prostate. Front Biosci (2006) 0.83
Identification of genes responsible for cell migration by a library of randomized ribozymes. Cancer Res (2003) 0.81
A synthetic camel anti-lysozyme peptide antibody (peptibody) with flexible loop structure identified by high-resolution affinity mass spectrometry. Chemistry (2006) 0.81
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature (2003) 9.79
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol (2005) 9.17
U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells. Nat Biotechnol (2002) 6.66
Retracted Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature (2004) 3.12
A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell (2004) 2.95
Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells. Nucleic Acids Res (2003) 2.31
Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell Cycle (2009) 2.31
Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs. EMBO Rep (2003) 2.16
Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference. Oncogene (2004) 1.76
Retracted Identification of genes by hybrid ribozymes that couple cleavage activity with the unwinding activity of an endogenous RNA helicase. EMBO Rep (2002) 1.72
Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res (2005) 1.65
A20 is a negative regulator of IFN regulatory factor 3 signaling. J Immunol (2005) 1.63
Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75. FEBS Lett (2002) 1.63
An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where? Cell Stress Chaperones (2002) 1.61
Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres. J Biol Chem (2007) 1.55
The Hydrolysis of RNA: From Theoretical Calculations to the Hammerhead Ribozyme-Mediated Cleavage of RNA. Chem Rev (1998) 1.49
Retracted Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cells. Nature (2003) 1.44
Optimization of an siRNA-expression system with an improved hairpin and its significant suppressive effects in mammalian cells. J Gene Med (2004) 1.43
Selective killing of cancer cells by Ashwagandha leaf extract and its component Withanone involves ROS signaling. PLoS One (2010) 1.40
Three faces of mortalin: a housekeeper, guardian and killer. Exp Gerontol (2006) 1.39
Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival. J Immunol (2006) 1.35
On the brotherhood of the mitochondrial chaperones mortalin and heat shock protein 60. Cell Stress Chaperones (2006) 1.33
Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides. J Biol Chem (2005) 1.33
Selective killing of cancer cells by leaf extract of Ashwagandha: identification of a tumor-inhibitory factor and the first molecular insights to its effect. Clin Cancer Res (2007) 1.32
Sequence-specific interference by small RNAs derived from adenovirus VAI RNA. FEBS Lett (2006) 1.31
Comparison of the suppressive effects of antisense oligonucleotides and siRNAs directed against the same targets in mammalian cells. Antisense Nucleic Acid Drug Dev (2003) 1.28
Functional analysis of microRNAs during the retinoic acid-induced neuronal differentiation of human NT2 cells. Nucleic Acids Res Suppl (2003) 1.27
Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo. Mol Ther (2004) 1.26
Effects on RNAi of the tight structure, sequence and position of the targeted region. Nucleic Acids Res (2004) 1.26
p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells. Cancer Res (2005) 1.25
Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-beta. Oncogene (2005) 1.25
Control of siRNA expression using the Cre-loxP recombination system. Nucleic Acids Res (2004) 1.24
Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease. Mol Cell Proteomics (2006) 1.21
BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis. Endocrinology (2005) 1.19
Exploration of human miRNA target genes in neuronal differentiation. Nucleic Acids Symp Ser (Oxf) (2005) 1.18
An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease. EMBO J (2004) 1.18
Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. Genes Dev (2002) 1.15
Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3'-ends of siRNAs. Antisense Nucleic Acid Drug Dev (2002) 1.15
Retracted siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells. Nucleic Acids Res (2003) 1.14
Essential role of ATF-1 in induction of NOX1, a catalytic subunit of NADPH oxidase: involvement of mitochondrial respiratory chain. Biochem J (2005) 1.13
Involvement of template-activating factor I/SET in transcription of adenovirus early genes as a positive-acting factor. J Virol (2006) 1.12
Overexpressed mortalin (mot-2)/mthsp70/GRP75 and hTERT cooperate to extend the in vitro lifespan of human fibroblasts. Exp Cell Res (2003) 1.12
Selective killing of cancer cells by leaf extract of Ashwagandha: components, activity and pathway analyses. Cancer Lett (2008) 1.12
MicroRNA-196 inhibits HOXB8 expression in myeloid differentiation of HL60 cells. Nucleic Acids Symp Ser (Oxf) (2004) 1.10
Effective inhibition of cell growth and invasion of melanoma by combined suppression of BRAF (V599E) and Skp2 with lentiviral RNAi. Int J Cancer (2006) 1.09
Retracted Identification of genes that function in the TNF-alpha-mediated apoptotic pathway using randomized hybrid ribozyme libraries. Nat Biotechnol (2002) 1.08
Activation of the CKI-CDK-Rb-E2F pathway in full genome hepatitis C virus-expressing cells. J Biol Chem (2004) 1.07
Myosin motor Myo1c and its receptor NEMO/IKK-gamma promote TNF-alpha-induced serine307 phosphorylation of IRS-1. J Cell Biol (2006) 1.07
Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease. Neurochem Int (2005) 1.06
Identification of genes involved in cell invasion by using a library of randomized hybrid ribozymes. Proc Natl Acad Sci U S A (2003) 1.06
Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60. Biochem J (2005) 1.06
Notch1 oncoprotein antagonizes TGF-beta/Smad-mediated cell growth suppression via sequestration of coactivator p300. Cancer Sci (2005) 1.05
Single small-interfering RNA expression vector for silencing multiple transforming growth factor-beta pathway components. Nucleic Acids Res (2005) 1.04
Strategies for generation of an siRNA expression library directed against the human genome. Oligonucleotides (2003) 1.04
Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin. Int J Cancer (2011) 1.03
Identification of a network involved in thapsigargin-induced apoptosis using a library of small interfering RNA expression vectors. J Biol Chem (2004) 1.03
Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) promotes tumor metastasis by induction of genes involved in extracellular matrix, cell movement, and angiogenesis. J Biol Chem (2013) 1.03
siRNA induced transcriptional gene silencing in mammalian cells. Cell Cycle (2005) 1.02
Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration, and differentiation of glioblastoma cells: combinational approach for enhanced differentiation. Cancer Sci (2009) 1.02
A direct and efficient synthesis method for dumbell-shaped linear DNA using PCR in vitro. Nucleic Acids Res Suppl (2003) 1.01
Retraction: Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cells. Nature (2003) 1.00
Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells. PLoS One (2011) 1.00
CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. J Biol Chem (2002) 1.00
MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region. Nucleic Acids Res (2011) 0.99
A functional gene discovery in the Fas-mediated pathway to apoptosis by analysis of transiently expressed randomized hybrid-ribozyme libraries. Nucleic Acids Res (2002) 0.98
Ligand-targeted delivery of therapeutic siRNA. Pharm Res (2006) 0.98
Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology. J Transl Med (2008) 0.98
Involvement of mortalin in cellular senescence from the perspective of its mitochondrial import, chaperone, and oxidative stress management functions. Ann N Y Acad Sci (2007) 0.97
Mortalin sensitizes human cancer cells to MKT-077-induced senescence. Cancer Lett (2007) 0.96
Development and application of siRNA expression vector. Nucleic Acids Res Suppl (2002) 0.96
Existence of efficient divalent metal ion-catalyzed and inefficient divalent metal ion-independent channels in reactions catalyzed by a hammerhead ribozyme. Nucleic Acids Res (2002) 0.96
NMR-based reappraisal of the coordination of a metal ion at the pro-Rp oxygen of the A9/G10.1 site in a hammerhead ribozyme. J Am Chem Soc (2004) 0.95
Vector-based in vivo RNA interference: dose- and time-dependent suppression of transgene expression. J Pharmacol Exp Ther (2003) 0.95
Identification of metastasis-related genes in a mouse model using a library of randomized ribozymes. J Biol Chem (2004) 0.95
Preincubation with the proteasome inhibitor MG-132 enhances proteasome activity via the Nrf2 transcription factor in aging human skin fibroblasts. Ann N Y Acad Sci (2006) 0.94
World of small RNAs: from ribozymes to siRNA and miRNA. Differentiation (2004) 0.94
Reduction in mortalin level by its antisense expression causes senescence-like growth arrest in human immortalized cells. J Gene Med (2004) 0.94
Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal. FEBS J (2013) 0.94
Transgenic small interfering RNA halts amyotrophic lateral sclerosis in a mouse model. J Biol Chem (2005) 0.93
Quantum dots in bio-imaging: Revolution by the small. Biochem Biophys Res Commun (2005) 0.93
Mortalin imaging in normal and cancer cells with quantum dot immuno-conjugates. Cell Res (2003) 0.93
Gene discovery by ribozyme and siRNA libraries. Nat Rev Mol Cell Biol (2005) 0.93
Ashwagandha leaf derived withanone protects normal human cells against the toxicity of methoxyacetic acid, a major industrial metabolite. PLoS One (2011) 0.93
Transcriptional gene silencing by short interfering RNAs. Curr Opin Mol Ther (2005) 0.92
Position-specific incorporation of a fluorophore-quencher pair into a single streptavidin through orthogonal four-base codon/anticodon pairs. J Am Chem Soc (2002) 0.92
Mortalin: present and prospective. Exp Gerontol (2002) 0.92
Escape from the interferon response associated with RNA interference using vectors that encode long modified hairpin-RNA. Mol Biosyst (2005) 0.92
Mortalin-MPD (mevalonate pyrophosphate decarboxylase) interactions and their role in control of cellular proliferation. Biochem Biophys Res Commun (2003) 0.92
Vectors for RNA interference. Curr Opin Mol Ther (2004) 0.91
Tumor suppression by apoptotic and anti-angiogenic effects of mortalin-targeting adeno-oncolytic virus. J Gene Med (2010) 0.90
Use of a randomized hybrid ribozyme library for identification of genes involved in muscle differentiation. J Biol Chem (2004) 0.90